scholarly journals Antihyperlidemic Efficiency of Abelmoschus esculentus (Okra) Fruits Varieties on Rats Fed High-Fat Diet

2020 ◽  
pp. 40-52
Author(s):  
A. A. Nuhu ◽  
D. H. Mhya ◽  
M. K. Atiku ◽  
A. M. Wudil
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
Active Agent ◽  
Chemical Compounds ◽  
Basal Diet ◽  
Negative Control ◽  
High Fat ◽  
Fruit Extract ◽  
Control Serum ◽  
Different Doses

Background: Okra fruits have been found to be efficient in managing hyperlipidemia. But, there are different varieties of Okra, and whether antihyperlipidemic efficiency varies with the varieties has not been reported. Aim of the Study: The aim of the study was to validate antihyperlipidemic efficiencies of some Okra fruits varieties on rats fed high-fat diet. Methods: The five varieties of okra fruit was each sliced, air dried and pulverized into powder then extracted with methanol (80%) using Soxhlet extractor and concentrated at 30∘C in a rotary evaporator then finally air dried. Qualitative and quantitative phytochemicals, and proximate analysis were conducted on the extracts. Hyperlipidemia was induce by feeding rats with high-fat diet for 35 days, followed by treating with two selected Okra fruit varieties (NHB-AI-B and Yar kolon)  which has the highest extract yield and phytochemicals for 21 days. Nine groups of five rats was used: groups 1-3 (hyperlipidemic rats received NHB-AI-B Okra fruit extract at different doses), group 4-6 (hyperlipidemic rats received Yar kolon Okra fruit extract at different doses), group 7 (positive control rats treated with 10mg/kg Atorvastatin), group 8 (normal control rats fed basal diet) and group 9 (negative control). Serum lipid profile were determined from each rat. Results: The study confirmed the presence of some important phytochemicals like saponins, tannins, phenolics, flavonoids, fibre etc but differs in concentrations among the varieties where Yar kolon variety emerge highest in almost all the chemical compounds. Rat fed high-fat diet for 35 days developed hyperlipidemia as evident by the elevated triglyceride, cholesterol, LDL-C, body weight and supressed HDL-C. When treated with extracts of NHB-AI-B and Yar kolon Okra fruits varieties, the altered lipid profile were significantly reversed toward normalcy with Yar kolon variety exerting the most efficient activity. Conclusion: The study showed the five Okra fruit varieties possess same chemical compounds but differs in concentrations among varieties. The extracts of Okra fruits varieties exert significant antihyperlipidemic effect but in varied degrees suggesting variations in their efficiency. This, therefore calls for further study to compare more Okra varieties to determine which one is the most potent and its active agent.

scholarly journals Anti-diabetic effect of Stachytarpheta jamaicensis on low dose streptozotocin-induced diabetic rats fed on a high-fat diet

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Mac Donald Idu ◽  
Owen – Obaseki Edehia ◽  
Benjamin Ogunma Gabriel
Keyword(s):  
High Fat Diet ◽  
Blood Glucose Concentration ◽  
Ethanol Extract ◽  
Scientific Basis ◽  
Negative Control ◽  
Diabetic Rats ◽  
Albino Rats ◽  
High Fat ◽  
Ameliorative Effect ◽  
Different Doses

Abstract Introduction This study evaluates the anti-diabetic effect of ethanol extract of Stachytarpheta jamaicensis leaf on streptozotocin (STZ) - induced diabetic rats fed on high-fat diet (HFD). Methods Sets of male albino rats of the Wistar strain weighing between 180 and 250 g were exposed to high fat diet (margarine and oil from vegetable sources in a ratio of 2:1 w/v) for 3 weeks. Then the animals were fasted overnight; hyperglycemic state was induced using reduced dose of streptozotocin (35 mg/kg) and animals were randomly divided into five groups (n = 7); group A received the HFD + STZ (35 mg/kg i.p.); group B received HFD + STZ + gliberclamide (10 mg/kg; i.p); groups C, D and E were administered the HFD + streptozotocin with different doses of the ethanol extract (30, 35 and 100 mg/kg p.o., respectively). Results Results showed significant (p < 0.05) decrease in blood glucose concentration of the rats treated with different doses of S. jamaicensis extract and those treated with gliberclamide compared to the untreated diabetic rats (negative control). Significant (p < 0.05) reductions in activities of serum AST, ALP, total protein and bilirubin were noticed in the groups in contrast to the control. Levels of urea, creatinine, potassium and chloride were considerably (p < 0.05) low while sodium and bicarbonate levels were high in the groups except the control. Lipid profile revealed significant (p < 0.05) reduction in total cholesterol, triacylglycerol, LDL, VLDL while HDL levels were high in the groups compared to the control. The extract significantly (p < 0.05) ameliorated weight loss. Histopathology of the liver, kidney and pancreas showed ameliorative effect of the extract against the deleterious changes occasioned by the HFD and STZ induced diabetic state. Conclusion These findings have provided scientific basis for the use of S. jamaicensis in the treatment of diabetes mellitus in ethnomedicinal practices in Nigeria.

scholarly journals The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet

2017 ◽  
Vol 1 (1) ◽  
pp. 8-13
Author(s):  
Radiyati Umi Partan ◽  
Rachmat Hidayat ◽  
Yeni Agustin ◽  
Mgs Irsan Saleh ◽  
Nita Parisa ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Male Rats ◽  
Control Group ◽  
High Fat ◽  
Fruit Extract ◽  
Reduce Body Weight

Background Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing.   Aim of Study Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet   Methods This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract  at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18.   Results Lerek fruit extract 100 mg/kgBW  was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control.   Conclusion Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level.   Keywords: Lerek fruit extract – body weight- triglyserida - leptin

scholarly journals Protective effect of ethanolic Feronia elephantum Correa fruit extract on high-fat diet induced steatohepatitis in rats

2021 ◽  
Vol 40 (1) ◽  
pp. 36
Author(s):  
Maruni Wiwin Diarti ◽  
Khoviya Yuwina Selinada Harmi ◽  
Dwi Nur Ahsani
Keyword(s):  
High Fat Diet ◽  
Histopathological Examination ◽  
Morphological Changes ◽  
Positive Control ◽  
Negative Control ◽  
High Fat ◽  
Fruit Extract ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Male Wistar Rats ◽  
Feronia Elephantum

BACKGROUND <br />A high-fat diet can lead to hyperlipidemia which will end up as liver damage (steatohepatitis). Ethanolic Feronia elephantum Correa fruit extract (EFEC) has an antioxidant activity which is expected to overcome hyperlipidemia in the liver. The objective of this study was to determine the effects of EFEC on liver function and morphological changes in rats.<br /><br />METHODS<br />This was an experimental study with a post-test only group design. A total of 20 male Wistar rats aged 2-4 months were randomized into 5 groups, A= negative control, B= positive control (high fat diet + 10 mg/kgBW simvastatin), C = high fat diet + 500 mg/kgBW EFEC fruit extract, D = high fat diet + 600 mg/kgBW EFEC, and E = high fat diet + 700 mg/kgBW EFEC). High-fat diet was given for 4 weeks (quail egg yolks, 10ml/200gBW). EFEC was administered for 4 weeks after induction of hypercholesterolemia. Examination of liver serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) was performed on rat blood serum and histopathological examination was carried out using steatohepatitis grading. One way ANOVA test and Post-Hoc Tamhane’s test were used to analyze the data. <br /><br />RESULTS<br />Administration of EFEC at 700 mg/kgBW improved the liver enzymes (p=0.00 for SGPT and SGOT) and steatohepatitis grading in high-fat diet induced rats (mild condition, E = 75% vs A = 100% mild)<br /><br />CONCLUSION<br />Ethanolic Feronia elephantum Correa fruit extract at 700 mg/kgBW was able to improve steatohepatitis in high-fat diet induced rats.

The ameliorative effect of the Pyracantha fortuneana (Maxim.) H. L. Li extract on intestinal barrier dysfunction through modulating glycolipid digestion and gut microbiota in high fat diet-fed rats

2019 ◽  
Vol 10 (10) ◽  
pp. 6517-6532 ◽  
Author(s):  
Hang Xu ◽  
Chunfang Zhao ◽  
Yutian Li ◽  
Ruiyu Liu ◽  
Mingzhang Ao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Intestinal Barrier ◽  
High Fat ◽  
Barrier Dysfunction ◽  
Fruit Extract ◽  
Intestinal Barrier Dysfunction ◽  
Beneficial Effects ◽  
Obese Rats ◽  
Ameliorative Effect

Pyracantha fortuneana fruit extract (PFE) exhibits beneficial effects on IBF in association with the modulation of glycolipid digestion and gut microbiota in HFD-fed obese rats.

Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet

2014 ◽  
Vol 94 (14) ◽  
pp. 2972-2977 ◽  
Author(s):  
Ganapathy Saravanan ◽  
Ponnusamy Ponmurugan ◽  
Machampalayam Arumugam Deepa ◽  
Balasubramanian Senthilkumar
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Lipid profile of mice fed a high-fat diet supplemented with a wax ester-rich marine oil

2014 ◽  
Vol 116 (12) ◽  
pp. 1718-1726 ◽  
Author(s):  
Alice Marie Pedersen ◽  
Wahida Salma ◽  
Anje Christina Höper ◽  
Terje Steinar Larsen ◽  
Ragnar Ludvig Olsen
Keyword(s):  
Lipid Profile ◽  
High Fat Diet ◽  
Wax Ester ◽  
High Fat ◽  
Marine Oil

scholarly journals The Comparison of Bay Leaf and Celery Leaf Infusion Effect on Decreasing LDL Level in Dyslipidemic Wistar Rats Model

1970 ◽  
Vol 1 (1) ◽  
pp. 21
Author(s):  
Anjani Putri Retnaninggalih ◽  
Erfan Efendi ◽  
Hairrudin Hairrudin
Keyword(s):  
Cholesterol Level ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Ldl Cholesterol ◽  
Wistar Rat ◽  
Positive Control ◽  
Negative Control ◽  
High Fat ◽  
Leaf P ◽  
One Way Anova

Coronary heart disease (CHD) is the cause of 7,3 million death globally in 2008. The main pathophysiology process that leads to CHD is atherosclerosis which is caused by high LDL cholesterol level. The aim of this study was to explore bay leaf and celery leaf infusion effect on reducing LDL cholesterol level in dyslipidemic rat model. The type of this study was true experimental research using wistar rat (Rattus novergicus) as the sample. The rats were induced by high fat diet and PTU for two weeks then each of the group were given either bay leaf infusion, celery leaf infusion, simvastatin (positive control), or aquadest (negative control) for a week. The measurement of LDL level used Friedewald formulation. Data was analyzed using paired sample t test and one way ANOVA. As the result there was a significance reduction on LDL level after treatment with bay leaf (p=0,013) and celery leaf infusion (p=0,035) but there was no significance difference between groups (p=0,293). It was concluded that bay leaf and celery leaf infusion could reduce the LDL level in dyslipidemic wistar rat but there was no difference on the capability of the two different leafs on reducing LDL level. Keywords: dyslipidemia, LDL, bay leaf, celery leaf, wistar rats

Lipid profile lowering effect of SoyproTMfermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats

BioFactors ◽  
2008 ◽  
Vol 33 (1) ◽  
pp. 49-60 ◽  
Author(s):  
Na-Hyung Kim ◽  
Hyung-Min Kim ◽  
Hyo-Jin An ◽  
Jae-Young Um ◽  
Phil-Dong Moon ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Lipid Profile ◽  
High Fat Diet ◽  
High Fat ◽  
Lowering Effect ◽  
Obese Rats
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