Public Health is Truly Interdisciplinary

No abstract available.

Knowledge on Uterine Prolapse and its Risk Factors among Married Women in Suklagandaki Municipality, Tanahun Nepal: A Cross Sectional Study

Correction: The page numbers were changed from 68-84 to 50-66 on 31/08/2020. Abstract: Not available.

Study of Drug Prescription Pattern of Obese and Non-Obese Patients with Type-II Diabetes with or without Hypertension

Correction: The page numbers were changed from 98-100 to 81-93 on 31/08/2020. Background: Obesity is regarded as worldwide health problems which may put a person at a higher risk of serious health conditions leading to morbidity and mortality. Obesity is a risk factor for many diseases of which hypertension and type-2 diabetes mellitus are the most important. Hypertension, diabetes mellitus and obesity together form 24% of the global risk for mortality. Cardiovascular diseases related to these life-style disorders has major effect on life expectancy and impaired quality of life. Objectives: The study was done to evaluate the drug prescribing pattern of type - 2 diabetes and hypertension in both obese and non-obese patients. Along with it, this study also attempt to find the contributing factors associated with it and different types of drugs selected in those conditions respectively. Method: A descriptive cross-sectional study was conducted in 2074 at Manmohan memorial teaching hospital. A total of 101 out-patient were interviewed, measurements were done to calculate BMI and waist to hip ratio and their prescriptions were reviewed. For Treatment Guideline of HTN, JNC 8[20] was followed and Updated Treatment Guidelines for Type 2 Diabetes by the American Diabetes Association (ADA) [21] was followed in case of diabetes. Result: Among 101 patients studied, 58 were males and 43 were females. Regarding physical activity, only 26.7% of total patients were involved in morning walk and 3% in yoga, remaining 71% of study patients did not involve in any kind of physical exercise. Regarding food habits, 22.8% were smokers, 49.5% were alcoholics and 96% were non-vegetarians. Waist to hip ratio was also observed higher in both males (35.6%) and females (39.6%). Among the101 total participants, the age group of 41-55 years were found to be more obese than other age group (34 in numbers) followed by age group 56-70 which were 16 in numbers. Male patients were more obese (41) than female patients (31). Highest number (31) of the obese patients were diagnosed with type 2 diabetes mellitus, followed by second highest number (26) of patients diagnosed with hypertension and 15 patients with both the conditions. The commonly prescribed oral hypoglycemic drugs were metformin (35.60%) followed by glimepiride (24.80%). Among anti-hypertensive drugs, amlodipine (22.80%) was most common in prescriptions followed by losartan (18.80%) and Telmisartan (17.80%). Conclusion: The results of the present study show that higher number of male patients (41) were obese than female patients (31). About 30% of patients were found obese-diabetic, 26% were obese-hypertensive and 15% were with both obese diabetic and hypertensive condition. Among oral hypoglycemic drugs, metformin (35.60%) was mostly prescribed followed by glimepiride (24.80%). Among antihypertensives, amlodipine (22.8%) was mostly prescribed followed by losartan (18.80%). Atorvastatin (11.9%) was mostly prescribed oral hypolipidemic agent.

Assessment of Patients’ Knowledge, Perception and Safety Regarding MRI Scan

Correction: The page numbers on this article were changed from 4-20 to 3-19 on 31/08/2020. Introduction: We presume that the knowledge of patients about Magnetic Resonance imaging (MRI) scan is of utmost importance for smooth workflow, patient comfort, patients’ safety and to mitigate patients’ compliance and save valuable scan time. Therefore, the purpose ofthis study was to determine the awareness of patients undergoing MRI scan regarding Knowledge, Perception and Safety. Methods: This descriptive cross-sectional study was carried out in Chitwan Medical College Teaching Hospital from April to September, 2018. Total of 310 patients referred to undergo MRI scan were assessed by a questionnaire form covering 4 parts: Part 1- aimed to gather the socio demographic data such as age, sex, occupation and educational status of patients, Part 2- included the knowledge regarding MRI and its safety, Part 3- comprised the patient perception before MRI scan and Part 4 constituted the patient perception after MRI scan.The form was filled by an investigator oneself in a face to face interview with the patients. Results: Among 310 patients, 35.2% were illiterate and 19.4% graduated from high school. Majority of 85.5% patients answered that MRI uses harmful ionizing radiation like CT scan and radiography. Almost 43 patients who answered MRI functions in disease treatment also answered decreased in pain after MRI scan (Male = 15 and Female = 28) were in age group between 25 years and 50 years. This study also revealed that majority of 26.8% (i.e. n = 83) patients faced problem as claustrophobia along with anxiety during the scan, out of which 13 patients have history of previous MRI scan. Conclusions: In our study decrease in pain was higher in diagnosis and treatment answer. Majority of the patients faced anxiety along with claustrophobia during the MRI scan. Assessment of patient knowledge, perception and safety regarding MRI scan can be the key to increase patient compliance and save valuable scan time.

Factors Associated for Caesarean Section among Mothers Attending in Teaching Hospital, Chitwan

Correction: The page numbers were changed from 57-67 to 39-49 on 31/08/2020. Background: Cesarean section (CS) rate has increased rapidly over the past two decades in world. It is serious concern for public health experts globally. Various medical and non-medical factors, such as maternal socio-demographics, are found to be responsible for this upsurge. Like in other countries, the rate of caesarean sections has increased in Nepal as well. Therefore, there is a need to investigate the factors behind this increase. Objectives: To identify the factors associate for caesarean section among mothers attending at teaching hospital, Chitwan Methods: A cross sectional analytical study was conducted using total enumerative sampling technique in the maternity ward of Chitwan Medical College Teaching Hospital. Interview was done with closed ended Questionnaire for data collection, a total number of 139 mothers after 24 hours cesarean section (CS). Results: The study shows that, nearly three- quarters (71.2%) of CS were performed as an emergency. There are mainly fetal, maternal and placental indication for cesarean section. The most frequent indications were: previous cesarean section (22.3%), thick Meconium stained liquor (12.2%), fetal distress (10.6%) and oligohydramnios (7.2%).

Traditional Healing Practices Using Herbal Dosage Forms and Other Agents by Magar Community of Gulmi District, Nepal

Correction: The page numbers were changed from 24-41 to 20-38 on 31/08/2020. Background: The distinctive climatic and ecological conditions make Gulmi a unique existence for a large Biodiversity. For thousands of years, Magars are living in this area and they are mostly dependent on agriculture. They follow their own ancient traditional healing practices. But socio-cultural activities of the Magars community are directly and indirectly related to the plants resources. Therefore, this study mainly focuses on the survey of traditional healing practice including plant used and dhami-jhakri of Magars community of Gulmi district Nepal. Objective: The main objective of the study was to explore the traditional healing practices and identify the plants used by Magar Community of Gulmi District, Nepal for their healing practices. Methodology: It was descriptive cross sectional study. A survey was performed using open ended questionnaires and face to face interview with the healers of Magar community of Gulmi, district Nepal. Result: Various belief of causes of diseases on traditional healers were found. They were vayu-batas,masan, bhut-pret, Grahadasha, Boksi, Pitri risako, kul deuta risako etc . Moreover the diseases were diagnosed by Observation of eye, Observation of nadi, Phukphak, Jantarmantar, Bali, Puja, Akcheta herne etc. Spiritual based four healing techniques and/or approaches, Phukphak, Bali, Jantar-mantar and kul bigreko, used by traditional healers. Healers were using 31 plant species belonged to 23 families for preparing different poly-herbal formulations to cure various ailments like arthritis, wound and injury, dysentery, fever, snake bite, jaundice, diabetes, hypertension , asthma, stone remover, eye infection, menstrual disorder, burn, allergy, toothache, fever, headache, pneumonia etc. Conclusion: All together 31 species of plants of 25 families were found to be used as traditional medicines formulation during the study. 24 different types of formulations have been observed throughout the research. Five different types of dosage forms were used. Nelumbo nucifera was widely used for the treatment of Jaundice than other allopathic medicine.

Comparative Study of Antimicrobial Efficacy of Azithromycin and Cefixime against Salmonella Typhi Infection

Correction: The page numbers were changed from 84-97 to 67-80 on 31/08/2020. Introduction: Enteric fever is systemic infection caused by the Salmonella enteric serovars typhi and para typhi A B and C. It is the significant cause of morbidity and mortality. It occurs in all parts of the world where water supplied and sanitation is substandard. Annually, it is estimated that more than 10 million cases and 100000 deaths are caused by typhoid fever. Regarding to the strains, a high prevalence of S. typhi and S. paratyphi. A strains in Nepal that showed resistance against the quinolone nalidixic acid (MIC> 256 mcg/ml with a corresponding decreased susceptibility against fluoroquinolones such as ciprofloxacin (MIC>0.125 mcg/ml. Objectives: The main objective of study was to compare the efficacy of Azithromycin and Cefixime in treatment of typhoid fever. Methodology: The in vitro antibacterial activity of azithromycin and Cefixime against 4 isolated colonies of Salmonella typhi from reference of salmonella typhi ATCC no. 14028 and blood culture isolates from three different hospitals was evaluated by disc diffusion (well) method. 0.25 ppm, 0.5 ppm, 4 ppm, 8 ppm, 32 ppm, 128 ppm concentration of both Azithromycin and Cefixime was used. The zone of inhibition was measured and data was analyzed using Excel. Results: In all isolates of Salmonella typhi, the zone of inhibition shown by both Azithromycin and Cefixime is same at low concentration (0.25ppm, 0.5ppm) but with increasing in concentration there is increase in difference in zone of inhibition shown by them. The zone of inhibition shown by Cefixime is greater in high concentration as compared to zone of inhibition shown by Azithromyci. Conclusion: Our result indicate Cefixime is better than Azithromycin in therapeutic option for enteric fever.

Therapeutic Agents (drug, biological and vaccine) Trial Against COVID-19 Virus: Pre-requisite to combat the current pandemic

Not available.

Phytochemical Screening, Biological Studiesand GC-MS Analysis of Extract of Biden pilosa L

Objective: The aim of the research work was to carry out the extraction of areal parts of Biden pilosa L by hydroalcholic and Hexane, ethyl acetate and acetone mixture followed by qualitative phytochemical analysis, acute oral toxicity test, anti-inflammatory test and GC-MS analysis of the extracts. Method: The hydro-alcoholic and HEA(n-hexane, ethyl acetate and acetone) extraction was done from aerial parts using ethanol and water in the ratio 70:30 and n-hexane, ethyl acetate and acetone in the ratio of 1:1:1 (HEA extract) respectively. Acute oral toxicity testwas performed OECD guidelines. The single spot in TLC was obtained using n-hexane as solvent for HEA fraction and finally phytocomponents were identified by GC-MS present in that spot.In vitro anti-inflammatory activity was performed by human RBC membrane stabilization method. Result: The phytochemical test results obtained indicate that hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. Both extracts showed significant in vitro anti-inflammatory activity in a concentration dependent manner. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds from partially separated extract from TLC plates. Conclusion: Hydro-alcoholic extract of aerial part of Bidens pilosa L. possess alkaloids, tannins, terpenoids and saponins whereas HEA extract possess alkaloids, flavonoids, tannins. Both hydro-alcoholic and HEA extracts were found to be safe up to the dose of 2000 mg/kg BW of the mice. The GC-MS analysis of HEA extract of aerial parts showed the presence of the sixteen different compounds.

Nepal’s Bumpy Transition to Federalism: Implications for the Health System

Not available.