scholarly journals Analgesic Efficacy of Perioperative Esmolol as an Adjunct to Morphine in Mastectomy- A Prospective Observational Study

Author(s):  
Jose Tania ◽  
Vadakkoot Raghavan Hema ◽  
Prabhakaran Vineetha

Introduction: Multimodal analgesia with opioids as the prime component is the mainstay of postoperative analgesia for mastectomy, which can lead to many opioid related unwanted side-effects. Esmolol infusion has been found as a useful adjunct in reducing opioid requirements. Aim: To find the effect of perioperative esmolol infusion on postoperative pain and opioid requirements. Materials and Methods: This prospective observational study was done in 140 American Society of Anaesthesiologists (ASA) physical status l and ll patients, between 20-65 years of age posted for mastectomy under general anaesthesia. Esmolol group (group E) received 0.25 mg/kg of esmolol bolus ten minutes before induction followed by continuous infusion 5 μg/kg/min till end of surgery while control group (group C) received equivalent volumes of saline. Primary outcome measures were Numerical Rating Scale (NRS) for pain, total postoperative opioid consumption and time to first rescue analgesic dosage till 24 hours. Intraoperative haemodynamics and other side-effects were secondary outcomes. Descriptive statistics of numerical rating scores and analgesic requirements were analysed in terms of mean and standard deviation. Independent t-test was used to compare numerical rating scores and analgesic requirement of the two groups. A p-value of <0.05 was considered statistically significant. Results: The mean numerical pain scores were significantly lower in the esmolol group for the first 24 hour. The mean time to first rescue analgesic was 17.59±5.012 hour in the esmolol group and 8.21±2.22 hour in the control group which was statistically significant (p<0.001). The total tramadol consumption was also significantly lesser in the esmolol group (42.14±29.03 mg), compared to control group (102.86±22.3 mg), (p=0.0001). Mean heart rate was statistically lower in the esmolol group, but there was no incidence of bradycardia requiring treatment. Mean Arterial Pressures (MAP) were comparable. Conclusion: Perioperative esmolol infusion when used as an adjunct to morphine decreased postoperative pain and analgesic requirements for the first 24 hours without any haemodynamic disturbances.

2021 ◽  
Vol 7 (2) ◽  
pp. 319-323
Author(s):  
Hani Septiani ◽  
Sri Wulan Ratna Dewi

COMPARISON OF THE EFFECT OF ENDORPHINE MASSAGE ENGINEERING WITH WARM COMPRESS IN REDUCING DISMENORE SCALE Background dysmenorrhea or menstrual pain is the symptom most often complained of by women of reproductive age. Pain or pain that is cyclic along with menstruation is often felt like cramps in the stomach and can be accompanied by pain radiating to the back, with nausea and vomiting, headaches or diarrhea. Menstrual pain can last from a few hours to a day. Sometimes, these symptoms can last more than 1 day but rarely exceed 72 hours. Accompanying systemic symptoms include nausea, diarrhea, headache and emotional changes. In general, the management of menstrual pain is divided into two categories, namely pharmacologically and non-pharmacologically. non-pharmacological methods are a safer alternative and have no side effects. Non-pharmacological management is safer to use because it does not cause side effects of drugs.Purpose to analyse the comparison of the decrease in dysmenorrhea by applying endorphin massage and warm compress technique. Method This study used quasi experiment in which applied pretest-posttest control group design approach with total samples of 78. Respondent sampling was conducted by using purposive sampling. Menstrual pain variables were measured with Numerical Rating Scale. The analysis process used Mann Whitney and Kruskal Wallis test.Results of the study show that there were a significant differences between endorphin massage and warm compress technique on the 1st, 2nd, and 3rd days of menstruation after being given a treatment for 15 minutes with the p-value of 0.000<α = 0.05.Conclusion Endorphin massage technique is faster in reducing the scale of dysmenorrhea than warm compress. This technique is safe, easy, free of charge, has no side effect, and can be done with the closest person or by yourself.Suggestion The results of the research can become a study material or reference for other researchers in subsequent studies and become a learning resource for readers, especially about endorphin massage as a non-pharmacological therapy to treat dysmenorrhea.  Keywords: endorphin massage, menstrual pain ABSTRAK Latar Belakang dismenore atau  nyeri haid merupakan gejala yang paling sering dikeluhkan oleh wanita usia reproduktif. Nyeri atau rasa sakit yang siklik bersamaan dengan menstruasi ini sering dirasakan seperti rasa kram pada perut dan dapat disertai dengan rasa sakit yang menjalar ke punggung, dengan rasa mual dan muntah, sakit kepala ataupun diare. Nyeri haid dapat berlangsung dalam beberapa jam sampai 1 hari. Kadang-kadang, gejala tersebut dapat  lebih  dari  1  hari  tapi  jarang  melebihi  72  jam.  Gejala  sistemik  yang menyertai berupa mual, diare, sakit kepala dan perubahan emosional. Secara umum penanganan nyeri haid terbagi dalam dua kategori yaitu secara farmakologi dan non farmakologi. metode non farmakologi menjadi alternatif yang lebih aman dan tidak ada efek samping. Manajemen nonfarmakologi lebih aman digunakan karena tidak menimbulkan efek samping obat-obatan.Tujuan penelitian ini menganalisis perbandingan penurunan dismenore menggunakan teknik endorphine massage dibandingkan dengan kompres hangat.Metode penelitian menggunakan quasi eksperimen dengan pendekatan pretest-posttest control grup design dengan jumlah sampel 78. Pengambilan sampel responden pada penelitian ini dilakukan dengan menggunakan purposive sampling. Variabel nyeri haid atau dismenore diukur dengan menggunakan Numerical Rating Scale(NRS). Analisis yang digunakan yaitu uji Mann Whitney.Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara teknik endophine massage dengan teknik kompres hangat pada hari ke 1,2 dan 3 menstruasi setelah diberikan treatmen selama 15 menit dengan hasil nilai p-value 0.000 < α= 0,05.Kesimpulan Teknik endorphine massage lebih cepat menurunkan skala dismenore dibandingkan dengan teknik kompres hangat. Teknik ini aman, mudah, tidak membutuhkan biaya dan tidak memiliki efek samping juga bisa dilakukan dengan orang terdekat ataupun sendiri.Saran Hasil penelitian dapat mejadi salah satu bahan kajian atau referensi untuk peneliti lain dalam penelitian-penelitian selanjutnya serta menjadi baham pembelajaran bagi para pembaca terutama tentang endorphin massage sebagai terapi non farmakologi untuk mengatasi dismenore. Kata kunci : endorphine massage, nyeri haid 


2020 ◽  
Vol 103 (10) ◽  
pp. 1028-1035

Background: Craniotomy causes acute and chronic pain. Uncontrolled postoperative pain may lead to adverse events. Perioperative scalp nerves block is not only effective in reducing intraoperative hemodynamic response, but it also reduces postoperative pain and postoperative analgesia requirement. Objective: To compare the benefits of adding dexmedetomidine to levobupivacaine in scalp nerves block before craniotomy for the duration of analgesia in supratentorial craniotomy. Materials and Methods: After approval by the Committee for Research, 50 supratentorial craniotomy patients were randomized into two groups. The control group received 30 mL scalp nerves block with 0.25% levobupivacaine with adrenaline 1:200,000, whereas the study group received 30 mL scalp nerves block with 0.25% levobupivacaine with adrenaline 1:200,000 plus dexmedetomidine 1 mcg/kg. The primary outcome was the time to first analgesic requirement postoperatively. The secondary outcomes included intraoperative fentanyl consumption, verbal numerical rating scale, tramadol consumption, and complications during the first 24 hours postoperatively. Results: Patients in the study group had significantly increase time to the first analgesic requirement in postoperative period and reduced intraoperative fentanyl consumption. The median time to first analgesic requirement was 555 (360 to 1,035) minutes in the study group versus 405 (300 to 520) minutes in the control group (p=0.023). Intraoperative fentanyl consumption 125 (75 to 175) mcg in the study group was significantly lower than 200 (150 to 250) mcg in the control group (p=0.02). The verbal numerical rating scale at 1, 4, 8, 12 and 24 hours postoperatively, tramadol consumption, and complications during the first 24 hours postoperatively were not statistically significant different. Conclusion: Preoperative scalp nerves block with 0.25% levobupivacaine with adrenaline (1:200,000) with dexmedetomidine 1 mcg/kg significantly increased the time to first analgesic requirement and reduced intraoperative fentanyl consumption compared to 0.25% levobupivacaine with adrenaline (1:200,000) without perioperative complications. Keywords: Scalp block, Dexmedetomidine, Post-craniotomy analgesia, Supratentorial tumor, Levobupivacaine


2018 ◽  
Vol 7 (2) ◽  
pp. 143
Author(s):  
Natalia Devi Oktarina ◽  
Suwanti Suwanti ◽  
M. Imron Rosyidi

Nyeri dismenore adalah nyeri di daerah panggul akibat menstruasi dan produksi zat prostaglandin yang membuat dinding rahim berkontraksi dan pembuluh darah sekitarnya terjepit (kontriksi) yang menimbulkan iskemi jaringan. Penanganan nyeri dismenore dapat dilakukan dengan nonfarmakologis diantaranya dengan pemberian minuman kunyit asam dan stimulasi kutaneus. Penelitian ini untuk mengetahui perbedaan efektivitas pemberian kunyit asam yang baisa dikonsumsi remaja dengan pemberian stimulasi kutaneusterhadap penurunan intensitas nyeri dismenore pada siswi remaja putri. Penelitian ini menggunakan desain penelitian quasy eksperiment dengan rancangan pretest-posttest with control group design. Pengambilan sampel dengan cara purposive sampling. Besarnya sampel adalah 40 remaja di Desa Candirejo Kabupaten Semarang. Instrumen penelitiannya berupa lembar observasi nyeri Numerical Rating Scale. Analisis data menggunakan uji statistik t-test independent. Hasil penelitian melalui uji statistik t-test independent menunjukkan nilai p-value 0,002  yang artinya ada perbedaan efektivitas pemberian kunyit asam dan stimulasi kutaneus terhadap penurunan intensitas nyeri haid dengan rata-rata penurunan skala nyeri lebih tinggi pada stimulasi kutaneus. Kesimpulannya adalah stimulasi kutaneus lebih efektif menurunkan skala nyeri dismenore pada remaja putri.Berdasarkan dari hasil penelitian yang dilakukan diharapkan intervensi stimulasi kutaneus dapat diterapkan dan diaplikasikan sebagai intervensi baru bagi remaja ataupun masyarakat untuk mengatasi dismenore. Kata kunci      : nyeri dismenore, kunyit asam, stimulasi kutaneus


2020 ◽  
Vol 10 (1) ◽  
pp. 1259-1265
Author(s):  
Uun Kurniasih

Salah satu ketidaknyamanan yang sering timbul pada kehamilan adalah nyeri punggung. Nyeri punggung merupakan gangguan yang banyak dialami oleh ibu hamil sepanjang masa-masa kehamilan hingga periode pasca natal . Salah satu upaya yang bisa dilakukan untuk mengurangi nyeri punggung selama kehamilan adalah dengan melakukan senam hamil. Penelitian ini bertujuan untuk mengetahui skala nyeri sebelum dan sesudah dilakukan senam hamil dan untuk mengetahui pengaruh senam hamil terhadap nyeri punggung pada ibu hamil di UPTD Puskesmas Mundu Kabupaten Cirebon Tahun 2018.Penelitan ini menggunakan desain penelitian quasi eksperimen dengan pretest–posttest with control group. Pengambilan sampel menggunakan purposive sampling dengan jumlah sampel 28 responden, 14 subjek untuk kelompok intervensi dan 14 subjek untuk kelompok  kontrol. Teknik pengumpulan data dengan cara observasi. Sedangkan instrumen yang digunakan adalah Numerical Rating Scale (NRS). Analisa data yang digunakan adalah uji Mann – Whitney.Hasil Penelitian ini menunjukkan bahwa hasil dari pre test dan post test pada kelompok kontrol mayoritas dengan intensitas nyeri sedang yaitu 7 orang (50%) dan nyeri berat yaitu 6 orang (42%), sedangkan pada melompok intervensi mayoritas nyeri ringan yaitu 7 orang (50%) dan nyeri sedang yaitu 7 orang (50%). Berdasarkan analisa statistik didapatkan niai p value adalah  0,001 maka Ho ditolak dan Ha diterima artinya senam hamil efektif menurunkan intensitas nyeri punggung pada ibu hamill di UPTD Puskesmas Mundu Kabupaten Cirebon tahun 2018Kata Kunci   : Senam, nyeri punggung, ibu hamil  ABSTRACTLow Back pain is one of the discomfort which often occurred during pregnancy. Lowback pain is a condition experienced by many pregnant women troughout pregnancy period to the post  delivery period. One of the solutionto address this issue is by doing exercise for pregnancy women. The studi was conducted to find out the effect of pregnancy exercisseto reduce low back paint issue.This studi aims to determine the scalae of pain before and after pregnancy exercise and to determine the effect of pregnancy exercise againt back pain in pregnancy women in UPTD puskesmas Mundu Cirebon Regency 2018. This research uses quasi experimental research design with Pretest –Posttest with Control Group. Sampling using purposive sampling with the number of samples of 28 respondent, 14 for the intervention group and 14 subjects for the control group. Data collection techniques by observation. While the instrument used is the Numerical Rating Scale (NRS). The data analysis used is Mann –Whitney test. The resukt of this study indicate that resukt of pre-test and post-test in the mayoritycontrol group with moderate pain intensisity of 7 people (50%) and severe pain that is 6 people (42,9%), while in the intervention group the majority of mild pain 7 peiple (50%). Based on statistical analysis in the value of p value is 0,001, then H0 is rejected reduce the intensity of back pain in pregnant women in UPTD Puskesmas Mundu Cirebon  2018.Keywords: Exercise, back pain, pregnancy women


2019 ◽  
Vol 12 (1) ◽  
pp. 11-20
Author(s):  
Denny Saputra ◽  
Asmawati Asmawati ◽  
Septiyanti Septiyanti

Nyeri pasca bedah SC akan menimbulkan reaksi fisik dan psikologi pada ibu postpartum seperti  gangguan mobilisasi, malas beraktifitas, sulit tidur, tidak nafsu makan, tidak mau merawat bayi sehingga diperlukan cara untuk mengontrol nyeri agar dapat beradaptasi dengan nyeri post operasi  sectio  caesarea. Tujuan penelitian ini adalah mengetahui pengaruh teknik relaksasi genggam jari yang dilakukan oleh suami terhadap nyeri post operasi Sectio Caesarea (SC). Desain penelitian ini adalah quasi eksperimen dengan pretest-posttest with control group Teknik pengambilan sampel menggunakan consequtive sampling. Jumlah responden 58 orang terdiri dari 29 orang kelompok kontrol dan 29 kelompok intervensi alat ukur yang digunakan menggunakan NRS (numerical rating scale). Hasil  penelitian menunjukkan bahwa rata-rata nyeri sebelum intervensi kelompok kontrol 5 skala nyeri dan kelompok intervensi 5,5. Setelah intervensi skala nyeri pada kelompok kontrol 4,1 dan kelompok intervensi 3,4. Ada perbedaan nyeri sebelum dan sesudah dilakukan intervensi genggam jari yang dilakukan oleh suami (p-value = 0,000)


2017 ◽  
Vol 3 (4) ◽  
pp. 420-425
Author(s):  
Hilda Yani Karo Karo ◽  
Noor Pramono ◽  
Sri Wahyuni ◽  
Imam Djamaluddin Mashoedi ◽  
Leny Latifah

Background: Labor and childbirth is an extremely painful process. Aromatherapy is considered as one of the nonpharmacological methods to reduce labor pain.Objective: To determine the effect of Lavender (Lavandula Angustifolia) aromatherapy on the level of pain in primipara in the first stage of labor.Methods: A quasy-experimental research with pretest and posttest design with control group conducted between October until November 2016. Forthy respondents selected using consecutive sampling, which 20 assigned in each group. a Numerical Rating Scale (NRS) pain scale was used. Paired and independent t-test were used for data analyses.Results: The results showed that the p-value of labor pain after intervention was 0.000 (<0.05), which indicated that there was statistically mean difference of labor pain between intervention (6.10) and control group (4.05) in primipara in the first active stage of labor.Conclusion: The women in the lavender aromatherapy group reported lower intensity of labor pain. The intervention study could be practiced in the community health centers for pregnant women in order for them to apply this healing method.


2019 ◽  
Vol 5 (1) ◽  
pp. 8-12
Author(s):  
Salman Waqar ◽  
Ali Ayaz ◽  
Irfan Karamat ◽  
Saba Anwar ◽  
James McLeod ◽  
...  

BackgroundDelivery of therapeutic agents via intravitreal (IVT) injections is well established as the mainstay of treatment for many ophthalmic conditions. High demand means that injections are increasingly being delivered either by ophthalmic nurse practitioners (UK) or by ophthalmologists in office-based settings (North America/mainland Europe). Most patients require frequent IVT injections, and there is a need to make the procedure more comfortable and safe.MethodsWe describe a novel device designed to ensure rapid, safe and precise delivery of injections while improving the patient experience. In addition, we present details of a local National Health Service pathway initiated to facilitate clinician-led innovations. It is hoped that this model can also be replicated internationally. We also present results from two sites: one, comparing outcomes of 25 patients who received the injection with the device, against 25 patients who received injections using the current standard method; the other a retrospective notes evaluation of 60 patients injected with the device.ResultsNo adverse events were noted and the device appears to be well tolerated by patients. Use of the guide did not result in a statistically significant increase in pain (p value > 0.05) but the mean score (on a unidimensional numerical rating scale) was noted to be slightly better. All patients gave very positive informal feedback.ConclusionsWe have described the design process and successful early-use results of a novel device developed to facilitate safe, precise and rapid delivery of IVT injections by both ophthalmologists and allied health professionals.


2014 ◽  
Vol 32 (3) ◽  
pp. 215-222 ◽  
Author(s):  
Vagia Ntritsou ◽  
Christos Mavrommatis ◽  
Christos Kostoglou ◽  
Georgios Dimitriadis ◽  
Nikolaos Tziris ◽  
...  

Objectives To study the analgesic effect of electroacupuncture (EA) as perioperative adjunctive therapy added to a systemic analgesic strategy (including tramadol and ketamine) for postoperative pain, opioid-related side effects and patient satisfaction. Methods In a sham-controlled participant- and observer-blinded trial, 75 patients undergoing radical prostatectomy were randomly assigned to two groups: (1) EA (n=37; tramadol+ketamine+EA) and (2) control (n=38; tramadol+ketamine). EA (100 Hz frequency) was applied at LI4 bilaterally during the closure of the abdominal walls and EA (4 Hz) was applied at ST36 and LI4 bilaterally immediately after extubation. The control group had sham acupuncture without penetration or stimulation. The following outcomes were evaluated: postoperative pain using the Numerical Rating Scale (NRS) and McGill Scale (SF_MPQ), mechanical pain thresholds using algometer application close to the wound, cortisol measurements, rescue analgesia, Spielberger State Trait Anxiety Inventory (STAI Y-6 item), patient satisfaction and opioid side effects. Results Pain scores on the NRS and SF_MPQ were significantly lower and electronic pressure algometer measurements were significantly higher in the EA group than in the control group (p<0.001) at all assessments. In the EA group a significant decrease in rescue analgesia was observed at 45 min (p<0.001) and a significant decrease in cortisol levels was also observed (p<0.05). Patients expressed satisfaction with the analgesia, especially in the EA group (p<0.01). Significant delays in the start of bowel movements were observed in the control group at 45 min (p<0.001) and 2 h (p<0.05). Conclusions Adding EA perioperatively should be considered an option as part of a multimodal analgesic strategy.


2018 ◽  
Vol 14 (1) ◽  
pp. 84
Author(s):  
Mutia Anwar ◽  
Titi Astuti ◽  
Merah Bangsawan

<p>Persalinan sectio caesarea memiliki nyeri lebih tinggi sekitar 27,3% dibandingkan dengan persalinan normal yang hanya sekitar 9% (Pratiwi dkk, 2012). Terdapat alternatif dalam penanganan nyeri dengan nonfarmakologi berupa teknik relaksasi pernapasan menggunakan aromaterapi lavender. Tujuan penelitian ini untuk mengetahui pengaruh teknik relaksasi aromatherapi lavender terhadap penurunan intensitas nyeri pada post operasi sectio caesarea.Metode penelitian <em>Quasi Experiment</em> dengan rancangan <em>non-equivalent control group</em>. Teknik pengambilan sampel <em>accidental sampling</em>, diperoleh sampel 24 responden yang terbagi dalam kelompok intervensi dan kontrol. Pengumpulan data menggunakan instrument <em>Numerical Rating Scale</em> (NRS). Uji statistik menggunakan <em>Uji </em><em>Wilcoxon</em>.Hasil penelitian menunjukkan bahwa ada penurunan rasa nyeri pada kelompok intervensi dari 6.92 menjadi 3.83 (skala nyeri ringan) dan didapatkan rata-rata skala nyeri ibu post operasi sectio caesareasebelum dan sesudah pada kelompok kontrol yaitu 6.92 dan5.25. Setelah dilakukan <em>Uji </em><em>Wilcoxon</em> menunjukkan bahwa ada perbedaan yang bermakna antara kelompok kontrol dan kelompok intervensi sebelum dan sesudah dilakukan teknik relaksasi aromatherapi lavender terhadap penurunan intensitas nyeri pada post operasi sectio caesarea dengan p value 0.000 (p value &lt; 0.05). Peneliti menyarankan agar pihak rumah sakit perlu mempertimbangkan agar perawat maupun bidan dapat mengaplikasikan pemberian aromatherapi sebagai terapi komplementer untuk menurunkan nyeri post <em>sectio caesar</em>ea sesuai keadaan pasien dan SOP yang ada.</p>


2020 ◽  
Vol 27 (02) ◽  
pp. 279-283
Author(s):  
Aamir Furqan ◽  
Azeem Gulzar ◽  
Bilal Nazar ◽  
Masood Alam ◽  
Rahat Akhtar ◽  
...  

Objectives: To determine the efficacy of Mini-CEX in assessing clinical expertise of anesthesia trainee during examination at Anesthesia department of Multan Hospitals. Study Design: Prospective Observational Study. Setting: Department of Anesthesia and Intensive Care Ch. Pervez Ellahi Institute of Cardiology and Nishtar Hospital Multan. Period: From January 2017 to March 2019. Material & Methods: The design of study was prospective observational study having the post-test with control group only. The size of the sample was based upon 70 trainee anesthesia being divided into two further groups: 35 trainee anesthesia were included in the control group whereas 35 trainee were part of the intervention group. The analysis of data was done by Mann Whitney test and it was descriptive type of test. Results: The mean result of Preoperative examination skills among the intervention group was greater than the control group. The mean score of Preoperative examination competence in control group was 72.11±4.56, while the mean score of Preoperative examination competence in intervention group was 81.28±2.86. The mean score of anesthesia trainees towards satisfaction of control and intervention group was 5.37±0.38 and 8.95±0.64, respectively. While the mean score of evaluators towards satisfaction of control and intervention group was 6.24±0.53 and 8.04±0.52, respectively. The difference of clinical abilities was significant among the two groups having the p value 0.000 (p<0.05). Conclusion: Clinical expertise among anesthesia trainee was significantly ameliorated after the use of Mini-CEX program. It is therefore suggested for anesthesia trainers to use the Mini-CEX program in order to determine the clinical skills among students.


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