scholarly journals Effect of Methanolic and Phenolic Extracts of Nigella sativa Seeds on Testicular Expression Levels of inhibin alpha and beta Genes in Mature Male Wistar Rats.

2016 ◽  
pp. 118-121 ◽  
Author(s):  
Jabbar Hamady ◽  
Kamal Ganim ◽  
Zainab Ali
Keyword(s):  
Wistar Rats ◽  
Nigella Sativa ◽  
Mature Male ◽  
Expression Levels ◽  
Male Wistar Rats ◽  
Phenolic Extracts

scholarly journals The effect of black cumin oil (Nigella sativa) on the reproduction of male Wistar rats

2021 ◽  
Vol 1 (2) ◽  
pp. 45-49
Author(s):  
Syahran Wael ◽  
Didik Wahyudi ◽  
Tayeb Wael ◽  
Zaid Mohamed Jaber
Keyword(s):  
Wistar Rats ◽  
Nigella Sativa ◽  
Cellular Damage ◽  
Control Group ◽  
Control Group Design ◽  
Black Cumin ◽  
Group Design ◽  
Nigella Sativa Oil ◽  
Post Test ◽  
Male Wistar Rats

Nigella sativa oil is antioxidant compound has the effect that serves to prevent cellular damage. The effect of Nigella sativa oil in the motility and total count of spermatozoa wistar rats. Experimental research with the design of post test only control group design. Wistar rats consists of 24 head and divided into 4 groups consist of control and treatment group. The control group was distilled. The first treatment was of Nigella sativa oil everydays as much with dose 150 mg/kgbw, 250 mg/kgbw, and 350 mg/kgbw, for 16 days, . Statistic test for motility and count of sperm wistar rats use the Kruskal-Wallis followed by Mann Whitney test. Avarage value of motility in the control (21.67±9.832) its lower than treatment. In dose 350 mg/kgbw its highest (52.33±13.292) compare in the treatment 250 mg/kgbw (40.67±17.512) and 150 mg/kgbw (30.67±8.165). avarage value of count sperm in the control (130.83±41.877) its lower than treatments. In dose 350 mg/kgbw its highest (199.67±23.480) compare in the treatment 250 mg/kgbw (187.50±74.538) and 150 mg/kgbw (140.83±32.568). Administration of Nigella sativa oil occur to enhancement motility and number of spermatozoa wistar rats.

scholarly journals Nigella sativa L. oil ameliorates insulin resistance caused by dexamethasone treatment in male Wistar rats

2017 ◽  
Vol 11 (11) ◽  
pp. 144-151 ◽  
Author(s):  
Abdul-Musawwir Alli-oluwafuyi ◽  
Abdulbasit Amin ◽  
Wahab Imam Abdulmajeed ◽  
Aminu Imam ◽  
Faatihah Niyi-odumosu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Dexamethasone Treatment ◽  
Male Wistar Rats

scholarly journals Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Heba M. A. Abdelrazek ◽  
Omnia E. Kilany ◽  
Muhammad A. A. Muhammad ◽  
Hend M. Tag ◽  
Aaser M. Abdelazim
Keyword(s):  
Lipid Profile ◽  
Pancreatic Islet ◽  
Wistar Rats ◽  
Nigella Sativa ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Hepatic Glycogen ◽  
Therapeutic Effects ◽  
Male Wistar Rats

Diabetes mellitus is one of the metabolic diseases having several complications. Nigella sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications. Thirty-two mature male Wistar rats were equally divided into four experimental groups: control, control NSO 2 mL/kg, streptozotocin- (STZ-) induced diabetic, and diabetic (STZ-induced) treated with oral NSO 2 mg/kg for 30 days. Fasting blood glucose (FBG), insulin, and lipid profile levels were determined. Pancreatic and hepatic tissues were used for catalase and GSH. Histopathology, hepatic glycogen contents, insulin immunohistochemistry, and pancreatic islet morphometry were performed. NSO 2 mL/kg was noticed to decrease (P<0.05) FBG and increase (P<0.05) insulin levels in diabetic rats than in diabetic nontreated animals. Lipid profile showed significant (P<0.5) improvement in diabetic rats that received NSO 2 mL/kg than in the diabetic group. Both pancreatic and hepatic catalase and GSH activities revealed a significant (P<0.05) increment in the diabetic group treated with NSO than in the diabetic animals. NSO improved the histopathological picture and hepatic glycogen contents of the diabetic group as well as increased (P<0.05) insulin immunoreactive parts % and mean pancreatic islet diameter. NSO exerts ameliorative and therapeutic effects on the STZ-induced diabetic male Wistar rats.

scholarly journals Changes of the Biochemical Parameters of the Blood Serum of Wistar rats Exposed to Chronic Stres

2019 ◽  
pp. 62-67
Author(s):  
K. A. Kidun ◽  
A. N. Litvinenko ◽  
T. S. Ugolnik ◽  
N. M. Golubykh ◽  
E. K. Solodova
Keyword(s):  
Blood Serum ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Mature Male ◽  
Control Group ◽  
Physiological Processes ◽  
Male Wistar Rats ◽  
Increased Activity ◽  
Sexually Mature ◽  
Experimental Group

Objective: to assess the effect of chronic nonspecific stress on changes of the biochemical parameters of the blood serum in male Wistar rats.Material and methods. The experimental study was performed on sexually mature male Wistar rats. The experimental group (n = 71) was exposed to chronic nonspecific stress according to the Ortiz method. The control group of the animals included intact animals (n = 31).Results. The study has revealed changes in the biochemical composition of the blood serum of the rats: increased activity of ALT, LDH, ALP, urea, uric acid, and cholesterol, a decreased level of triglycerides.Conclusion. These changes may indicate the alteration of the level of the intensity of the physiological processes of energy supply in the conditions of chronic stress.

scholarly journals EFEK NIGELLA SATIVA OIL TERHADAP UKURAN DIAMETER ULKUS TRAUMATIKUS PADA MALE WISTAR RATS SECARA IN VIVO

2016 ◽  
Vol 3 (2) ◽  
pp. 94
Author(s):  
Linda Septiana ◽  
Ratnawati Hendari ◽  
Erwid Fatchur Rahman ◽  
Diyah Fatmasari
Keyword(s):  
Wistar Rats ◽  
Nigella Sativa ◽  
Pathological Condition ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Epithelial Tissue ◽  
Nigella Sativa Oil ◽  
Male Wistar Rats

Background: Ulcer is a pathological condition characterized by loss of epithelial tissue. Ulcer will experience healing within 2 weeks after trauma source is removed. Nigella sativa Oil has been known to heal wounds. The purpose of this study was to evaluate the effect of NSO on healing of ulcers in male wistar rats from the use of chemicals.Method: This study design was quasi-experimental methods. Ten male wistar rats were exposing the H2O2 on the mandibular anterior gingiva. divided into negatif control group and NSO group. NSO group treated twice daily for 10 days. Observaton wound size was measured on 0, 3,7, 10 days. The results were analayzed with Repeated Anova test and LSD test.Result: The observations difference diameter of traumatic ulcer negative control group and NSO on 0-10 days was 1.458 mm and 2.182 mm. The results of data analysis showed that there are significant differences (p<0,05) between negatif control group and NSO.Conclusion: NSO has an influence of the size reduction of the diameter of traumatic ulcers.

scholarly journals Thymoquinone, theNigella sativaBioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Hanene Jrah Harzallah ◽  
Rahma Grayaa ◽  
Wafa Kharoubi ◽  
Aya Maaloul ◽  
Mohamed Hammami ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Status ◽  
Wistar Rats ◽  
Normal Values ◽  
Nigella Sativa ◽  
Colon Carcinogenesis ◽  
Conjugated Diene ◽  
Male Wistar Rats ◽  
Erythrocyte Lipid

We have performed this study to investigate the modulatory effect of thymoquinone (TQ), theNigella sativaactive compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages.

scholarly journals The effect of dietary supplementation of Nigella sativa (black seeds) on cell mediated immunological function of male Wistar rats

2020 ◽  
Author(s):  
Hany Mahmoud ◽  
Amani Almallah ◽  
Heba Gad EL-Hak ◽  
Tahany Aldayel ◽  
Heba Abdelrazek ◽  
...  
Keyword(s):  
Immune Response ◽  
Weight Gain ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Histopathological Examination ◽  
Nigella Sativa ◽  
Interleukin 12 ◽  
Cell Mediated Immune Response ◽  
Male Wistar Rats ◽  
Black Seeds

Abstract This experiment aimed to investigate the effect of dietary Nigella sativa on cell mediated immune response. A total of eighteen male Wistar rats were divided equally into control and black seeds at 30 and 50 g/kg/diet (Sa30 and Sa50), respectively for 30 days. Weight gain, feed intake, feed conversion ratio (FCR), cell mediated immune response was monitored after injection of 0.1 mL of 10% phytohemagglutinin (PHA). Intumesce Index, serum total antioxidant capacity (TAC), Catalase (CAT), Interleukin-12 (IL-12), gamma interferon (γ-IF) and tumor necrosis factor alpha (TNF-α) were determined. Histopathological examination and immunohistochemistry of splenic caspase-3 and CD 8 were done. Nigella sativa significantly (p<0.05) improved weight gain and FCR in Sa30 and Sa50 groups. Significant increase for Intumesce Index in Sa50 group was observed. Total TAC, CAT, IL-12, γ-IF and TNF-αincreased significantly (P<0.05) in Sa30 and Sa50 groups. Histological examination of PHA stimulated foot pads showed more leukocytes infiltration and edema in a dose dependent pattern. Splenic caspase-3 and CD 8 showed significant (P<0.05) decrease and increase, respectively in Sa30 and Sa50 groups. Nigella sativa seeds had immunostimulatory ability through their antioxidant potential, cytokines induction, CD 8 promotion and reducing splenic apoptosis.

Sign in / Sign up

Export Citation Format

Share Document