scholarly journals Surgical Treatment of Intramuscular, Infiltrating Lipoma

2011 ◽  
Vol 96 (1) ◽  
pp. 56-59 ◽  
Author(s):  
Chin-Horng Su ◽  
Jui-Kuo Hung ◽  
Ing-Lin Chang
Keyword(s):  
Local Recurrence ◽  
Preoperative Evaluation ◽  
Surgical Margin ◽  
Surgical Excision ◽  
Surgical Results ◽  
Marginal Excision ◽  
Changhua Christian Hospital ◽  
Christian Hospital ◽  
Complete Tumor

Abstract Lipoma may occasionally be found within the muscle, which is the intramuscular, infiltrating lipoma. Intramuscular, infiltrating lipoma is an uncommon lesion, and local recurrence can be expected if the surgical margin is not clear. We report 8 patients in a 2-year period diagnosed with intramuscular, infiltrating lipoma who were treated by marginal excision combined with wide excision in the Department of Orthopaedic Surgery, Changhua Christian Hospital. The surgical results were satisfactory, and no local recurrence was noted in an average follow-up period of 40 months. Surgical excision is the best way to treat the symptomatic intramuscular, infiltrating lipoma. Careful preoperative evaluation and complete tumor excision with clear margins are most important to ensure successful surgical results.

scholarly journals Clinical application of contrast-enhanced ultrasound after percutaneous renal tumor ablation

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190183 ◽  
Author(s):  
Fang Guo ◽  
Bing Hu ◽  
Lei Chen ◽  
Jia Li
Keyword(s):  
Local Recurrence ◽  
Tumor Ablation ◽  
Renal Tumors ◽  
Ablation Zone ◽  
Recurrent Tumors ◽  
Contrast Enhanced Ct ◽  
Contrast Enhanced ◽  
Enhanced Ct ◽  
Complete Tumor

Objective: To evaluate the effectiveness of contrast-enhanced ultrasound (CEUS) in detecting incomplete ablation and local recurrence of renal tumors after percutaneous radiofrequency ablation (RFA). Methods: 31 patients were included for RFA treatment and underwent CEUS examination after RFA, ablation zone and contrast distribution in the ablation area were observed, CEUS images were compared with enhanced CT/MRI images to determine the residual tumors and local recurrence of renal tumors. Results: The average maximum diameters of the tumor and the ablation zone after the first RFA were 32.3 ± 14.7 mm and 35.9 ± 12.2 mm, respectively. A higher rate of complete tumor ablation was achieved if the ablation zone was larger than the primary tumor (p = 0.026). Within 1 month after RFA, contrast-enhanced CT/MRI examinations demonstrated incomplete ablation in 9 of 31 patients (29.0%), while CEUS revealed incomplete ablation in 8 of 31 patients (25.8%). The sensitivity, specificity, positive predictive value and negative predictive value of CEUS in evaluating complete ablation of renal tumors were 88.9%, 100%, 100%, 95.7%, respectively. During the follow-up period, local recurrence was reported in 2 (7.4%) of the 27 patients with complete tumor ablation. Tumor recurrence signs in the two patients were identified by both CEUS and contrast-enhanced CT/MRI. Therefore, both the sensitivity and specificity of CEUS for the evaluation of tumor recurrence were 100%. Conclusion: After percutaneous RFA of renal tumors, the effectiveness of CEUS in the follow-up assessment of residual and recurrent tumors is basically the same as that of contrast-enhanced CT/MRI. Advances in knowledge: In this study, we evaluated the effectiveness of CEUS in the follow-up assessment of residual and recurrent tumors after RFA is basically the same as that of contrast-enhanced CT/MRI. Combining multiple follow-up methods may improve the detection rate of residual or recurrent tumors.

scholarly journals Frozen section analysis for organ-conserving surgery in penile cancer: Assessing oncological outcomes and trends of local recurrence

2020 ◽  
Vol 13 (6) ◽  
pp. 419-424
Author(s):  
T Ellul ◽  
P Grice ◽  
A Mainwaring ◽  
N Bullock ◽  
A Shanahan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Penile Cancer ◽  
Frozen Section ◽  
Surgical Margin ◽  
Positive Margin ◽  
Surgical Excision ◽  
Recurrence Rates ◽  
Level Of Evidence ◽  
Positive Margins ◽  
Positive Margin Rate

Introduction and objectives: The local recurrence rate of penile cancer following surgical excision is reported in many series to be between 6 and 29%. Intra-operative frozen section (FS) is a useful tool to ensure safe microscopic margins in organ-sparing procedures in penile cancer. In this series, we assessed the rates of positive margins and patterns of local recurrence in a multicentre cohort of patients undergoing penile-preserving surgery assisted by intra-operative FS analysis. Materials and methods: We reviewed all those patients for whom intra-operative FS was employed during penile-preserving surgery in three tertiary referral centres between 2003 and 2016. We assessed whether the use of FS altered the surgical technique and what affect it had on positive margins and recurrence rates. Results: A total of 169 patients were identified. Of these, intra-operative FS examination of the surgical margin was positive in 21 (12%) cases. Final histological examination confirmed cancer-free margins in all but one patient (99.4%). Overall, 9 patients developed local recurrence (5.3%). Conclusions: In this series, intra-operative FS contributed to a very low rate (5.3%) of local recurrence. We noted an extremely low positive margin rate (0.6%) which highlights the benefit of incorporating FS analysis into organ-preserving surgery for penile cancer. Level of evidence: Not applicable for this multicentre audit.

Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature

2015 ◽  
Vol 129 (S2) ◽  
pp. S86-S90 ◽  
Author(s):  
N Kikuchi ◽  
T Nakashima ◽  
J Fukushima ◽  
K Nariyama ◽  
S Komune
Keyword(s):  
Case Report ◽  
Parapharyngeal Space ◽  
Case Reports ◽  
Surgical Margin ◽  
Neck Region ◽  
Surgical Excision ◽  
Curative Therapy ◽  
Long Term Follow Up ◽  
Well Differentiated

AbstractBackground:Liposarcomas rarely occur in the parapharyngeal space and only a few case reports exist. For curative therapy of liposarcoma, surgical excision remains the dominant modality. Although a wide surgical margin is important to prevent local recurrence, wide excision is often difficult in the head and neck region.Case report:We report a case of a 19-year-old female with a well-differentiated liposarcoma arising in the parapharyngeal space. We removed the tumour surgically utilising a cervical–parotid approach. The histological diagnosis was well-differentiated sclerosing liposarcoma. There is no recurrence after five years and nine months of follow up.Conclusion:The patient's age and the tumour site made it difficult for us to make a quantitative diagnosis before the operation. Well-differentiated liposarcoma rarely develop distant metastasis, but often recur locally. The benefit of adjuvant radiotherapy for well-differentiated liposarcoma is still not clear and careful and long-term follow up is necessary.

Impact of brachytherapy on local recurrence after sublobar resection: Results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small cell lung cancer (NSCLC).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 7502-7502 ◽  
Author(s):  
Hiran Chrishantha Fernando ◽  
Rodney Jerome Landreneau ◽  
Sumithra J. Mandrekar ◽  
Francis C Nichols ◽  
Shauna L Hillman ◽  
...  
Keyword(s):  
High Risk ◽  
Local Recurrence ◽  
Staple Line ◽  
Randomized Study ◽  
Surgical Margin ◽  
Phase Iii ◽  
Oncologic Outcomes ◽  
Sublobar Resection ◽  
Local Progression

7502 Background: Prior studies suggest that adjuvant brachytherapy reduces local recurrence (LR) after sublobar resection (SR) for NSCLC. A multicenter randomized study was undertaken in patients (pts) with stage I NSCLC ≤3cm comparing SR to SR with brachytherapy (SRB). Methods: High-risk operable patients with NSCLC were randomized to SR or SRB. Brachytherapy involved placement of I125 seeds incorporated into Vicryl sutures or into Vicryl mesh placed over the staple line. Wedge or segmental resection was allowed. The primary endpoint was time to local recurrence (LR) defined as recurrence within the primary tumor lobe at the staple line (local progression), away from the staple line or within hilar nodes. The trial was designed to have 90% power to detect a hazard ratio (HR) of 0.315 in favor of the SRB arm using a one-sided α of 0.05 with a sample size of 100 eligible pts per arm. Follow-up CT scans were obtained serially for 36 months. Results: 224 pts were randomized; 213 (109 SR,104 SRB) were eligible. Median (range) age was 71 (49-87) yrs; 94 (44%) were male. No differences were found in baseline characteristics. Adverse events, previously reported, were not different between arms. Median (range) follow-up was 4.06 (0.04, 5.0) yrs. There was no difference between arms in time to LR (HR = 0.87; 5% CI: 0.41, 1.86, p=0.72) or to LR or death (LRD) (HR = 0.81, 95% CI: 0.50, 1.32, p=0.40). There was no difference between arms in pattern of LR (table). In subgroups of pts with potentially compromised surgical margin (margin < 1cm; margin:tumor ratio <1; positive staple line cytology) SRB did not reduce LR or LRD at 3-yrs. Overall 3-yr survival was similar for SR (71%) and SRB (72%) (p=0.81). Conclusions: LR remains a concern after sublobar resection. However, local progression at the staple line was low. This trial demonstrated that adjuvant brachytherapy does not impact oncologic outcomes. Clinical trial information: NCT00107172. [Table: see text]

Nasal haemangiopericytoma: report of two cases with literature review

1999 ◽  
Vol 113 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Rémi Marianowski ◽  
Michel Wassef ◽  
Philippe Herman ◽  
Partice Tran Ba Huy
Keyword(s):  
Local Recurrence ◽  
Literature Review ◽  
Paranasal Sinuses ◽  
Surgical Excision ◽  
Lateral Rhinotomy ◽  
Vascular Tumour ◽  
Wide Surgical Excision ◽  
Incomplete Removal ◽  
Midfacial Degloving

AbstractHaemangiopericytoma (HPC) is a rare vascular tumour produced by proliferation of pericytes. One hundred and thirty-three cases of HPC have been reported in the nose and the paranasal sinuses. We present two more cases. Wide surgical excision via lateral rhinotomy, midfacial degloving, or endonasal removal is the treatment of choice. Radiotherapy has been used post-operatively in cases of incomplete removal. Life-long follow-up is required to evaluate local recurrence and late metastases.

Chondrogenic neoplasms of the nasal cavity

1987 ◽  
Vol 101 (5) ◽  
pp. 500-505 ◽  
Author(s):  
O. E. El-Silimy ◽  
L. Harvey ◽  
M.R.C. Path ◽  
P. J. Bradley
Keyword(s):  
Local Recurrence ◽  
Nasal Cavity ◽  
Initial Treatment ◽  
Distant Metastases ◽  
Surgical Excision ◽  
Natural Course ◽  
Facial Skeleton ◽  
Histological Differentiation

Chondrogenic neoplasms of the nasal cavity are rare. Clinically, presentation is often late, with expansion and destruction of the middle facial skeleton. Local radical surgical excision is the preferred treatment, with regular life-long follow-up. Risk of local recurrence and distant metastases may Qccur many years after initial treatment. All chondrogenic tumours should be carefully followed up because the natural course of the disease may not match the histological differentiation.

Outcome at 8 Years After Breast-Conserving Surgery and Radiation Therapy for Invasive Breast Cancer: Influence of Margin Status and Systemic Therapy on Local Recurrence

2000 ◽  
Vol 18 (8) ◽  
pp. 1668-1675 ◽  
Author(s):  
Catherine C. Park ◽  
Michihide Mitsumori ◽  
Asa Nixon ◽  
Abram Recht ◽  
James Connolly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Logistic Regression ◽  
Radiation Therapy ◽  
Local Recurrence ◽  
Systemic Therapy ◽  
Surgical Margin ◽  
Breast Conserving Surgery ◽  
Margin Status ◽  
Positive Margins

PURPOSE: To examine the relationship between pathologic margin status and outcome at 8 years after breast-conserving surgery and radiation therapy. PATIENTS AND METHODS: The study population comprised 533 patients with International Union Against Cancer/American Joint Committee on Cancer clinical stage I or II breast cancer who had assessable margins, who received at least 60 Gy to the primary tumor bed, and who had more than 8 years of potential follow-up. Each margin was scored (according to the presence of invasive or in situ disease that touched the inked surgical margin) as one of the following: negative, close, focally positive, or extensively positive. Outcome at 8 years was calculated using crude rates of first site of failure. A polychotomous logistic regression analysis was performed. Median follow-up time was 127 months. RESULTS: At 8 years, patients with close margins and those with negative margins both had a rate of local recurrence (LR) of 7%. Patients with extensively positive margins had an LR rate of 27%, whereas patients with focally positive margins had an intermediate rate of LR of 14%. In the polychotomous logistic regression model, margin status and the use of systemic therapy were the only two variables that had significant effects on the risk ratio of LR to remaining alive and free of disease. Among the 45 patients with focally positive margins who received systemic therapy, the crude LR rate was 7% at 8 years (95% confidence interval, 1% to 20%). CONCLUSION: Pathologic margin status and the use of adjuvant systemic therapy are the most important factors associated with LR among patients treated with breast-conserving surgery and radiation therapy.

Clinical Characterization of Canine Acanthomatous Ameloblastoma (CAA) in 263 dogs and the Influence of Postsurgical Histopathological Margin on Local Recurrence

2017 ◽  
Vol 34 (4) ◽  
pp. 241-247 ◽  
Author(s):  
Stephanie L. Goldschmidt ◽  
Cindy M. Bell ◽  
Scott Hetzel ◽  
Jason Soukup
Keyword(s):  
Local Recurrence ◽  
Tumor Recurrence ◽  
Surgical Margin ◽  
Medical Surveillance ◽  
Local Tumor ◽  
Local Tumor Recurrence ◽  
Curative Intent ◽  
Data Set

Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient. This study raises questions about what the recommended surgical margin should be for treatment of CAA. It also serves as a stimulus for discussion as to whether further treatment for CAA is required when inadequate surgical margins are obtained, or if medical surveillance would be an appropriate management recommendation. Prospective studies are necessary to answer these questions.

Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors

2004 ◽  
Vol 40 (2) ◽  
pp. 124-130 ◽  
Author(s):  
David R. Davies ◽  
Kenneth M. Wyatt ◽  
John E. Jardine ◽  
Ian D. Robertson ◽  
Peter J. Irwin
Keyword(s):  
Mast Cell ◽  
Local Recurrence ◽  
Adjunctive Therapy ◽  
Marginal Excision ◽  
Mast Cell Tumors ◽  
Cutaneous Mast Cell ◽  
Residual Microscopic Disease ◽  
Related Mortality

Twenty-seven dogs with inadequately excised, cutaneous mast cell tumors (MCT; 20 residual microscopic disease, seven marginal excision) were treated with a vinblastine and prednisolone chemotherapeutic protocol. Twenty dogs were available for follow-up examination after 12 months. One dog suffered local recurrence of the tumor, four dogs developed new cutaneous tumors, and one dog had both events. Fourteen dogs were free of MCT. There was no confirmed tumor-related mortality. Although toxicity from the chemotherapy was generally mild, one dog died of sepsis during treatment.

Clinical Outcome for MCTs of Canine Pinnae Treated with Surgical Excision (2004–2008)

2014 ◽  
Vol 50 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Timothy M. Schwab ◽  
Catherine Popovitch ◽  
John DeBiasio ◽  
Michael Goldschmidt
Keyword(s):  
Local Recurrence ◽  
Surgical Excision ◽  
Tumor Grade ◽  
Published Data ◽  
Disease Free Interval ◽  
Mast Cell Tumors ◽  
Grade 3 ◽  
Record Review ◽  
Disease Free

Canine mast cell tumors (MCTs) are the most common cutaneous neoplasm in the dog. It has been suggested that MCT in certain locations may behave in a more biologically aggressive fashion than MCTs located in others; however, no published data are available for MCTs of canine pinnae treated with surgical excision. A retrospective study of 28 animals with surgical excision of MCTs of pinnae was completed with a medical record review and follow-up questionnaire to the operating veterinarian. The effect of tumor grade, clean or dirty excision, cartilage penetration, and mitotic index (MI) on local recurrence and survival time (ST) was evaluated. There was local recurrence in one dog with a grade 2 MCT and in seven of eight dogs with grade 3 MCTs. The median ST of animals with grade 1 and 2 MCTs was not reached, whereas the median ST of animals with grade 3 MCTs was 10 mo. There was no statistical association between histologically clean and dirty margins and either local recurrence or ST. A prolonged disease free interval without local recurrence may be achieved with local excision of grade 1 and 2 MCTs. Animals with grade 3 MCTs had a uniformly poor outcome with short times to local recurrence and death.

Sign in / Sign up

Export Citation Format

Share Document