scholarly journals A Prospective Randomised Case Control Study on the Role of Probiotics in Controlling Chronic Kidney Disease Progression

2021 ◽  
pp. 264-271
Author(s):  
A. Sai Keshava Reddy ◽  
P. Dhana Lakshmi ◽  
N. Hima Bindu ◽  
R. E. Ugandar ◽  
Y. Sai Vani
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Case Control Study ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression ◽  
Control Study

Aim:  To study the role of probiotics in controlling chronic kidney disease progression. Sample: To correlate renal parameters like creatinine, urea, uric acid, PCR in patients with chronic kidney disease. Study Design: It is a Prospective case control study Place and Duration of the Study: Department of Nephrology, Santhiram Medical college and General Hospital, between December 2020 – May 2021. Methodology: We included 150 patients with chronic kidney disease from in and out patient departments. In this study patients are divided into two groups; case and control group. Control group is treated with normal conventional therapy whereas the case group is treated with conventional therapy along with probiotics. The lab parameters like creatinine, PCR, urea, uric acid were analyzed before and after the therapy in both groups. Results: The lab parameters were analyzed by paired student`s t- test and the p value of these parameters were found to be in control group creatinine ranges from (4.42+/- 2.84 to 3.54+/- 2.73) and in case/ interventional group creatinine ranges from (5.13+/-2.43 to 2.29+/-1.57) shows <0.001. It shows significant improvement in these parameters in both control and case group. CKD stages were analyzed by Chi- square test, the p value of CKD stages in case group was found to be <0.0001 and in control group it was found to be 0.03. Conclusion: It shows that there is significant improvement is found in both interventional (case) and non-interventional (control) groups. But more betterment is observed in case group than in control group. Hence probiotics are used as a natural bio-treatment to control the progression of CKD and improves the quality of life.

scholarly journals Obesity and chronic kidney disease progression—the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1

2018 ◽  
Vol 12 (3) ◽  
pp. 420-426 ◽  
Author(s):  
Diego Barbieri ◽  
Marian Goicoechea ◽  
Maria Dolores Sánchez-Niño ◽  
Alberto Ortiz ◽  
Eduardo Verde ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Related Protein ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression ◽  
Necrosis Factor

Evidence for a role of uromodulin in chronic kidney disease progression

2010 ◽  
Vol 25 (6) ◽  
pp. 1896-1903 ◽  
Author(s):  
S. Prajczer ◽  
U. Heidenreich ◽  
W. Pfaller ◽  
P. Kotanko ◽  
K. Lhotta ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Disease Progression ◽  
Chronic Kidney Disease Progression ◽  
Kidney Disease Progression

scholarly journals The role of Chlamydia trachomatis in preterm delivery: a case-control study in Besat Hospital, Sanandaj, Iran (2018-2019)

2020 ◽  
Author(s):  
Seyedeh Jahan Ahmadi ◽  
Fariba Farhadifar ◽  
Seyedeh Reyhaneh Yousefi Sharami1 ◽  
Shamsi Zare ◽  
Masomeh Rezaei ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Preterm Delivery ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Igg Antibody ◽  
Cervical Swab ◽  
Control Study

Background and Objectives: Preterm delivery is an important subject in gynecology, obstetrics and pediatrics. It is defined as regular uterine contractions every five to eight minutes or less, lasting for 30 seconds. It is associated with progressive changes in the cervix, resulting in delivery after 22 weeks and before 37 weeks of gestation. This study aimed to evaluate the role of Chlamydia trachomatis infection in women with preterm delivery. Materials and Methods: This case-control study was performed on 75 women with preterm delivery (case group) and 75 women with term delivery (control group). The research tools included a questionnaire, polymerase chain reaction (PCR) assay of cervical swab samples and ELISA assay of umbilical cord blood samples. Fisher’s exact test and t test were also performed to compare qualitative variables between the two groups. Results: In this study, the mean age of subjects was 26.55 ± 0.53 years in the control group and 26.76 ± 0.56 years in the case group. The prevalence of C. trachomatis in the cervical swab samples was 7 (9.33%) in the control group and 2 (2.67%) in the case group. There was no C. trachomatis IgM antibody in either of the groups, while there was 1 (1.33%) C. trachomatis IgG antibody in both groups. Conclusion: The results of the present study showed that there was no significant relationship between C. trachomatis infection and preterm delivery.

scholarly journals Role of matrilin-1 (MATN1) polymorphism in class III skeletal malocclusion with mandibular prognathism in Deutero-Malay race: a case-control study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Avi Laviana ◽  
Bergman Thahar ◽  
Ani Melani ◽  
Endah Mardiati ◽  
Lita Putri ◽  
...  
Keyword(s):  
Risk Factor ◽  
Case Control Study ◽  
Control Group ◽  
Case Group ◽  
Class Iii ◽  
Mandibular Prognathism ◽  
Skeletal Malocclusion ◽  
Malay Population ◽  
Control Study

Abstract Background Several studies have identified different genes that control the final dimension and structure of the mandible. Prognathism of the mandible is thought to correlate with these genes; however, no specific gene has been assigned as a risk factor due to various genome-wide scan results in different races. Previous studies that involved the Han ethnic group in China and Korea suggested matrilin-1 (MATN1) polymorphism as the contributor for mandibular prognathism. To date, no study has been conducted to understand the role of MATN1 in Deutero-Malay population. This study aimed to detect MATN1 gene polymorphism in the promoter and exon 5 regions, which is a proposed risk factor in class III skeletal malocclusion with mandibular prognathism in Deutero-Malay population. This was a case-control study with purposive sampling method that involved 47 class III skeletal malocclusion subjects with mandibular prognathism (case group) and 47 class I skeletal relation subjects (control group) performed in the Molecular Genetics Laboratory of Faculty of Medicine, Universitas Padjadjaran, Indonesia. DNA isolated from buccal mucous epithelia and MATN1 gene was amplified using the polymerase chain reaction (PCR) and sequencing technique. Data were then analyzed statistically to observe the frequency of allele/genotype MATN1 in class III skeletal malocclusion and mandibular prognathism patients in comparison with the normal mandibular as well as to identify the risk factor of mandibular prognathism. Result The frequency of the 354 T > C(rs20566) CC genotype gene polymorphism in the case group was significantly higher than in the control group. The odd ratio (OR) value of the case group was also higher than in the control group (χ2 = 4.89; p = 0.027; OR = 6.27). Conclusions Our results show that the polymorphism of 354 T > C in the exon 5 region of the CC genotype MATN1 gene is a risk factor for class III skeletal malocclusion with mandible prognathism in Deutero-Malay population.

Assessment of semen parameters and Anti-müllerian hormone level in patients with chronic kidney disease on hemodialysis: a case control study

2021 ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Sperm Motility ◽  
Seminal Plasma ◽  
Case Control Study ◽  
Case Control ◽  
Semen Parameters ◽  
Case Group ◽  
Stage 4 ◽  
Control Study

Background and Objective: Chronic kidney disease (CKD) is a common health problem which is accompanied by considerable morbidity and mortality. Anti-müllerian hormone (AMH) is one of the hormones that are affected by CKD. The objective was to assess semen parameters and AMH level in CKD patients on hemodialysis. Material and methods: This study was a case control study of 20 patients with stage 4 and 5 CKD on hemodialysis, attending Nephrology Outpatient Clinic and Renal Dialysis Unit of Suez Canal University hospital and 20 healthy fertile controls. Full history, clinical examination, kidney function tests and semen analysis were performed. AMH level in serum and seminal plasma was measured using ELISA. Results: The mean AMH level in serum of case group was 3.35 ± 2.43 ng/mL versus 4.13 ± 3.17 ng/mL in the controls respectively (p > 0.05) while mean AMH level in semen of the case group was 2.13 ± 2.64 ng/mL compared to 9.37 ± 3.79 ng/mL in controls respectively (p < 0.05). There was a positive correlation between AMH in seminal plasma and sperm count, total sperm motility, progressive sperm motility and sperm viability, while the AMH level in serum was insignificantly related. Conclusion: Semen parameters in CKD patients on hemodialysis were significantly poorer than normal controls AMH in seminal plasma was significantly decreased in CKD patients (stage 4–5 on hemodialysis) and significantly correlated with the semen parameters.

scholarly journals Effect of Chronic Kidney Disease on Olfactory Function: A Case–Control Study

2021 ◽  
pp. 014556132199662
Author(s):  
T. Yusuf ◽  
Y. R. Raji ◽  
A. Daniel ◽  
O. T. Bamidele ◽  
A. J. Fasunla ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Case Control Study ◽  
Case Control ◽  
Olfactory Dysfunction ◽  
Olfactory Function ◽  
Control Group ◽  
Olfactory Pathway ◽  
Significant Difference ◽  
Control Study

Background: Olfactory function of patients with chronic kidney disease (CKD) has been found to be defective, and patients are often unaware of it. This predisposes them to malnutrition with consequence on health recovery and quality of life. Aim: To assess the olfactory function and determine the pattern of olfactory dysfunction in patients with CKD attending the University College Hospital, Ibadan. Materials and Methods: This was a prospective, hospital-based case–control study of adult patients with CKD. The control group were age- and sex-matched individuals without CKD. Olfactory threshold (OT), odor discrimination (OD), and odor identification (OI) tests were carried out in participants using the “Sniffin Sticks.” Results: There were 100 patients with CKD and 100 healthy controls, age ranges between 19 to 86 years (mean ± SD = 46.3 ± 13.9 years) and 20 to 85 years (mean ± SD = 43.4 ± 14.9 years), respectively. There was no statistically significant difference between cases and control gender distribution ( P = .57). The mean olfactory scores were significantly lower among the cases than control, OI 11.2 ± 2.3 and 13.1 ± 1.2 ( P < .001), OD 8.5 ± 2.4 and 10.9 ± 1.5 ( P < .001), OT 6.4 ± 2.5 and 9.6 ± 1.9 ( P < .001), and threshold discrimination and identification 26.0 ± 5.7 and 33.6 ± 3.3 ( P < .001), respectively. Prevalent olfactory dysfunction among patients with CKD was 77% (hyposmia 72%, anosmia 5%), and the control was 16% (all hyposmia; P < .001). Conclusion: There was high prevalence of olfactory dysfunction among patients with CKD, and the affectation is more at the central olfactory pathway.

scholarly journals Determination of the Effect of High-Dose Intralipid in Compared to Its Gradual Dose in Very Low Birth Weight Newborns: A Case-control Study

2019 ◽  
pp. 1-7
Author(s):  
Mandana Kashaki ◽  
Arash Bordbar ◽  
Ali Mazouri ◽  
Nikta Nikbakht ◽  
Babak Jafarvand
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Case Control Study ◽  
Very Low Birth Weight ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
High Dose ◽  
Control Study ◽  
Gradual Dose

Objective: The aim of this study was to determine the effect of high dose intralipid in compared to its gradual dose in very low birth weight newborns in Iran.  Methods: This study was a case-control study that conducted on 104 very low birth weight infants (<1500 g) referred to Akbarabadi hospital of Tehran (Iran) in 2016. The infants were randomly assigned to two groups (case group: 52 vs. control group: 52). The control group received intralipid 20% with a dose of 1 g/kg/24 h in the first and second day of the study, then from 3rd day to 3 g/kg /24h was raised. But, the case group received 3 g/kg/24 h of intralipid 20% from the first day and continued until the end of the study. In both groups, the study lasted for up to 30 days. Data were collected and analyzed using SPSS22 software. Also P-Value <0.05 was considered as a significant level. Results: The results showed mean daily weight gain in case group is higher than control group and this difference was significant statistically (P-Value < 0.05). Also, although the mean of blood sugar, triglyceride, HCO3, the number of positive blood culture and the number of positive CPR in case group were higher than control group, but these differences were not statistically significant (P-Value >0.05). Conclusion: Given that the better and faster growth of newborns in the intralipid group with high-dose in compared to intralipid group with gradual dose, the use of higher initial doses is recommended in newborns with very low birth weight.

Sign in / Sign up

Export Citation Format

Share Document