scholarly journals Phase 1 – Community Forums Deaf ACCESS: Adapting Consent Through Community Engagement and State-Of-The-Art Simulation [English and Spanish versions]

2017 ◽  
Vol 14 (6) ◽  
Author(s):  
Melissa L. Anderson ◽  
Timothy Riker ◽  
Kurt Gagne ◽  
Stephanie Hakulin ◽  
Todd Higgins ◽  
...  
Keyword(s):  
Community Engagement ◽  
State Of The Art ◽  
Phase 1

scholarly journals Enhancing Label Representations with Relational Inductive Bias Constraint for Fine-Grained Entity Typing

2021 ◽  
Author(s):  
Jinqing Li ◽  
Xiaojun Chen ◽  
Dakui Wang ◽  
Yuwei Li
Keyword(s):  
State Of The Art ◽  
Phase 1 ◽  
Phase 2 ◽  
Two Phase ◽  
Inductive Bias ◽  
Fine Grained ◽  
Wide Range ◽  
Dynamic Experiments ◽  
Novel Method ◽  
Public Datasets

Fine-Grained Entity Typing (FGET) is a task that aims at classifying an entity mention into a wide range of entity label types. Recent researches improve the task performance by imposing the label-relational inductive bias based on the hierarchy of labels or label co-occurrence graph. However, they usually overlook explicit interactions between instances and labels which may limit the capability of label representations. Therefore, we propose a novel method based on a two-phase graph network for the FGET task to enhance the label representations, via imposing the relational inductive biases of instance-to-label and label-to-label. In the phase 1, instance features will be introduced into label representations to make the label representations more representative. In the phase 2, interactions of labels will capture dependency relationships among them thus make label representations more smooth. During prediction, we introduce a pseudo-label generator for the construction of the two-phase graph. The input instances differ from batch to batch so that the label representations are dynamic. Experiments on three public datasets verify the effectiveness and stability of our proposed method and achieve state-of-the-art results on their testing sets.

scholarly journals Deaf ACCESS: Adapting Consent through Community Engagement and State-of-the-Art Simulation [English and Spanish versions]

2017 ◽  
Vol 14 (12) ◽  
Author(s):  
Melissa L. Anderson ◽  
Timothy Riker ◽  
Kurt Gagne ◽  
Stephanie Hakulin ◽  
Jonah Meehan ◽  
...  
Keyword(s):  
Community Engagement ◽  
State Of The Art

scholarly journals Eagle Project phase 2: clinical skills unit

2009 ◽  
Vol 91 (3) ◽  
pp. 82-83 ◽  
Author(s):  
WEG Thomas
Keyword(s):  
State Of The Art ◽  
Clinical Skills ◽  
Phase 1 ◽  
Surgical Skills ◽  
Course Delivery ◽  
Course Development ◽  
Second Phase ◽  
Phase 2 ◽  
Close Cooperation ◽  
The Impact

Following the outstanding success of phase 1 of the Eagle Project, the Wolfson Surgical Skills Centre, it is with great excitement and anticipation that the College launches phase 2, the clinical skills unit. The completion of this very ambitious second phase of the multimillion-pound project is a tribute to teamworking and has only been possible through close cooperation between the College, generous benefactors and industry. The impact that this new unit will have is enormous. It will provide flexible state-of-the-art facilities that will allow much stronger engagement with course development and course delivery.

Identification and Implementation of End-User Needs During Development of a State-of-the-Art Modeling Toolset

2011 ◽  
Author(s):  
Roger Seitz ◽  
Mark Freshley ◽  
Mark Williamson ◽  
Paul Dixon ◽  
Kurt Gerdes ◽  
...  
Keyword(s):  
Environmental Management ◽  
User Interfaces ◽  
State Of The Art ◽  
Phase 1 ◽  
National Laboratory ◽  
User Involvement ◽  
End Users ◽  
Department Of Energy ◽  
User Needs ◽  
End User

The U.S. Department of Energy (US DOE) Office of Environmental Management, Technology Innovation and Development is supporting a multi-National Laboratory effort to develop the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is an emerging state-of-the-art scientific approach and software infrastructure for understanding and predicting contaminant fate and transport in natural and engineered systems. These modular and open-source high performance computing tools and user interfaces will facilitate integrated approaches that enable standardized assessments of performance and risk for EM cleanup and closure decisions. The ASCEM team recognized that engaging end-users in the ASCEM development process would lead to enhanced development and implementation of the ASCEM toolsets in the user community. End-user involvement in ASCEM covers a broad spectrum of perspectives, including: performance assessment (PA) and risk assessment practitioners, research scientists, decision-makers, oversight personnel, and regulators engaged in the US DOE cleanup mission. End-users are primarily engaged in ASCEM via the ASCEM User Steering Committee (USC) and the ‘user needs interface’ task. Future plans also include user involvement in demonstrations of the ASCEM tools. This paper will describe the details of how end users have been engaged in the ASCEM program and will demonstrate how this involvement has strengthened both the tool development and community confidence. ASCEM tools requested by end-users specifically target modeling challenges associated with US DOE cleanup activities. The demonstration activities involve application of ASCEM tools and capabilities to representative problems at DOE sites. Selected results from the ASCEM Phase 1 demonstrations are discussed to illustrate how capabilities requested by end-users were implemented in prototype versions of the ASCEM tool.

scholarly journals Community engagement in Genomics research; Challenges and lessons learnt in the AWI-Gen study at Dikgale Health and Demographic Surveillance System (HDSS) Site, South Africa

2020 ◽  
Vol 3 ◽  
pp. 38
Author(s):  
Felistas Mashinya ◽  
Marianne Alberts ◽  
Reneilwe G. Mashaba ◽  
Paulina O. Tindana
Keyword(s):  
Community Engagement ◽  
Health Research ◽  
Surveillance System ◽  
Phase 1 ◽  
Research Process ◽  
Demographic Surveillance System ◽  
Phase 1 Study ◽  
Lessons Learnt ◽  
Genomics Research ◽  
Integral Process

As health research often requires consent from participants and permission from community gate keepers, community engagement is considered an integral process of health research. Community engagement is also important in building trust between the research team and participants, gathering information on the needs and expectations of the community with respect to the project and present the community with an opportunity to gain more information on the goals of the research. Although there are published guidelines on how to conduct community engagement activities, the concept itself and the way in which it is put into practice is highly contextual. In this paper we reflect on the community engagement strategy used in the AWI-Gen Phase 1 study at the Dikgale Health and Demographic Surveillance System (Dikgale HDSS) site, the challenges encountered throughout the research process and the lessons learnt. Lastly, we highlight possible improvements to the CE strategic framework for AWI-Gen Phase 2 in Dikgale HDSS that may enhance the participation of the community.

Morbus Alzheimer – State of the art und Blick in die Zukunft

2018 ◽  
Vol 75 (7) ◽  
pp. 432-437
Author(s):  
David Winkler ◽  
Thomas Leyhe
Keyword(s):  
State Of The Art ◽  
Phase 1 ◽  
Amyloid Β ◽  
Morbus Alzheimer ◽  
Neurodegenerative Erkrankung ◽  
Alzheimer Krankheit

Zusammenfassung. Die Alzheimer-Krankheit ist die häufigste neurodegenerative Erkrankung und die häufigste Demenzursache. Die heutige Routinediagnostik basiert auf der klinischen Untersuchung, einer kraniellen Bildgebung sowie Laboruntersuchungen zum Ausschluss anderer behandelbarer Ursachen. Je nach Befundkonstellation können ergänzend eine Lumbalpunktion mit Bestimmung von Amyloid-β-, Tau- und phospo-Tau-Proteinen, eine PET-Bildgebung sowie ggfs. weitere Untersuchungen erfolgen. Als symptomatische Therapien stehen verschiedene Acetylcholinesterasehemmer sowie der NMDA-Rezeptor-Antagonist Memantine zur Verfügung. Neue, kurative Therapieansätze sind in der Entwicklung. Führend sind aktuell Immuntherapien, welche gegen Amyloid-β- und Tau-Proteine gerichtet sind. Nach initial enttäuschenden klinischen Resultaten von Amyloid-β Immuntherapien zeigen sich nun bei Therapiebeginn im Frühstadium der Erkrankung erste positive Resultate dieses Ansatzes. Zudem erreichen die ersten Tau-orientierten Immuntherapien die klinischen Phasen 2 und 3, nachdem positive Signale auch bezüglich des kognitiven Verlaufes in Phase 1 vermeldet wurden. Weiter werden über 70 nicht-immunbasierte Therapieansätze in klinischen Studien geprüft. Auch zeigen sich Fortschritte in der Diagnostik. Mit Hilfe spezifischer Liganden können Amyloid-β und Tau im PET dargestellt werden, was wiederum die Differenzierung von Patienten in den Studien zur Therapieentwicklung erleichtert. Nebst technischen Verbesserungen der Liquordiagnostik werden erste blut-basierte Tests entwickelt, welche in Studien bereits eine gute Korrelation mit Liquor- und PET-Befunden erreichen.

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