scholarly journals Effects of Proton Pump Inhibitors on Serum Calcium Level: A Study on Rabbit Model

2021 ◽  
pp. 361-366
Author(s):  
Rizwan Ahmed Memon ◽  
Fazeela Rizwan Memon ◽  
Ali Raza Memon ◽  
Jamshaid Ul Qadir Memon ◽  
Jawaid Hussain Laghari ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Calcium Absorption ◽  
Rabbit Model ◽  
The Body ◽  
Significant Relation ◽  
Different Levels

Background: Proton Pump inhibitors (PPI) are widely used all over the world as therapeutic agents as well as prophylactic agent at different age groups for multiple gastrointestinal disorders etc. it inhibits the hydrogen potassium pump (H/K ATPase Pump). PPI interferes the calcium absorption and thus disturbs acid secretion which leads to decrease the calcium level in the body. Objective: The present design is to evaluate the effects of PPI on serum calcium level in rabbit model. Study Design: Randomized Control Trial/ Study on Rabbit Model. Place and Duration of Study: This experimental study was done at Department of Pharmacology Isra Medical University Hyderabad (November 2020 to March 2021 Material & Methods: A total 20 healthy male rabbits with weight between 1-2kg were included in this study. While female rabbits, ill rabbits and rabbits with weight less than 1kg were excluded from study. Ten rabbits were given omeprazole sachet of 20mg orally dissolve in water once a day and 10 rabbits were given sachet of esomeprazole of 20mg dissolve in water once a day upto 90 days regularly. At different levels of study blood samples were obtained from vein near ear of rabbits and samples were centrifuged for 10minutes to obtain the serum. Then serum was sent to Isra Diagnostic Laboratory for analysis of serum calcium levels of all samples at different levels of study. Results: Serum calcium levels of all rabbits were analyzed at three different levels of study, at zero level before starting of experiment, at level I after completion of one month of experiment and level II after the completion of three months of experiment. The normal serum calcium level in rabbits is 13-15mg/dl.8There was a significant decline in serum calcium level in Group A (Omeprazole Group), while in Group B (Esomeprazole Group) there was no significant relation between decreased serum calcium levels. Conclusion: The study concluded that there is significant relation of longterm usage of PPI on serum calcium level.

“COMPARATIVE STUDY OF CALCIUM LEVEL IN PREECLEMPTIC AND NORMAL PREGNANT TRIBAL & NON-TRIBAL WOMEN IN JHARKHAND”

2021 ◽  
pp. 20-21
Author(s):  
Sourami Saha ◽  
Rajendra Kumar
Keyword(s):  
Pregnant Women ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Physiological Stress ◽  
The Body ◽  
Total Serum ◽  
Tribal Women ◽  
Total Serum Calcium ◽  
Total Serum Calcium Level

Introduction- Pregnancy is a physiological stress in which many biochemical changes changes occur in the body. Preeclampsia, the complication of pregnancy, refers to a syndrome of new onset of hypertension proteinurea after 20 weeks of gestation in previously normotensive women, is due to rise in blood pressure,which is related with calcium change in blood. Recent study, implicated alterations in calcium metabolism in the pathogenesis of hypertension in pregnancy. Serum calcium level of 75 Material & Methodnd rd normal pregnant and 75 preeclemptic Tribal & non-tribal women at 2 & 3 trimesters were estimated by using Arsenazo 3 method, one of the most standard method used for estimation of serum calcium based on colorimetric principle and compared.Observation & Result- The Mean serum calcium level in cases of normal pregnant women in Jharkhand 9.65±0.58mg/dl while mean total serum calcium level of pre-eclamptic was 6.97mg/dl is lesser in comparison to normal pregnancy. There is signicant Conclusion- decrease in total serum calcium level in preeclemptic as compare to normal pregnant women in Jharkhand.

GENERAL EFFECTS OF α-MELANOCYTE STIMULATING HORMONE IN THE RABBIT

1965 ◽  
Vol 48 (4) ◽  
pp. 609-618 ◽  
Author(s):  
H. K. Dyster-Aas ◽  
C. E. T. Krakau
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Systemic Effects ◽  
List Type ◽  
Aqueous Flare ◽  
Melanocyte Stimulating Hormone ◽  
Blood Aqueous Barrier

ABSTRACT In addition to the previously described permeability disturbance in the blood aqueous barrier of the eye, measured as an increase of the aqueous flare, a series of transitory systemic effects have been recorded following the subcutaneous injection of synthetic α-MSH: marked increase of the free fatty acids in plasma, decrease in the serum calcium level, decrease in the blood pressure, increase in the skin temperature, increased frequency and diminished amplitude of respiration, presence of slow waves in the EEG. There is a correlation between the magnitude of the aqueous flare increase and the increase of free fatty acids in plasma and also between the aqueous flare and the minimum serum calcium level.

scholarly journals The Effect of Lithium Carbonate on Egg Shell Formation and Serum Calcium Level of the Hen

1971 ◽  
Vol 50 (2) ◽  
pp. 577-580 ◽  
Author(s):  
R.D. Creek ◽  
Pauline Lund ◽  
O.P. Thomas ◽  
W.O. Pollard
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Lithium Carbonate ◽  
Shell Formation ◽  
Egg Shell

scholarly journals Association of dietary calcium intake, total and ionized serum calcium levels with preeclampsia in Ethiopia

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rahel D. Gebreyohannes ◽  
Ahmed Abdella ◽  
Wondimu Ayele ◽  
Ahizechukwu C. Eke
Keyword(s):  
Serum Calcium ◽  
Calcium Intake ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Dietary Calcium ◽  
Ionized Calcium ◽  
Dietary Calcium Intake ◽  
Total Serum ◽  
Total Serum Calcium ◽  
Total Serum Calcium Level

Abstract Background Preeclampsia is a well-known cause of maternal mortality and morbidity in Ethiopia. The exact pathophysiology has not been fully understood. Calcium and magnesium deficiencies have been given emphasis to play roles in the pathophysiology. Although evidence is abundant, they are equivocal. The study aimed to see the association of dietary calcium intake, serum total calcium level and ionized calcium level with preeclampsia. It also evaluated the association between dietary calcium intake and serum calcium levels. Materials and methods An unmatched case–control study was conducted in Gandhi Memorial, Tikur Anbessa, and Zewditu Memorial Hospitals, all in Addis Ababa, between October to December, 2019. Cases were 42 women with preeclampsia and controls were 42 normotensive women. The medical and obstetric history was gathered using a structured questionnaire and the dietary calcium intake information using a 24-h dietary recall. The serum levels of total serum calcium and ionized (free) calcium were measured using an inductively coupled mass spectrophotometer. Bivariate and multivariate logistic regression and Pearson correlation test were utilized during data analysis. Results In comparison with controls, women with preeclampsia had lower mean (± 1SD) levels of ionized calcium level (1.1 mmol/l ± 0.11), total serum calcium level (1.99 mmol/l ± 0.35) and lower median (IQR) dietary calcium intake (704 mg/24 h,458–1183). The odds of having preeclampsia was almost eight times greater in those participants with low serum ionized calcium level (OR 7.5, 95% CI 2.388–23.608) and three times higher in those with low total serum calcium level (OR 3.0, 95% CI 1.024–9.370). Low dietary calcium intake also showed statistically significant association with preeclampsia (OR 3.4, 95% CI 1.092 -10.723). Serum ionized calcium level and total serum calcium level showed positive correlation of moderate strength (p = 0.004, r = 0.307), but no correlation was found between dietary calcium intake with both forms of serum calcium levels. Conclusion This study showed significant association between low dietary calcium intake and low serum calcium levels with preeclampsia, hence this can be used as a supportive local evidence for the current context-specific recommendation of calcium supplementation in societies with low-dietary calcium consumption in an attempt to prevent preeclampsia, therefore implementation study should be considered in Ethiopia to look for the feasibility of routine supplementation.

Phototherapy Induced Hypocalcemia in Neonates with Unconjugated Hyperbilirubinemia

2021 ◽  
Vol 11 (1) ◽  
pp. 4-8
Author(s):  
Amna Khan ◽  
Anila Farhat ◽  
Hamayun Anwar ◽  
Sajid Shamim ◽  
Mujeeb Ur Rehman ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Neonatal Intensive Care ◽  
Cross Sectional Study ◽  
Categorical Variables ◽  
P Value ◽  
Cross Sectional ◽  
Unconjugated Hyperbilirubinemia ◽  
Before And After

Objective: To determine the frequency of hypocalcemia in neonates with unconjugated hyperbilirubinemia receivingphototherapy.Study design and setting: Cross sectional study conducted at neonatal intensive care unit, King Abdullah Teaching Hospital,Mansehra for one year from December 2017 to November 2018.Methodology: Total 213 full term stable neonates of either gender with jaundice were studied in this study. Out of which,143 with unconjugated hyperbilirubinemia were exposed to phototherapy while 70 neonates with exaggerated physiologicalhyperbilirubinemia taken as control were not exposed to phototherapy. Serum calcium level was determined through bloodtest before and after 24 hours of phototherapy. SPSS version 22 was used to analyze the data. Frequency and percentageswere used to describe categorical variables like gender and hypocalcemia. Hypocalcemia was stratified by age and genderto see effect modifiers. Post stratified chi-square test was applied in which p value = 0.05 was considered as significancevalue.Results: In study group, 143 neonates who received phototherapy had mean age of 7 days ± 2.62 SD. Total 65% neonateswere male and 35% neonates were female. Mean serum calcium level of neonates before and after provision of phototherapywas 9.28 mg/dl ± 0.23 and 8.54 mg/dl ± 0.68 respectively, which is statistically significant. The frequency of hypocalcemiawas 40% in neonates with unconjugated hyperbilirubinemia after 24 hours of phototherapy.Conclusion: Hypocalcemia is an important complication in neonates with unconjugated hyperbilirubinemia after continuousphototherapy. Hypocalcemia has clinical impact and adds to morbidity, and if left untreated, can lead to mortality.

scholarly journals Effect of Pepsin on the Rabbit Serum Calcium Level

1952 ◽  
Vol 72 (9) ◽  
pp. 1164-1167
Author(s):  
Yosoji Ito ◽  
Eigo Takabatake ◽  
Michiko Yamagata
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Rabbit Serum

scholarly journals Metabolic Changes Associated with Endocrine Activity and the Reproductive Cycle in XENOPUS LAEVIS

1934 ◽  
Vol 11 (3) ◽  
pp. 267-272
Author(s):  
H. A. SHAPIRO ◽  
H. ZWARENSTEIN
Keyword(s):  
Xenopus Laevis ◽  
Serum Calcium ◽  
Normal Level ◽  
Calcium Level ◽  
Calcium Metabolism ◽  
Serum Calcium Level ◽  
Intact Animal ◽  
Ovarian Tissue ◽  
Endocrine Activity ◽  
Gonadotropic Hormone

1. Experiments are described which show that active extracts of ovarian tissue minus corpus luteum can be obtained which significantly raise the lowered level of the serum calcium in ovariectomised toads; and also raise the serum calcium level in normal toads above the normal level. 2. Injection of adequate doses of antuitrin (Parke, Davis and Co.), raises the lowered level of serum calcium in hypophysectomised toads almost to normal; and of ovariectomised toads to the normal level. The effect is obtained more readily in the ovariectomised condition. 3. Injection of pituitrin (Parke, Davis and Co.), depresses the serum calcium level in normal, ovariectomised and completely hypophysectomised toads. The effect is more readily obtained in the normal intact animal than in the ovariectomised or the totally hypophysectomised state, when the ovaries have undergone involution. 4. It is suggested that there is evidence that the principles exerting a hormonelike action on calcium metabolism are not, in the case of the ovary, either oestrin or the luteal hormone, or in the case of the pituitary, the gonadotropic hormone.

scholarly journals EFFECT OF TYRE SMOKE EXPOSURE ON SOME HAEMATOLOGICAL PARAMETERS OF SELECTED ABATTOIR WORKERS: A TRANS-AMADI (OGINIGBA TOWN) SLAUGHTER MARKET STUDY

2020 ◽  
Vol 8 (11) ◽  
pp. 484-493
Author(s):  
Agbai C.M. ◽  
◽  
Chuku L.C. ◽  
Chinaka N.C. ◽  
◽  
...  
Keyword(s):  
Serum Albumin ◽  
Serum Calcium ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Study Groups ◽  
Smoke Inhalation ◽  
Control Population ◽  
Medical Attention ◽  
Test Population ◽  
Abattoir Workers

This investigation was conducted to study the effect of exposure to tyre smoke on serum calcium (Ca) and albumin (Alb) of selected abattoir workers in Oginigba area of Obio Akpor L.G.A., Rivers State. A total of 50 participants were recruited for the study (35 test and 15 control). The test population was divided into five study groups 1-3, 4-6, 7-9, 10-15 and above 15 years of service (exposure years) at the abattoir. Blood samples were collected by veinupuncture and analyzed for serum calcium and albumin using the colorimetric and bromocresol-green method respectively. Compared to 3% of the control population, 49% of the test population had a serum calcium level below the standard reference of 2.20-2.55mmol/l. Results of serum albumin showed that 23% of the test population had levels above the standard reference of 3.5-5.0g/dl whereas the control population had values within the reference range. When the respective test groups were compared with the control, groups 1-3, 7-9 and 10-15 showed significant reduction in serum calcium level while groups 7-9 and 10-15 showed significant increase in the serum albumin level. Serum calcium was observed to significantly differ from the control at the least level of exposure (1-3 years) while serum albumin differed significantly from the control at 7 years of exposure for non-smokers and 4 years of exposure amongst smokers. The data was also grouped into two study groups based on genotypes AA and AS. It was observed that participants with genotype AS were more susceptible to the effect of the smoke inhalation and recorded low serum calcium level. The result of this research has demonstrated that abattoir workers (roasters) are prone to developing hypocalcaemia and hyperalbuminaemia, and as such require periodic medical attention, care and better animal processing (dehairing) practice/method.

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