scholarly journals Proximate Composition and Phytochemical Constituents of Matured Carica papaya Seed Extracts

2021 ◽  
pp. 28-33
Author(s):  
M. A. Kanadi ◽  
R. Yila ◽  
M. P. Ibrahim ◽  
A. I. Yaradua ◽  
A. Nasir
Keyword(s):  
Ethyl Acetate ◽  
Proximate Composition ◽  
Carica Papaya ◽  
Chloroform Extract ◽  
Phytochemical Analysis ◽  
Crude Fibre ◽  
Phytochemical Constituents ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Seed Extracts

Aim: To investigate the proximate composition and phytochemical constituents of matured Carica papaya seed. Study Design: Proximate composition was determined on Carica papaya seed powder while extracts for phytochemical analysis were obtained, in turn using five different solvents of varying polarity, namely n-hexane, chloroform, ethyl acetate, methanol and water. Place and Duration of Study: Department of Biochemistry, Faculty of Basic Medical sciences, Bayero University Kano, Nigeria. The study was carried out between March- April, 2019. Results: The proximate composition of matured Carica papaya seed showed it contained crude fat (27.72%), carbohydrate (23.34%), crude fibre (21.25%), ash (10.25%), crude protein (9.65%) and moisture (7.34%). Qualitative phytochemical screening of Carica papaya seed extracts detected major phytochemicals except anthraquinones and quantitative analyses of these phytochemicals in all the five extracts showed that flavonoids was the most abundant phytochemical with 38.68%, 35.85%, 36.76%, 34.04% and 23.50% for methanol, aqueous, chloroform, n-hexane and ethyl acetate fractions respectively while tannins was the least abundant phytochemical with 0.03% for methanol extract, 0.04% for n-hexane extract, 0.09% for aqueous and ethyl acetate extracts, and 0.14% for the chloroform extract. Conclusion: Seeds of matured Carica papaya contain major nutrients that may be useful in nutrition. The presence of phytochemicals such as flavonoids, alkaloids and saponins in considerable quantities explained the medicinal activity of the plant material as encountered in its therapeutic uses.

scholarly journals Effects of Pawpaw (Carica papaya) Seed Flour Addition on the Quality of Wheat Bread

2021 ◽  
pp. 51-63
Author(s):  
O. A. Kure ◽  
E. D. Inelo ◽  
N. S. Donaldben
Keyword(s):  
Proximate Composition ◽  
Crude Protein ◽  
Carica Papaya ◽  
Control Sample ◽  
Absorption Capacity ◽  
Wheat Bread ◽  
Crude Fibre ◽  
Seed Flour ◽  
Carica Papaya Seed ◽  
Papaya Seed

The effects of pawpaw (Carica papaya) seed flour addition to wheat based bread was studied. Matured, ripen pawpaw fruits were washed, and the seeds were collected, extracted, dried and milled. Different proportions of wheat and pawpaw seed flour with increasing level of pawpaw seed flour at 0, 2.5, 5, 7.5, 10 and 12.5% addition in wheat were prepared. Control sample was 100% wheat flour and its bread. The functional properties of the flours of wheat and pawpaw seed were determined. The proximate composition (breads and pawpaw seed flour), vitamins content and sensory attributes of the bread samples were determined using standard procedures. The GENSTAT Statistical Software (version 17.0) was used for data analyses. The Data obtained showed an increased oil absorption capacity (0.62-1.23 g/g), foaming capacity (14.54-19.88%) and a decreased water absorption capacity (1.88-1.35 g/g) and bulk density (0.78-0.41 g/cm3) with increased pawpaw seed flour addition. The proximate composition of the bread samples showed significant (p<0.05) increase in moisture (23.80-30.83%), ash (0.78-3.00%), crude fibre (0.58-1.48%), crude fat (2.20-9.68%) and crude protein (11.46-17.71%) but decrease in carbohydrate (61.19-37.31%) contents with increased pawpaw seed flour addition. The pawpaw seed flour showed proximate composition of 8.15% moisture, 7.46% ash, 5.44% crude fibre, 25.41% crude fat, 28.18% crude protein and 25.38% carbohydrate. Vitamin C (0.57-12.95 mg/100 g) and pro-vitamin A (0.26-7.37 µg/100 g) significantly (p<0.05) increased with increased pawpaw seed flour percentage while Vitamin B3 decreased with increased addition. Appearance and taste panel scores indicated that up to 5% addition of pawpaw seed flour was acceptable in bread formulation.

Impact of the Chloroform Extract of Carica papaya Seed on Oestrous Cycle and Fertility in Female Albino Rats

2005 ◽  
Vol 5 (4) ◽  
pp. 337-343 ◽  
Author(s):  
Y. Raji ◽  
A.O. Morakinyo . ◽  
A.K. Oloyo . ◽  
O.S. Akinsomisoye . ◽  
Olufadekemi . ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Chloroform Extract ◽  
Oestrous Cycle ◽  
Albino Rats ◽  
Carica Papaya Seed ◽  
Papaya Seed

scholarly journals ANTI-PROLIFERATIVE POTENTIAL OF Carica papaya LEAVES ON BREAST CANCER CELLS – MCF-7

2021 ◽  
Vol 9 (5) ◽  
pp. 678-686
Author(s):  
Sasikala Mariyappan ◽  
◽  
Sivakumar Ramalingam ◽  
Lavanya Murugan ◽  
Renuka Saravanan ◽  
...  
Keyword(s):  
Free Radical ◽  
Ethyl Acetate ◽  
Dna Fragmentation ◽  
Carica Papaya ◽  
Radical Scavenging ◽  
Chloroform Extract ◽  
Free Radical Scavenging ◽  
Phytochemical Analysis ◽  
Proliferative Effect ◽  
Mcf 7

The study's objective is to identify the phytoconstituents and determine the anti-cancer potential of Carica papaya leaves against the MCF 7 cell line. Chloroform, ethyl acetate, and methanol extracts of C. papaya leaves were prepared by cold maceration method and qualitative phytochemical analysis was performed. The anti-proliferative effect of these extracts was determined by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and apoptotic assay by acridine orange/ethidium bromide staining method on MCF 7 cells. The effect of the extracts, with different concentrations, on DNA fragmentation, was also performed on MCF 7 cells. Qualitative analysis revealed the presence of alkaloids, flavonoids, terpenoids, steroids, saponins, tannins, glycosides, phenols, anthraquinones, proteins, and carbohydrates. Chloroform, methanol, and ethyl acetate extracts of C. papaya leaves were observed with potential DPPH free radical scavenging activity with 72%, 75%, and 78% respectively. Of these extracts, the chloroform extract (72%) was found to possess a more free radical scavenging effect against DPPH and also showed a dose-dependent effect, the maximum at 100µg/ml, on DNA fragmentation in MCF 7 cells. Further, chloroform extract showed a maximum anti-proliferative effect on MCF-7 cells with IC50 at 22±1.5µg/ml, whereas methanol and ethyl acetate extract at 30±0.5 µg/ml and 28±0.5 µg/ml respectively. Increased apoptosis in MCF 7 cells was observed with an increased concentration of chloroform extract of C. papaya. From the results of this study, it can be concluded that leaf extract of C. papaya found to possess an anti-proliferative effect and antioxidant potential and it could be due to the presence of rich secondary metabolites of the plant.

scholarly journals In-vitro and In-vivo Evaluation of Anti-trypanosomal Activity of Carica papaya Seed Extracts and Fractions in Albino Wister Rats

2020 ◽  
pp. 13-25
Author(s):  
H. Kinjir ◽  
M. A. Madusolumuo ◽  
S. Sarkiyayi
Keyword(s):  
Carica Papaya ◽  
Oral Toxicity ◽  
Infection Level ◽  
In Vivo Evaluation ◽  
Trypanocidal Activity ◽  
Carica Papaya Seed ◽  
Papaya Seed ◽  
Seed Extracts

Aims: This study presents baseline data on the In-vitro and In-vivo evaluation of anti-trypanosomal activity of Carica papaya seed extracts and fractions in Albino Wister rats. Study Design: Mention the design of the study here. Place and Duration of Study Sample: Department of Biochemistry, Modibbo Adama University of Technology, Yola, between June 2009 and July 2010. Methodology: 56 Wister rats of both sexes were randomly divided into 8 groups (I – VIII) of 7 rats each were used for this study. Four concentrations (100, 200, 400 and 800 mg/kg) of different extracts of seed carica papaya were screened for trypanocidal activity against Trypanosoma brucei In vitro and In vivo. The effect of the extracts was evaluated for trypanocidal activity in rats infected and not infected with the parasite. Administration of the extract and the drugs was orally daily for 5 consecutive days from day 7 of post infection. Level of parasitemia and body weight was taken daily for 21 days. Results: The extracts inhibited parasite motility and totally eliminated the organisms at the concentrations used In vitro. The extract also showed promising in vivo trypanocidal activity. The observed In vitro and In vivo trypanocidal activities may be due to the presence of bioactive compounds present in the extracts as seen in this study. The extract also improved the observed decreases in haematological parameters of the treated rats, which may be due to their ability to decrease parasite load. The LD50 was estimated to be ≥2,000 mg/Kg (v/v) for acute oral toxicity test (because all the rats survived at the end of the 14-day observation period). This is an indication of very low toxicity, implying that the extract could be administered with some degree of safety. A significant decreased (p<0.05) were observed in weight of rats at 100 mg/kg, 200 mg/kg 400 mg/kg 800 mg/kg negative control and prophylactic at four to eight days of infections, while significantly increased (p<0.05) were observed in weight of rats for berenil control and normal control. Conclusion: The decrease in weight of rats could be as a result of loss of appetite due to severe fever and also the trypanosome.

scholarly journals Methanolysis of Carica papaya Seed Oil for Production of Biodiesel

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Foluso O. Agunbiade ◽  
Tolulope A. Adewole
Keyword(s):  
Specific Gravity ◽  
Carica Papaya ◽  
Seed Oil ◽  
Fossil Fuel ◽  
Biodiesel Production ◽  
Copper Strip ◽  
Saponification Value ◽  
Biodiesel Synthesis ◽  
Carica Papaya Seed ◽  
Papaya Seed

The future of fossil fuel sources of energy has necessitated the need to search for renewable alternatives. Thus, Carica papaya seed oil (CPSO) was employed as feedstock for the production of biodiesel by methanolysis. The seed was obtained locally, dried, and extracted with n-hexane. The CPSO was analyzed for specific gravity, viscosity, iodine value, and saponification value, among others using standard methods. The oil was transesterified by two-stage catalysis with oil to methanol mole ratio of 1 : 9. The biodiesel produced was subjected to standard fuel tests. The seed has an oil yield of 31.2% which is commercially viable. The kinematic viscosity of the oil at 313 K was 27.4 mm2s−1 while that of Carica papaya oil methylester (CPOME) was reduced to 3.57 mm2s−1 and the specific gravity was 0.84 comparable with other seed-oil biodiesels and number 2 diesel. Other oil properties were compared favourably with seed oils already documented for biodiesel synthesis. CPOME’s cloud and pour points were 275 K and 274 K, respectively, and relatively higher than other biodiesels and number 2 diesel. CPOME exhibits moderate corrosion of copper strip. The methanolysis improved the fuel properties of the CPOME similar to other biodiesels. CPSO therefore exhibits a potential for biodiesel production.

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