Antimycobacterial Activities of an Edible Mushroom Extract and its Synergy with the Standard Antituberculous Drugs

AbstractEdible mushroom (Agaricus bisporus) extract was used to synthesize gold nanoparticles (AuNPs) through hydrothermal process (at a pressure of 15 psi and a temperature of 121°C for 15 min). Response surface methodology was applied to monitor the influence of the synthesis parameters, namely: the mushroom extract concentration (1–9 gr DP/100 ml distilled water) and the amount of HAuCL4·3H2O solution (8–12 ml) on the particle size and concentration of fabricated AuNPs. The obtained results demonstrated that while the main and quadratic terms of the synthesis parameters had significant (p<0.05) effects on the response variables, their interactions had insignificant effect on them. The results indicated that spherical synthesized AuNPs using 10 ml of HAuCl4·3H2O solution (1 mm) and 1 ml of mushroom extract with concentration of 5 gr DP/100 ml had mean particle size (25 nm) and maximum concentration (534 ppm) and stability (zeta potential of –45.8 mV). The results revealed that mushroom extract could act as both reducing and stabilizing agents due to its bioactive compounds. Fourier-transform infrared analysis showed that polyols and carbonyl groups in mushroom extract had strong effects on formation of stable AuNPs. The fabricated AuNPs exhibited high antifungal activity againstAspergillus flavusas compared to theAspergillus terreus.

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ANTAGONISTIC EFFECT OF EDIBLE MUSHROOM EXTRACT ON CANDIDA ALBICANS GROWTH

Brazilian Journal of Microbiology ◽

10.1590/s1517-83822001000300003 ◽

2001 ◽

Vol 32 (3) ◽

pp. 176-178 ◽

Cited By ~ 7

Author(s):

Edneia A. de Souza Paccola ◽

Cristina Sayuri Maki ◽

Gisele M.A. de Nobrega ◽

Luzia Doretto Paccola-Meirelles

Keyword(s):

Candida Albicans ◽

Edible Mushroom ◽

Antagonistic Effect ◽

Mushroom Extract

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The Medical Effects of Edible Mushroom Extract on Aflatoxin B1

Journal of Biological Sciences ◽

10.3923/jbs.2011.481.486 ◽

2011 ◽

Vol 11 (8) ◽

pp. 481-486 ◽

Cited By ~ 2

Author(s):

Q.A. Nogaim ◽

H.A.S. Amra ◽

S.A. Nada

Keyword(s):

Aflatoxin B1 ◽

Edible Mushroom ◽

Mushroom Extract

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Biogenic Synthesis of Selenium Nanoparticles with Edible Mushroom Extract: Evaluation of Cytotoxicity on Prostate Cancer Cell Lines and Their Antioxidant, and Antibacterial Activity

Biointerface Research in Applied Chemistry ◽

10.33263/briac106.66296639 ◽

2020 ◽

Vol 10 (6) ◽

pp. 6629-6639 ◽

Cited By ~ 1

Keyword(s):

Prostate Cancer ◽

Cell Lines ◽

Spherical Shape ◽

Edible Mushroom ◽

Selenium Nanoparticles ◽

High Concentration ◽

Biogenic Synthesis ◽

Mushroom Extract ◽

Transmission Electron ◽

Uv Visible

We report edible mushroom extract (EME) as a robust and environmentally friendly precursor for the biogenic synthesis of selenium nanoparticles (SeNPs). The as-synthesized SeNPs were characterized by UV-visible spectrophotometer (UV-vis), Fourier-transform infrared spectroscopy (FTIR), Transmission electron microscope (TEM), and Dynamic light scattering (DLS) techniques. The results obtained from TEM and DLS suggested that the SeNPs synthesized with EME are in the size of ~ 8 nm with a spherical shape and monodispersity. The occurrence of antioxidants in the EME has been confirmed with FTIR and thereby confirmed that flavonoids and phenolic compounds played a pivotal role in the biosynthesis of SeNPs from Na2SeO3. In addition, EME-SeNPs exhibited no cytotoxicity on the cell lines of prostate cancer (PC-3) at concentrations ranging from 0.5-1.5 μM. At a concentration of 0.25 mM against 1,1-diphenyl-2-picrylhydrazyl, the average scavenging level of EME-SeNPs was found to be > 80.20 %. Moreover, the percentage viability of gram-negative E.coli and gram-positive E.faecium was recorded at a high concentration of EME-SeNPs and found to be 82 % and 65 %, respectively.

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