scholarly journals Creatinine is a biochemical marker for assessing how untrained people adapt to fitness training loads

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9137
Author(s):  
Andrii Chernozub ◽  
Vladimir Potop ◽  
Georgiy Korobeynikov ◽  
Olivia Carmen Timnea ◽  
Oleg Dubachinskiy ◽  
...  

Background To study the peculiarities of changes in creatinine concentration in blood serum of untrained men during the prolonged usage of training loads different in volume and intensity, and to determine the value of this biochemical marker for the assessment of adaptive body changes during fitness training. Methods We examined 50 untrained men aged 18–20 years who had no contraindications for practicing fitness. Taking into account the aim of the research, we divided these people into two groups: group A and group B. The research participants used training load regimes different in volume and intensity: representatives of group Aused low intensity training load regime (Ra = 0.53) and representatives of group B used high intensity training load regime (Ra = 0.72). To assess the adaptive body changes in the examined contingent, we used the anthropometry method (circumference body size) and bioimpedansometry (body composition indicators). We also determined the features of adaptation-compensatory body reactions to different training loads by means of biochemical control of creatinine concentration in blood serum. Results The obtained results showed a significant increase in basal level of creatinine concentration in blood serum (by 17.6%) of group B representatives fixed after 3 months of practicing fitness in high intensity training load regime (Ra = 0.72). This group representative also revealed the most pronounced manifestation of adaptive body changes confirmed by the results of the maximal muscle strength growth (1RM) and circumference body size, which was almost 2.5 times higher than the results of group A representatives for the same period of time. The parameters indicating the load volume in a set (Wn) were almost 62.0 % higher in group A representatives in comparison with group B during all stages of control. Nonetheless, the highest creatinine concentration in blood serum (by 11.1 % (p < 0.05) was fixed in group A representatives in response to training load after 3 months of practicing. This fact testifies to the important role of the creatine phosphokinase mechanism of energy supply of muscular activity in the conditions of high volume and low intensity training load regime (Ra = 0.53). Conclusion The analysis of the results obtained during a series of experimental studies indicates the need and feasibility of using the indicator of basal level of creatinine concentration in blood during fitness training, especially in the conditions of high intensity and low volume training load regime (Ra = 0.72), as an informative marker for assessing the process of long-term adaptation.

2010 ◽  
Vol 35 (1) ◽  
pp. 17-22 ◽  
Author(s):  
James Hopker ◽  
Damian Coleman ◽  
Louis Passfield ◽  
Jonathan Wiles

The impact of different intensity training on cycling efficiency in competitive cyclists is unknown. Twenty-nine endurance-trained competitive male cyclists completed 3 laboratory visits during a 12-week training period. At each visit, their cycling efficiency and maximal oxygen uptake were determined. After the first visit, cyclists were randomly split into 2 groups (A and B). Over the first 6 weeks, between tests 1 and 2, group A was prescribed specific high-intensity training sessions, whereas group B was restricted in the amount of intensive work undertaken. After test 2 and for the second 6-week period, group B was allowed to conduct high-intensity training. Gross efficiency (GE) increased in group A (+1.6 ± 1.4%; p < 0.05) following the high-intensity training, whereas no significant change was seen in group B (+0.1 ± 0.7%; p > 0.05). Group B cyclists increased their GE between tests 2 and 3 (+1.4 ± 0.8%; p < 0.05) but no changes in GE were observed in group A over this period (+0.4 ± 0.4%; p > 0.05). Delta efficiency (DE) did not change significantly in either group across the study period. This study demonstrates that GE is increased following high-intensity training in competitive male cyclists after 12 weeks.


2020 ◽  
Vol 52 (7S) ◽  
pp. 1099-1099
Author(s):  
Camilla R. Holland ◽  
Michael G. Roberts ◽  
Matthew W. Furber ◽  
Lindsy S. Kass ◽  
Lindsay Bottoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eugenia Murawska-Ciałowicz ◽  
Gilmara Gomes de Assis ◽  
Filipe Manuel Clemente ◽  
Yuri Feito ◽  
Petr Stastny ◽  
...  

AbstractThis study examined the effects of a nine-week intervention of four different high-intensity training modalities [high-intensity functional training (HIFT), high-intensity interval training (HIIT), high-intensity power training (HIPT), and high-intensity endurance training (HIET)] on the resting concentration of brain-derived neurotropic factor (BDNF). In addition, we evaluated the BDNF responses to Graded Exercise Test (GXT) and Wingate Anaerobic Test (WAnT) in men. Thirty-five healthy individuals with body mass index 25.55 ± 2.35 kg/m2 voluntarily participated in this study and were randomly assigned into four training groups. During nine-weeks they completed three exercise sessions per week for one-hour. BDNF was analyzed before and after a GXT and WAnT in two stages: (stage 0—before training and stage 9—after nine weeks of training). At stage 0, an increase in BDNF concentration was observed in HIFT (33%; p < 0.05), HIPT (36%; p < 0.05) and HIIT (38%; p < 0.05) after GXT. Even though HIET showed an increase in BDNF (10%) this was not statistically significant (p > 0.05). At stage 9, higher BDNF levels after GXT were seen only for the HIFT (30%; p < 0.05) and HIIT (18%; p < 0.05) groups. Reduction in BDNF levels were noted after the WAnT in stage 0 for HIFT (− 47%; p < 0.01), HIPT (− 49%; p < 0.001), HIET (− 18%; p < 0.05)], with no changes in the HIIT group (− 2%). At stage 9, BDNF was also reduced after WAnT, although these changes were lower compared to stage 0. The reduced level of BDNF was noted in the HIFT (− 28%; p < 0.05), and HIPT (− 19%;p < 0.05) groups. Additionally, all groups saw an improvement in VO2max (8%; p < 0.001), while BDNF was also correlated with lactate and minute ventilation and selected WAnT parameters. Our research has shown that resting values of BDNF after nine weeks of different forms of high-intensity training (HIT) have not changed or were reduced. Resting BDNF measured at 3th (before GXT at stage 9) and 6th day after long lasting HITs (before WAnT at stage 9) did not differed (before GXT), but in comparison to the resting value before WAnT at the baseline state, was lower in three groups. It appears that BDNF levels after one bout of exercise is depended on duration time, intensity and type of test/exercise.


2016 ◽  
Vol 44 (3) ◽  
pp. 208-216 ◽  
Author(s):  
Mehdi Kargarfard ◽  
Eddie T. C. Lam ◽  
Ardalan Shariat ◽  
Mahmoud Asle Mohammadi ◽  
Saleh Afrasiabi ◽  
...  

2000 ◽  
Vol 279 (1) ◽  
pp. R152-R160 ◽  
Author(s):  
Niels Ørtenblad ◽  
Per K. Lunde ◽  
Klaus Levin ◽  
Jesper L. Andersen ◽  
Preben K. Pedersen

To evaluate the effect of intermittent sprint training on sarcoplasmic reticulum (SR) function, nine young men performed a 5 wk high-intensity intermittent bicycle training, and six served as controls. SR function was evaluated from resting vastus lateralis muscle biopsies, before and after the training period. Intermittent sprint performance (ten 8-s all-out periods alternating with 32-s recovery) was enhanced 12% ( P < 0.01) after training. The 5-wk sprint training induced a significantly higher ( P < 0.05) peak rate of AgNO3-stimulated Ca2+ release from 709 (range 560–877; before) to 774 (596–977) arbitrary units Ca2+ ⋅ g protein− 1 ⋅ min− 1(after). The relative SR density of functional ryanodine receptors (RyR) remained unchanged after training; there was, however, a 48% ( P < 0.05) increase in total number of RyR. No significant differences in Ca2+ uptake rate and Ca2+-ATPase capacity were observed following the training, despite that the relative density of Ca2+-ATPase isoforms SERCA1 and SERCA2 had increased 41% and 55%, respectively ( P < 0.05). These data suggest that high-intensity training induces an enhanced peak SR Ca2+ release, due to an enhanced total volume of SR, whereas SR Ca2+ sequestration function is not altered.


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