scholarly journals Detection of Dental Caries Using Salivary Biomarkers – A Systematic Review

2021 ◽  
pp. 125-134
Author(s):  
Krishnapriya Umashankar ◽  
Pratibha Ramani
Keyword(s):  
Systematic Review ◽  
Dental Caries ◽  
Web Search ◽  
Soft Tissues ◽  
Research Question ◽  
Salivary Protein ◽  
Caries Detection ◽  
Protein Biomarkers ◽  
Salivary Biomarkers ◽  
Electronic Database Search

Background: Saliva is a mixture of organic and inorganic components that comes in constant contact with the hard and soft tissues of the oral cavity. One of the most frequent disorders is dental caries, which is a multifactorial microbial disease of the tooth. Of which saliva plays a significant role in the process of dental caries. Aim: To systematically identify and evaluate the ability of salivary biomarkers in detection of dental caries. Methods: A comprehensive search was done using electronic data bases such as PubMed Central, Cochrane Database of Systematic Reviews, Google Scholar and direct web search. The title scan was used to find relevant articles, which were then read and appraised for inclusion. This review analyses all research that investigated the use of salivary protein biomarkers to detect dental caries. Results: Electronic database search identified 16 articles. After evaluating the title, abstract, and full text of these articles, only 4 were selected for the present systematic review. A final of 4 studies were included based on the inclusion criteria to meet the research question. All the studies analyzed the salivary biomarkers in dental caries detection. Conclusion: Salivary biomarkers are a significant indicator in detection of dental caries and can be used in determining the further treatment planning.

scholarly journals Accuracy and Reliability of Soft Tissue Landmarks Using Three-Dimensional Imaging in Comparison With Two-Dimensional Cephalometrics: A Systematic Review

2020 ◽  
Vol 54 (4) ◽  
pp. 289-296
Author(s):  
Adeeba Ali ◽  
Anil K. Chandna ◽  
Anshul Munjal
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
3D Imaging ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Database Search ◽  
Cochrane Library ◽  
Two Dimensional ◽  
Imaging Tool ◽  
Electronic Database Search

Background: Concerns about the accuracy and reliability of soft tissue landmarks using two-dimensional (2D) and three-dimensional (3D) imaging. Objective: The aim of the systematic review is to estimate accuracy and reliability of soft tissue landmarks with 2D imaging and 3D imaging for orthodontic diagnosis planning and treatment planning purposes. Data Sources: Electronic database search was performed in MEDLINE via PubMed, Embase via embase.com, and the Cochrane library website. Selection Criteria: The data were extracted according to two protocols based on Centre for Evidence-Based Medicine (CEBM) critical appraisal tools. Next, levels of evidence were categorized into three groups: low, medium, and high. Data Synthesis: Fifty-five publications were found through database search strategies. A total of nine publications were included in this review. Conclusion According to the available literature, 3D imaging modalities were more accurate and reliable as compared to 2D modalities. Cone beam computed tomography (CBCT) was considered the most reliable imaging tool for soft tissues.

scholarly journals Dental Caries Diagnosis and Detection Using Neural Networks: A Systematic Review

2020 ◽  
Vol 9 (11) ◽  
pp. 3579
Author(s):  
María Prados-Privado ◽  
Javier García Villalón ◽  
Carlos Hugo Martínez-Martínez ◽  
Carlos Ivorra ◽  
Juan Carlos Prados-Frutos
Keyword(s):  
Neural Network ◽  
Systematic Review ◽  
Neural Networks ◽  
Dental Caries ◽  
Near Infrared ◽  
Data Extraction ◽  
Infrared Light ◽  
Caries Detection ◽  
Detection And Diagnosis

Dental caries is the most prevalent dental disease worldwide, and neural networks and artificial intelligence are increasingly being used in the field of dentistry. This systematic review aims to identify the state of the art of neural networks in caries detection and diagnosis. A search was conducted in PubMed, Institute of Electrical and Electronics Engineers (IEEE) Xplore, and ScienceDirect. Data extraction was performed independently by two reviewers. The quality of the selected studies was assessed using the Cochrane Handbook tool. Thirteen studies were included. Most of the included studies employed periapical, near-infrared light transillumination, and bitewing radiography. The image databases ranged from 87 to 3000 images, with a mean of 669 images. Seven of the included studies labeled the dental caries in each image by experienced dentists. Not all of the studies detailed how caries was defined, and not all detailed the type of carious lesion detected. Each study included in this review used a different neural network and different outcome metrics. All this variability complicates the conclusions that can be made about the reliability or not of a neural network to detect and diagnose caries. A comparison between neural network and dentist results is also necessary.

Do Patients with Extrinsic Black Tooth Stains Have a Lower Dental Caries Experience? A Systematic Review and Meta-Analysis

2019 ◽  
Vol 53 (6) ◽  
pp. 617-627 ◽  
Author(s):  
Vanessa Silva de Rezende ◽  
Thiago Fonseca-Silva ◽  
Clarissa Lopes Drumond ◽  
Maria Letícia Ramos-Jorge ◽  
Saul Martins Paiva ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Caries ◽  
Protective Factor ◽  
Meta Analysis ◽  
Scientific Evidence ◽  
Research Question ◽  
Caries Experience ◽  
Eligibility Criteria ◽  
Cross Sectional ◽  
Newcastle Ottawa Scale

Studies have suggested that individuals affected by extrinsic black tooth stains have less dental caries experience in comparison to those without this condition. The aim of the present study was to perform a systematic review and meta-analysis to determine whether there is scientific evidence demonstrating that extrinsic black stains are a protective factor for the occurrence of dental caries. This systematic review was developed in accordance with the PRISMA statement and the research question was determined using the PECO strategy. Electronic searches were conducted in the PubMed, Science Direct, Virtual Health Library, Cochrane, Web of Science, and Google Scholar databases for relevant articles published up to September 2018. All articles included were submitted to an appraisal of methodological quality using the Newcastle-Ottawa Scale and the data were extracted for meta-analysis. The search strategy resulted in the retrieval of 9,108 publications. After the application of the eligibility criteria, 18 articles were selected for analysis, 13 of which were included in the meta-analysis. The meta-analysis demonstrated that individuals with extrinsic black stains involving primary (median, MD: –0.78 [–1.09; –0.48]; I2 = 44%) and permanent (MD: –0.50 [–0.93; –0.08]; I2 = 86%) teeth have a lower dental caries experience in comparison to those without this condition. Patients with extrinsic black tooth stains have a lower dental caries experience in cross-sectional studies.

Salivary protein biomarkers associated with orthodontic tooth movement: A systematic review

2019 ◽  
Vol 22 (S1) ◽  
pp. 14-20 ◽  
Author(s):  
Riley K. Allen ◽  
Alexander R. Edelmann ◽  
Aous Abdulmajeed ◽  
Sompop Bencharit
Keyword(s):  
Systematic Review ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Salivary Protein ◽  
Protein Biomarkers

scholarly journals Salivary protein polymorphisms and risk of dental caries: a systematic review

2017 ◽  
Vol 31 (0) ◽  
Author(s):  
Andrea LIPS ◽  
Leonardo Santos ANTUNES ◽  
Lívia Azeredo ANTUNES ◽  
Andrea Vaz Braga PINTOR ◽  
Diana Amado Baptista dos SANTOS ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Caries ◽  
Salivary Protein ◽  
Protein Polymorphisms

scholarly journals Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring

2021 ◽  
Vol 11 (3) ◽  
pp. 235
Author(s):  
Pune N. Paqué ◽  
Christopher Herz ◽  
Daniel B. Wiedemeier ◽  
Konstantinos Mitsakakis ◽  
Thomas Attin ◽  
...  
Keyword(s):  
Dental Caries ◽  
Proteolytic Enzymes ◽  
Principal Component ◽  
Disease Status ◽  
Oral Bacteria ◽  
Caries Detection ◽  
Protein Markers ◽  
Salivary Biomarkers ◽  
Potential Association ◽  
Caries Lesions

This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression.

scholarly journals Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 20 (14) ◽  
pp. 3585 ◽  
Author(s):  
Analú Barros de Oliveira ◽  
Túlio Morandin Ferrisse ◽  
Raquel Souza Marques ◽  
Sarah Raquel de Annunzio ◽  
Fernanda Lourenção Brighenti ◽  
...  
Keyword(s):  
Systematic Review ◽  
Photodynamic Therapy ◽  
Dental Caries ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Research Question ◽  
Microbial Reduction ◽  
Cochrane Library ◽  
Study Protocols

The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries.

Does non-institutionalized elders have a better oral health status compared to institutionalized ones? A systematic review and meta-analysis

2020 ◽  
Vol 25 (6) ◽  
pp. 2177-2192 ◽  
Author(s):  
Ilky Pollansky Silva e Farias ◽  
Simone Alves de Sousa ◽  
Leopoldina de Fátima Dantas de Almeida ◽  
Bianca Marques Santiago ◽  
Antonio Carlos Pereira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Status ◽  
Oral Health ◽  
Dental Caries ◽  
Meta Analysis ◽  
Oral Health Status ◽  
Cochrane Library ◽  
Caries Experience ◽  
Institutionalized Elderly ◽  
Periodontal Status

Abstract This systematic review compared the oral health status between institutionalized and non-institutionalized elders. The following electronic databases were searched: PubMed (Medline), Scopus, Web of Science, Lilacs and Cochrane Library, in a comprehensive and unrestricted manner. Electronic searches retrieved 1687 articles, which were analyzed with regards to respective eligibility criteria. After reading titles and abstracts, five studies were included and analyzed with respect their methodological quality. Oral status of institutionalized and non-institutionalized elderly was compared through meta-analysis. Included articles involved a cross-sectional design, which investigated 1936 individuals aged 60 years and over, being 999 Institutionalized and 937 non-institutionalized elders. Studies have investigated the prevalence of edentulous individuals, the dental caries experience and the periodontal status. Meta-analysis revealed that institutionalized elderly have greater prevalence of edentulous (OR = 2.28, 95%CI = 1.68-3.07) and higher number of decayed teeth (MD = 0.88, 95%CI = 0.71-1.05) and missed teeth (MD = 4.58, 95%CI = 1.89-7.27). Poor periodontal status did not differ significantly between groups. Compared to non-institutionalized, institutionalized elders have worse dental caries experience.

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