Hyperhomocysteinemia as an Independent Risk Factor for Coronary Heart Disease. Comparison with Conventional Risk Factors

The present study was designed to evaluate the strength of association of raised plasma homocysteine concentration as a risk factor for coronary heart disease independent of conventional risk factor. It was a case control study conducted at Punjab Institute of Cardiology Lahore. A total of 210 subjects aged 25 to 60 years comprising of 105 newly admitted patients of CHD as cases and 105 age and sex matched healthy individuals with no history of CHD as control were recruited for the study. Fasting blood samples were obtained from cases and controls. Plasma homocysteine was analyzed by fluorescence polarization immunoassay (FPIA) method on automated immunoassay analyzer (Abbott IMX). Total cholesterol, triglyceride and HDL cholesterol were analyzed using calorimetric kit methods. The concentration of LDL cholesterol was calculated using Friedewald formula. The patients were also assessed for traditional risk factors such as age, sex, family history of CVD, hypertension, smoking and physical activity, and were compared with control subjects. The collected data was entered in SPSS version 24 for analysis and interpretation.The mean age in controls and experimental groups were 43.00± 8.42 years and 44.72± 8.59 years with statistically same distribution (p- value= 0.144). The mean plasma homocysteine for cases was 22.33± 9.22 µmol/L where as it was 12.59±3.73 µmol/L in control group. Highly significant difference was seen between the mean plasma level of homocysteine in cases and controls (p˂0.001).Simple logistic regression indicates a strong association of coronary heart disease with hyperhomocysteinemia (OR 7.45), which remained significantly associated with coronary heart disease by multivariate logistic regression (OR 7.10, 95%C1 3.12-12.83, p=0.000). The present study concludes that elevated levels of Plasma homocysteine is an independent risk factor for coronary heart disease independent of conventional risk factors and can be used as an indicator for predicting the future possibility for the onset of CVD.

Infectious keratitis in Vietnam: etiology, organisms, and management at Vietnam National Eye Hospital

AIM: To report the etiologies, risk factors, treatments, and outcomes of infectious keratitis (IK) at a major Vietnamese eye hospital. METHODS: This is a retrospective review of all cases of IK at Vietnam National Eye Hospital (VNEH) in Hanoi, Vietnam. Medical histories, demographics, clinical features, microbiological results, and treatment outcomes were reviewed. RESULTS: IK was diagnosed in 1974 eyes of 1952 patients, with ocular trauma being the greatest risk factor for IK (34.2%), frequently resulting from an agriculture-related injury (53.3%). The mean duration between symptom onset and presentation to VNEH was 19.3±14.4d, and 98.7% of patients had been treated with topical antibiotic and/or antifungal agents prior to evaluation at VNEH. Based on smear results of 1706 samples, the most common organisms identified were bacteria (n=1107, 64.9%) and fungi (n=1092, 64.0%), with identification of both bacteria and fungi in 614 (36.0%) eyes. Fifty-five of 374 bacterial cultures (14.7%) and 426 of 838 fungal cultures (50.8%) were positive, with the most commonly cultured pathogens being Pseudomonas aeruginosa, Streptococcus pneumonia, Fusarium spp., and Aspergillus spp. Corneal perforation and descemetocele developed in 391 (19.8%) and 93 (4.7%) eyes, respectively. Medical treatment was successful in resolving IK in 50.4% eyes, while 337 (17.1%) eyes underwent penetrating or anterior lamellar keratoplasty. Evisceration was performed in 7.1% of eyes, most commonly in the setting of fungal keratitis. CONCLUSION: Ocular trauma is a major risk factor for IK in Vietnam, which is diagnosed in almost 400 patients each year at VNEH. Given this, and as approximately one quarter of the eyes that develop IK require corneal transplantation or evisceration, greater emphasis should be placed on the development of prevention and treatment programs for IK in Vietnam.

Impact of Online Emotions and Netiquette on Phubbing from a Gender Perspective: Educational Challenges

During adolescence, the Internet is mainly used for purposes of socialization. Non-verbal elements limit online communication, thus leading to widespread use of emotional resources. It would be preferable if virtual interaction did not reduce the quality of person-to-person contacts, particularly thanks to the adoption of netiquette (respectful treatment of others online). Phubbing, the tendency to check one’s mobile phone during a face-to-face conversation, has become a widespread practice that causes anxiety and can lead to social exclusion. Educating on this behavior could be related with emotional content and with netiquette. This study’s objectives are to analyze the extent to which the use of netiquette and online emotional content are associated with and can predict phubbing, taking gender differences into account. 935 adolescents (ages 12-17, 55,1% female) from 13 schools in the region of Aragon (Spain) responded to our questionnaire. Results are revealing: the level of online emotional content increases the level of phubbing; online emotional expression is the most influential risk factor in both genders; netiquette protects girls to a greater degree. We discuss the educational challenges posed by guaranteeing the responsible use of social networks.

Evaluation of Risks Related to Transfer of Rural Housing Land for Tourism Development in the Context of “Separation of Three Rights” Reform in China

In this paper, based on a field survey on typical villages in a Chinese metropolis suburb, we employ a risk matrix and the Borda ranking method to evaluate risks related to transfer of rural housing land for tourism development from the perspectives of different stakeholders. We also make suggestions regarding how to standardize transfers and revitalize utilization of rural housing land use rights. Combining qualitative analysis and quantitative analysis, the risk matrix determines the various risk levels faced by different stakeholders in the circulation of rural housing land for tourism development from two dimensions: risk impact degree and risk occurrence probability. Then, the Borda ranking method can subdivide the risk types within each risk level, thus identifying the most critical risks. Our results indicate that (1) unfair distribution of income from land transfers is the major risk faced by farm households and directly decides their willingness to transfer their housing land; (2) market instability is the prime risk factor faced by social investors, and together with project progress risk, indirectly leads to occurrence of operation risk and severely affects the motivation of social investors to invest in transfer, development and operation of rural housing land for tourism development; (3) disappearance of countryside characteristics is the critical risk factor faced by village collectives, and coordination and management risk is the main impediment that blocks the process of transfer of rural housing land for tourism development; and (4) other risks confronted by stakeholders in land transfer, although not the main ones, still need to be granted great importance and followed up closely. Therefore, it is necessary not only to establish appropriate risk avoidance measures for different critical risk factors faced by different stakeholders of such land transfers, but also to strengthen study of the association between the risks, identify the conduction effect of direct and indirect risks, macro and micro risks, and before action and after action risks, and improve the ability to prevent and mitigate these risks.

False Additives in Canned Meats as a Source of Food Allergens

The introduction of undeclared ingredients into a food product formulation can lead to serious health problems, especially in people with allergic diseases. Identification of the composition of a food product helps to prevent possible negative consequences of the influence of allergic additives. The present study was carried out by the histological method using the example of canned meat as the most frequently falsified product. Plant-based protein products and thickening food additives were found in many samples. Conclusions are made about a high level of counterfeiting of this type of product, including allergens, which is a risk factor for human health.