scholarly journals Bioinspired biliverdin/silk fibroin hydrogel for antiglioma photothermal therapy and wound healing

Theranostics ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 11719-11736
Author(s):  
Qing Yao ◽  
Qing-Hua Lan ◽  
Xinyu Jiang ◽  
Chu-Chu Du ◽  
Yuan-Yuan Zhai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Photothermal Therapy

scholarly journals Sustained Release of Insulin-Like Growth Factor-1 from Bombyx mori L. Silk Fibroin Delivery for Diabetic Wound Therapy

2021 ◽  
Vol 22 (12) ◽  
pp. 6267
Author(s):  
Meng-Jin Lin ◽  
Mei-Chun Lu ◽  
Hwan-You Chang
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Sustained Release ◽  
Silk Fibroin ◽  
Granulation Tissue ◽  
Release Rate ◽  
Insulin Like Growth Factor ◽  
Diabetic Wound ◽  
Diabetic Mice ◽  
Wound Therapy

The goals of this study are to develop a high purity patented silk fibroin (SF) film and test its suitability to be used as a slow-release delivery for insulin-like growth factor-1 (IGF-1). The release rate of the SF film delivering IGF-1 followed zero-order kinetics as determined via the Ritger and Peppas equation. The release rate constant was identified as 0.11, 0.23, and 0.09% h−1 at 37 °C for SF films loaded with 0.65, 6.5, and 65 pmol IGF-1, respectively. More importantly, the IGF-1 activity was preserved for more than 30 days when complexed with the SF film. We show that the IGF-1-loaded SF films significantly accelerated wound healing in vitro (BALB/3T3) and in vivo (diabetic mice), compared with wounds treated with free IGF-1 and an IGF-1-loaded hydrocolloid dressing. This was evidenced by a six-fold increase in the granulation tissue area in the IGF-1-loaded SF film treatment group compared to that of the PBS control group. Western blotting analysis also demonstrated that IGF-1 receptor (IGF1R) phosphorylation in diabetic wounds increased more significantly in the IGF-1-loaded SF films group than in other experimental groups. Our results suggest that IGF-1 sustained release from SF films promotes wound healing through continuously activating the IGF1R pathway, leading to the enhancement of both wound re-epithelialization and granulation tissue formation in diabetic mice. Collectively, these data indicate that SF films have considerable potential to be used as a wound dressing material for long-term IGF-1 delivery for diabetic wound therapy.

Generation of Nano-pores in Silk Fibroin Films Using Silk Nanoparticles for Full-Thickness Wound Healing

2021 ◽  
Vol 22 (2) ◽  
pp. 546-556
Author(s):  
Jian Liu ◽  
Ran Huang ◽  
Gang Li ◽  
David L. Kaplan ◽  
Zhaozhu Zheng ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Full Thickness ◽  
Full Thickness Wound

scholarly journals Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17914-17923
Author(s):  
Reza Eivazzadeh-Keihan ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Fateme Radinekiyan ◽  
Mohammad Sobhani ◽  
Farzane khalili ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Biological Activity ◽  
Silk Fibroin ◽  
Agarose Hydrogel ◽  
Novel Scaffold ◽  
Fibroin Solution ◽  
Zinc Chromite

Given the important aspects of wound healing approaches, in this work, an innovative biocompatible nanobiocomposite scaffold was designed and prepared based on cross-linked lignin–agarose hydrogel, extracted silk fibroin solution, and zinc chromite (ZnCr2O4) nanoparticles.

Silk Fibroin/Poly-(L-lactide-co-caprolactone) Nanofiber Scaffolds Loaded with Compound Phellodendron Liquid to Accelerate Diabetic Wound Healing

2021 ◽  
pp. 111557
Author(s):  
Xiaoqing Xu ◽  
Xiangsheng Wang ◽  
Chengxue Qin ◽  
Atta ur Rehman Khan ◽  
Wenjie Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Diabetic Wound ◽  
Nanofiber Scaffolds ◽  
Diabetic Wound Healing

Muscle-inspired MXene/PVA hydrogel with high toughness and photothermal therapy for promoting bacteria-infected wound healing

2022 ◽  
Author(s):  
Yan Li ◽  
Miao-miao Han ◽  
Yue Cai ◽  
Bing Jiang ◽  
Yuanxin Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Bacterial Infection ◽  
Human Health ◽  
Photothermal Therapy ◽  
Infected Wound ◽  
Traditional Therapy ◽  
High Toughness ◽  
Pva Hydrogel

The process of wound healing is often accompanied by bacterial infection, which is a serious threat to human health. The abuse of antibiotics in traditional therapy aggravates the resistance of...

scholarly journals Silk derived formulations for accelerated wound healing in diabetic mice

PeerJ ◽  
2021 ◽  
Vol 9 ◽  
pp. e10232
Author(s):  
Muniba Tariq ◽  
Hafiz Muhammad Tahir ◽  
Samima Asad Butt ◽  
Shaukat Ali ◽  
Asma Bashir Ahmad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silk Fibroin ◽  
Chronic Wounds ◽  
Histological Analysis ◽  
Healing Process ◽  
Aloe Vera ◽  
Wound Contraction ◽  
Wound Dressings ◽  
Control Group ◽  
Diabetic Mice

Background The present study aimed to prepare effective silk derived formulations in combination with plant extract (Aloe vera gel) to speed up the wound healing process in diabetic mice. Methods Diabetes was induced in albino mice by using alloxan monohydrate. After successful induction of diabetes in mice, excision wounds were created via biopsy puncture (6 mm). Wound healing effect of silk sericin (5%) and silk fibroin (5%) individually and in combination with 5% Aloe vera gel was evaluated by determining the percent wound contraction, healing time and histological analysis. Results The results indicated that the best biocompatible silk combination was of 5% silk fibroin and 5% Aloe vera gel in which wounds were healed in 13 days with wound contraction: 98.33 ± 0.80%. In contrast, the wound of the control group (polyfax) healed in 19 day shaving 98.5 ± 0.67% contraction. Histological analysis revealed that the wounds which were treated with silk formulations exhibited an increased growth of blood vessels, collagen fibers, and much reduced inflammation. Conclusion It can be concluded that a combination of Bombyx mori silk and Aloe vera gel is a natural biomaterial that can be utilized in wound dressings and to prepare more innovative silk based formulations for speedy recovery of chronic wounds.

scholarly journals Silk fibroin/chitosan/alginate multilayer membranes as a system for controlled drug release in wound healing

2020 ◽  
Vol 152 ◽  
pp. 803-811 ◽  
Author(s):  
Murilo Santos Pacheco ◽  
Gustavo Eiji Kano ◽  
Letícia de Almeida Paulo ◽  
Patricia Santos Lopes ◽  
Mariana Agostini de Moraes
Keyword(s):  
Wound Healing ◽  
Drug Release ◽  
Silk Fibroin ◽  
Controlled Drug Release ◽  
Multilayer Membranes

A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds

2020 ◽  
Vol 8 (32) ◽  
pp. 7197-7212 ◽  
Author(s):  
Zhiyong Qian ◽  
Yating Bai ◽  
Jin Zhou ◽  
Linhao Li ◽  
Jing Na ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Silver Nanoparticles ◽  
Silk Fibroin ◽  
Broad Spectrum ◽  
Electrolyte Balance ◽  
Infected Wounds ◽  
Multifunctional Properties

The CTS-SF/SA/Ag-Exo dressing possessed multifunctional properties including broad-spectrum antimicrobial activity, promoting wound healing, retaining moisture and maintaining electrolyte balance.

Polydopamine-Coated Antheraea pernyi (A. pernyi) Silk Fibroin Films Promote Cell Adhesion and Wound Healing in Skin Tissue Repair

2019 ◽  
Vol 11 (38) ◽  
pp. 34736-34743 ◽  
Author(s):  
Jie Wang ◽  
Yuping Chen ◽  
Guanshan Zhou ◽  
Yuyin Chen ◽  
Chuanbin Mao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Adhesion ◽  
Silk Fibroin ◽  
Tissue Repair ◽  
Skin Tissue ◽  
Antheraea Pernyi ◽  
Promote Cell Adhesion
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