scholarly journals Predictors of Death in Severe COVID-19 Patients at Millennium COVID-19 Care Center in Ethiopia: A Case-Control Study

Author(s):  
Endalkachew H. Maru ◽  
Tigist W. Leulseged ◽  
Ishmael S. Hassen ◽  
Wuletaw C. Zewde ◽  
Nigat W. Chamesew ◽  
...  

ABSTRACTBackgroundAs the number of new cases and death due to COVID-19 is increasing, understanding the characteristics of severe COVID-19 patients and identifying characteristics that lead to death is a key to make an informed decision. In Ethiopia, as of September 27, 2020, a total of 72,700 cases and 1165 deaths were reported.ObjectiveThe study aimed to assess the determinants of death in Severe COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.MethodsA case-control study of 147 Severe COVID-19 patients (49 deaths and 98 discharged alive cases) was conducted from August to September 2020. A comparison of underlying characteristics between cases (death) and controls (alive) was assessed using a chi-square test and an independent t-test with a p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the predictor variables and outcome of Severe COVID-19 (Alive Vs Death) where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results.ResultsHaving diabetes mellitus (AOR= 3.257, 95% CI= 1.348, 7.867, p-value=0.00), fever (AOR=0.328, 95% CI: 0.123, 0.878, p-value= 0.027) and Shortness of breath (AOR= 4.034, 95% CI= 1.481, 10.988, p-value=0.006) were found to be significant predictors of death in Severe COVID-19 patients.ConclusionsThe outcome of death in Severe COVID-19 patients is found to be associated with exposures to being diabetic and having SOB at admission. On the other hand, having a fever at admission was associated with a favorable outcome of being discharged alive.

2020 ◽  
Author(s):  
Tigist Workneh Leulseged ◽  
Degu G. Alemahu ◽  
Ishmael S. Hassen ◽  
Endalkachew H. Maru ◽  
Wuletaw C. Zewde ◽  
...  

Abstract Background: Studies show that having some symptoms seems to be associated with more severe disease and poor prognosis. Therefore, knowing who is more susceptible to symptomatic COVID-19 disease is important to provide targeted preventive and management practice. The aim of the study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.Methods: A case-control study was conducted from August to September 2020 among a randomly selected 765 COVID-19 patients (372 Asymptomatic and 393 Symptomatic patients). Chi-square test and independent t-test were used to detect the presence of a statistically significant difference in the characteristics of the cases (symptomatic) and controls (asymptomatic), where p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the independent variables and developing symptomatic COVID-19 where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results. Results: The result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients.Conclusions: Developing a symptomatic COVID-19 disease was found to be determined by exposures of old age, male sex, and being diabetic. Therefore, patients with the above factors should be given enough attention in the prevention and management process, including inpatient management, to pick symptoms earlier and to manage accordingly so that these patients can have a favorable treatment outcome.


Author(s):  
Tigist W. Leulseged ◽  
Degu G. Alemahu ◽  
Ishmael S. Hassen ◽  
Endalkachew H. Maru ◽  
Wuletaw C. Zewde ◽  
...  

ABSTRACTBackgroundStudies show that having some symptoms seems to be associated with more severe disease and poor prognosis. Therefore, knowing who is more susceptible to symptomatic COVID-19 disease is important to provide targeted preventive and management practice. The aim of the study was to assess the determinants of having symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia.MethodsA case-control study was conducted from August to September 2020 among a randomly selected 765 COVID-19 patients (372 Asymptomatic and 393 Symptomatic patients). Chi-square test and independent t-test were used to detect the presence of a statistically significant difference in the characteristics of the cases (symptomatic) and controls (asymptomatic), where p-value of <0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the independent variables and developing symptomatic COVID-19 where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results.ResultsThe result of the multivariable binary logistic regression shows that age group (AOR= 1.818, 95% CI= 1.210, 2.731, p-value=0.004 for 30-39 years; AOR= 1.611, 95% CI= 1.016, 2.554, p-value=0.043 for 40-49 years and AOR= 4.076, 95% CI= 2.582, 6.435, p-value=0.0001 for years and above), sex (AOR= 1.672, 95% CI= 1.216, 2.299, p-value=0.002) and history of diabetes mellitus (AOR= 2.406, 95% CI= 1.384, 4.181, p-value=0.002) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients.ConclusionsDeveloping a symptomatic COVID-19 disease was found to be determined by exposures of old age, male sex, and being diabetic. Therefore, patients with the above factors should be given enough attention in the prevention and management process, including inpatient management, to pick symptoms earlier and to manage accordingly so that these patients can have a favorable treatment outcome.


2018 ◽  
Vol 2 (2) ◽  
pp. 227-238
Author(s):  
Farissa Ulfa ◽  
Oktia Woro Kasmini Handayani

ABSTRAK Kasus demam tifoid di Kabupaten Tegal pada tahun 2016 yaitu sebanyak 11.387 kasus dan Puskesmas Pagiyanten merupakan puskesmas dengan jumlah kasus demam tifoid tertinggi yaitu sebanyak 377 kasus. Tujuan penelitian ini adalah untuk mengetahui faktor-faktor yang berhubungan dengan kejadian demam tifoid di Puskesmas Pagiyanten Kabupaten Tegal.  Jenis penelitian yang digunakan adalah studi case control dengan sampel sebesar 43 kasus dan 43 kontrol. Instrumen yang digunakan adalah lembar kuesioner. Analisis data dilakukan secara univariat dan bivariat dengan menggunakan uji chi-square. Hasil yang didapatkan faktor yang berhubungan dengan kejadian demam tifoid meliputi kebiasaan makan di luar rumah (p-value=0,001), kebiasaan mencuci tangan sebelum makan (p-value=0,02), kebiasaan mencuci tangan setelah BAB (p-value=0,04), kebiasaan mencuci bahan makanan mentah (p-value=0,007), dan jamban sehat (p-value=0,04). Simpulan penelitian ini adalah terdapat hubungan antara kebiasaan makan di luar rumah, kebiasaan mencuci tangan sebelum makan, kebiasaan mencuci tangan setelah BAB. kebiasaan mencuci bahan makanan mentah, dan jamban sehat dengan kejadian demam tifoid di Puskesmas Pagiyanten Kabupaten Tegal.   Kata Kunci: Faktor Risiko, Demam Tifoid   ABSTRACT Typhoid fever in Tegal regency in 2016 were 11,387 cases, and Puskesmas Pagiyanten with the highest number of cases of typhoid fever of 377 cases. The purpose of this study was to determine the factors associated with the incidence of typhoid fever in Puskesmas Pagiyanten Tegal regency. The research used case control study with 43 cases and 43 controls. The instrument used is a questionnaire. The data were analyzed by univariate and bivariate using chi-square test. The results of factors related to the occurrence of typhoid fever include eating habits outside the home (p-value=0.001), hand washing before eating habits (p-value=0.02), hand washing habit after defecate (p-value=0.04), the habit of washing raw food (p-value=0,007), and healthy latrines (p-value=0,04). The conclusion of this research is there is a relationship between eating habits outside the home, the habit of washing hands before eating, habit of washing hands after defecate, the habit of washing raw food, and healthy latrines with the incidence of typhoid fever in Puskesmas Pagiyanten Kabupaten Tegal. Keywords: Risk Factors, Typhoid Fever


Author(s):  
Cledinaldo Lira Junior ◽  
Diego Henrique Pires Gonçalves ◽  
Kamilly de Lourdes Ramalho Frazão ◽  
Sandra Aparecida Marinho ◽  
Sérgio Henrique Gonçalves De Carvalho ◽  
...  

Aims: To evaluate the mandibular bone cortical of patients with mucopolysaccharidosis on panoramic radiograph, through radiomorfometric indices. Study Design: Case-control study. Place and Duration of Study: Sample: Department of Diagnostic Imaging of the Universidade Estadual da Paraíba, Campus VIII, in the city of Araruna, PB, between January and December of 2015. Methodology: Panoramic radiographs of sixteen patients with mucopolysaccharidosis and 32 controls, organized by gender and age, composed the sample. The mandibular panoramic index, gonial index, antegonial index and mental index were evaluated. Pearson's Chi-square test, Fisher's exact test and Mann-Whitney test were used to statistical analysis with a level of significance of 5.0%. Results: Mucopolysaccharidosis patients were mostly female (62.5%), with a mean age of 12.31 + 7.16 years, MPS VI (50.0%) being the most prevalent. Patients with mucopolysaccharidosis had higher values in the gonial (1.86+0.48), the antegonical (4.36+1.24) and the mental (5.24+1.21). However, only the antegoniac index presented a significant difference (P=0.047). Conclusion: The antegoniac index was higher in patients with mucopolysaccharidosis and the other radiomorphometric measures were similar to those observed in the control group. Apparently, mucopolysaccharidosis is not related to decreased bone to mandibular quality.


2019 ◽  
Vol 4 (2) ◽  
pp. 1
Author(s):  
Siti maisyaroh Fitri Siregar

ABSTRACT               The objective of the research was to analyze the risk factors of  women with the history of normal childbirth had delivery by section caesarea.             The research used observational analytic method with case-control study design. The samples consisted of 42 cases and 42 controls, taken by using consecutive sampling technique. Dependent variable was childbirth with CS and independent variables were parity, accompanied illness, and reference. The gathered data were analyzed by using univatriate analysis, bivariate analysis with chi square test, and multivatriate analysis at α = 0.05.             The result of the research from multivariate analysis showed that the variables which had significant influence on childbirth with SC were parity (p = 0.006; OR = 5.801 95% CI = 1.642-19.110),accompanied illness (p = 0.03; OR = 6.382 95% CI = 1.198-33.992), and reference (p = 0.003; OR = 6.350 95% CI = 1.874-21.522). The variable which had the most dominant influence childbirth with CS was accompanied illness. p-value = 97% which indicated that childbirth women with the parity > 2 had accompanied illness and the reference to the hospital had the possibility to give birth with CS of 97%.             It is recommended to do family planning programme, and prevent the illness during pregnant, apply ANC according to the standard, and make sure that the childbirth is safe from Period I to Period III.   Keywords: Risk Factor, Caesarea, Case-Control


2017 ◽  
Vol 16 (1) ◽  
pp. 8
Author(s):  
Wary Purnama

Judul : Faktor Lingkungan dan Perilaku Yang Berhubungan Dengan Kejadian Filariasis di Kecamatan Muara Pawan Kabupaten Ketapang, Kalimantan BaratLatar belakang: Tahun 2015, terdapat 79 kasus filariais di Kecamatan Muara Pawan Kabupaten Ketapang dengan micrifilaria rate sebesar 2,5%. Penelitian ini bertujuan untuk menganalisis hubungan antara faktor lingkungan dan perilaku dengan kejadian filariasis, serta mengidentifikasi spesies nnyamuk yang diduga sebagai vektor filariasis.Metode: Penelitian ini merupakan penelitian observasional dengan rancangan case control. Subyek penelitian terdiri dari 32 kasus dan 32 kontrol. Pengumpulan data dilakukan dengan wawancara dan observasi. Analisis data menggunakan uji Chi-square dengan taraf signifikasi 0,05.Hasil: Dari 419 nyamuk yang ditangkap. Tidak ditemukan adanya larva cacing dalam tubuh nyamuk. Hasil identifikasi nyamuk menemukan 6 spesies yaitu Anopheles letifer, Mansonia uniformis, Culex tritaeniorhyncus, Culex vishnui, Culex cressipes, and Mansonia annulifera. Analisis statistik menunjukkan bahwa keberadaan breeding places, resting places, pengetahuan, dan kebiasaan keluar pada malam hari merupakan faktor risiko kejadian filariasis di Kecamatan Muara Pawan Kalimantan Barat.Simpulan: Faktor lingkungan dan perilaku masyarakat merupakan faktor risiko kejadian filariasis di Kecamatan Muara Pawan Kabupaten Ketapang. ABSTRACTTitle: Enviromental and Community Behaviour Factors Associated with the incidence of Lymphatic Filariasis in Muara Pawan Distrct of Ketapang Regency, West KalimantanBackground: In the year of 2015, there were 79 cases of filariasis in Ketapang Regency and in Muara Pawan District, in particular, from 32 cases who contracted microfilariae resulted in Mf rate = 2,5% while for prevalence rate (PR) = 2,18. The objectives of this research were to analyze correlation between evironmental and community behavioral factors associated with cases of filariasis as well as to identify the mosquitos which are being the potential vector of filariasis.  Methode: The research was an observational one with a case-control study. The cases and the control of this research were both using 32 respondents. The data were collcted by doing observation and interviews. The collected data were than analyzed using chi-square test. Results: From the surgery of 419 mosquitos, it was revealed that the mosquitoes contained zero filarial larvae, while for the species identification, there were six species of mosquitoes indentified, i.e Anopheles letifer, Mansonia uniformis, Culex tritaeniorhyncus, Culex vishnui, Culex cressipes, and Mansonia annulifera. The resulth of statistical analysis revealed that there were 4 variables associated with the cases of filariasis in Muara Pawan Distict of Ketapang Regency, ie. breeding places (p-value = 0,047), resting places (p-value = 0,007), knowledge (p-value = 0,045), and habit of going out at night (p-value = 0,043)Conclusion: It is concluded that there is a correlation between 4 mentioned variables with the cases of filariasis in Muara Pawan Dictrict of Ketapang Regency.


Author(s):  
Dr. Jayaram Sankar. KR ◽  
Dr. Sunil Daniel ◽  
Dr. Rekha Rachel Philip

Objective: To identify the clinical and laboratory profile and risk factors of bloodstream candida infection in newborns and to assess the immediate outcome of candidemia in newborns. Design: Case -control study. Setting: Tertiary care NICU of Govt. T.D. Medical College, Alappuzha, Kerala from 1st January 2010 to 31st December 2014. Methods: Through consecutive sampling, we got 94 cases and 188 controls. For comparison, chi-square test was used, and for strength association Odds ratio was used. Analysis was done using SPSS V18. Binary logistic regression has been used to identify independent risk factors.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tigist W. Leulseged ◽  
Degu G. Alemahu ◽  
Ishmael S. Hassen ◽  
Endalkachew H. Maru ◽  
Wuletaw C. Zewde ◽  
...  

Abstract Background Studies show that having some symptoms seems to be associated with more severe disease and poor prognosis. Therefore, knowing who is more susceptible to symptomatic COVID-19 disease is important to provide targeted preventive and management practice. The aim of the study was to assess factors associated with the development of symptomatic disease among COVID-19 patients admitted to Millennium COVID-19 Care Center in Ethiopia. Methods A case-control study was conducted from August to September 2020 among a randomly selected 730 COVID-19 patients (337 Asymptomatic and 393 Symptomatic patients). Chi-square test and independent t-test were used to detect the presence of a statistically significant difference in the characteristics of the cases (symptomatic) and controls (asymptomatic), where p-value of < 0.05 considered as having a statistically significant difference. Multivariable binary logistic regression was used to assess a statistically significant association between the independent variables and developing symptomatic COVID-19 where Adjusted Odds ratio (AOR), 95% CIs for AOR, and P-values were used for testing significance and interpretation of results. Results The result of the multivariable binary logistic regression shows that age group (AOR = 1.89, 95% CI = 1.25, 2.87, p-value = 0.002 for 30–39 years; AOR = 1.69, 95% CI = 1.06, 2.73, p-value = 0.028 for 40–49 years and AOR = 4.42, 95% CI = 2.75, 7.12, p-value = 0.0001 for ≥50 years), sex (AOR = 1.76, 95% CI = 1.26, 2.45, p-value = 0.001) and history of diabetes mellitus (AOR = 3.90, 95% CI = 1.92, 7.94, p-value = 0.0001) were found to be significant factors that determine the development of symptomatic disease in COVID-19 patients. Conclusions Developing a symptomatic COVID-19 disease was found to be associated with exposures of old age, male sex, and being diabetic. Therefore, patients with the above factors should be given enough attention in the prevention and management process, including inpatient management, to pick symptoms earlier and to manage accordingly so that these patients can have a favorable treatment outcome.


2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)


2020 ◽  
Vol 6 (1) ◽  
pp. 20-28
Author(s):  
Miftahul Jannah ◽  
Asnawi Abdullah ◽  
Melania Hidayat ◽  
Qatratul Asrar

Latar Belakang: Pneumonia merupakan pembunuh utama balita di seluruh dunia. Berdasarkan Laporan Dinas Kesehatan Banda Aceh tahun 2018, jumlah balita penderita Pneumonia meningkat setiap tahunnya. Kasus Pneumonia balita yang paling banyak terdapat di UPTD Puskesmas Banda Raya. Penelitian ini bertujuan untuk mengetahui faktor risiko yang berhubungan dengan kejadian Pneumonia pada Balita di wilayah kerja UPTD Puskesmas Banda Raya Kota Banda Aceh tahun 2019. Metode: Penelitian ini menggunakan desain Case Control Study atau Retrospective Study. Penelitian ini menggunakan total populasi dengan jumlah sampel adalah 142 anak balita berusia 12–59 bulan. Data dianalisis secara Univariat dan Bivariat. Analisis Bivariat menggunakan Uji Chi-Square dengan derajat kepercayaan 95% (p value0.05). Hasil: Hasil penelitian menunjukkan bahwa faktor risiko yang berhubungan dengan kejadian pneumonia adalah luas ventilasi rumah (OR=15.81; CI 95%=4.70-53.12; p value=0.0001); sedangkan umur balita (OR=1.15; CI 95%=0.54-2.43; p value=0.705); jenis kelamin (OR=1.11; CI 95%=0.57-2.16; p value=0.737); pengetahuan ibu (OR=0.38; CI 95%=0.12-1.24; p value=0.112); dan kepadatan hunian (OR=1.80; CI 95%=0.78-4.13; p value=0.163), tidak terbukti secara signifikan sebagai faktor risiko pneumonia balita di UPTD Puskesmas Banda Raya Kota Banda Aceh. Kesimpulan: Faktor risiko yang berhubungan dengan kejadian Pneumonia balita adalah luas ventilasi rumah. Oleh karena itu diperlukannya sanitasi lingkungan yang sehat sebagai upaya preventif terhadap kejadian Pneumonia, serta memperbaiki pola perilaku hidup bersih dan sehat.


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