scholarly journals Solitary skin-colored nodule on a child’s face

2022 ◽  
Vol 13 (1) ◽  
pp. 105-106
Author(s):  
Mariem Tabka ◽  
Refka Frioui ◽  
Taghrid Tlili ◽  
Nedia Fetoui ◽  
Amina Ounallah ◽  
...  
Keyword(s):  
Excisional Biopsy ◽  
Skin Tumor ◽  
White Background ◽  
Histopathological Analysis ◽  
Mandibular Angle ◽  
Her Family ◽  
Cowden’S Disease ◽  
Storiform Pattern ◽  
Dermal Collagen ◽  
Collagen Density

Sir, A healthy, six-year-old boy presented with a slowly grown dome-shaped nodule on the mandibular angle region present for two years. The patient’s past medical and family history were unremarkable. A physical examination revealed a solitary, 1.3 × 1 cm, firm, painless, flesh-colored tumor (Fig. 1). Dermoscopy showed branching, serpentine vessels on a pink background (Fig. 2a). These features disappeared when slight pressure was exerted on the dermoscope and the tumor exhibited a central, white, structureless area (Fig. 2b). An excisional biopsy was performed. A microscopic examination showed a well-circumscribed, paucicellular dermal tumor composed of eosinophilic collagen bundles separated by clefts and forming a storiform pattern. Scattered fibroblasts were found among the collagen bundles. The overlying epidermis was slightly flattened (Fig. 3). The diagnosis of solitary sclerotic fibroma was established. Sclerotic fibroma (SF), also known as storiform collagenoma, is a rare benign skin tumor. It usually manifests itself as an asymptomatic, slowly growing, white-to-skin-colored papule or nodule [1]. It was first described in patients with Cowden’s disease, yet may also occur sporadically [2]. There were no mucocutaneous features of Cowden’s disease (tricholemmomas, oral fibromas, acral keratoses, palmar pits, and gingival and palatal papules) in the patient and her family members. Dermatofibroma, the main differential diagnosis of SF, usually exhibits hyperplastic changes of the epidermis instead of atrophy, and the boundaries of the lesion are unclear [2]. Only two papers have been published describing the dermoscopic findings of SF, consisting of a white background with peripheral arborizing vessels [3]. A white background may be related to an increased dermal collagen density. It is also described in dermatofibroma, typically with a peripheral pigmentation network. Although dermoscopy may improve the clinical diagnosis of SF, histopathological analysis is required.

scholarly journals HGG-40. EXCEPTIONAL SYNCHRONOUS OCCURENCE OF A BRAF V600E MUTANT GLIOBLASTOMA AND A H3.3K27M MUTANT DIFFUSE INTRINSIC PONTINE GLIOMA: A CASE REPORT

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii351-iii351
Author(s):  
Emilie De Carli ◽  
Blandine Boisselier ◽  
Luc Le Fournier ◽  
Stéphane Supiot ◽  
Coralie Mallebranche ◽  
...  
Keyword(s):  
Parietal Lobe ◽  
Genetic Alterations ◽  
Braf V600e ◽  
Driver Gene ◽  
Histopathological Analysis ◽  
Repair System ◽  
Who Grade ◽  
Brainstem Lesion ◽  
Her Family ◽  
Concomitant Radiochemotherapy

Abstract We report herein the case of a 17-year-old female who presented with intracranial hypertension and diplopia. Magnetic resonance imaging showed a large left cystic and solid temporoparietal lesion, associated with an infiltrating lesion of the brainstem, hypointense in T1 and hyperintense in FLAIR sequences, without enhancement after injection of gadolinium. Complete resection of the parietal mass and biopsy of the brainstem lesion were performed. Histopathological analysis of the parietal mass showed glioblastoma (WHO grade IV) with no IDH1/2 or H3.3/H3.1 gene mutation detected by Sanger sequencing. Immunohistochemistry found the expression of the proteins of mismatch repair system. Whole exome and RNA sequencing identified a BRAF-V600E mutation. The brainstem lesion was a diffuse midline glioma, H3K27M-mutant (grade IV) according to the 2016 WHO classification. Pan-genomic SNP arrays of the 2 tumors showed distinct genetic alterations. The parietal glioblastoma displayed complex genomic alterations whereas the brainstem glioma harbored chromosome 7q gain, chromosome 9p and 10 losses, and RB, TP53 and CDKN2A homozygous deletions. The patient was treated by concomitant radiochemotherapy (according to Stupp protocol). After 12 cycles of temozolomide, there was complete remission persistant in the parietal lobe. The brainstem tumor was stable but progressed after 3 months of temozolomide discontinuation. Treatment with mTOR inhibitors was initiated. At 21-month follow-up, the patient remains with few symptoms. No predisposition syndrome was identified in the patient or her family. Concurrent glioblastomas with distinct driver gene mutations are exceptional.

scholarly journals About a Rare Case of Chronic Ankle Pain: Unusual Localization of the schwannoma

2020 ◽  
Vol 8 (3) ◽  
pp. 29
Author(s):  
Naoufal Elghoul ◽  
Mohammed Benchakroun ◽  
Azzelarab Bennis ◽  
Omar Zaddoug ◽  
Ali Zine ◽  
...  
Keyword(s):  
Lower Limb ◽  
Rare Case ◽  
Radiological Finding ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Ankle Pain ◽  
Lateral Aspect ◽  
First Diagnosis

Schwannoma in the lower limb is extremely rare and only few cases were reported., they are often overlooked in the first diagnosis and often confused with other common lesions in this localization. Herein we report a 62 years old man who presented pain and paresthesia on the lateral aspect of the ankle since 3 months. The clinical and radiological finding prompting the patient to undergo surgery in which an excisional biopsy of the mass of the leg was realized. The post-operative was uneventful. Two weeks later, the histopathological analysis was in favor of schwannoma with a good result at the last follow up. At last, we emphasis that schwannoma should be considered as a possible diagnosis in patient with chronic ankle pain, particularly if all other injury has been ruled out which can raises the awareness about this tumor.

scholarly journals 999 Case Report: A Rare Congenital Granular Cell Epulis In a Newborn Female Infant

2021 ◽  
Vol 108 (Supplement_6) ◽  
Author(s):  
R O'Rorke ◽  
D Ramkumar ◽  
S Jones
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Infant Feeding ◽  
Benign Lesion ◽  
Granular Cell ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Anterior Maxilla ◽  
Congenital Granular Cell Epulis

Abstract Background A congenital granular cell epulis (CGCE) is a rare benign lesion of uncertain histologic origin that is found on the mucosa of the alveolar ridges of newborn babies. There have been less than 250 reported cases of CGCE. They are most commonly found in the anterior maxilla region in female infants. Case Report An 8-week-old female was referred from the Neonatal team with a 10mmX5mm lesion found at birth on the mucosa of the anterior maxilla. She was seen in the Oral and Maxillofacial Department where her parents reported that the lesion was causing discomfort when feeding and they were keen for its removal. On initial medical examination the patient was diagnosed with a Grade 1 ejection systolic murmur and was awaiting further cardiac investigations. With this in mind and the young age of the patient, it was decided an excisional biopsy of the lesion under local anaesthesia (LA) would be the safest option. The lesion was excised uneventfully when the patient was 9 weeks old. It was shown to be a congenital granular cell epulis following histopathological analysis. The patient was reviewed 8 weeks post-operatively. There were no signs of recurrence, the infant’s feeding had improved drastically, and she was thriving. Discussion CGCE is a rare and interesting lesion in neonates. Early diagnosis and treatment of CGCE is essential in facilitating infant feeding. This report highlights that a well-planned surgical excision under LA is a well-tolerated and safer option which is welcomed by parents.

scholarly journals A case report and literature review: post-traumatic mammary myofibroblastoma

2019 ◽  
Vol 6 (4) ◽  
pp. 1385 ◽  
Author(s):  
Hadi Abdullah Alaskar ◽  
Ahmed Mohammed AlMuhsin ◽  
Mirza Faraz Saeed ◽  
Amro Salem
Keyword(s):  
Case Report ◽  
Malignant Tumors ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Clinical Findings ◽  
Histopathological Analysis ◽  
Minor Trauma ◽  
Elderly Age ◽  
Rare Benign Tumor ◽  
A Minor

Mammary myofibroblastoma is a rare benign tumor of the breast, with a higher incidence in elderly age group. It is diagnosed via radiologic and histologic findings, as clinical findings share the same presentation with other, more common, benign breast pathologies. Surgical excision is the only treatment modality used to treat this tumor. We report the case of a 56-years-old-male, who presented with the complaint of left-sided chest swelling for 1 year following a minor trauma to the chest. Ultrasonographic imaging of the mass was the initial investigation and it revealed a well-defined hypoechoic lesion, excisional biopsy was done, followed by histopathological analysis of the mass, which gave the diagnosis of mammary myofibroblastoma. The aim of this case-report is to further study and characterize this rare lesion and its relationship to previous minor or major trauma and other risk factors, in addition, a proper diagnosis should be taken when encountering a similar mass as it mimics many benign and malignant tumors, furthermore a follow up plan should be established to assess the rate of possible recurrence.

scholarly journals Radiographic assessment of pulmonary metastatic lesions in superficial cutaneous and mammary neoplasms in dogs.

2021 ◽  
Vol 52 (4) ◽  
Author(s):  
Lekshmi S.L. ◽  
Sudheesh S Nair ◽  
Sajitha I.S. ◽  
Soumya Ramankutty ◽  
Narayanan M.K. ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Pulmonary Nodules ◽  
Excisional Biopsy ◽  
Lung Parenchyma ◽  
Needle Aspiration ◽  
Histopathological Analysis ◽  
Metastatic Pattern ◽  
Mammary Neoplasms ◽  
Metastatic Lesions ◽  
Needle Aspiration Cytology

The present study was carried out to assess the pulmonary metastatic lesions in cases of canine superficial and mammary neoplasms presented to the University Veterinary Hospitals, Mannuthy and Kokkalai, Kerala Veterinary and Animal Sciences University during a twelve month period from February 2019 to February 2020. Twenty-four cases of neoplasms in dogs consisting of 12 cases of superficial neoplasms and 12 cases of mammary neoplasms were subjected to fine needle aspiration cytology (FNAC) for the confirmation of malignancy of neoplasm and three view thoracic radiographs were taken to assess the pulmonary metastatic pattern. The results were correlated with the malignancy detected in histopathological analysis after excisional biopsy. The most commonly observed pulmonary metastatic lesions were pulmonary nodules followed by pulmonary micronodules, miliary nodules, and pulmonary mass. These lesions were more evident in malignant mammary neoplasms especially in tubulopapillary carcinoma, ductal carcinoma, and medullary mammary carcinoma with spatial arrangements more in the perihilar region followed by caudodorsal, midventral, and cranioventral area of lung parenchyma. In case of superficial neoplasms miliary patterns and pulmonary microndules were mostly detected as pulmonary metastatic pattern in soft tissue sarcoma, round cell tumour, and malignant fibrohistiocytoma.

scholarly journals Microsatellite polymorphism in the Heme oxygenase-1 gene promoter is associated with dermal collagen density in Japanese obese male subjects

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0199994 ◽  
Author(s):  
Ai Ibuki ◽  
Takeo Minematsu ◽  
Mikako Yoshida ◽  
Shinji Iizaka ◽  
Masaru Matsumoto ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Gene Promoter ◽  
Microsatellite Polymorphism ◽  
Heme Oxygenase 1 ◽  
Dermal Collagen ◽  
Collagen Density ◽  
Male Subjects ◽  
Obese Male

scholarly journals An Unusual Clinical Presentation of Solitary Fibrous Tumor in the Oral Cavity

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Everton Freitas de Morais ◽  
Deborah Gondim Lambert Moreira ◽  
Viviane Alves De Oliveira ◽  
Rodrigo Rodrigues Rodrigues ◽  
Adriano Rocha Germano ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Solitary Fibrous Tumor ◽  
Surgical Excision ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Normal Morphology ◽  
S 100 ◽  
History Of ◽  
Fibrous Tumor

Solitary fibrous tumor is a rare neoplasm of mesenchymal origin that usually affects the pleura. This rarity becomes more relevant in the oral cavity since the clinical features are nonspecific. A 66-year-old female patient presented with a 3-month history of a swelling in the floor of the mouth, measuring 2 cm in greatest diameter, and pain symptomatology. Occlusal and panoramic radiographs showed no bone involvement. Ultrasonography of the submandibular and parotid salivary glands revealed normal morphology, dimensions, and echogenicity. During this exam, a nodular image of low echogenicity measuring about 2.7 × 1.8 cm was detected. An excisional biopsy was performed and histopathological analysis revealed a well-defined tumor-like lesion with alternation between hypercellular areas without a defined pattern and hypocellular areas. On immunohistochemistry, the tumor was positive for CD34 and CD99 and negative forα-SMA, S-100, and bcl-2. Combining the histopathological and immunohistochemical features, the diagnosis was solitary fibrous tumor. The patient is under periodical clinical follow-up and shows no signs of recurrence 7 months after surgical excision of the tumor. The combination of clinical-pathological and immunohistochemical features is necessary for the diagnosis.

scholarly journals Rare Report Case of Oral Verruca Vulgaris on Torus Palatinus

2021 ◽  
Author(s):  
Lee Kian Khoo ◽  
Low Eng Chai ◽  
Bishwa Prakash Bhattarai ◽  
Dinesh Rokaya ◽  
Boonaur Yongvanichakorn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Excisional Biopsy ◽  
Surgical Removal ◽  
Histopathological Analysis ◽  
Papilloma Virus ◽  
Verruca Vulgaris ◽  
Torus Palatinus ◽  
Common Warts ◽  
Hands And Feet ◽  
Rare Report

AbstractVerruca vulgaris, also known as common warts, is most often seen on the skin of hands and feet. Human papilloma virus (HPV) plays an aetiological role in the development of this lesion. Oral verruca vulgaris (OVV) may occur on the palate, buccal mucosa, and tongue. Although asymptomatic and benign, HPV has been linked to squamous cell carcinoma in the oral cavity and oropharyngeal areas. Therefore, prompt surgical removal of OVV is warranted. We report a case of a OVV in a 48-year-old male patient on palate. The lesion was a white nonscrapable lesion in the middle of a torus palatinus. Excisional biopsy was done together with surgical removal of torus palatinus. Histopathological analysis confirmed the diagnosis of OVV.

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

scholarly journals Benign fibrous histiocytoma of the tongue: a case report

2017 ◽  
Vol 20 (2) ◽  
pp. 152
Author(s):  
Michele Fonseca Brantes ◽  
Rebeca Souza Azevedo ◽  
Silvia Paula Oliveira ◽  
Adriele Ferreira Gouvêa ◽  
Ademar Takahama Jr
Keyword(s):  
Fibrous Histiocytoma ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Correct Diagnosis ◽  
Excisional Biopsy ◽  
Histopathological Analysis ◽  
Benign Fibrous Histiocytoma ◽  
Soft Tissue Neoplasm ◽  
Traumatic Neuroma ◽  
Spindle Cells

<p>The fibrous histiocytoma is a soft tissue neoplasm that affects the dermis and the subcutaneous tissue, rarely is found in the oral cavity and perioral regions, and is originated from the proliferation of fibroblasts and histiocytes. The objective of this paper is to report a case of Benign Fibrous Histiocytoma in a 30-year-old male patient, complaining of a painless nodule in the tongue for about six months. With the clinical diagnostic hypotheses of Fibrous Hyperplasia or Traumatic Neuroma an excisional biopsy was performed. The histopathological examination revealed a non-encapsulated proliferation of spindle cells with some giant multinucleated cells in the periphery of the lesion.  Immunohistochemical reactions were performed, staining only for vimentin in the spindle cells and for CD68 in the multinucleated giant cells. According to these characteristics, the final diagnosis was Benign Fibrous Histiocytoma. The correct diagnosis of spindle shaped cell neoplasia must be performed with the aid of histopathological analysis and immunohistochemistry, mainly because the morphological similarities with other benign and malignant lesions. </p>

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