PROTECTIVE EFFECT OF ETHANOLIC LEAF EXTRACT OF ANNONA MURICATA LINN ON SOME EARLY EVENTS IN CYCAS-INDUCED COLORECTAL CARCINOGENESIS IN RATS

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.

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Toxicological evaluation and protective effect of ethanolic leaf extract of Launaea taraxacifolia on gentamicin induced rat kidney injury

Asian Pacific Journal of Tropical Biomedicine ◽

10.1016/j.apjtb.2017.06.011 ◽

2017 ◽

Vol 7 (7) ◽

pp. 640-646 ◽

Cited By ~ 6

Author(s):

Lydia Enyonam Kuatsienu ◽

Charles Ansah ◽

Michael Buenor Adinortey

Keyword(s):

Protective Effect ◽

Leaf Extract ◽

Rat Kidney ◽

Kidney Injury ◽

Toxicological Evaluation ◽

Ethanolic Leaf Extract

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Gastro Protective effect of Standardized Ethanolic leaf extract of Indigofera tinctoriao on experimental Gastric Ulcers in Rats

Research Journal of Pharmacy and Technology ◽

10.5958/0974-360x.2018.00098.7 ◽

2018 ◽

Vol 11 (2) ◽

pp. 527

Author(s):

P. Manimekalai ◽

P. Maheshwari ◽

R. Velmurugan ◽

M. Gurumoorthy ◽

S. Hansraj Kumar ◽

...

Keyword(s):

Protective Effect ◽

Leaf Extract ◽

Gastric Ulcers ◽

Ethanolic Leaf Extract

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Protective Effect of Ipomoea biloba on Myocardial Antioxidant Status in Isoproterenol Induced Myocardial Infarction Male Albino Rats

Asian Journal of Research in Biochemistry ◽

10.9734/ajrb/2021/v9i330204 ◽

2021 ◽

pp. 36-45

Author(s):

R. Vallipriya ◽

M. Shabana Begum

Keyword(s):

Myocardial Infarction ◽

Vitamin C ◽

Protective Effect ◽

Leaf Extract ◽

Oral Treatment ◽

Albino Rats ◽

Heart Homogenate ◽

Significant Difference ◽

Myocardial Infraction ◽

Ethanolic Leaf Extract

The protective effect of ethanolic leaf extract of Ipomoea biloba in isoproterenol (ISO)-induced cardiotoxicity and the antioxidant activity involved in this protection were investigated in rats. Myocardial infraction was produced in rats with 20 mg/kg b.wt of ISO administered subcutaneously twice at an interval of 24 h. Effect of EEIB oral treatment for 28 days at two doses (100 mg and 200 mg/kg body weight) was evaluated against ISO – induced cardiac necrosis. Level of enzymatic (SOD, CAT, GPx and GST), non-enzymatic (GSH, Vitamin C and E) and of membrane bound ATPases (Na+K+ATPase, Mg2+ATPase and Ca2+ATPase) were assayed in heart homogenate. Significant myocardial infarction, depletion of endogenous antioxidants enzymatic and non-enzymatic were observed in ISO-treated animals when compared with the normal animals. Rats induced with ISO, showed a significant (P<0.05), decrease in the activities of GSH, Vitamin C and Eon comparison with normal rats. EEIB elicited a significant cardioprotective activity by elevated the levels of GSH, SOD, CAT, GPx and GR. A significant decrease in the activity of Na+/K+ ATPase and a corresponding increase in the activities of Ca2+ ATPase and Mg2+ ATPase were observed in isoproterenol induced rats when compared to normal control rats. Pretreatment with EEIB was able to efficiently prevent the increase in activity of Mg2+ ATPase and maintain the activities of Na+ /K+ ATPase and Ca2+ ATPase at near normality. There is no significant difference between the control and plant alone treated rats. The aim of this investigation is to evaluate the antioxidant effects on the main cardioprotective activity of ethanolic leaf extract Ipomoea biloba.

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