Flavonol Glycosides from the Aerial Parts of Indigofera hirsuta and Anti-inflammatory Activity of n-butanol Fraction

This study investigated the anti-inflammatory and antiulcer activities of different extracts from the aerial parts and the roots of Anchusa azurea Miller var. azurea (Boraginaceae), as well as their major constituent, rosmarinic acid. The extracts were water (AWa, RWa) and methanol (AMe, RMe) extracts prepared from the aerial parts and the roots of A. azurea, respectively. The AMe extract was found to exert anti-inflammatory effects; so it was evaporated to dryness and the residue was dissolved in distilled water (AMeWa) and then further fractionated with n-hexane (AMeHe) and n-butanol (AMeBu). Anti-inflammatory activity was investigated in rats using carrageenan-induced acute inflammation, and antiulcer activity was investigated using indomethacin-induced gastric damage. The methanolic extract from the aerial parts, its n-butanol fraction, and rosmarinic acid, which was isolated from the n-butanol fraction of the AMe extract, showed signifi cant dose-dependent antiinflammatory activity. During the acute phase of inflammation, the anti-inflammatory activity of rosmarinic acid was comparable to that of ibuprofen. No antiulcer activity was observed. The experimental data demonstrate that A. azurea Miller var. azurea and rosmarinic acid display significant anti-inflammatory activity.

Download Full-text

In-vivo anti-inflammatory activity and safety assessment of the aqueous extract of Algerian Erica arborea L. (Ericaceae) aerial parts

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.113881 ◽

2021 ◽

Vol 271 ◽

pp. 113881

Author(s):

Djouher Amroun ◽

Meriem Hamoudi ◽

Seddik Khennouf ◽

Sabrina Boutefnouchet ◽

Daoud Harzallah ◽

...

Keyword(s):

Aqueous Extract ◽

Safety Assessment ◽

Inflammatory Activity ◽

Aerial Parts ◽

Erica Arborea ◽

Anti Inflammatory

Download Full-text

Anti-Inflammatory Activity of Flavonol Glycosides and Salicin Derivatives from the Leaves ofPopulus tremuloides

Planta Medica ◽

10.1055/s-2006-961318 ◽

1990 ◽

Vol 56 (06) ◽

pp. 660-660 ◽

Cited By ~ 7

Author(s):

M. Albrecht ◽

A. Nahrstedt ◽

N.-P. Luepke ◽

N. Theisen ◽

G. Baron

Keyword(s):

Flavonol Glycosides ◽

Inflammatory Activity ◽

Anti Inflammatory

Download Full-text

Comparative evaluation of anti-inflammatory activity between n-butanol fraction, leaf and stem methanolic extract obtained from Olax psittacorum

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.114697 ◽

2022 ◽

Vol 283 ◽

pp. 114697

Author(s):

Raja Majumder ◽

Moonmun Dhara ◽

Lopamudra Adhikari ◽

Amitav Panigrahi

Keyword(s):

Comparative Evaluation ◽

Methanolic Extract ◽

Inflammatory Activity ◽

Butanol Fraction ◽

Anti Inflammatory

Download Full-text

Chemical Constituents from Farfugium Japonicum Var. formosanum

Natural Product Communications ◽

10.1177/1934578x1200700405 ◽

2012 ◽

Vol 7 (4) ◽

pp. 1934578X1200700 ◽

Cited By ~ 1

Author(s):

Sung-Fei Hsieh ◽

Tain-Jye Hsieh ◽

Mohamed El-Shazly ◽

Ying-Chi Du ◽

Chin-Chung Wu ◽

...

Keyword(s):

Chemical Constituents ◽

Cancer Cell Line ◽

Inflammatory Activity ◽

Human Neutrophils ◽

Spectral Techniques ◽

Methanolic Extracts ◽

Aerial Parts ◽

Anti Inflammatory ◽

Farfugium Japonicum ◽

First Time

Two new eremophilenolides, 6β8β10β-trihydroxyeremophil-7(11)-en-12,8-olide (1) and 3βacetoxy-8α-hydroxy-6β-methoxyeremophila-7(11),9-dien-12,8-olide (2) along with twenty-nine other compounds were obtained from the methanolic extracts of the aerial parts and rhizomes of Farfugium japonicum (L.) Kitam. v ar. formosanum (Hayata) Kitam. (Compositae = Asteraceae). The structures of the isolated compounds were characterized and identified by spectral techniques. Compounds 5, 6, 10, 12-24, 29, and 30, were reported for the first time from this genus. Cytotoxicity and anti-inflammatory activity of the isolated compounds were evaluated. Compounds 3 and 16 possessed moderate cytotoxicity against human breast cancer cell line (MCF 7). Compounds 3, 16, 25 and 26 exhibited moderate cytotoxicity against hepatoma cells (Hep G2 and Hep 3B). With respect to the anti-inflammatory activity, compounds 15 and 16 (each 10 μg/mL) inhibited superoxide anion generation by human neutrophils in response to fMLP/CB by 92.0% and 87.3%, respectively.

Download Full-text

ASSESMENT OF ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF FREEZE DRIED HYDROALCOHOLIC EXTRACT OF Bidens andicola ON ISOLATED NEUTROPHILS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i6.17574 ◽

2017 ◽

Vol 10 (6) ◽

pp. 160

Author(s):

Vinueza D ◽

LÓpez E ◽

Acosta K ◽

Abdo S

Keyword(s):

Freeze Drying ◽

Water Soluble ◽

Inflammatory Activity ◽

Hydroalcoholic Extract ◽

Cytotoxicity Assays ◽

Aerial Parts ◽

Controlled Conditions ◽

Freeze Dried ◽

Anti Inflammatory

Objective: The aim of this study was to evaluate anti-inflammatory activity and cytotoxicity in vitro of hydroalcoholic extract of Bidens andicola.Methods: B. andicola hydroalcoholic extract was obtained from aerial parts of B. andicola, following a standardized methodology. Briefly, aerial parts of B. andicola were extracted with ethanol 70% v/v and defatted with n-hexane, hydroalcoholic fraction was concentrated under controlled conditions in a rotary evaporator, and finally the residue was freeze-drying to obtain the hydroalcoholic extract of B. andicola. Anti-inflammatory activity and cytotoxicity assays were carried out using in vitro isolated neutrophils model using stable water-soluble tetrazolium salts.Results and Conclusions: The in vitro anti-inflammatory assay on isolated neutrophils demonstrated that the hydroalcoholic extract showed antiinflammatoryactivity compared to aspirin, with inflammatory inhibition percent values of 80.138±0.729 to hydroalcoholic extract of B. andicola and 82.117±0.762 to aspirin, each tested in five replicates at the concentration of 200 ppm of hydroalcoholic extract or reference.

Download Full-text

Terpenoid and phenolic derivatives from the aerial parts of Elsholtzia rugulosa and their anti-inflammatory activity

Phytochemistry ◽

10.1016/j.phytochem.2020.112543 ◽

2021 ◽

Vol 181 ◽

pp. 112543

Author(s):

Fan Yang ◽

Hang-Yi Pu ◽

Aftab Yaseen ◽

Bin Chen ◽

Fu Li ◽

...

Keyword(s):

Inflammatory Activity ◽

Aerial Parts ◽

Phenolic Derivatives ◽

Anti Inflammatory

Download Full-text

Phytochemical Screening, Biological Studiesand GC-MS Analysis of Extract of Biden pilosa L

Journal of Manmohan Memorial Institute of Health Sciences ◽

10.3126/jmmihs.v5i1.24076 ◽

2019 ◽

Vol 5 (1) ◽

pp. 79-93

Author(s):

Dharma Prasad Khanal ◽

Rupa Rana ◽

Bechan Raut ◽

Rabindra Prasad Dhakal

Keyword(s):

Ethyl Acetate ◽

Aerial Part ◽

Inflammatory Activity ◽

Alcoholic Extract ◽

Acute Oral Toxicity ◽

Oral Toxicity ◽

Bidens Pilosa ◽

Aerial Parts ◽

Ms Analysis ◽

Anti Inflammatory

Objective: The aim of the research work was to carry out the extraction of areal parts of Biden pilosa L by hydroalcholic and Hexane, ethyl acetate and acetone mixture followed by qualitative phytochemical analysis, acute oral toxicity test, anti-inflammatory test and GC-MS analysis of the extracts. Method: The hydro-alcoholic and HEA(n-hexane, ethyl acetate and acetone) extraction was done from aerial parts using ethanol and water in the ratio 70:30 and n-hexane, ethyl acetate and acetone in the ratio of 1:1:1 (HEA extract) respectively. Acute oral toxicity testwas performed OECD guidelines. The single spot in TLC was obtained using n-hexane as solvent for HEA fraction and finally phytocomponents were identified by GC-MS present in that spot.In vitro anti-inflammatory activity was performed by human RBC membrane stabilization method. Result: The phytochemical test results obtained indicate that hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. Both extracts showed significant in vitro anti-inflammatory activity in a concentration dependent manner. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds from partially separated extract from TLC plates. Conclusion: Hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds.

Download Full-text