scholarly journals Short Report: Adherence to Neuropsychological Recommendations in Patients with Multiple Sclerosis

2019 ◽  
Vol 21 (2) ◽  
pp. 70-75
Author(s):  
Marnina Stimmel ◽  
Shaina Shagalow ◽  
Elizabeth K. Seng ◽  
Jeffrey G. Portnoy ◽  
Roseann Archetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Rehabilitation ◽  
Neuropsychological Testing ◽  
Treatment Recommendations ◽  
Phone Call ◽  
Short Report ◽  
Test Results ◽  
Adherence To Treatment ◽  
Other Information ◽  
Record Review

Abstract Background: Adherence to nonmedication recommendations is typically low, as seen in various health populations. Because literature on adherence to treatment recommendations made after neuropsychological testing in multiple sclerosis (MS) is lacking, this study evaluated adherence and reasons for nonadherence. Relationships between adherence to recommendations and various other factors in patients with MS were also evaluated. Methods: Of 66 adult patients seen for neuropsychological testing at an MS center, 55 were eligible for this study. Forty-five patients (mean age, 43.4 years; 75.6% women) were reached by phone, and all agreed to an interview involving questions regarding adherence to treatment recommendations. Other information was obtained through retrospective medical record review. Results: Overall self-reported adherence to recommendations made from neuropsychological testing was 38%. Adherence rates varied by recommendation type: psychopharmacological management had the highest rate (80%), and referrals for cognitive rehabilitation had the lowest (6.5%). Reasons for nonadherence included needing more information and wanting to speak with one's physician regarding the recommendations. Adherence was associated with patients' ability to spontaneously recall at least some of their recommendations and with receiving both a written report and a phone call with test results. Conclusions: Adherence to recommendations made after neuropsychological testing for patients with MS is low. Points of intervention may be to give directed feedback for each recommendation and to provide both a written report and a phone call with results and recommendations. Asking patients to repeat back the recommendations may be a simple and efficient way to increase understanding and improve adherence.

scholarly journals Computerized Neuropsychological Test Battery CogniSoft for Assessment of Cognition in Patients with Multiple Sclerosis

2020 ◽  
Vol 24 (4) ◽  
pp. 371-380
Author(s):  
Lyudmila Todorova ◽  
◽  
Valentina Ignatova ◽  
Jivko Surchev ◽  
◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Rehabilitation ◽  
Neuropsychological Test ◽  
Neuropsychological Testing ◽  
Poor Quality ◽  
Cognitive Status ◽  
Global Trends ◽  
Significant Difference ◽  
Overall Evaluation

Cognitive dysfunction is a leading cause of disability in multiple sclerosis (MS) and is associated with unemployment, need of assistance with daily activities and poor quality of life. The introduction of neuropsychological testing and monitoring of cognitive status as part of the overall evaluation of MS patients in parallel with clinical and paraclinical parameters is highly recommended. Recent studies have demonstrated a better perception and preference for computerized cognitive tests than classic variants, with no significant difference in results. In accordance with global trends, a bilingual computer system CogniSoft for assessment and rehabilitation of cognitive status in persons with MS has been developed, including: 1) a set of diagnostic tests for evaluation of memory and executive functions based on the nature of Brief International Cognitive Assessment for MS (BICAMS); 2) a set of games for cognitive rehabilitation. Questionnaire for depression (Beck Depression Inventory – BDI-II) will be filled before conduction of the neuropsychological tests for differentiation of possible depression which could interfere with the results. The CogniSoft information system will incorporate two approaches for evaluation of neuropsychological results which will allow early detection of cognitive impairments in these patients, which will initiate timely cognitive rehabilitation.

scholarly journals Relationship Between Anxiety and Cognition in Multiple Sclerosis

2019 ◽  
Vol 21 (4) ◽  
pp. 151-156 ◽  
Author(s):  
Nicholas A. Vissicchio ◽  
Caroline Altaras ◽  
Amanda Parker ◽  
Shonna Schneider ◽  
Jeffrey G. Portnoy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Indirect Effect ◽  
Processing Speed ◽  
Neuropsychological Testing ◽  
Verbal Learning ◽  
Information Processing Speed ◽  
Eligibility Criteria ◽  
Mediation Analyses ◽  
Record Review ◽  
Relationship Of

Abstract Background: Anxiety, which is very prevalent in multiple sclerosis (MS) but understudied, has been shown to negatively affect cognition in many different populations. Slowed information processing speed underlies most cognitive impairments in MS, including verbal learning. The aim of this study was to look at how anxiety influences cognition—specifically processing speed and verbal learning—in MS. Methods: Eligibility criteria were adults (≥18 years) who had a diagnosis of clinically definite MS and had participated in neuropsychological research projects. A retrospective medical record review was conducted on the neuropsychological testing data. Two hierarchical multiple regressions were conducted to determine the unique contributions of processing speed and anxiety on verbal learning in MS, after adjusting for demographic and disability variables. Two separate mediation analyses were conducted to determine the relationship between processing speed, verbal learning, and anxiety. Results: Participants (N = 141) ranged in age from 18–91 years. Based on the multiple regression analyses, processing speed (β = 0.55, ΔR2 = 0.27, P < .001) and anxiety (β = −0.34, ΔR2 = 0.11, P < .001) were uniquely significant predictors of verbal learning. Based on the mediation analyses, there was a significant indirect effect of anxiety on verbal learning through processing speed (ab = −0.31, 95% CI = −0.60 to −0.09). There was also a significant indirect effect of processing speed on verbal learning through anxiety (ab = −0.05, 95% CI = 0.01 to 0.12). Conclusions: Results suggest a bidirectional relationship of anxiety and processing speed on verbal learning in MS. Anxiety has a significant effect on cognition and should not be overlooked. Interventions targeting anxiety may improve cognition in MS.

scholarly journals Remote administration of the symbol digit modalities test to individuals with multiple sclerosis is reliable: A short report

2021 ◽  
Vol 7 (1) ◽  
pp. 205521732199485
Author(s):  
Tehila Eilam-Stock ◽  
Michael T Shaw ◽  
Kathleen Sherman ◽  
Lauren B Krupp ◽  
Leigh E Charvet
Keyword(s):  
Multiple Sclerosis ◽  
Correlation Analysis ◽  
Gold Standard ◽  
Short Report ◽  
Strongly Correlated ◽  
Cognitive Screening ◽  
Pearson’S Correlation ◽  
Screening Approach ◽  
Pearson's Correlation ◽  
Pearson’S Correlation Analysis

Background The Symbol Digit Modalities Test (SDMT) is the gold standard for cognitive screening in multiple sclerosis (MS). Objective Due to the recent COVID-19 pandemic and the increased need for virtual clinical visits, we examined the reliability of remote administration of the SDMT vs. standard in-person administration to individuals with MS. Methods Pearson’s correlation analysis was performed between SDMT scores on the in-person and remote administrations. Results For n = 132 participants, remote and in-person SDMT scores were strongly correlated (r = .80, p = .000). Conclusion Remote administration of the SDMT is a reliable cognitive screening approach in MS.

scholarly journals THink: Inferring Cognitive Status from Subtle Behaviors

AI Magazine ◽  
2015 ◽  
Vol 36 (3) ◽  
pp. 49-60 ◽  
Author(s):  
Randall Davis ◽  
David Libon ◽  
Roda Au ◽  
David Pitman ◽  
Dana Penney
Keyword(s):  
Neuropsychological Testing ◽  
Cognitive Status ◽  
Major Advance ◽  
Test Results ◽  
Clock Drawing Test ◽  
The Past ◽  
Drawing Test ◽  
Testing Technology ◽  
Opening Up

The digital clock drawing test is a fielded application that provides a major advance over existing neuropsychological testing technology. It captures and analyzes high precision information about both outcome and process, opening up the possibility of detecting subtle cognitive impairment even when test results appear superficially normal. We describe the design and development of the test, document the role of AI in its capabilities, and report on its use over the past seven years. We outline its potential implications for earlier detection and treatment of neurological disorders. We set the work in the larger context of the THink project, which is exploring multiple approaches to determining cognitive status through the detection and analysis of subtle behaviors.

Cognitive rehabilitation in children and adolescents with multiple sclerosis

2010 ◽  
Vol 31 (S2) ◽  
pp. 275-278 ◽  
Author(s):  
Emilio Portaccio ◽  
Benedetta Goretti ◽  
Valentina Zipoli ◽  
Bahia Hakiki ◽  
Marta Giannini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Children And Adolescents ◽  
Cognitive Rehabilitation

scholarly journals Economic implications of non-adherence to treatment recommendations for hemodialysis patients with anemia

2006 ◽  
Vol 35 (11) ◽  
pp. 660-671 ◽  
Author(s):  
Laura T. Pizzi ◽  
Nikita M. Patel ◽  
Vittorio M. Maio ◽  
David S. Goldfarb ◽  
Beckie Michael ◽  
...  
Keyword(s):  
Hemodialysis Patients ◽  
Treatment Recommendations ◽  
Adherence To Treatment ◽  
Economic Implications

A-149 Demographic Correlates of a Short-Form Test of Executive Functioning

2021 ◽  
Vol 36 (6) ◽  
pp. 1203-1203
Author(s):  
Arthur M Horton ◽  
Cecil Reynolds
Keyword(s):  
Multiple Sclerosis ◽  
Traumatic Brain Injury ◽  
Executive Functioning ◽  
Private Practice ◽  
Short Form ◽  
Statistical Significance ◽  
Neuropsychological Testing ◽  
Card Sorting ◽  
Demographic Correlates ◽  
Education Levels

Abstract Objective This poster explores demographic correlates of a recently developed Short-Form Test of Executive Functioning. Method Subjects were 23 adults referred by neurologists and psychiatrist for neuropsychological testing to a private practice. All subjects signed informed consent documents. Subjects included 12 males and 11 females, 20 subjects were Caucasians and 3 were African-Americans, 22 were right handed. The subjects’ ages ranged from 20 to 74 (M-52.04, SD-14.87) and the subjects education levels ranged from 10–20 (M-15.87, SD-3.45). Diagnoses included Stroke-12, Traumatic Brain Injury-6, Alzheimer’s disease-2, Multiple Sclerosis-1, Parkinson’s disease-1 and Epilepsy-1. All subjects were administered neuropsychological testing including the Short-Form Test of Executive Functioning (SF-TEF) The Sf-TEF is composed of 3 card sorting subtests of the Test of Verbal and Conceptual Fluency (TVCF) but rather than administering 116 cards only 58 are administered and full scales scores prorated to save time. The scales are Number Correct, Perseveration Errors and Number of Categories. The 3 short form subjects were each correlated with the subjects age and education variables. Results The correlations between the Number Correct, Perseveration Errors and Number of Categories scores and age scores were 0.247, 0.01, and 0.08 and correlations between the Number Correct, Perseveration Errors and Number of Categories scores and education levels were 0.21, 0.273 and 0.12 which were all non-significant at the P < 0.05 level of statistical significance. Conclusions These results suggest that the scores of the Number Correct, Perseveration Errors and Number of Categories subtests were not unduly influenced by the subjects’ age and education.

Apraxia screening predicts Alzheimer pathology in frontotemporal dementia

2018 ◽  
Vol 90 (5) ◽  
pp. 562-569 ◽  
Author(s):  
Matthias Pawlowski ◽  
Viktoria Joksch ◽  
Heinz Wiendl ◽  
Sven G Meuth ◽  
Thomas Duning ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Clinical Presentation ◽  
Neuropsychological Testing ◽  
High Sensitivity ◽  
Clinical Syndrome ◽  
Test Results ◽  
Discriminative Power ◽  
Bedside Test ◽  
Neurodegenerative Dementias ◽  
Alzheimer Pathology

ObjectivesFrontotemporal dementia (FTD) is a heterogeneous clinical syndrome linked to diverse types of underlying neuropathology. Diagnosis is mainly based on clinical presentation and accurate prediction of underlying neuropathology remains difficult.MethodsWe present a large cohort of patients with FTD spectrum diseases (n=84). All patients were thoroughly characterised by cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers, neuroimaging, neuropsychological testing and standardised apraxia screening.ResultsA potential AD pathology was found in 43% of patients with FTD. CSF AD biomarker levels positively correlated with AD-typical apraxia scores in patients with FTD. The discriminative power of apraxia test results indicative of AD pathology was high (sensitivity: 90%, specificity: 66%).ConclusionsApraxia is common in neurodegenerative dementias but under-represented in clinical workup and diagnostic criteria. Standardised apraxia screening may serve as bedside test to objectify an AD-typical apraxia profile as an early and robust sign of AD pathology in patients with FTD.

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