Liver Enzymes and HIV-infected Adults on HARRT: Evidence from a Randomised Cross-sectional Study in UPTH

2021 ◽  
pp. 42-55
Author(s):  
Chinwe F. Anyanwu ◽  
Eric O. Aigbogun Jr.
Keyword(s):  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

The Biochemical Parameters and Vitamin D Levels in ICU Patients with Covid-19: A Cross-Sectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Hamed Abdollahi ◽  
Farahnaz Salehinia ◽  
Mostafa Badeli ◽  
Elmira Karimi ◽  
Hossein Gandomkar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Immune System ◽  
Liver Enzymes ◽  
Serum Vitamin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elevated Liver Enzymes ◽  
Vitamin D Levels

Background: In Covid-19 infection, leukopenia, inflammation, and elevated liver enzymes are found in most patients. Also, vitamin D deficiency attenuate the immune system and predispose a person more susceptible to infection. In this context, we aimed to evaluate vitamin D, Electrolytes, Complete blood count, Liver enzymes, Urea, Creatinine, Albumin, CRP and ESR levels in patients with Covid-19. Methods: We conducted a cross-sectional study on 118 patients with Covid-19 who were hospitalized from 2020/2/19 to 2020/4/3 in ICU. Serum levels of electrolytes, liver enzymes, blood factors, urea, creatinine, CRP and ESR as well as anthropometric parameters and serum vitamin D concentration were measured. Results: A total of 118 patients (80 male and 38 female) was enrolled in the study (65.05±15.75 years). Only 5.08% of patients had no risk factors and 55.9% had ≥ 2 risk factors. Diabetes (44.1%) and obesity (23.7%) were more common among patients. Laboratory finding showed that 80.50% of patients had hyponatremia, but other electrolytes included K, Mg, Ca and P were normal in majority of participants as well as CBC, Cr, Urea, Alb, ALT and ALKP. The AST concentration increased in most patients (66.94%). All patients had high levels of inflammatory factors such as CRP and ESR. The mean of 25-hydroxy-vitamin D levels in participants (25.95 ± 14.56 ng/mL) was lower than its levels in general papulation. However, it was not statistically significant (P= 0.88). A significant negative correlation found between vitamin D and ALT (P= 0.02, -0.21) as well as vitamin D and CRP (P= 0.05, -0.17). Conclusion: Regarding to the regulatory role of vitamin D in immune system and low levels of vitamin D in Covid-19 infected patients, the evaluation of vitamin D levels and prescribe supplements if necessary is suggested.

scholarly journals Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Ho Jeong Do ◽  
Joon-Shik Shin ◽  
Jinho Lee ◽  
Yoon Jae Lee ◽  
Me-riong Kim ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mineral Density ◽  
Cross Sectional

scholarly journals Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Shiful Islam ◽  
Sadaqur Rahman ◽  
Tangigul Haque ◽  
Abu Hasan Sumon ◽  
AZ Mahbub Ahmed ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elevated Liver Enzymes

scholarly journals Association of liver enzymes levels with fasting plasma glucose levels in Southern China: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e025524 ◽  
Author(s):  
Ling-Ling Huang ◽  
Dong-Hui Guo ◽  
Hui-Yan Xu ◽  
Song-Tao Tang ◽  
Xiao Xiao Wang ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Liver Enzymes ◽  
Southern China ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Sectional Study ◽  
Cross Sectional ◽  
Fasting Plasma ◽  
Overweight Or Obesity

ObjectiveAccording to several studies, liver enzymes levels are associated with fasting plasma glucose (FPG) levels. However, the association stratified by body mass index (BMI) remains to be elucidated, especially in Southern China. Therefore, the aim of this study was to investigate the correlation between liver enzymes levels and FPG levels stratified by BMI in Southern China.DesignCross-sectional study.Participants and setting3056 individuals participated in real-time interviews and blood tests in Southern China. Participants were divided into three groups (underweight, normal weight and overweight or obesity) based on BMI cut-offs.Main outcome measuredPartial correlation analysis was performed to investigate the relationship between FPG levels and liver tests. Multivariate logistic regression analyses were applied to calculate the adjusted ORs for FPG levels based on liver enzymes levels.ResultsThere was no association between liver enzymes and FPG either in the underweight group or in the normal weight group; however, a significant correlation was observed in the overweight or obesity group (alanine transaminase (ALT), p<0.01; aspartate aminotransferase (AST), p<0.05). After adjusting for confounding factors, the highest tertiles of ALT still remained significantly positively related to FPG levels in the overweight or obesity group, with an OR of 2.205 (95% CI 1.442 to 3.371) for the 5.56≤FPG<7.00 mmol/L vs the FPG<5.56 mmol/L group and with an OR of 2.297 (95% CI 1.017 to 5.187) for the FPG≥7.00 mmol/L vs the FPG<5.56 mmol/L group, but this correlation was not found for AST.ConclusionsThe association of liver enzymes levels with FPG levels differed based on different BMI cut-offs. ALT levels were significantly positively associated with FPG levels in the overweight or obesity group, but not in the other two groups; AST levels were not associated with FPG levels in any group.

scholarly journals The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study

PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0177925
Author(s):  
Masahiro Sogabe ◽  
Toshiya Okahisa ◽  
Masahiko Nakasono ◽  
Hiroshi Fukuno ◽  
Yoshihiko Miyamoto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Liver ◽  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Magnitude, outcome, and associated factors of anti-tuberculosis drug-induced hepatitis among tuberculosis patients in a tertiary hospital in North Ethiopia: A cross-sectional study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241346
Author(s):  
Liwam Kidane Gezahegn ◽  
Ermias Argaw ◽  
Belete Assefa ◽  
Azeb Geberesilassie ◽  
Mengistu Hagazi
Keyword(s):  
Liver Disease ◽  
Serum Albumin ◽  
Associated Factors ◽  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Northern Ethiopia ◽  
Regression Analyses ◽  
Sectional Study ◽  
Drug Induced ◽  
Cross Sectional

Background Short-course chemotherapy comprising isoniazid, rifampicin, ethambutol, and pyrazinamide has proved to be highly effective in the treatment of tuberculosis (TB). However, the most common adverse effect of this regimen leading to interruption of therapy is hepatotoxicity. There is a paucity of evidence in Tigray region on anti-tuberculosis drug-induced hepatitis. Therefore, this study aims to determine the magnitude, outcomes, and associated factors of drug-induced hepatitis in Ayder specialized comprehensive hospital tuberculosis clinic. Methods An institution-based cross-sectional study was done on 188 cases of patients who took anti-tuberculosis drugs from August 4, 2015 to June 30, 2018 in tuberculosis clinic, Ayder Comprehensive Specialized Hospital, Northern Ethiopia. Data on socio-demography, clinical characteristics and magnitude of the incidence and outcome of anti-tuberculosis drugs-induced hepatitis were collected using structured checklist from patients’ records using census method. Then, we entered and analyzed the data using statistical packages for social sciences (SPSS) statistical software version 21. Descriptive statistics were done in tables, counts, proportions, median and range. Bivariate and multivariable regression analyses were done to identify factors that are associated with drug-induced hepatitis. Confidence interval was taken at 95% and p-value of less than 0.05 was used to denote significance. Results We approached a total of 226 patients’ records, and we collected data from188 records (83.2%response rate). Anti-tuberculosis drug-induced hepatitis was found in 26 (13.8%) of the patients, of which 3 (11.54%) have died. Using multivariable logistic regression analyses, preexisting liver disease (AOR: 42.01, 95% CI: 4.22–417.49), taking other hepatotoxic drugs (AOR: 23.66, 95% CI: 1.77–314.79), and having lower serum albumin (AOR: 10.55, 95% CI: 2.57–43.32) were found to be significantly associated with the development of anti-tuberculosis drug-induced hepatitis. Conclusion and recommendation The incidence of anti-tuberculosis drug-induced hepatitis was high. Patients with low baseline serum albumin, taking other hepatotoxic drugs and having preexisting liver disease should be followed with serial liver enzymes after initiation of anti-tuberculosis medications. These patients should be followed with frequent measurement of liver enzymes to assess for the development of drug-induced hepatitis.

SERUM ANTIOXIDANT CAROTENOIDS INVERSELY ASSOCIATE WITH SERUM LIVER ENZYMES: CROSS-SECTIONAL STUDY FROM THE MIKKABI STUDY

2009 ◽  
pp. 589-594
Author(s):  
M. Sugiura ◽  
H. Matsumoto ◽  
Y. Ikoma ◽  
K. Ogawa ◽  
M. Yano ◽  
...  
Keyword(s):  
Liver Enzymes ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional
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