scholarly journals Third molar agenesis in modern humans with and without agenesis of other teeth

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e10367
Author(s):  
Maya Scheiwiller ◽  
Elias S. Oeschger ◽  
Nikolaos Gkantidis
Keyword(s):  
Case Control Study ◽  
Matched Control ◽  
Third Molar ◽  
Control Group ◽  
Evolutionary Trend ◽  
Third Molars ◽  
Modern Humans ◽  
Third Molar Agenesis ◽  
Evolutionary Aspects ◽  
Control Study

Background The number of teeth in the human dentition is of interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light on the most variable tooth class in the dentition. Materials and Methods For this reason, we investigated third molar formation in a sample of 303 individuals with agenesis of teeth other than third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without agenesis of teeth other than third molars. Results The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the agenesis in other teeth factor. When considering the amount of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the maxilla, as well as in the mandible, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the maxilla and 8.9% in the mandible. Conclusion The present results indicate that genetic factors involved in tooth agenesis affect also the dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in agenesis of other teeth and they are more often affected as a whole. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.

scholarly journals Third molar agenesis in modern humans with and without agenesis of other teeth

2020 ◽  
Author(s):  
Maya Scheiwiller ◽  
Elias S. Oeschger ◽  
Nikolaos Gkantidis
Keyword(s):  
Case Control Study ◽  
Matched Control ◽  
Third Molar ◽  
Control Group ◽  
Evolutionary Trend ◽  
Third Molars ◽  
Modern Humans ◽  
Third Molar Agenesis ◽  
Evolutionary Aspects ◽  
Control Study

Abstract Background The number of teeth in the human dentition is of interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light on the most variable tooth class in the dentition. Methods For this reason, we investigated third molar formation in a sample of 303 individuals with agenesis of teeth other than third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without agenesis of teeth other than third molars. Results The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the agenesis in other teeth factor. When considering the amount of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the maxilla, as well as in the mandible, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the maxilla and 8.9% in the mandible. Conclusion The present results indicate that genetic factors involved in tooth agenesis affect also the dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in agenesis of other teeth and they are more often affected as a whole. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.

scholarly journals Third molar agenesis in modern humans with and without other tooth agenesis

2019 ◽  
Author(s):  
Maya Scheiwiller ◽  
Elias S. Oeschger ◽  
Nikolaos Gkantidis
Keyword(s):  
Third Molar ◽  
Control Group ◽  
Tooth Agenesis ◽  
Evolutionary Trend ◽  
Third Molars ◽  
Modern Humans ◽  
Lower Jaw ◽  
Third Molar Agenesis ◽  
Evolutionary Aspects ◽  
Control Study

Abstract Background The number of teeth in the human dentition attracts special interest both from developmental and evolutionary aspects. The present case-control study focused on the formation of third molars in modern humans aiming to shed more light in this long lasting enigma.Methods For this reason, we investigated third molar formation in a sample of 303 individuals with tooth agenesis other than in third molars (agenesis group) and compared it to a sex and age matched control group of 303 individuals without tooth agenesis other than in third molars.Results The prevalence of third molar agenesis in the agenesis group was 50.8%, which is significantly higher than the 20.5% in the control group (p < 0.001). The chance of a missing third molar in the agenesis group was increased by 38.3% (p < 0.001), after controlling for the other tooth agenesis factor. When considering the percentages of the number of missing third molars per individual, a clear tendency towards more missing third molars was evident in the agenesis group compared to the control group. The frequency of bilaterally missing third molars in the agenesis group was 29% in the upper as well as in the lower jaw, which is about three times higher than the frequency of unilaterally missing third molars (p < 0.001). In the control group, bilaterally missing third molars occurred in 8.6% in the upper and 8.9% in the lower jaw.Conclusion The present results indicate that genetic factors involved in certain tooth agenesis also affect the entire dentition as a whole. Furthermore, the third molars are more vulnerable to factors involved in other tooth agenesis and they are more often affected as a total. These findings seem to be associated with the evolutionary trend in humans towards reduced molar number.

Association of Thrombin-Activatable Fibrinolysis Inhibitor with Acute Pulmonary Embolism

2021 ◽  
Author(s):  
Abdulkerim Yıldız ◽  
Didem Katar ◽  
Ayşe Özden Soydaş ◽  
Murat Albayrak
Keyword(s):  
Case Control Study ◽  
Matched Control ◽  
Smoking Status ◽  
Control Group ◽  
Thrombin Activatable Fibrinolysis Inhibitor ◽  
Fibrinolysis Inhibitor ◽  
History Of ◽  
Impact On Treatment ◽  
And Gender ◽  
Control Study

Abstract Background Thrombin-activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis and high levels may have an association with thrombosis. The aim of the current study was to investigate the association of TAFI antigen levels with pulmonary thromboembolism (PTE). Patients and Methods A case–control study was conducted with 29 patients with PTE and 17 age- and gender-matched control individuals. Plasma levels of TAFI were measured at the time of diagnosis, then at 3 and 6 months after the event. Results Initial TAFI levels (%) were higher in patients with PTE than in the control group Initial TAFI levels (%) were higher in patients with PTE than in the control group (190,0 [65,0–250,0] vs 133,0 [83,0–153,0]; p = 0.003). TAFI levels significantly decreased at the third and sixth months after initial diagnosis (p < 0.05). The percentage reductions in TAFI levels were 12 and 36.8% at 3 and 6 months, respectively. The Odss ratio (OR) of TAFI level for PTE was found to be 1.024 (95% CI: 1.007–1.040; p = 0.005). There was no significant correlation of initial TAFI levels with age, gender, smoking status, history of thrombosis, pulmonary artery pressure, and D-dimer levels (p > 0.05). In the sixth month of treatment, patients with residual thrombosis were seen to have similar baseline levels and reductions of TAFI as patients without residual thrombosis (p > 0.05). Conclusion The result of this study suggests that high TAFI levels may have a role in the occurrence of PTE without impact on treatment outcome.

scholarly journals Hand anthropometry in patients with carpal tunnel syndrome: a case-control study with a matched control group of healthy volunteers

2015 ◽  
Author(s):  
Marek Trybus ◽  
Beata Stepańczak ◽  
Mateusz Koziej ◽  
Maksymilian Gniadek ◽  
Małgorzata Kołodziej ◽  
...  
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Healthy Volunteers ◽  
Carpal Tunnel ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Control Group ◽  
Matched Control Group ◽  
Tunnel Syndrome ◽  
Control Study

scholarly journals Third Molar Agenesis and Craniofacial Morphology

2009 ◽  
Vol 79 (3) ◽  
pp. 473-478 ◽  
Author(s):  
María José Sánchez ◽  
Ascensión Vicente ◽  
Luis Alberto Bravo
Keyword(s):  
Third Molar ◽  
Craniofacial Morphology ◽  
Control Group ◽  
Third Molars ◽  
Discrimination Analysis ◽  
Third Molar Agenesis ◽  
Mandibular Plane ◽  
Wisdom Teeth ◽  
Group 2 ◽  
Mandibular Third Molars

Abstract Objective: To test the null hypothesis that agenesis of wisdom teeth is not related with any particular craniofacial morphology. Materials and Methods: Ninety-seven patients (aged 13–19 years) were selected and divided into three groups: (1) bilateral agenesis of maxillary third molars, (2) bilateral agenesis of mandibular third molars, and (3) control group without agenesis. Presence or absence of third molars was determined using ortopantomographs. Cephalometric analysis was carried out from lateral teleradiographs, which included linear, angular, and proportional measurements. When data obtained were distributed normally it was analyzed by means of single-factor variance analysis and the Scheffé test (P &lt; .05). When data did not show normality, the Kruskal-Wallis test (P &lt; .05) and the Mann-Whitney test were applied using Bonferroni correction (P &lt; .017). Multivariance discrimination analysis was also carried out. Results: Values obtained for the mandibular plain of Groups 1 and 2 were significantly lower than those of the Control Group (P =.00 and P =.00, respectively). For Group 2 lower face height was significantly less than for the control group (P =.01), whilst the mandibular arch and the articular angle were significantly greater than in the Control Group (P =.000 and P = .02, respectively). Multivariance discrimination analysis obtained a correct classification in 58.8% of cases. Conclusion: The hypothesis is rejected. Agenesis of the maxillary third molars was related to a reduced mandibular plane angle. Patients with agenesis of the mandibular third molars showed a diminished lower third and a mandibular morphology characteristic of the brachyfacial pattern.

scholarly journals Relationship between Third Molar Agenesis and Other Dental Anomalies

2019 ◽  
Vol 07 (01) ◽  
pp. 023-027
Author(s):  
Stuti Gulati ◽  
Divya Singla ◽  
Sanjay Mittal ◽  
Mandeep Bhullar ◽  
Isha Aggarwal ◽  
...  
Keyword(s):  
Third Molar ◽  
Control Group ◽  
Third Molars ◽  
Dental Anomalies ◽  
Supernumerary Teeth ◽  
Chi Square ◽  
Impacted Canines ◽  
The North ◽  
Third Molar Agenesis ◽  
Chi Square Test

Abstract Objective The purpose of this study was to find the prevalence of dental abnormalities in patients with third molar agenesis, and a comparison was made for the prevalence of those anomalies within the north Indian natives. Materials and Methods Pretreatment records of 518 patients were collected. Out of 518 patients whose records were analyzed, 472 patient records were selected on the basis of inclusion and exclusion standards. Panoramic radiographs and dental casts were analyzed in patients who had an absence of at least one third molar in which absence of any other tooth, presence of supernumerary teeth, presence of impacted canines, and peg-shaped lateral incisors were further assessed. The prevalence of these anomalies was compared with a randomly selected group of patients with presence of third molars that served as controls. Statistical analysis was done using the chi-square test (p < 0.05) and odds ratio. Results The incidence of third molar nondevelopment was found to be 19.2%. The presence of other anomalies was 39.5% in patients with third molar nondevelopment, and difference was statistically significant. The occurrence of impacted canines in patients with absence of third molars was 22%, and presence of third molars was 6.6%. The presence of other dental anomalies, that is, supernumerary teeth and tooth agenesis, was 7.7% in the agenesis group, which was also higher than that in the control group (3.3%) but was not statistically significant. The incidence of peg-shaped lateral incisors was similar in both the groups. Conclusion Impacted canines and total dental anomalies are more often related with absence of third molars than with the presence of third molars.

scholarly journals Third molar tooth agenesis and pattern of impaction in patients with palatally displaced canines

2018 ◽  
Vol 89 (1) ◽  
pp. 64-70
Author(s):  
Elham S. Abu Alhaija ◽  
Fedaa T. Wazwaz
Keyword(s):  
Third Molar ◽  
Control Group ◽  
Tooth Agenesis ◽  
Third Molars ◽  
Missing Teeth ◽  
Control Groups ◽  
Third Molar Agenesis ◽  
High Prevalence ◽  
The Difference ◽  
And Control

ABSTRACT Objectives: To investigate the association between third molar agenesis and pattern of impaction, missing teeth, and peg-shaped lateral incisor with palatal canine displacement (PDC). Materials and Methods: The pretreatment orthodontic orthopantomograms of 438 patients (122 males and 316 females) diagnosed with PDC were included. A total of 338 patients with normally erupted canines who had a preexisting radiograph as part of their orthodontic treatment (125 males and 313 females) served as controls. Orthopantomograms were evaluated for missing third molars, third molar eruption status, and type of impaction, third molar spaces, third molar width, and angulation. Results: In the PDC group, at least one third molar was missing in 48% and 19% in the upper and lower arches, respectively. Also, 38% and 67% of PDC patients had at least one third molar impaction in the upper and lower arches, respectively. The difference between the PDC and control groups was significant for both missing and impacted third molars (P &lt; .001 for each). The most common type of third molar impaction in the upper arch was vertical and distoangular in the PDC and control groups, respectively. Upper and lower third molar width and spaces were reduced in PDC patients when compared with the control group (P &lt; .001). In PDC patients, missing teeth and peg-shaped lateral incisors were recorded in 5.6% and 9.1%, respectively. Conclusions: PDC patients showed a high prevalence of third molar agenesis and impaction. Upper and lower third molar width and space were reduced in the PDC patients. There were no significant associations between tooth agenesis (other than third molars) and the PDC anomaly.

scholarly journals Health-Related Quality of Life in Ankle Osteoarthritis: A Case-Control Study

Cartilage ◽  
2021 ◽  
pp. 194760352110258
Author(s):  
Liam D.A. Paget ◽  
Johannes L. Tol ◽  
Gino M.M.J. Kerkhoffs ◽  
Gustaaf Reurink
Keyword(s):  
General Population ◽  
Mental Component Summary ◽  
Case Control Study ◽  
Matched Control ◽  
Case Control ◽  
Control Group ◽  
Ankle Osteoarthritis ◽  
End Stage ◽  
Control Study

Objective Ankle osteoarthritis (OA) has a prevalence of 3.4% in the general population of which 70% to 78% is posttraumatic, affecting younger patients with a longer projected life span compared with hip and knee OA. The current literature reports the physical and mental quality of life (QoL) of patients with ankle OA, to be similar to end-stage hip OA, end-stage kidney disease and digestive heart failure. However, the QoL of ankle OA patients has not yet been determined compared with a matched control group representing the general population. Our aim is to determine the physical and mental QoL compared with a matched control group. Design The Physical and Mental Component Summaries of the Short Form–36 of 100 patients with ankle OA were compared with 91 age- and gender-matched controls. This case-control study is a substudy of the PRIMA trial, in which the efficacy of platelet-rich plasma injections for ankle OA is determined. Results A clinically relevant difference was found for both the Physical ( P=0.003; 95% CI −6.7 to −1.3) and Mental Component Summary scores ( P < 0.001; 95% CI −10 to −6). Patients with ankle OA had a median of 45 points (matched controls 52 points) and 43 points (matched controls 53 points) for the Physical and Mental Component summary scores, respectively. Conclusions Patients with ankle OA had a clinically relevant poorer mental and physical QoL compared with matched controls from the general population. Furthermore, the physical QoL of patients with ankle OA from younger age categories was affected more than those in older age categories.

Rorschach Characteristics in Adolescents with Systemic Lupus Erythematosus

2006 ◽  
Vol 28 (1) ◽  
pp. 100-118 ◽  
Author(s):  
J. Santoantonio ◽  
L. Yazigi ◽  
E. I. Sato
Keyword(s):  
Lupus Erythematosus ◽  
Case Control Study ◽  
Activity Index ◽  
Disease Activity Index ◽  
Female Adolescents ◽  
Control Group ◽  
Intelligence Scale ◽  
The Mean ◽  
Experimental Group ◽  
Control Study

The purpose of this study was to investigate the personality characteristics in adolescents with SLE. The research design is a case-control study by means of the Rorschach Method and the Wechsler Intelligence Scale. Study group: 30 female adolescents with lupus, 12–17 years of age. The SLE Disease Activity Index was administered during the period of psychological evaluation. Control group: 32 nonpatient adolescents were matched for age, sex, and socioeconomic level. In the Wechsler Intelligence Scale the mean IQ of the experimental group was significantly lower than that of the control group (77 and 98, respectively, p < .001). In the Rorschach, the lupus patients showed greater difficulty in interpersonal interactions, although they displayed the resources to process affect and to cope with stressful situations. A positive moderate correlation (p = .069) between the activity index of the disease and the affect constriction proportion of the Rorschach was observed: the higher the SLEDAI score, the lower the capacity to process affect. There is a negative correlation between the activity index of the disease and the IQ (p = .001): with a higher activity index of the disease, less intellectual resources are available.

Assessment of Craniofacial Morphology in Mouth Breathing Children. A retrospective case-control study

2019 ◽  
Vol 70 (10) ◽  
pp. 3649-3653
Author(s):  
David Angelescu ◽  
Teodora Angelescu ◽  
Meda Romana Simu ◽  
Alexandrina Muntean ◽  
Anca Stefania Mesaros ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Craniofacial Morphology ◽  
Respiratory Pattern ◽  
Control Group ◽  
Upper Lip ◽  
Retrospective Case ◽  
Oral Breathing ◽  
Facial Height ◽  
Control Study

The aim of this retrospective case-control study is to determine a possible correlation between breathing mode and craniofacial morphology. The study was carried out in the Department of Pedodontics,Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. The sample comprised 80 patients, age between 6 and 13 years, which were divided in two groups based on respiratory pattern: control group composed of 38 nasal breathing children and case group composed of 42 oral breathing children. Three quantitative craniofacial parameters were measured from the frontal and lateral photos: facial index, lower facial height ratio and upper lip ratio. The statistical analysis showed a significant higher facial index (p=0.006*) and an increase lower facial height (p=0.033*) for the oral breathers group. No differences in facial morphology were found between genders and age groups, when comparing the data between the same type of respiratory pattern children. Spearman�s rho Correlation show a significant positive correlation (p=0.002*) between facial index and lower facial height and a significant negative correlation between facial index and upper lip (p=0,005*). Long faces children are more likely to develop oral breathing in certain conditions, which subsequently have a negative effect on increasing the lower facial height by altering the postural behavior of mandible and tongue.

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