Nodular Subcutaneous Phaeohyphomycosis due to Medicopsis romeroi in an Immunocompetent Patient

Fungal infections like subcutaneous phaeohyphomycosis are uncommon but are increasing lately, especially in tropical regions like India. Identification of correct aetiologic agent is essential as different species can have different organ tropism. Here, a rare case of nodular subcutaneous phaeohyphomycosis in an immunocompetent 62-year-old male patient who developed nodule over right dorsum of foot is reported. After various diagnostic tests a rare dematiaceous fungus Medicopsis romeroi was identified as a causative agent in the nodular material by Internal Transcribed Spacer (ITS) sequencing. Surgical excision and antifungal therapy of itraconazole proved beneficial with no recurrence during a six months of follow-up. Medicopsis romeroi has been debated for its role in human infections however, it should be considered as one of the aetiologic agents of subcutaneous phaeohyphomycosis.

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Invasive sino-orbital aspergillosis: surgical decisions and dilemmas

The Journal of Laryngology & Otology ◽

10.1258/00222150360600887 ◽

2003 ◽

Vol 117 (4) ◽

pp. 280-285 ◽

Cited By ~ 41

Author(s):

M. Dhiwakar ◽

A. Thakar ◽

S. Bahadur

Keyword(s):

Adjuvant Chemotherapy ◽

Progressive Disease ◽

Fungal Infections ◽

Present Report ◽

Surgical Excision ◽

Favourable Outcome ◽

Histopathological Diagnosis ◽

Orbital Exenteration ◽

The Common ◽

Orbital Disease

Invasive aspergillosis, one of the common paranasal sinus fungal infections, often secondarily involves the orbit. We report six such cases with orbital extension, all occurring in apparently immunocompetent hosts, to specifically address the difficult diagnostic and therapeutic issues involved. Limited biopsy procedures were often inconclusive, necessitating wide surgical excision to establish the histopathological diagnosis. Conservative orbital debridement proved adequate for cases with disease limited to the infero-medial compartment of the orbit, but resulted in residual progressive disease in the two of the four cases with retro-orbital and apical extension. Orbital exenteration in this latter group, however, proved successful in controlling disease. The present report emphasizes the importance of near-complete extirpation and adjuvant chemotherapy in ensuring a favourable outcome in invasive Aspergillus infections. Orbital exenteration appears justified for posterior orbital disease, regardless of the functional status of the eye, but is inappropriate for anterior orbital disease.

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Fungal infections

Oxford Textbook of Medicine ◽

10.1093/med/9780199204854.003.070701_update_003 ◽

2010 ◽

pp. 998-1018

Author(s):

Roderick J. Hay

Keyword(s):

Fungal Infections ◽

Yeast Form ◽

Daughter Cells ◽

Life Threatening ◽

Candida Infections ◽

End To End ◽

Human Infections

The mycoses are disorders caused by fungi, which are saprophytic or parasitic organisms found in every continent and environment. Many are common commensals in nature, but others cause agricultural disease. The mycoses that are human infections include diseases ranging from those that are worldwide and common, such as dermatophytosis and candida infections, to those that are rare and often potentially life threatening, e.g. histoplasmosis. In humans, fungi usually adopt one of two morphologies: (1) the yeast form—where individual cells produce daughter cells by a process of budding and subsequently separate; or (2) the hyphal form—where cells do not separate but multiply to produce chains of cells joined end to end....

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Fatal Case of Fungemia by Wickerhamomyces anomalus in a Pediatric Patient Diagnosed in a Teaching Hospital from Brazil

Journal of Fungi ◽

10.3390/jof6030147 ◽

2020 ◽

Vol 6 (3) ◽

pp. 147

Author(s):

Vitor Rodrigues Dutra ◽

Leonardo Francisco Silva ◽

Adriana Nazaré Miziara Oliveira ◽

Emília Freitas Beirigo ◽

Vanessa Mello Arthur ◽

...

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Fungal Infections ◽

Ductus Arteriosus ◽

Fatal Case ◽

Previous History ◽

Medical Diagnostics ◽

Clinical State ◽

Its Sequencing ◽

Wickerhamomyces Anomalus

In recent decades, emerging fungal infections have changed the clinical mycology scenario as a consequence of the advances in medical diagnostics and therapeutic procedures, long hospitalization times, and the growing number of individuals with debilitating chronic diseases and impaired immune systems. This report presents a 19 months old Brazilian female patient who developed a severe fungal sepsis by an uncommon yeast. She was admitted at the intensive care unit with severe pneumonia, bronchopulmonary dysplasia, and weight-for-age z score of less than −2. She remained more than 30 days in the intensive care unit where she had a femoral venous catheter placement, enteral nutrition, broad-spectrum antibiotic therapy, and prophylaxis with fluconazole. Moreover, pericardiocentesis was performed due to cardiac tamponade. She had a previous history of prematurity, cardiac surgery due to patent ductus arteriosus, and a long period of hospital stay. Despite the antifungal prophylaxis, two yeast isolates were recovered from blood and then identified by classical mycological methods and internal transcribed spacer (ITS) sequencing as Wickerhamomyces anomalus. Both isolates exhibited susceptibility to amphotericin B, ketoconazole, itraconazole, voriconazole, and fluconazole. Her clinical state worsened, presenting anasarca, epistaxis, and hemorrhagic suffusions in the mouth, sclera, oliguria, and bradycardia. Two days after the first positive culture, she presented a gradual reduction of the white blood cells count, with severe leukopenia and neutropenia. She died five days after.

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Prevalence and genetic diversity of Salmonella spp. in a river in a tropical environment in Mexico

Journal of Water and Health ◽

10.2166/wh.2014.051 ◽

2014 ◽

Vol 12 (4) ◽

pp. 874-884 ◽

Cited By ~ 13

Author(s):

Maribel Jiménez ◽

Jaime Martinez-Urtaza ◽

Maria Xose Rodriguez-Alvarez ◽

Josefina Leon-Felix ◽

Cristobal Chaidez

Keyword(s):

Genetic Diversity ◽

Disease Transmission ◽

Generalized Additive Models ◽

Environmental Parameters ◽

Additive Models ◽

Salmonella Spp ◽

Tropical Regions ◽

Northwestern Region ◽

Source Contamination ◽

Human Infections

The capability of Salmonella to survive outside a host is especially relevant in tropical regions, where the environmental conditions could be more suitable for its long-term persistence. This study investigated the prevalence and genetic diversity of salmonellae within rivers of the Culiacan Valley in the northwestern region of Mexico. From July 2008 to June 2009, a total of 138 water samples were evaluated for the presence of Salmonella spp.; additionally, its association with environmental parameters was determined using Generalized Additive Models (GAMs). Salmonella spp. were isolated from 111 (80.4%) samples without any statistical influence on the environmental parameters investigated, according to the GAM analysis. Twenty-four serotypes were identified; the most frequently isolated serotypes were Salmonella Oranienburg (25%), Salmonella Saintpaul (9%) and Salmonella Minnesota (6%). Diverse genetic variants of Salmonella Oranienburg were found distributed across the valley with no distinctive geographical or temporal patterns. The high persistence of Salmonella spp. and the lack of differentiation of types found along the river basins suggest the existence of non-point source contamination. Furthermore, the discrepancy between the prevailing serotypes in human infections and those identified in this study denotes a limited influence of these aquatic environments in bacterial dissemination and disease transmission.

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Isolated sinusitis sphenoidalis caused by Trichoderma longibrachiatum in an immunocompetent patient with headache

Journal of Medical Microbiology ◽

10.1099/jmm.0.059485-0 ◽

2013 ◽

Vol 62 (8) ◽

pp. 1249-1252 ◽

Cited By ~ 12

Author(s):

Etelka Molnár-Gábor ◽

Ilona Dóczi ◽

Lóránt Hatvani ◽

Csaba Vágvölgyi ◽

László Kredics

Keyword(s):

Sequence Analysis ◽

Fungal Infections ◽

Fatal Outcome ◽

Immunocompetent Patient ◽

Causal Agent ◽

Healthy People ◽

Trichoderma Longibrachiatum ◽

Sinus Sphenoidalis

We present a case of isolated sinusitis sphenoidalis caused by Trichoderma longibrachiatum, an emerging causal agent of fungal infections with an often fatal outcome. A Trichoderma strain was isolated from secretion obtained from the sinus sphenoidalis of a rhinosinusitis patient and identified by sequence analysis of two loci as Trichoderma longibrachiatum from the Longibrachiatum Clade of the genus Trichoderma. T. longibrachiatum can trigger a fatal pathomechanism in immunodeficient patients, but only rarely causes disease in healthy people. The case presented is unique because the patient was not immunocompromised.

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Subcutaneous phaeohyphomycosis caused by Bipolaris hawaiiensis in an immunocompetent patient

Indian Journal of Dermatology Venereology and Leprology ◽

10.4103/0378-6323.144198 ◽

2014 ◽

Vol 80 (6) ◽

pp. 554 ◽

Cited By ~ 2

Author(s):

Biju Vasudevan ◽

Puneet Bhatt ◽

Veena Kharayat ◽

Gagandeep Kaur ◽

Rajesh Verma ◽

...

Keyword(s):

Immunocompetent Patient ◽

Subcutaneous Phaeohyphomycosis

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Strongyloidiasis: The Cause of Multiple Gastrointestinal Ulcers in an Immunocompetent Individual

Case Reports in Medicine ◽

10.1155/2014/346256 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 4

Author(s):

Shail Sheth ◽

Fady Asslo ◽

Rabih Hallit ◽

Raymund Sison ◽

Muhammad Afridi ◽

...

Keyword(s):

Eosinophil Count ◽

Acute Abdominal Pain ◽

Strongyloides Stercoralis ◽

Immunocompetent Patient ◽

Parasitic Disease ◽

Peripheral Eosinophilia ◽

Laboratory Examination ◽

Tropical Regions ◽

Immunocompetent Individual ◽

First Case

Strongyloidiasis is a common parasitic disease in tropical regions of the world. Infection withStrongyloides stercoralisusually remains asymptomatic with peripheral eosinophilia and uncontrolled growth. Consequently, immunocompromised individuals are at a higher risk of complications of this disease. We present a case of an immunocompetent patient whose complaint of acute abdominal pain was found to be due to gastric and duodenal ulcerations. Laboratory examination revealed significantly elevated absolute eosinophil count at 11,466/mm3(normal 0–700/mm3). The duodenal biopsy revealed parasitic ova and adult worms suggestive ofStrongyloides stercoralisnematode with increased eosinophils in the tissue. We report the first case of multiple gastric and duodenal ulcerations due toStrongyloides stercoralisin an immunocompetent patient. We suggest that the elevated eosinophil count played a central role in the pathogenesis.

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Subcutaneous phaeohyphomycosis caused byExophiala jeanselmeitreated with wide surgical excision and posaconazole: case report

International Journal of Dermatology ◽

10.1111/j.1365-4632.2011.04877.x ◽

2011 ◽

Vol 52 (2) ◽

pp. 255-256 ◽

Cited By ~ 4

Author(s):

Beatriz Aranegui ◽

Carlos Feal ◽

Celia Posada García ◽

Ana Batalla ◽

Teresa Abalde ◽

...

Keyword(s):

Case Report ◽

Surgical Excision ◽

Wide Surgical Excision ◽

Subcutaneous Phaeohyphomycosis

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A PANORAMIC VIEW ON ARGEMONE MEXICANA: ITS MEDICINAL IMPORTANCE AND PHYTOCHEMICAL POTENTIALS.

PLANT ARCHIVES ◽

10.51470/plantarchives.2021.v21.no1.006 ◽

2021 ◽

Vol 21 (no 1) ◽

Author(s):

Sunanda Kulshrestha ◽

Anjana Goel

Keyword(s):

Medicinal Plant ◽

Fungal Infections ◽

The Internet ◽

Panoramic View ◽

Argemone Mexicana ◽

Tropical Regions ◽

Medicinal Properties ◽

Set Up

Argemone mexicana, a prickly plant commonly called as prickly poppy is found in sub tropical regions and is well known for its medicinal properties. Its potential as a medicinal plant has been practiced traditionally and been prescribed as medicines by Ayurvedic, Unani, Siddha and Homeopathic practices since several years. Each part of plant posses bio active compounds that help in curing ailments like HIV, malaria, ring worm infections, fungal infections, cancer etc. These activities have been studied in vivo and in vitro set up and results have been obtained in favor. Further, phytochemical evaluation has unveiled the presence of compounds like berberine, argemonine, protopine etc, which show curative actions and could be used for treatment of diseases with future preception. This review is a sum up of all literature available through the internet and was searched using keywords ‘Argemone mexicana’, ‘phytochemical importance of Argemone’ and many other exclusive words with respect to different activities scanned for reviewing. The references provided in the papers were also given a thorough look and retrieved the respected data from them too. ‘Scopus’, ‘Pubmed’, ‘Google Scholar’, ‘Research Gate’ were used to search for the relevant papers through different journals available. The literature has then been framed in a way with up gradation about Argemone mexicana and its promising affects seen with the potential of the plant which is still undiscovered but could be utilized as curative methods

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Chronic granulomatous invasive fungal rhinosinusitis in Nigeria: challenges of management

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203189 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1417

Author(s):

Chinyere N. Asoegwu ◽

Rita O. Oladele ◽

Okezie O. Kanu ◽

Clement C. Nwawolo

Keyword(s):

Clinical Presentation ◽

Surgical Excision ◽

Antifungal Drugs ◽

Duration Of Symptoms ◽

Female Ratio ◽

Tropical Regions ◽

Delay In Diagnosis ◽

Fungal Rhinosinusitis ◽

Management Protocol ◽

Invasive Fungal Rhinosinusitis

Background: Chronic granulomatous invasive fungal rhinosinusitis affects mainly immunocompetent patients and has been widely reported in tropical regions such as South East Asia and North Africa. Nigeria has a tropical climate, however, there is paucity of data on this disease condition in Nigeria. This study documents the clinical, diagnostic, therapeutic challenges of managing patients with this condition in Nigeria.Methods: A retrospective study of patients diagnosed and treated for chronic granulomatous invasive fungal rhinosinusitis between 2010 and 2019. Diagnosis was based on clinical presentation, computed tomographic scan findings and confirmed by histopathology and/or microbiology results. Results: Ten patients aged 12 to 49 years with mean age of 33.9±13.8 years were studied. Male to female ratio was 2.3:1. All were immunocompetent. Duration of symptoms before presentation ranged from 3 months to 8 years with a mean duration of 3.5±2.4 years. Commonest clinical presentation was unilateral proptosis 80% followed by nasal mass 50%. Commonest sinus involved was the ethmoid (80%). There was orbital extension in 70% and intracranial involvement in 50%. Aspergillus species was the commonest fungal agent cultured. Treatment was by surgical excision followed by antifungal drugs. Some of the challenges we encountered in the management included; late presentation, delay in diagnosis, limited experience in histopathologic and mycology diagnosis and high cost of treatment amidst scarce resource.Conclusions: Chronic invasive granulomatous rhinosinusitis is not rare in Nigeria. A high index of suspicion is however needed for the diagnosis. Development of a National management protocol for this disease is recommended to avoid misdiagnosis.

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