scholarly journals The emerging function and clinical significance of circRNAs in Thyroid Cancer and Autoimmune Thyroid Diseases

2021 ◽  
Vol 17 (7) ◽  
pp. 1731-1741
Author(s):  
Yu Zhang ◽  
Dong-Dong Jia ◽  
Yi-Fei Zhang ◽  
Meng-Die Cheng ◽  
Wen-Xiu Zhu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Clinical Significance ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Clinical Significance of Autoantibodies to Parietal Cells in Patients with Autoimmune Thyroid Diseases

Folia Medica ◽  
2013 ◽  
Vol 55 (2) ◽  
pp. 26-32 ◽  
Author(s):  
Julieta B. Gerenova ◽  
Irena M. Manolova ◽  
Vania I. Tzoneva
Keyword(s):  
Atrophic Gastritis ◽  
Clinical Significance ◽  
Thyroid Function ◽  
Hashimoto’S Thyroiditis ◽  
Thyroid Diseases ◽  
Parietal Cells ◽  
Hashimoto's Thyroiditis ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Function Group

ABSTRACT Clinical significance of autoantibodies to parietal cells (PCA) in patients with autoimmune thyroid diseases (ATD) remains contradictory. AIM: To characterize the frequency of PCA in patients with ATD; to clarify the role of gender and age in PCA positivity; to analyze the association of PCA with gastric or haematologic symptoms and with the levothyroxine dose required to achieve a serum TSH level within the normal range in treated Hashimoto’s thyroiditis (HT) patients. PATIENTS AND METHODS: PCA were measured using ELISA in 137 HT patients, divided into tree subgroups according to the thyroid function: group I included subjects with normal thyroid function; group II included patients with hypothyroidism, in group III were enrolled subjects treated with levothyroxine (LT4). We also studied the PCA positivity in 14 patients with active Graves’ disease and in 23 healthy controls. RESULTS: PCA positivity was found in 51 patients with autoimmune thyroid diseases, with an overall prevalence of 33.8%. No significant differences in PCA were observed between the groups of HT patients. The frequency of PCA in both genders was similar and there were no difference depending on age. In 7.3% of HT patients in different stages of disease we found clinically relevant gastric and/or haematologic symptoms; in 70% of them PCA were positive (OR = 5.5; 95% CI: 1.2 - 28.4; p = 0.009). PCA positive hypothyroid HT patients required higher LT4 doses than PCA negative (1.46 μg/kg vs 1.24 μg/kg, p = 0.04). CONCLUSIONS: PCA may be present in different stages in HT patients; this does not depend on the severity of disease. PCA concentrations may predict symptoms of atrophic gastritis in patients with Hashimoto’s thyroiditis. PCA positive HT patients require higher replacement doses of LT4. Presence of anemia, particularly microcytic anemia, was suggestive of undiagnosed atrophic gastritis.

scholarly journals The Human Microbiota in Endocrinology: Implications for Pathophysiology, Treatment, and Prognosis in Thyroid Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Giovanni Docimo ◽  
Angelo Cangiano ◽  
Roberto Maria Romano ◽  
Marcello Filograna Pignatelli ◽  
Chiara Offi ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Bacterial Infections ◽  
Association Studies ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Human Microbiota ◽  
Organ Specific ◽  
Benign Nodules ◽  
The Impact

The human microbiota is an integral component in the maintenance of health and of the immune system. Microbiome-wide association studies have found numerous diseases associated to dysbiosis. Studies are needed to move beyond correlations and begin to address causation. Autoimmune thyroid diseases (ATD) are one of the most common organ-specific autoimmune disorders with an increasing prevalence, higher than 5% worldwide. Most frequent manifestations of ATD are Hashimoto’s thyroiditis and Graves’ disease. The exact etiology of ATD remains unknown. Until now it is not clear whether bacterial infections can trigger ATD or modulate the efficacy of treatment and prognosis. The aim of our review is to characterize the microbiota and in ATD and to evaluate the impact of dysbiosis on treatment and prognosis. Moreover, variation of gut microbiome has been associated with thyroid cancer and benign nodules. Here we will characterize the microbioma in benign thyroid nodules, and papillary thyroid cancer to evaluate their implications in the pathophysiology and progression.

scholarly journals Development and Application of a Novel Sensitive Immunometric Assay for Calcitonin in a Large Cohort of Patients with Medullary and Differentiated Thyroid Cancer, Thyroid Nodules, and Autoimmune Thyroid Diseases

2014 ◽  
Vol 3 (2) ◽  
pp. 117-124 ◽  
Author(s):  
Cléber P. Camacho ◽  
Susan C. Lindsey ◽  
Teresa S. Kasamatsu ◽  
Alberto L. Machado ◽  
João Roberto M. Martins ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Thyroid Nodules ◽  
Thyroid Diseases ◽  
Large Cohort ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Immunometric Assay

scholarly journals Autoimmune Thyroid Diseases and Thyroid Cancer in Pemphigus: A Big Data Analysis

2018 ◽  
Vol 5 ◽  
Author(s):  
Khalaf Kridin ◽  
Mogher Khamaisi ◽  
Doron Comaneshter ◽  
Erez Batat ◽  
Arnon D. Cohen
Keyword(s):  
Big Data ◽  
Thyroid Cancer ◽  
Data Analysis ◽  
Big Data Analysis ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Vitamin D deficiency and autoimmune thyroid diseases

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
N Körber-Hafner ◽  
C Körber
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Analysis of chosen polymorphisms in FoxP3 gene in children and adolescents with autoimmune thyroid diseases

2014 ◽  
Author(s):  
Artur Bossowski ◽  
Hanna Borysewicz-Sanczyk ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Mieczyslaw Szalecki ◽  
Beata Wikiera ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Foxp3 Gene ◽  
Autoimmune Thyroid

Analysis of association of vitamin D receptor gene Cdx2 (rs11568820) polymorphism with autoimmune thyroid diseases

2018 ◽  
Author(s):  
Adam Maciejewski ◽  
Michal J Kowalczyk ◽  
Teresa Gasinska ◽  
Waldemar Herman ◽  
Anna Szeliga ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Thyroid Diseases ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid
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