Comparative Investigation of the Effects of the Commonly-consumed Aqueous Extracts of Hibiscus sabdariffa (Zobo Drinks) on Body Weight, Glucose Level and Lipid Profile Using Normal Wistar Albino Rats

2017 ◽  
Vol 16 (4) ◽  
pp. 1-8
Author(s):  
Chukwu ◽  
Charles Nnanna ◽  
Akaninwor ◽  
Joyce Oronne ◽  
Ikewuchi ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Glucose Level ◽  
Comparative Investigation ◽  
Albino Rats ◽  
Hibiscus Sabdariffa ◽  
Aqueous Extracts ◽  
Wistar Albino Rats

scholarly journals Efficacy of Zanthoxylum armatum fruit on isoproterenol induced myocardial infarction in rats

2019 ◽  
Vol 8 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Malathi Mangalanathan ◽  
Tamiloli Devendhiran ◽  
Saraswathi Uthamaramasamy ◽  
Keerthika Kumarasamy ◽  
K Mohanraj ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Body Weight ◽  
Lipid Profile ◽  
Troponin T ◽  
Serum Markers ◽  
Albino Rats ◽  
Zanthoxylum Armatum ◽  
Creatine Kinase Mb ◽  
Enzymic Antioxidants ◽  
Wistar Albino Rats

The present study was elucidating the cardioprotective activity of hydroethanoic extract of Zanthoxylum armatum (Z. armatum) fruit on serum cardiac markers, lipid profile and the level of antioxidants in experimentally induced myocardial infarction (MI). The hydroethanolic extract of Z. armatum fruit was administered at a dose of 200 and 400 mg/kg body weight for 30 days to male Wistar albino rats. On 28th and 29th day, isoproterenol (ISO) (8.5mg/100g body weight) wasadministered to induce MI. Animals were sacrificed; blood and heart tissues were removed and the biochemical parameters were carried out. Serum markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB) and troponin –T were significantly (p<0.05) increased after ISO treatment. Altered lipid profile and significant changes in enzymic and non- enzymic antioxidants were also observed in MI. The altered levels were brought back to near normal by the administration of hydroethanoic extract of Z. armatum fruit which might be due to the active phytoconstituents present in it.

Evaluation of the Effect of Starvation on Blood Glucose Level and Body Weight of Wistar Albino Rats

2015 ◽  
Vol 8 (4) ◽  
pp. 1-8
Author(s):  
Okoro Ruth ◽  
Eze Adaora ◽  
N Victor ◽  
Onyia Felix ◽  
C Stanley ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Wistar Albino Rats

scholarly journals Efficacy of the Aqueous Extracts of Justicia Galeopsis Leaves on the Improvement of Hematological Parameters in Anemic Rats

2020 ◽  
Vol 9 (5) ◽  
pp. 14
Author(s):  
Ahou L. Loukou ◽  
Moussa Gbogbo ◽  
Raissa S. Assi ◽  
Louise Atchibri-Anin ◽  
Kouakou Brou
Keyword(s):  
Body Weight ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Hematological Parameters ◽  
Hemoglobin Level ◽  
Albino Rats ◽  
Aqueous Extracts ◽  
Reference Drug ◽  
Phenylhydrazine Hydrochloride ◽  
Wistar Albino Rats

Antianemc potential of aqueous of Justicia galeopsis leaves was studied using Wistar Albino rats after induction of anemia by phenylhydrazine hydrochloride. Forty rats (20 male and 20 female) subdivided into five groups of eight rats were used. There was a group as control (not anemic) and four other anemic groups which had received by gavage respectively 1 ml/kg of distilled water, 1 ml/kg of body weight of Vitafer (reference drug commonly used to treat anemia), 100 mg/kg of body weight of extract of J. galeopsis leaves cooked during 30 min and 30 mg/kg of body weight of extract of J. galeopsis leaves cooked during 45 min. Hematological parameters (red blood cells, hemoglobin and hematocrit) were analyzed as indices of anemia and the weights of specific organs (liver, spleen and kidney) were evaluated. The results of this investigation had showed that aqueous extract of J. galeopsis leaves cooked improved red blood cells, hemoglobin and hematocrit levels. These extracts were not toxic for liver, spleen and kidney. The administration of 100 mg/kg/day of extract of leaves cooked leaves during 30 min promotes a better recovery rate of the number of red blood cells (94.80 %), hemoglobin level (159.53 %) and hematocrit (117.72 %) than Vitafer and the extract of leaves cooked for 45 min. This is suggestive that aqueous extracts of Justicia galeopsis leaves cooked during 30 min may be exploited during 2 weeks in the treatment of anemia.

scholarly journals Chemopreventive and Therapeutic Efficacy of Enhalus Acoroides Against Diethylnitrosamine Induced Hepatocellular Carcinoma in Wistar Albino Rats

2021 ◽  
Author(s):  
Amudha Parthasarathy ◽  
R. VIDYA
Keyword(s):  
Hepatocellular Carcinoma ◽  
Body Weight ◽  
Lipid Profile ◽  
Therapeutic Efficacy ◽  
Ethanolic Extract ◽  
Albino Rats ◽  
Antioxidant Defence ◽  
Enhalus Acoroides ◽  
Liver Markers ◽  
Wistar Albino Rats

Abstract Background: Hepatocellular carcinoma plays an inadequate mention in the second cause of death because of cancer worldwide. An alternative therapy with high rate of prognosis and also without side effects. Several data indicated the therapeutic efficacy of Enhalus acoroides. There were no scientific studies on chemopreventive and antioxidant potential of Enhalus acoroides against hepatocellular carcinoma.Purpose: To investigate the hepatoprotective efficacy of ethanolic extract of Enhalus acoroides (EEEA) against DEN induced hepatocellular carcinoma using wistar albino rats.Study design: Animals were divided into five groups each comprising six rats. Normal saline given to Group I- Control rats. By using DEN, liver cancer was induced to Group II, III, IV and V rats as single intraperitoneally injection (100 mg/kg body weight). At the beginning of 6th week, Groups III rats received EEEA (200mg/kg body weight/day) upto 16 weeks. Group IV rats received EEEA for one week before the administration of DEN and continued till the 16th week. After the administration of DEN, Group V positive control rats received Silymarin (100 mg/kg body weight) at the beginning of 6th week and continued upto 16 weeks. The efficacy of Enhalus acoroides for its Hepatoprotective and antioxidant properties during its simultaneous treatment against DEN induced liver damage was evaluated in rats. Methods: The hepatoprotective efficacy of EEEA (200 mg/kg) was investigated against DEN (100 mg/kg/b.w) induced hepatotoxicity, was measured by evaluating serum liver markers levels (ALT, AST, GGT and ALP), Kidney markers (Urea and Creatinine), Lipid profile (TG, HDL, LDL & Total cholesterol) and Serum tumor markers (DNA, RNA, AFP and CEA). EEEA-aided antioxidant defence against hepatotoxic insult of DEN was measured by evaluating various Antioxidant biomarkers (GSH, SOD, CAT, GPx, Vit C and Vit E) Morphometric gross analysis and Histopathological studies were done to support the outcomes of the present study.Results: A significant increased antioxidant defence and reduced MDA levels in the serum of EEEA treated animals compared to the DEN induced animals. The resulting data showed that the administration of EEEA decreased the serum liver markers levels, kidney markers, Lipid profile and serum tumor markers when compared to the untreated rats. The histopathological anomalies were altered on administration of EEEA indicating its protective effects on hepatocytes when compared with untreated rats.Conclusions: Our consequences established that crude ethanolic extract of Enhalus acoroides shown an effective impact against DEN-induced hepatocellular carcinoma, and serves as a better option for chemopreventive treatments.

scholarly journals Treatment of Diabetic Condition in Streptozotocin Induced Diabetic Wister Rats Using Food Blends Such as Unripe Plantain, Soybean and Ginger

2019 ◽  
pp. 1-12
Author(s):  
I. Iwanegbe ◽  
M. Suleiman ◽  
A. Jimah
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Lipid Profile ◽  
Cell Volume ◽  
Glucose Level ◽  
Normal Control ◽  
Packed Cell Volume ◽  
Diabetic Rats ◽  
Diabetic Patients

Aims: To investigate the effect of food blends (plantain, soybean and ginger) on the blood glucose, lipid profile and haematological indices on streptozotocin induced diabetic rats. Methodology: A total of 35 rats of mean body weight 219.07 g separated into7 groups (5 per group) where induced by a single intraperitoneal (I.P) injection of streptozotocin (0.1 g dissolved in 5 ml of freshly prepared sodium citrate buffer 0.1 M, pH 4.5) at a dose of 40 mg/kg body weight after fasting for 12 hours and fed with flours/blends. The flours were produced from plant materials for different treatments/blends (blend A=100% unripe plantain, B=80% unripe plantain, 14% soybean, 6% ginger, C=70% unripe plantain, 26% soybean, 4% ginger, D= 60% unripe plantain, 38% soybean, 2% ginger, E= 50% unripe plantain, 50% soybean) and the phytochemicals and minerals content were determined. Blood glucose was determined at 5 days interval for 25 days. Diabetes was confirmed in rats with blood glucose concentrations >200 mg/dl. After 25 days rats were anaesthetized with chloroform vapour and blood samples collected by cardiac puncture for haematology and lipid profile determination. Results: The results showed that unripe plantain, soya beans and ginger in adequate proportion(C=70% unripe plantain, 26% soybean, 4% ginger or D= 60% unripe plantain, 38% soybean, 2% ginger) could help to reduce blood glucose, improve haematological parameters and lipid profile. Significant reduction was observed in the blood glucose level of rats fed blends C and D from 286 to 85 mg/dl and 307 to 90 mg/dl respectively at the end of experiment. These results also demonstrated that the inclusion of ginger at 6% causes rise in blood glucose level. Total cholesterol (TC) increased in all the blends. However, the lowest concentration of TC was observed in blends C and D. The highest packed cell volume (60%) and Haemoglobin (20 g/dl) level observed in rats fed blend C was significantly higher than the normal control fed conventional feeds. The increase in packed cell volume (PCV) (50%) and Hb (17 g/dl) in diabetic rats demonstrated that the formulated blend C was able to raise PCV and Hb above 50% and 17 g/dl (Normal control NC) respectively. Significant increase (P<0.05) in low density lipoprotein cholesterol (LDLc) was also observed in all the blends with blend C having the least (4.0 mg/dl) close to NC (2.0 mg/dl). Conclusion: From the results it is evident that blend C will manage and improve the health status of diabetic patients.

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