scholarly journals Determination of the Effect of High-Dose Intralipid in Compared to Its Gradual Dose in Very Low Birth Weight Newborns: A Case-control Study

Author(s):  
Mandana Kashaki ◽  
Arash Bordbar ◽  
Ali Mazouri ◽  
Nikta Nikbakht ◽  
Babak Jafarvand

Objective: The aim of this study was to determine the effect of high dose intralipid in compared to its gradual dose in very low birth weight newborns in Iran.  Methods: This study was a case-control study that conducted on 104 very low birth weight infants (<1500 g) referred to Akbarabadi hospital of Tehran (Iran) in 2016. The infants were randomly assigned to two groups (case group: 52 vs. control group: 52). The control group received intralipid 20% with a dose of 1 g/kg/24 h in the first and second day of the study, then from 3rd day to 3 g/kg /24h was raised. But, the case group received 3 g/kg/24 h of intralipid 20% from the first day and continued until the end of the study. In both groups, the study lasted for up to 30 days. Data were collected and analyzed using SPSS22 software. Also P-Value <0.05 was considered as a significant level. Results: The results showed mean daily weight gain in case group is higher than control group and this difference was significant statistically (P-Value < 0.05). Also, although the mean of blood sugar, triglyceride, HCO3, the number of positive blood culture and the number of positive CPR in case group were higher than control group, but these differences were not statistically significant (P-Value >0.05). Conclusion: Given that the better and faster growth of newborns in the intralipid group with high-dose in compared to intralipid group with gradual dose, the use of higher initial doses is recommended in newborns with very low birth weight.

Author(s):  
Annibal Sabino ◽  
Eduardo de Souza ◽  
Ana Goulart ◽  
Adriana Lima ◽  
Nelson Sass

Objective To evaluate whether the presence of maternal blood pressure reduces the risks of morbidity, perinatal mortality and morbidity at 24 months of age in very low birth weight infants (VLBWIs) compared with a control group. Methods A retrospective, observational, case-control study. Total 49 VLBWIs were allocated to the study group, called the maternal arterial hypertension group (AHG), and matched with 44 in the control group (CG). The infants were assessed during hospitalization and at 12 and 24 months corrected age at a specialized clinic. For the assessment of growth, the World Health Organization (WHO) Anthro software (Geneva, 2006) was used, and for the psychomotor assessment, the Denver II test was used. Results In relation to the antenatal variables, the infants of the AHG had more centralized circulation assessed by Doppler, received more corticosteroids and magnesium sulfate, and were born by cesarean section more frequently. In terms of the postnatal and in-hospital outcomes, the AHG had a higher gestational age at birth (30.7 versus 29.6 weeks) and a lower frequency of 5-minute Apgar scores of less than 7 (26.5% versus 52.3%). The CG had a higher rate of pulmonary dysplasia (30.2% versus 8.3%). There were no differences in terms of hospital mortality, complications, somatic growth and functional problems at 24 months of corrected age. Conclusion The presence of maternal hypertension, especially preeclampsia, was not a protective factor against morbidity, mortality and evolution in VLBWIs aged up to 24 months. Therefore, the clinical practice should be focused on prolonging the pregnancy for as long as possible in these conditions as well.


2010 ◽  
Vol 44 (1) ◽  
pp. 90-101 ◽  
Author(s):  
Monica Yuri Takito ◽  
Maria Helena D'Aquino Benício

OBJECTIVE: To investigate the relationship between physical activity during the second trimester pregnancy and low birth weight, preterm birth, and intrauterine growth restriction. METHODS: Case-control study including 273 low birth weight newborns and 546 controls carried out in the city of São Paulo, Southeastern Brazil, in 2005. Low birth weight cases were grouped into two subsamples: preterm birth (n=117) and intrauterine growth restriction (n=134), with their related controls. Information was collected by means of interviews with mothers shortly after birth and transcription of medical records. Data were analyzed using conditional multiple and hierarchical logistic regression. RESULTS: Light physical activity for over 7 hours per day was shown to be protective against low birth weight (adjusted OR=0.61; 95% CI 0.39-0.94) with a dose-response relationship (p-value for trend=0.026). A similar trend was found for intrauterine growth restriction (adjusted OR=0.51; 95% CI 0.26-0.97). Homemaking activities were associated as a protective factor for both low birth weight and preterm birth (p-value for trend=0.013 and 0.035, respectively). Leisure-time walking was found to be protective against preterm birth. CONCLUSIONS: Mild physical activity during the second trimester of pregnancy such as walking has an independent protective effect on low birth weight, preterm birth, and intrauterine growth restriction.


2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Abdallah Oulmaati ◽  
Stephane Hays ◽  
Mohamed Ben Said ◽  
Delphine Maucort-Boulch ◽  
Isabelle Jordan ◽  
...  

Author(s):  
Arash Bordbar ◽  
Azade Noroozi Vahid ◽  
Mandana Kashaki

Very Low Birth Weight (VLBW) infants have higher nutritional needs than term infants. Energy and protein are two important factors influencing their growth. Breastfeeding is not enough to meet VLBW infants’ needs, for this reason, complementary protein is required by them. Hence, the present study aimed at investigation of renal function among VLBW infants receiving complementary proteins. The study was conducted on two groups of intervention and control (n= 18 in each group) (Case study: VLBW infants born in Akbarabadi hospital of Tehran in 2014 2015). The intervention group includes 3-year-old children who weighting less than 1200 grams at birth and have received protein supplementation at the course of NICU hospitalization, protein was added to maternal milk when the amount of milk reaches to 100 cc/kg/day, at this time parenteral nutrition was discontinued and the volume of feeding was increased 20cc/kg/day until reached to 150-180cc/kg/day. We also added the fortifier to breast milk at this time. The fortification and the protein supplementation were stopped when the weight of the baby reached to 1500 grams. The control group was fed similar to the intervention group but had received no complementary protein . The renal function was evaluated by measuring such criteria as BUN, Cr, ALB and U/A. After data collection, a statistical analysis was performed using SPSS software Ver. 22. Following to BUN evaluation, a significant correlation was seen between BUN and received protein (p-value=0.010). However, there was no significant correlation between Cr and received protein as well as mean values of the two groups (p-value=0.0766). Similarly, an insignificant correlation was found between the two groups following to investigation of ALB (p-value=0/257), while the mean values of the two groups were similar. The both groups were also equal in U/A. The complementary protein increased the BUN with no effect on Cr, ALB and U/A, providing no impact on renal function. Therefore, complementary protein intake made no conflict in renal function.


2016 ◽  
Vol 27 (04) ◽  
pp. 341-345 ◽  
Author(s):  
Dilek Isik ◽  
Ahmet Bas ◽  
Zehra Arslan ◽  
Nihal Demirel ◽  
Sezin Unal

Introduction The incidence and risk factors for inguinal hernia (IH) is not a thoroughly evaluated issue of preterms. Prematurity is the single most important risk factor. There exists no study in our country which reported the incidence of IH in preterms. The purpose of this study is to investigate the incidence and time of diagnosis of IH in very low-birth-weight (VLBW) infants. Patients and Methods This retrospective case–control study was conducted in Etlik Zubeyde Hanim Women's Health Training and Research Hospital and included discharged VLBW infants with gestational age less than 32 weeks. Control group included gender, birth weight, and gestational age matched VLBW infants without IH. Results The incidence of IH was 10.1% in VLBW infants (70/693) and 16.1% in extremely low-birth-weight infants (19/174). Male/female ratio was found as 3.4:1. Most IH appeared as bilateral (40.0%). Time of diagnosis was 39 (37–42) weeks of postmenstrual age while 68.6% of infants were diagnosed after discharge. IH development increased by 2.3-folds by having respiratory distress syndrome and by 4.5 folds by achieving full enteral feeds on or after the 10th day. Conclusion Preterms with respiratory distress syndrome and those reach full enteral feeding on or after the 10th day should be monitored carefully for IH development. Bearing in mind that a significant amount of IH cases exhibit symptoms after discharge, neonatologists should inform the parents of premature infants of the issue and close attention should be paid in postdischarge follow-up examinations.


2018 ◽  
Vol 5 (2) ◽  
pp. 617
Author(s):  
Malavika P. Santappanavar ◽  
Habeeb U. Khan ◽  
Jaidev M. D. ◽  
Pavan Hegde

Background: More and more women are focusing on obtaining higher education and reaching career objectives. This has in turn, lead to delayed marriage and child birth at a later age. Advanced maternal age at birth has been found to be associated with preterm delivery, low birth weight, intrauterine fetal death and increased perinatal morbidity and mortality. The aim of our study was to know the neonatal outcome in elderly mothers and young mothers, and to compare the neonatal outcome of these two groups. Methods: Present study was a cross sectional, analytical case control study, done in babies delivered to mothers >35 years and <35 years. Information like period of gestation, birth weight, APGAR at 1 minute and 5 minutes, NICU admissions, neonatal outcome like respiratory distress, jaundice, convulsion, etc. were recorded in a proforma. Collected data was analysed using appropriate statistical tests.Results: In the present study, total sample size was 460 (230 cases and 230 controls). Incidence of preterm deliveries, Low birth weight, NICU admissions were significantly more in case group (babies born to mothers >35 years) than the control group (babies born to mothers between 19 to 35 years).Conclusions: It was observed that low birth weight, prematurity and NICU admissions were more common in babies born to elderly mothers.


Sign in / Sign up

Export Citation Format

Share Document