scholarly journals Evaluation of COX-2 Inhibitor Injurious Effects on Proximal Convoluted Tubular Diameter of Kidney with Favorable Impact of Lycopene in Albino Rats on the Basis of Microscopic Features

2021 ◽  
pp. 462-468
Author(s):  
Sadia Sundus ◽  
Aisha Hassan ◽  
Ashok Kumar ◽  
Shah Jabeen ◽  
Nadira Hameed ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Harmful Effect ◽  
Albino Rats ◽  
Renal Structure ◽  
Healthy Adult Male ◽  
Microscopic Features ◽  
Cox 2 ◽  
Animal House ◽  
Tubular Diameter ◽  
Research Animal

Objective: To analyze the harmful effect of COX-2 inhibitor on proximal convoluted tubular diameter of kidney, amendment by lycopene.  Research Design: Experimental Research. Abode of Research: Animal House, JPMC, Karachi. Materials and Methods: 90-120 days old, forty healthy adult male Albino rats of 200-220gm weight were taken for this study and distributed into 4 cliques, set 1was chosen as control, in Set 2 Celecoxib was given 0.05g/1000g by gavage, in set 3 Celecoxib was given0.05g/1000g by gavage with lycopene 0.05g/1000g by gavage and set4 lycopene was given0.05g/1000g by gavage for 30 days. At accomplishment of study, animals were sacrifice and tissues were preserved for staining. Results: Inset 2 proximal convoluted tubular diameter became distended due to apoptosis of lining epithelial cells. They turn into low cuboidal from simple cuboidal cells along with ill-defined brush border at the luminal surface due to scarce microvilli and had disrupted basement membrane, however renal structure were amended in set3 which were given celecoxib with lycopene. Conclusion: This study reveals that lycopene amended the apoptotic changes of set2.

Safety and Tolerance ofLactobacillus reuteriin Healthy Adult Male Subjects

1994 ◽  
Vol 8 (2) ◽  
Author(s):  
B. W. Wolf ◽  
K. A. Garleb ◽  
D. G. Ataya ◽  
I. A. Casas
Keyword(s):  
Adult Male ◽  
Healthy Adult ◽  
Healthy Adult Male ◽  
Male Subjects

Protective role of protocatechuic acid in carbon tetrachloride-induced oxidative stress via modulation of proinflammatory cytokines levels in brain and liver of Wistar rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anne A. Adeyanju ◽  
Folake O. Asejeje ◽  
Olorunfemi R. Molehin ◽  
Olatunde Owoeye ◽  
Esther O. Olatoye ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Protocatechuic Acid ◽  
Liver Toxicity ◽  
Total Cholesterol Level ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
Antioxidant Enzyme Activities ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
The Brain

Abstract Objectives Protocatechuic acid (PCA) possesses numerous pharmacological activities, including antioxidative and anti-inflammatory activities. This study seeks to investigate its underlying mechanism of action in the liver and brain toxicity induced by CCl4 in male albino rats. Methods Rats were given PCA at 10 and 20 mg/kg daily and orally as a pretreatment for seven days. A single injection of CCl4 was given 2 h later to induce brain and liver toxicity. Results CCl4 moderately elevated the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). PCA lowered AST level significantly when compared to control. Total protein and albumin levels presented insignificant changes (p>0.05) in all groups while lipid profile showed increased total cholesterol level and reduced high-density lipoprotein (HDL) by CCl4. PCA (10 mg/kg) significantly reduced the cholesterol level while the 20 mg/kg dose moderately prevented HDL reduction. There was an increased MDA production with a corresponding low GSH level in the group treated with CCl4. Activities of superoxide dismutase, catalase, and glutathione-S-transferase in both organs also declined. PCA, especially at 10 mg/kg attenuated lipid peroxidation by increasing GSH level in the organs. Biochemical assays revealed the improvement of antioxidant enzyme activities by PCA in these organs. Furthermore, PCA lowered the level of proinflammatory cytokine COX 2 in the brain and liver while NF-kB expression was inhibited in the brain. Histopathology reports validated the effects of PCA. Conclusions PCA exhibited protection against toxicity in these tissues through antioxidant and anti-inflammatory activities and the potential mechanism might be through modulation of the NF-κB/COX-2 pathway.

scholarly journals Dobutamine stress echocardiography in healthy adult male rats

2005 ◽  
Vol 3 (1) ◽  
Author(s):  
Eric Plante ◽  
Dominic Lachance ◽  
Marie-Claude Drolet ◽  
Élise Roussel ◽  
Jacques Couet ◽  
...  
Keyword(s):  
Adult Male ◽  
Stress Echocardiography ◽  
Healthy Adult ◽  
Dobutamine Stress Echocardiography ◽  
Dobutamine Stress ◽  
Male Rats ◽  
Healthy Adult Male

To Study the Deteriorating Effects of Lithium Carbonate on Thyroid Gland - A Study in Albino Rats

2021 ◽  
Vol 15 (12) ◽  
pp. 3292-3293
Author(s):  
Tazeen Kohari ◽  
Zaffar Iqbal Malik ◽  
Aftab Ahmad ◽  
Rana M. Asad Khan
Keyword(s):  
Thyroid Gland ◽  
Harmful Effect ◽  
Lithium Carbonate ◽  
Diet Group ◽  
Human Thyroid ◽  
Control Group ◽  
Albino Rats ◽  
Weight Changes ◽  
Group A ◽  
Group B

Background: The human thyroid gland is located in the front of neck. It consists of two lobes. The two lobes are joined with each other by isthmus. The mood stabilizer Lithium Caronate has deleterious effects on the thyroid gland. Aim: To observe and report the data of the harmful effect of Lithium on the weight changes of thyroid gland. Methods: Sixteen rats were selected for this experimental study. The rodents were divided into two groups. Group A comprised of eight animals which were given laboratory diet, Group B contained eight albinos who were given Tablet Lithium Carbonate in powder form at a dose of 60 mg/day for four weeks. After completion of the study time animals were sacrificed and thyroid gland weight were recorded and compared in both groups. Results: The results in both groups were recorded and compared .It was reported that Group B animals had a highly significantly decreased thyroid weight after four weeks Lithium ingestion than Group A control group. Conclusion: The results of our study concluded that Lithium Carbonate damages thyroid glandular tissue and causes its weight to decline. Key words: Thyroid gland, Isthmus, deteriorating

scholarly journals Evaluation of analgesic activity of levofloxacin in adult albino rats

2020 ◽  
Vol 10 (1) ◽  
pp. 85
Author(s):  
Prasanna Kumari S. ◽  
Latha K. ◽  
Meeradevi A.
Keyword(s):  
Analgesic Activity ◽  
Bacterial Infections ◽  
Albino Rats ◽  
Tail Flick ◽  
Albino Rat ◽  
Group Iii ◽  
Group I ◽  
Analgesic Agents ◽  
Active Isomer ◽  
Animal House

Background: Levofloxacin is a fluorinated quinolone antimicrobial used in the treatment of various bacterial infections and was active against both gram positive and gram negative bacteria. Levofloxacin is an optically active isomer of ofloxacin. Apart from its antibacterial action, it also exhibit antinociceptive properties. This study was conducted with the aim to evaluate the analgesic activity of Levofloxacin in albino rat in comparison with aspirin.Methods: Thirty adult albino rats weighing 150-250 gm were obtained from central animal house. The animals were divided into five groups of six animals each. Group I served as control received normal feed and water. Group II served as standard received tablet aspirin 100 mg/kg (oral) and Group III, IV, V served as test T1, T2, T3 and received tablet levofloxacin 10 mg/kg, 20 mg/kg and 40 mg/kg (oral), respectively. The analgesic effect of levofloxacin was evaluated using Eddy’s hot plate and tail flick methods and compared with standard analgesic aspirin. The values obtained were expressed as mean±SD. Statistical analysis of difference between groups were carried out using one-way analysis of variance (ANOVA). Probability p<0.05 was taken as the level of statistical significance.Results: Levofloxacin at 40 mg/kg showed statistically (p<0.05) elevation in pain threshold and a higher antinociceptive activity in comparison to control and standard groups.Conclusions: In the present study, levofloxacin has showed promising results as an analgesic when compared to the control and standard groups. It may be a lead compound for identifying newer adjuvant analgesic agents.

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