Modulatory Effect of Ethanolic Leaf Extract of Annona muricata Pre-treatment on Liver Damage Induced by Dimethylnitrosamine (DMN) in Rats

2015 ◽  
Vol 8 (3) ◽  
pp. 1-9
Author(s):  
Usunobun Usunomena ◽  
Okolie Ngozi ◽  
Eze Ikechi
Keyword(s):  
Liver Damage ◽  
Leaf Extract ◽  
Annona Muricata ◽  
Pre Treatment ◽  
Ethanolic Leaf Extract

scholarly journals EVALUATION OF ANTIDIARRHEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF ERIOBOTRYA JAPONICA LINDL

2018 ◽  
Vol 11 (9) ◽  
pp. 502
Author(s):  
Davie Rexon Kamadyaapa ◽  
Mavuto Masopera Gondwe ◽  
Mathulo Shauli ◽  
Constance Sewani Rusike ◽  
Jehu Iputo
Keyword(s):  
Castor Oil ◽  
Leaf Extract ◽  
Eriobotrya Japonica ◽  
Cytotoxicity Test ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Adrenoceptor Blocker ◽  
Antidiarrheal Activity ◽  
Pre Treatment ◽  
Ethanolic Leaf Extract

Objective: The study was carried out to investigate the antidiarrheal activity of ethanolic leaf extract of Eriobotrya japonica (EEJ) using various models of experimental diarrhea.Methods: Antidiarrheal property of EEJ at 100, 200, and 400 mg/kg/bwt was evaluated using castor oil-induced diarrhea, castor oil-induced enteropooling, and gastrointestinal propulsive models of experimental diarrhea in Sprague Dawley rats of both sexes, weighing 200–250 g. Cytotoxicity test of EEJ was performed using brine shrimp bioassay.Results: Toxicity assay of EEJ showed a lethal concentration value of 1225 μg/ml suggesting non-toxicity. EEJ significantly (p<0.05) and dose-dependently (100, 200 and 400 mg/kg/bwt) inhibited castor oil-induced diarrhea by 38.1%, 76.19%, and 100%, respectively, and enteropooling by 28%, 56%, and 88%, respectively, compared with control. Pre-treatment with yohimbine, α2-adrenoceptor blocker significantly reversed the protective effect of EEJ (400 mg/kg) against castor oil-induced diarrhea and against castor oil-induced enteropooling, suggesting the involvement of α2-adrenoceptors in antidiarrheal property of EEJ. Furthermore, EEJ significantly (p<0.05) and dosedependently (100, 200, and 400 mg/Kg/bwt) inhibited gastrointestinal motility by 28%, 62%, and 83.92%, respectively.Conclusion: The study has demonstrated the antidiarrheal potential of ethanolic leaf extract of EEJ, which may be attributable to its dual antisecretory and antimotility activities probably through activation of the sympathetic α2-adrenergic pathway.

scholarly journals ANNONA MURICATA LINN. ETHANOLIC LEAF EXTRACT AMELIORATES REPRODUCTIVE COMPLICATIONS IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

2020 ◽  
Vol 18 (1) ◽  
pp. 166-175
Author(s):  
O. E. ADELEYE ◽  
N. A. ABOAJAH ◽  
A. I. ADELEYE ◽  
E. A.O. SOGEBI ◽  
F. M. MSHELBWALA ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Sperm Count ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Male Rats ◽  
Annona Muricata ◽  
Major Health Problem ◽  
Ethanolic Leaf Extract

Diabetes mellitus is an endocrine and metabolic disorder of humans and animals characterized by hyperglycemia and low blood insulin levels or insensitivity of target organs to insulin and it’s a major health problem affecting patient’s quality of life due to its many complications. Infertility is one of the major secondary complications in diabetes. Although numerous drugs have been used for intervention studies on diabetes-induced infertility worldwide, there are currently no treatments for diabetes associated infertility in humans. This study was performed to investigate the effects of Annona muricata ethanolic leaf extract (AMELE) on fertility of male diabetic rats and levels of blood glucose. Twenty male Wistar rats (150-200g) were randomly distributed into 4 groups (n=5) treated thus: CTRL (control), DNT, DT1 and DT2 (diabetic, single intraperitoneal injection, streptozotocin, 60 mg/kg). Group DT1 and DT2 received AMELE orally at 100 mg/kg and 200 mg/kg respectively daily for fourteen days. Data were analysed using ANOVA at α0.05. The animals were sacrificed after 2 weeks via thiopental injection and testicular weights were recorded. Fasting blood glucose was determined using a digital glucometer. Sperm count, motility, viability and morphology were assessed microscopically. Testes were histologically evaluated. The results showed that oral administration of AMELE at 100 mg/kg and 200 mg/kg to diabetic male rats for fourteen days significantly decreased blood glucose level and also ameliorated diabetes-induced decreases in sperm functions in streptozotocin-induced diabetic male rats.    

Acute Toxicity Assessment of Ethanolic Leaf Extract of Macrotyloma uniflorum L. on Wistar Albino Rats

2017 ◽  
Vol 24 (1) ◽  
pp. 22 ◽  
Author(s):  
S. Priyanga ◽  
S. Hemmalakshmi ◽  
B. Vidya ◽  
P. Chella Perumal ◽  
V. K. Gopalakrishnan ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Leaf Extract ◽  
Toxicity Assessment ◽  
Albino Rats ◽  
Macrotyloma Uniflorum ◽  
Wistar Albino Rats ◽  
Ethanolic Leaf Extract

scholarly journals Antidiarrheal Activity of Dissotis multiflora (Sm) Triana (Melastomataceae) Leaf Extract in Wistar Rats and Subacute Toxicity Evaluation

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Alian Désiré Afagnigni ◽  
Maximilienne Ascension Nyegue ◽  
Chantal Florentine Ndoye Foe ◽  
Youchahou Njankouo Ndam ◽  
Frédéric Nico Njayou ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Leaf Extract ◽  
Shigella Flexneri ◽  
Female Rats ◽  
Male Rats ◽  
Dependent Manner ◽  
Subacute Toxicity ◽  
Antidiarrheal Activity ◽  
Dose Dependent ◽  
Ethanolic Leaf Extract

The present work was undertaken to evaluate antidiarrheal activity of ethanolic leaf extract of Dissotis multiflora (Sm) Triana (D. multiflora) on Shigella flexneri-induced diarrhea in Wistar rats and its subacute toxicity. Diarrhea was induced by oral administration of 1.2 × 109 cells/mL S. flexneri to rats. Antidiarrheal activity was investigated in rats with the doses of 111.42 mg/kg, 222.84 mg/kg, and 445.68 mg/kg. The level of biochemical parameters was assessed and organs histology examined by 14 days’ subacute toxicity. S. flexneri stool load decreased significantly in dose-dependent manner. The level of ALT increased (p<0.05) in male rats treated with the dose of 445.68 mg/kg while creatinine level increased in rats treated with both doses. In female rats, a significant decrease (p<0.05) of the level of AST and creatinine was noted in rats treated with the dose of 222.84 mg/kg of D. multiflora. Histological exams of kidney and liver of treated rats showed architectural modifications at the dose of 445.68 mg/kg. This finding suggests that D. multiflora leaf extract is efficient against diarrhea caused by S. flexneri but the treatment with doses lower than 222.84 mg/kg is recommended while further study is required to define the exact efficient nontoxic dose.

scholarly journals Protective effects of Erythronium japonicum and Corylopsis coreana Uyeki extracts against 1,3-dichloro-2-propanol-induced hepatotoxicity in rats

2020 ◽  
Vol 50 (1) ◽  
Author(s):  
Seunghyun Kim ◽  
Hee-Ock Boo ◽  
Taeho Ahn ◽  
Chun-Sik Bae
Keyword(s):  
Liver Damage ◽  
Enzyme Activities ◽  
Oxygen Species ◽  
Protective Effects ◽  
Catalytic Activities ◽  
Anti Oxidant ◽  
Cyp2e1 Activity ◽  
Pre Treatment ◽  
Histopathological Studies ◽  
Erythronium Japonicum

AbstractErythronium japonicum (E. japonicum) and Corylopsis coreana Uyeki (C. coreana Uyeki, Korean winter hazel) have been shown to significantly decrease 1,3-dichloro-2-propanol (1,3-DCP)-induced generation of reactive oxygen species and CYP2E1 activity in HuH7, human hepatocytes. In this study, we expanded upon the previous study and investigated the effects of E. japonicum and C. coreana Uyeki extracts on 1,3-DCP-induced liver damage in rats. The pre-treatment of rats with these extracts alleviated a decrease in body weight and reduced 1,3-DCP-induced increase in catalytic activities of hepatic enzymes, such as aspartate aminotransferase and alanine aminotransferase, in the serum. Moreover, treatment with the extracts restored the 1,3-DCP-induced decreases in anti-oxidant enzyme activities, such as the activities of superoxide dismutase and catalase, in the rat liver. Histopathological studies also strongly supported the results of enzyme activities. These results suggest a possibility that the extracts of E. japonicum and C. coreana Uyeki can be a remedy for alleviating 1,3-DCP-induced liver damage in animals.

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