scholarly journals Association of Helicobacter pylori Infection and Atrophic Gastritis with Chronic Renal Insufficiency in Yaounde Cameroon, Using Gastropanel® Serological Biomarker Panel (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter pylori Igg)

2021 ◽  
pp. 62-67
Author(s):  
Alonge Ivo Ebule ◽  
Valentine Ngum Ndze ◽  
Ngouana Kammalac Thierry ◽  
Guenou Etienne ◽  
Moche Mboudja Morel Ornella ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Atrophic Gastritis ◽  
Teaching Hospital ◽  
Helicobacter Pylori Infection ◽  
University Teaching ◽  
Renal Diseases ◽  
Pepsinogen I ◽  
Software Application ◽  
The Mean ◽  
H Pylori

Introduction: Helicobacter pylori infection is associated with an atrophic gastritis peptic and duodenal ulcer and gastric cancer. Patients with chronic renal diseases usually have dyspeptic symptoms. Several investigations have demonstrated an association between H. pylori infection and chronic kidney disease, although their results are still conflicting. We therefore aimed, to clarify the prevalence of H. pylori infection in patients receiving dialysis. Materials and Methods: Patients undergoing hemodialysis were recruited at the University Teaching Hospital of Yaounde, between January and May 2019. The clinical and socio-demographic information of the patients was recorded. 5 ml of blood were collected aseptically for Pepsinogen I and II enzymes, gastrin17 hormone and IgG anti H. pylori anti-body. The test parameters were analyzed using a GastroSoft software application. The data was analyzed using Epi Info 7.0. All statistics were 95% CI. Ethical clearance was also obtained from the National Ethics Committee. Authorization was obtained atthe University Teaching Hospital. Results: A total of 60 subjects were recruited aged 25-74 years, (mean±SD 52.03 ± 12,78) years;22(45.16%) females, aged 29 to 71years(mean±SD 47,45 ± 11.46) years and 38(54.84%) males aged 25 to 74 (mean±SD 56,47±12.25) years. Female / male ratio was 1.2. Overall, 26(43.33%) subjects were positive for H. pylori infection (IgG≥30EIU). The prevalence of atrophic gastritis obtained was (23.33%)(PG1< 30µg/l). The mean H. pylori IgG antibodies were significantly higher in obese than non obese subjects (F=3.59; p=0,01). A significant increase in the mean creatinine(P=0.008), andurea (P=0,05) was observed in H. pylori positive than negative ones. Conclusion: H. pylori infection is highly prevalent amongst patients with chronic renal failure and may thus require continuous follow up.

scholarly journals Prevalence of Helicobacter Pylori Infection and Associated Factors Among Gastritis Patents in Yekatit 12 Teaching Hospital Addis Ababa Ethiopia

2020 ◽  
Author(s):  
Awraris Hailu ◽  
Bekureamanuel Sileshi ◽  
Hazaratali Panari
Keyword(s):  
Helicobacter Pylori ◽  
Teaching Hospital ◽  
Rural Areas ◽  
Associated Factors ◽  
Addis Ababa ◽  
Helicobacter Pylori Infection ◽  
Work Place ◽  
P Value ◽  
Hand Wash ◽  
H Pylori

Abstract Introduction: Helicobacter pylori colonize the stomach of about ~50% of the world’s human population and infection is more in clients with dyspeptic conditions and its associated with the severity of gastritis. The present study revealed that the magnitude of H. Pylori and burden of the bacterial infection as well as the contribution of H. Pylori for gastritis and also assesses the current prevalence of H. Pylori infection.Objective: To evaluate the prevalence of Helicobacter Pylori infection and associated factors among gastritis patents in Yekatit 12 Hospital.Methodology: An institutional based cross-sectional study was conducted in Yekatit 12 teaching hospital Addis Ababa city, Ethiopia. The participants were those patients come to the hospital for treatment of gastritis and send to the laboratory to confirm Helicobacter pylori infection in the data collection period. A total of 394 participants were interviewed by using a structured pre tested questionnaire. The data were coded and entered into Epi Data 3.1 version , cleaned and exported to version 20, SPSS. Multiple Logistic regression was used to estimate Adjusted (AORs) with a 95% confidence interval (CI) of positive responses to the different risk factors. P-value < 0.05 was considered as significant.Result: The total occurrence of H. Pylori in observers was 25.9%. Regarding income of family, those participants who have less income and living in rural areas were extra prone to be infected with H. Pylori (AOR=5.857, CI 95% = 1.389-24.686, P = 0.016 and AOR=3.663, CI 95% = 1.068-12.557, P =0.039) respectively. Further, the prevalence of study was significant association with participants who had experience of gastrointestinal illness, mouth to mouth kissing, unable to hand wash regularly before meal and after latrine used (AOR=4.270, 95%CI=1.785-10.21, P=0.01, AOR=53.085, 95%CI=16.185-174.114, P=0.000, AOR=7.316, 95%CI=1.944-27.536, P=0.003, AOR=3.374, 95%CI=1.024-11.114, P=0.046) respectively.Conclusion and recommendation: The finding shows that H. Pylori infection was significantly associated with occupational status,gender, smoking tobacco and hand washing regularly before meal and after toilet. I recommend making clean and saving the work place; regular hand wash, before food preparation, before feeding and after latrine. A health professional should give health education by using different media about the transition and health biro also should give emphases.

scholarly journals Association of Helicobacter Pylori Infection with Cardiovascular Diseases Subjects from Cameroon, Using GastroPanel® Serological Biomarker Panel (Pepsinogen I; Pepsinogen II; Gastrin-17; Helicobacter Pylori IgG)

2021 ◽  
pp. 20-26
Author(s):  
Alonge Ivo Ebule ◽  
Valentine Ngum Ndze ◽  
Ngouana Kammalac Thierry ◽  
Guenou Etienne ◽  
Chatchweng Kamtchweng Marie Felicite ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Cardiovascular Diseases ◽  
Disease Risk ◽  
Cardiovascular Complications ◽  
Helicobacter Pylori Infection ◽  
Central Hospital ◽  
Pepsinogen I ◽  
Informed Consent Form ◽  
Artery Disease ◽  
H Pylori

Introduction: Helicobacter pylori infection is associated with gastrointestinal diseases including atrophic gastritis and gastric cancer. Epidemiologic studies have demonstrated associations between H. pylori infection andextra gastrointestinal organ involvements including coronary artery disease and peripherical artery disease, dyslipidemia, insulin resistance and hematologic disorders. We sought to evaluate the prevalence of H. pylori infection in patients suffering cardiovascular diseases attending the Yaounde Central Hospital. Materials and Methods: Patients suffering from various cardiovascular complications were recruited at the Yaounde Central Hospital, between January and May 2019. The clinical and socio-demographic information of the patients was recorded. Five ml of blood were collected aseptically for Pepsinogen I and II enzymes, gastrin17 hormone and IgG anti H. pylori anti-body. The test parameters were analyzed using a GastroSoft software application. The data was analyzed using Epi Info 7.0. All statistics were 95% CI. Ethical clearance was also obtained from the National Ethics Committee. The study was accepted by the authorities of the  Yaounde CentralHospital.  All patients signed an informed consent form. Results: A total of 62 subjects were recruited aged 30-75 years, (mean±SD 52.03 ± 12,78 years); 34(54,84%) females aged 30 to 75years (mean±SD 54,47 ± 13,47 years) and 28 (45,16%) males aged 30 to 65,(mean±SD 49,07± 11,44years). Female/male ratio was 1:2.  H. pylori  seropisitivity occurred in 58 (93,55%) of the subjects (IgG ≥30 EIU). H. pylori seropositivity was significantly associated with high blood pressure (RR=2.2 95%C.I 1.67 -2.96, p=0, 024).  Significantly low Triglyceride concentrations were observed in H. pyloripositive(0,51±0,03g/l) compared to negative subjects (1,04 ± 0,50g/l), (p=0.03). A significant inverse correlation was observed between IgG levels and blood glucose levels (r= 0,4  p=0, 004). Conclussion: The study indicates that H. pylori infection is highly associated with various cardiovascular complications and disease risk factors.

scholarly journals Helicobacter pylori infection and vitamin B-12 deficiency- A cross sectional study

2017 ◽  
Vol 8 (4) ◽  
pp. 16-20 ◽  
Author(s):  
K. Ravi ◽  
Jacob Joseph ◽  
David Mathew Thomas
Keyword(s):  
Helicobacter Pylori ◽  
Vitamin B12 ◽  
Atrophic Gastritis ◽  
Histopathological Examination ◽  
Serum Vitamin ◽  
Vitamin B12 Deficiency ◽  
Helicobacter Pylori Infection ◽  
Blood Levels ◽  
B12 Deficiency ◽  
H Pylori

Background: Vitamin B12 deficiency is a common, often overlooked medical problem in adult  population. Diagnosis of vitamin B12 deficiency is incomplete without the evaluation of underlying cause. In majority of the cases Vitamin B12 deficiency is attributed to malnutrition. H. pylori infection plays an important role in the development of atrophic gastritis and related malabsorption. Hence it is suggested that there may be a relationship between h. pylori infection and vitamin B12 deficiency.Aims and Objective: To evaluate correlation of helicobacter pylori infection and blood levels of vitamin B12.Materials and Methods: A total of 120 patients with deficient serum vitamin B12 levels were evaluated. Upper GI Endoscopy was performed and gastric biopsies were obtained for Histopathological examination and histological evidence of H. pylori infection.Results: Tissue biopsy revealed chronic atrophic gastritis in 65 patients and chronic antral gastritis in 39 patients. H. pylori infection by histology was positive in 68 patients. There was significant correlation between atrophic gastritis and H. pylori as well as between H. pylori and B12 deficiency.Conclusion: H.pylori has an effect on gastric mucosa, which influences the absorption of vitamin B12. Thus individuals with B12 deficiency must be subjected for diagnostic evaluation of H.pylori infection and appropriate therapy must be initiatedAsian Journal of Medical Sciences Vol.8(4) 2017 16-20

scholarly journals HELICOBACTER PYLORI INFECTION

2013 ◽  
Vol 20 (05) ◽  
pp. 667-671
Author(s):  
MUHAMMED KHALID SHAIKH ◽  
JAVED AKHTAR SAMO ◽  
SAMINA SHAIKH ◽  
Syed Zulfiquar Ali Shah
Keyword(s):  
Helicobacter Pylori ◽  
Blood Sample ◽  
Tertiary Care ◽  
Helicobacter Pylori Infection ◽  
C Reactive Protein ◽  
Female Population ◽  
Reactive Protein ◽  
Disposable Syringe ◽  
The Mean ◽  
H Pylori

Objective: To determine the frequency of raised C-reactive protein in patients with Helicobacter pylori infection. Design:Cross sectional descriptive study. Setting: Department of Medicine at Liaquat University Hospital (tertiary care teaching hospitals).Period: April 2012 to September 2012. Patients and methods: All patients above 12 years of age, of either gender with history of nausea,vomiting, recurrent abdominal pain, dyspepsia or abdominal discomfort, heartburn, bloating and halitosis through casualty outdoordepartment (COD) or admitted in medical unit were evaluated and enrolled in the study. For the detection of Helicobacter pylori the 3 ccvenous blood sample of relevant patients was taken in a disposable syringe. After detecting the H. pylori infection, the H. pylori individualswere further evaluated for serum C-reactive protein by taking 3cc venous blood sample in a disposable syringe and sent to laboratory foranalysis. The patients with raised CRP were also evaluated for their lipid profile to detect dyslipidemia. The data was collected onpredesigned proforma and then entered, saved and analyzed in SPSS version 10.00. Results: During six month study period total 92patients with Helicobacter pylori infection were recruited and studied for serum C-reactive protein. The mean age ± SD for overallpopulation was 43.22±8.31, whereas the mean age ±SD for male and female population was 41.24±7.94 and 44.76±9.42respectively. The raised CRP was detected in 61(66%) patients (p=0.02). The mean value ± SD of raised CRP in male and femalepopulation was 6.30±2.86 and 7.82±3.21 respectively. Of 61(66%) patients with raised CRP the dyslipidemia was identified in 45(74%)patients (p=0.03). Out of 45, the raised triglycerides was observed in 08(18%) patients, low HDL in 10(22%) patients, raised LDL in13(29%), raised cholesterol in 07(16%) whereas 07(16%) patients had mix dyslipidemia. Conclusions: The raised CRP was identified inpatients with Helicobacter pylori infection, the dyslipidemia was observed in raised CRP population.

Helicobacter pylori infection: place of serological and cultural diagnostics in clinical guidelines

2021 ◽  
Vol 66 (8) ◽  
pp. 496-501
Author(s):  
L. A. Kornoukhova ◽  
V. L. Emanuel ◽  
N. L. Denisov ◽  
E. L. Nikonov
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Blood Serum ◽  
Clinical Guidelines ◽  
Reference Intervals ◽  
Healthy People ◽  
Helicobacter Pylori Infection ◽  
Pepsinogen I ◽  
H Pylori ◽  
Pepsinogen Ii

The purpose of this work was to familiarize doctors with the methods and significance of serological and cultural diagnostics of H. pylori infection on the example of the test for diagnosing the state of the gastric mucosa «Gastropanel». Blood serum tests were performed for 1057 patients and 122 healthy people aged 18-64 years: pepsinogen I (PG I), pepsinogen II (PG II), gastrin-17 (G-17), basal/stimulated), antibodies (IgGHp) to H. pylori (Biohit Oyj, Finland). The medians of the studied group indicators did not exceed the reference intervals. 398 (34%) patients have negative H. pylori status (IgGHp-). 275 (26%) patients with serum PG I≤70 mcg/ml were identified. The ratio of PG I/II≤3 in 84 (8%), 36 of them (43% of the group PG I/II≤3) - IgGHp-.

scholarly journals Polyphenols Reduce Gastritis Induced by Helicobacter pylori Infection or VacA Toxin Administration in Mice

2006 ◽  
Vol 50 (7) ◽  
pp. 2550-2552 ◽  
Author(s):  
P. Ruggiero ◽  
F. Tombola ◽  
G. Rossi ◽  
L. Pancotto ◽  
L. Lauretti ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastric Mucosa ◽  
Atrophic Gastritis ◽  
Helicobacter Pylori Infection ◽  
Gastric Epithelium ◽  
Human Gastric Mucosa ◽  
H Pylori

ABSTRACT Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.

scholarly journals Helicobacter pylori Infection, Gastric Cancer and Gastropanel

2016 ◽  
Vol 54 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Alexandra Loor ◽  
D.L. Dumitraşcu
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Atrophic Gastritis ◽  
Chronic Atrophic Gastritis ◽  
Helicobacter Pylori Infection ◽  
Invasive Test ◽  
High Cancer Risk ◽  
Important Challenge ◽  
Reduction Of Mortality ◽  
H Pylori

Abstract Gastric cancer (GC) is one of the most widespread types of cancer worldwide. Helicobacter pylori infection has been clearly correlated with gastric carcinogenesis. At present and in the near future, the most important challenge is and will be the significant reduction of mortality due to GC. That goal can be achieved through the identification of higher-risk patients, such as those with atrophic gastritis, intestinal metaplasia and dysplasia. In this review we intend to discuss the importance of diagnosing H. pylori infection and chronic atrophic gastritis in preventing gastric cancer, using a new non-invasive test called GastroPanel. This test is a classification algorithm including four biochemical parameters pepsinogen I and II (PGI and PGII), gastrin-17 (G17), and anti-Helicobacter pylori antibodies (Ig G anti-Hp) measured in fasting sera, which allows to classify patients as having atrophic or non-atrophic gastritis and to find whether gastritis is associated or not with H. pylori infection. GastroPanel is not a “cancer test”, but it can and should be used in the screening and diagnosis of subjects with a high cancer risk; still, a careful diagnostic made by superior digestive endoscopy is compulsory to find possible precancerous or cancerous lesions at an early and curable stage.

scholarly journals Frequency of helicobacter pylori in patients with functional dyspepsia.

2019 ◽  
Vol 26 (08) ◽  
pp. 1261-1265
Author(s):  
Tooba ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Helicobacter Pylori ◽  
Functional Dyspepsia ◽  
Histopathological Examination ◽  
Epigastric Pain ◽  
Helicobacter Pylori Infection ◽  
Cross Sectional ◽  
Male Predominance ◽  
Duration Of Disease ◽  
The Mean ◽  
H Pylori

To evaluate the frequency of Helicobacter pylori in individuals with functional dyspepsia. Study Design: Cross sectional descriptive study. Period: Six months from 01-May-2014 to 31-10-2014. Setting: Liaquat National Hospital, Karachi. Materials and Methods: All the patients between 18 to 70 years of age diagnosed as functional dyspepsia for more than 03 months duration were admitted and evaluated for Helicobacter pylori infection through histopathological examination. Results: Total 121 subjects with functional dyspepsia were screened for Helicobacter pylori infection. The mean ±SD for age of subjects with functional dyspepsia was 41.74±08.87. The mean age ±SD of Helicobacter pylori infected individuals was 40.70±7.82 while the mean ±SD of age in helicobacter pylori negative patients was 40.55±10.63. Majority of the subjects were out-patients, 30-39 years of age with male predominance. The most common duration of disease observed was 6-9 months with epigastric pain and burning the predominant symptoms. The Helicobacter pylori infection was observed in 78(64.4%) individuals, of which 55 were males and 23 were males (p=<0.01). Conclusion: The functional dyspeptic patients are prone to acquire Helicobacter pylori infection therefore present study reported 64.4% prevalence for H. pylori infection with male gender predominance.

scholarly journals A descriptive cross-sectional study of helicobacter pylori infection in non-ulcer dyspepsia patients in a tertiary care teaching hospital In the Eastern part of Nepal

2016 ◽  
Vol 5 (2) ◽  
pp. 10-16
Author(s):  
Rishab Shrestha ◽  
Gaurav Chhetri ◽  
Arbind Deo ◽  
Rabindra Nath Das
Keyword(s):  
Helicobacter Pylori ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Helicobacter Pylori Infection ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
Non Ulcer Dyspepsia ◽  
H Pylori

Background In Gastroenterology practice, worldwide, the most common cause of dyspepsia is functional. Functional or non-ulcer dyspepsia is established by gastroduodenoscopy which rules out structural disorders in dyspeptic patients. Helicobacter pylori, a gram-negative bacterium in gastric mucosa is associated with non-ulcer dyspepsia, chronic gastritis, gastriculcer and cancer. Worldwide prevalence of Helicobacter pylori infection is higher but its association with non-ulcer dyspepsia is less clear.Material and Methods The aim of this study was to see the prevalence of H. pylori infection in non-ulcer dyspepsia. A cross-sectional study of 340 patients presented at Nobel Teaching Hospital in one year with dyspeptic symptoms underwent clerking, physical examination, gastroduodenoscopy and RUT. Symptomatic patients without any structural lesions were designated as functional dyspepsia. RUT when turned red indicated positive for H. pylori infection.Result Out of 340 patients, 180 (52.9%) were female and 160(47.1%) were male. Mean age of male and female patients was 35.88 ± 11.8 and 38.11 ± 11.7 respectively. Amongst all participants 150 (44.11%) were housewives and 69(20.3%) were students. Endoscopic findings showed gastritis 205(60.29%) and duodenitis 15(4.42%). RUT was found positive in 62% of gastritis and 86.7% of duodenitis patients (p value=0.001).Conclusion High prevalence of H pylori infection in present study may be one of the causative factors in producing symptomatic non-ulcer dyspepsia. Hence, early detection and complete eradication of H.pylori infection is mandatory. It will reduce usage of PPIs and also improve quality of life.Journal of Nobel Medical College Vol.5(2) 2016; 10-16

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