Estimation of Cardiovascular Risk Factors & Their Relative Impact in Diabetic Mellitus-2 Adult Patients’ in Mnazi Mmoja Hospital - Zanzibar

Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. We aimed to estimate the cardiovascular risk factors and their correlation with type 2 diabetes mellitus (T2DM) in Zanzibar (Mnazi MMoja Hospital) hypothesizing that early detection and treatment of lipid abnormalities can minimize the risk for atherogenic cardiovascular disorders and cerebrovascular accident in patients with T2DM. Methods: The study populations were those patients who presented themselves at Mnazi Mmoja hospital with T2DM, and who are within the age bracket of 18 to 45 years. Fasting blood glucose (FBG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels were evaluated. Pearson’s correlation studies were performed between the variables of blood glucose and serum lipid profiles and also within the lipid profile parameters. Results: TC, TG, LDL-C mean levels were significantly higher in diabetics compared with the control subjects p< 0.05. The HDL-C was however lower in diabetics compared with the controls. Also, the mean FBG, TC, TG, and LDL-C were significantly higher in female diabetic subjects compared to the male counterparts p< 0.05. A positive correlation was observed between FBG and TC, TG and LDL-C (r=0.643 p=0.0021; r=0.679, p=0.0001; r=0.534, p=0.0091 respectively) while HDL-C showed a negative correlation (r= -0.799, p= 0.0021). TC also showed a positive correlation with TG and LDL-C (r=0.590, p=0.0021; r= 0.628, p=0.0001) and negative correlation with HDL-C ( r=-0.670, p=0.0041). Conclusion: There is an influence of gender on cardiovascular disease risk factors with more of the females seriously at risk. Measurement of serum lipid profile should be introduced to the management plan of diabetes mellitus. There is an urgent need for the establishment of regional and national training courses for diabetic educators and also the creation of new evidence-based management plan for diabetics in Zanzibar for a better healthcare.

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Serum lipid profile and its association with some cardiovascular risk factors in an urban chinese population

Pathology ◽

10.3109/00313029309090854 ◽

1993 ◽

Vol 25 (4) ◽

pp. 344-350 ◽

Cited By ~ 17

Author(s):

E. Lau ◽

J. Woo ◽

C.S. Cockram ◽

A. Chan ◽

C.W.K. Lam ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Lipid Profile ◽

Cardiovascular Risk Factors ◽

Chinese Population ◽

Serum Lipid ◽

Serum Lipid Profile

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Cardiovascular risk factors in children with type 1 diabetes mellitus

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2018-0382 ◽

2019 ◽

Vol 32 (7) ◽

pp. 699-705 ◽

Cited By ~ 4

Author(s):

Ying Zhang ◽

Han Zhang ◽

Pin Li

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Cardiovascular Disease ◽

Type 1 Diabetes ◽

Cardiovascular Risk ◽

Type 1 Diabetes Mellitus ◽

Cardiovascular Risk Factors ◽

Density Lipoprotein ◽

Diabetic Children

Abstract Objective Cardiovascular disease is a major complication among children with type 1 diabetes mellitus (T1DM). This prospective study aimed at examining the presence of cardiovascular risk factors in children with T1DM. Methods We evaluated several cardiovascular risk factors, including atherosclerosis, artery intima-media thickness (IMT) and metabolic responses, in 175 children with T1DM, with 150 non-diabetic children as normal controls. Results The diabetic children had significantly higher carotid IMT (cIMT) and aortic IMT (aIMT), higher values for diastolic wall stress (DWS), incremental elastic modulus (IEM), and flow-mediated dilatation (FMD) than the controls. The levels of tumor necrosis factor-α (TNF-α), interleukin-4 (IL4), high-sensitivity C-reactive protein (hs-CRP) and leptin were significantly higher in T1DM patients. In T1DM children, the cIMT and aIMT were correlated with several risk factors, including age, weight, body mass index (BMI), duration of diabetes, waist/hip ratio, as well as levels of total cholesterol, triglycerides and apolipoprotein B (apoB). In addition to common risk factors, cIMT was also associated with systolic blood pressure (BP). Other risk factors, such as height, diastolic BP, low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio, apolipoprotein A1 (apoA1) and S-creatinine levels, were not all independent risk factors of cardiovascular disease in T1DM children. Conclusions T1DM is associated with early impairment of the common carotid and aortic artery structure and function, and the diabetic state may be the main risk factor for arterial wall stiffening and thickening.

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Acupuncture and related techniques for obesity and cardiovascular risk factors: a systematic review and meta-regression analysis

Acupuncture in Medicine ◽

10.1136/acupmed-2018-011646 ◽

2020 ◽

Vol 38 (4) ◽

pp. 227-234

Author(s):

Jianrong Chen ◽

Dongping Chen ◽

Qing Ren ◽

Weifeng Zhu ◽

Sheng Xu ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Body Weight ◽

Cardiovascular Risk ◽

Blood Glucose ◽

Cardiovascular Risk Factors ◽

Density Lipoprotein ◽

Moderate Quality ◽

Meta Regression ◽

Quality Evidence

Objective: To assess how acupuncture and related techniques affect weight-related indicators and cardiovascular risk factors compared with non-acupuncture interventions in overweight and obese patients. Methods: We searched PubMed, Embase and CENTRAL up to 19 April 2018 and included relevant randomised controlled trials (RCTs). Weighted mean differences (WMDs) and 95% confidence intervals (CI) were pooled using the inverse variance method with random-effects model. Prespecified hypotheses were tested in meta-regression to investigate the source of heterogeneity. Statistical software packages used were RevMan 5.3.5 and Stata 14.0. Results: Thirty-three RCTs were included (n=2503 patients). Compared with non-acupuncture interventions, acupuncture produced a greater reduction in body weight (WMD −1.76 kg, 95% CI −2.22 to −1.30, I2=77%; moderate quality), body mass index (WMD −1.13 kg/m2, 95% CI −1.38 to −0.88, I2=85%; low quality) and waist circumference (WMD −2.42 cm, 95% CI −3.22 to −1.62, I2=75%; moderate quality). Acupuncture plus lifestyle intervention resulted in a greater reduction in body weight than acupuncture alone (MD −1.94 kg, 95% CI −3.17 to −0.70). Acupuncture also led to a greater reduction in total cholesterol (WMD −12.87 mg/dL, 95% CI −22.17 to −3.57, I2=87%; very low quality) and low-density lipoprotein cholesterol (WMD −13.52 mg/dL, 95% CI −21.47 to −5.58, I2=74%; low quality). The differences were not statistically significant for blood glucose or blood pressure. Conclusion: In the short term, acupuncture and related techniques may produce a small but statistically significant degree of weight loss based on moderate- to low-quality evidence, and improve serum lipid parameters based on low- to very-low-quality evidence. Their effects on blood glucose and blood pressure remain uncertain.

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Association between Serum Lipid Profile and Glycated Hemoglobin in Middle Aged Pre-Diabetic Individuals: The Bangladesh Study

International Journal of Diabetes & Metabolic Disorders ◽

10.33140/ijdmd/02/01/00003 ◽

2017 ◽

Vol 2 (1) ◽

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Lipid Profile ◽

Total Cholesterol ◽

Serum Lipid ◽

Glycated Hemoglobin ◽

Density Lipoprotein ◽

Serum Lipid Profile ◽

Middle Aged ◽

Significant Difference

Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is often preceded by a prodromal condition termed pre-diabetes. Pre-diabetes is a condition in which the blood glucose level is above normal but below the diagnostic threshold for diabetes mellitus. Impaired lipid profile is commonly present in type 2 diabetes and can also occur in pre-diabetes. The present study was undertaken to evaluate the association between serum lipid profile and glycated hemoglobin in pre-diabetic individuals in middle-aged Bangladeshi subjects. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) hospital, from July 2013 - June 2014. A total 131 subjects of age within the range of 30-45 years were selected for the purpose and classified into apparently healthy control (n=62), pre-diabetes (n= 69) groups based on the values of OGTT. Blood glucose – both fasting and 2hr after glucose, HbA1C, total cholesterol, triglyceride, high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol level were measured in all study subjects. Among the middle aged Bangladeshi subjects attending BIRDEM hospital, mean±SD of HbA1c values were 5.3±1.1% in control group and 5.9±1.2% in pre-diabetes. There was no significant difference in total cholesterol, triglyceride, HDL-c and LDL-c in patients with normal and Pre-diabetic individuals. According to this study, HbA1c value does not correlate well with total cholesterol, triglyceride and LDL-c (p=0.47, 0.93, 0.49) in patients with pre-diabetic individuals. Studies on larger population are required to determine the prognostic

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Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

Toxicology Research ◽

10.1039/c9tx00227h ◽

2019 ◽

Vol 8 (6) ◽

pp. 979-987 ◽

Cited By ~ 1

Author(s):

Saavia Alice Naame ◽

Decheng Li ◽

Ruixue Huang

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Cardiovascular Risk ◽

Randomized Controlled Trials ◽

Cardiovascular Risk Factors ◽

Red Wine ◽

Density Lipoprotein ◽

Diabetic Patients ◽

Controlled Trials ◽

Randomized Controlled

Abstract Background: Diabetes mellitus is of major public health concerns; its incidence is continuously increasing. Diabetes mellitus is associated with a high risk of cardiovascular complications such as hypertension. Red wine has been reported to reduce cardiovascular risk factors. We quantified the effects of red wine on cardiovascular factors. Methods: We retrieved English-language articles published from January 1990 to April 2019. Cardiovascular risk factors were compared using means with 95% confidence intervals (95% CIs). Results: We identified five eligible randomized controlled trials. Diabetic patients who drank red wine exhibited significantly reduced systolic blood pressure (BP) (mean difference [MD] −1.33, 95% CI −1.81, −0.85) and diastolic BP (MD −1.31, 95% CI −1.80, −0.83) than those who did not. Compared to the observations for diabetics who did not drink red wine, the high-density lipoprotein (HDL) level was significantly higher in red wine drinkers (MD −0.24, 95% CI −0.39, −0.09). However, red wine had no effect on the body mass index (BMI) (MD −0.27, 95% CI −1.80, 1.25), the total cholesterol level (MD 0.13, 95% CI −0.17, 0.44), or the low-density lipoprotein (LDL) level (MD 0.08, 95% CI −0.21, 0.37). Conclusions: Red wine consumption significantly lowered BP and increased the HDL level in diabetics. Red wine had no significant effect on BMI or cholesterol and LDL levels. Given the heterogeneity of the studied populations and the lack of standardization and completeness across the published studies, caution is required while interpreting these findings.

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Cardiovascular Risk Factors in Acromegaly: What's the Impact of Disease Control?

Experimental and Clinical Endocrinology & Diabetes ◽

10.1055/s-0043-124668 ◽

2018 ◽

Vol 126 (08) ◽

pp. 505-512 ◽

Cited By ~ 4

Author(s):

Ana Amado ◽

Fernando Araújo ◽

Davide Carvalho

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Disease Control ◽

Lipid Profile ◽

Cardiovascular Risk Factors ◽

Antithrombin Iii ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Coagulation Status ◽

The Impact

Abstract Objective Cardiovascular disease is one of the most important causes of death in acromegalic patients. The aim of this study is to compare the prevalence of cardiovascular risk factors among acromegalic patients and to evaluate the impact of disease control on these factors. Material and Methods 11 acromegalic patients with active disease and 12 controlled patients were evaluated for blood pressure, body mass index, glucose, coagulation status, and lipid profile. A group of 11 patients with non-functioning pituitary adenomas was used as control population. Results Significant differences were found in lipid profile, glucose and coagulation status in both active and controlled patients. Higher levels of fasting glucose (151.2±102.5 mg/dL, p=0.05 and 108.3±23.4 mg/dL, p=0.02 for active and controlled patients respectively) and fibrinogen (427.1±61.9 mg/dL, p=0.02 and 437.3±106.6 mg/dL, p=0.04 for active and controlled patients respectively) were present in both acromegalic groups. Active patients had higher levels of antithrombin III (1.1±0.1 U/mL, p=0.005) and the controlled ones had higher levels of high density lipoprotein cholesterol (56.1±12.5 mg/dL, p=0.05), compared with the non-functioning group. The differences between active and controlled acromegalic patients are that the latter have reduced total cholesterol (170.4±31.7 vs 201.7±34.6 mg/dL, p=0.02), lower density lipoprotein cholesterol (96,8±25,2 vs 130.8±31.5 mg/dL, p=0.01) and antithrombin III (1.0±0.2 vs 1.1±0.1 U/mL, p=0.05). Conclusion There is some reduction in cardiovascular risk factors with control of the disease, but possibly without the return to basal levels.

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Characteristics of Cardiovascular Risk Factors and Their Correlation with the Sex and Age of Patients in the Latvian Population

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/v10046-009-0040-7 ◽

2009 ◽

Vol 63 (4-5) ◽

pp. 125-130

Author(s):

Inga Stuķēna ◽

Andrejs Kalvelis ◽

Guntis Bahs ◽

Uldis Teibe ◽

Pēteris Tretjakovs ◽

...

Keyword(s):

Risk Factors ◽

Blood Pressure ◽

Cardiovascular Risk ◽

Blood Glucose ◽

Cardiovascular Risk Factors ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Age Group ◽

Reactive Protein

Characteristics of Cardiovascular Risk Factors and Their Correlation with the Sex and Age of Patients in the Latvian Population Various cardiovascular risk factors (RFs) were determined in 773 out-patients (mean age 55.8 ± 14.5 years). Male individuals had a larger waist circumference (WC) than did female patients (99.1 ± 13.6 cm vs 93.3 ± 15.2 cm), higher diastolic blood pressure (DBP) (83.6 ± 9.6 mmHg vs 81.8 ± 9.6 mmHg), and higher levels of blood glucose (5.73 ± 1.4 mmol/L vs 5.49 ± 1.3 mmol/L) and triglycerides (TG) (1.89 ± 1.3 mmol/L vs 1.60 ± 1.0 mmol/L), but lower levels of total cholesterol (TC) (5.54 ± 1.2 mmol/L vs 5.79 ± 1.2 mmol/L) and high-density lipoprotein cholesterol (HDL-C) (1.21 ± 0.4 mmol/L vs 1.44 ± 0.4 mmol/L). Compared with the younger age group (i.e., males, < 7 years; females, < 65 years), patients in the older age group had a larger WC (98.4 ± 14.2 cm vs 92.8 ± 15.1 cm), higher systolic blood pressure (SBP) (144.2 ± 19.2 mmHg vs 131.6 ± 18.5 mmHg), higher DBP (84.5 ± 8.8 mmHg vs 80.9 ± 9.8 mmHg), higher blood glucose level (5.74 ± 1.3 mmol/L vs 5.46 ± 1.3 mmol/L), and higher low-density lipoprotein cholesterol level (LDL-C) (3.68 ± 1.0 mmol/L vs 3.52 ± 1.0 mmol/L), but lower HDL-C level (1.3 ± 0.4 mmol/L vs 1.41 ± 0.4 mmol/L). Age was significantly correlated with all RFs, with the exception of the level of C-reactive protein. In conclusion, analysis of cardiovascular RFs in different age subgroups of both sexes clearly showed individual peculiarities of risk profile. This conclusion challenges the usual way of risk calculation using "universal" markers like adiposity or dyslipidemia in all population. The new approach requires individual attention depending on sex and age also in management of risk.

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