Prevalence of Nutritional Anemia and Its Causes among Adolescent Girls

Background: Nutritional anemia is a disorder that cause due to a lack of one or more vital nutrients, such as iron, protein, vitamin B12, and other vitamins and minerals. In this condition hemoglobin content in the blood is lower than usual. Nutritional anemia has been described as correlated with reduced childhood emotional, physical, and cognitive function and is a major risk factor for maternal mortality. Objective: 1. To assess the prevalence of nutritional anemia among adolescent girls. 2. To assess the causes of nutritional anemia among adolescent girls. 3. To associate the demographic variable with prevalence and causes of nutritional anemia among adolescent girls. Methodology: This is a cross sectional observational study will be conducted among the adolescent girls where age is between 10-14 years, the sample size can be calculated statistically by using the prevalence of previous studies which done in India and the sample size is 220 adolescent girls selected in a particular rural community area of Wardha district. Non-probability convenience sampling will be using for sample collection. The standard haemoglobinometer (Accusure HB meter) for analyzing the haemoglobin according to WHO criteria and structure questionnaire scale is made upon the causes behind the nutritional anemia. According to some previous studies, the prevalence rate has been shown high in the adolescent age group so this study help to find the prevalence rate in a particular community and the causes of nutritional anemia among adolescent girls. Expected Results: In this study the researcher evaluate the prevalence and its causes of nutritional anemia among adolescent girls, this study will show the rate of prevalence in the particular community area and also the causes of nutritional anemia among adolescent girls. Conclusion: The conclusion will be drawn from the results.

Food Choice Decisions of Collegiate Division I Athletes: A Qualitative Exploratory Study

Limited research has examined athletes’ food and health beliefs and decisions and the congruence of these decisions with recommendations from nutrition professionals. This study aimed to improve understanding of athletes’ food-related beliefs and practices to enable nutrition professionals to more effectively enhance performance while protecting athletes’ health. Division I college athletes (n = 14, 64% female) from a variety of sports were recruited to participate in 20-min semi-structured phone interviews about food and nutrition-related behaviors and cognitions. Data were content analyzed to identify themes and trends. Prominent factors influencing athletes’ food choices were potential benefits to health and performance, availability of foods, and recommendations from sports dietitians. Foods commonly consumed by athletes, including fruits, vegetables, and lean protein, were generally healthy and aligned with sports nutrition recommendations. Athletes avoided energy-dense nutrient-poor foods, such as fast food and fried foods, with the goal of improving performance. Some athletes took supplements (i.e., multivitamin, iron, protein) on the premise that they would improve health and enhance performance or recovery. While athletes’ nutrition behaviors are generally congruent with current recommendations, findings highlighted misconceptions held by athletes related to the benefits of some supplements and the belief that packaged/processed foods were inherently less healthy than other options. Nutrition misconceptions held by athletes and incongruities between athletes’ nutrition knowledge and behaviors suggest that dietitians should aim to dispel misconceptions held by athletes and provide additional guidance and information to support athletes’ current healthful behaviors to ensure these behaviors extend beyond their college athletic career.

Moringa (Moringa oleifera L.): An underutilized and traditionally valued tree holding remarkable potential

Moringa (Moringa oleifera L.) commonly known as “drumstick tree” belongs to the family Moringaceae. It is now grown worldwide but its native region is India. It is a fast-growing tree that responds to low inputs and has high regeneration potential after cutting. Its nutritional value and capacity to grow economically in different soils and environmental conditions make it a wonder tree. It is highly nutritious and each part is being utilized in various forms. It is widely cultivated for its young pods, flowers, and leaves for use as traditional herbal medicine and vegetable. It is also used by indigenous people in the tropics and sub-tropics as a source of remedies. The leaves are also used as a source of fodder in many countries of the world as they can sustain green fodder availability around the year without extra efforts. Various parts of this tree are good sources of ascorbic acid, calcium, iron, protein, and antioxidant compounds. Hence, its remarkable properties help to fight nutritional deficiency, human diseases and improve the performance of livestock.

STUDY OF THE SAFETY OF ANTIANEMIC PREPARATIONS BY METHOD OF THE SYSTEM OF PROBLEMS RELATED TO MEDICINAL PREPARATIONS

Iron deficiency is the most common micronutrient deficiency worldwide. Prevention and treatment of iron deficiency conditions are some of the most important health problems in many countries of the world. At the same time, the main problems for it remain the timely diagnosis, elimination of the cause, as well as the choice of replacement therapy with iron-containing drugs and correction of adverse reactions (ADR) that occur during their use.The aim. This research aims to study the peculiarities of the development of antianaemic drugs ADRs in patients living in the territory of the Republic of Crimea.Materials and methods. The objects of research were cases of ADR occurrence associated with the use of a group of antianaemic drugs and revealed during the 2009-2018 period in the territory of the Republic of Crimea. The main tasks in the analysis of notification forms were the study of the ADR severity, the causality assessment for suspected drugs and ADRs, as well as analysis of particular problems associated with the use of antianaemic drugs (Drug-related problems, DRP).Results. Iron supplements in combination with other drugs became the leaders in the incidence of ADR among antianaemic drugs (28 cases, 42.4% of all cases of ADR). The largest number of cases was registered in patients aged from 18 to 30 years, with female patients prevailing. Among the clinical manifestations of ADR, the most cases were drug hypersensitivity reactions of varying severity (40 cases) and disorders of the gastrointestinal tract (18 cases). The study of the problems associated with the use of antianaemic drugs made it possible to determine that the highest rates of DRP values were observed with the use of iron preparations for parenteral use and cyanocobalamine. The minimal DRP values were observed when prescribing iron protein succinylate preparations.Conclusion. The basis of pharmacotherapy for various types of anemias is the replenishment of iron and vitamin B12 (cyanocobalamin) depots. The effectiveness of the treatment in these cases largely depends on the patient's adherence to treatment, which is, in turn, depends on the frequency and severity of ADRs that occur during the use of antianaemic drugs.

Nutrological Management in Bariatric Surgery: A Narrative Review

Nutrology based on the analysis of benefits and harms generated by the ingestion of nutrients and assessing individual organic needs promotes the maintenance of health and the reduction of disease risk, as well as the treatment of manifestations of deficiency or excess. Obesity is defined by a body mass index greater than 30 kg/m². Its manifestation is the sum of genetic and environmental factors, this through sedentary lifestyle and caloric intake greater than energy consumption. There are many ways to deal with obesity, from behavioral changes such as a balanced diet and physical exercises, pharmacological and even surgical measures of different modalities, with Roux-en-Y gastric bypass surgery being the most used technique in Brazil. The most common postoperative nutritional deficiencies are iron, protein, calcium, folate, thiamine, zinc, copper, and vitamins D, B12, A, C, and K. In this case, we present the importance of nutrology in monitoring patients after bariatric surgery. This research made use of a bibliographic survey, giving priority to articles dated from the last 5 years, using the databases Lilacs, Medline, bireme, where articles, dissertations, and theses were consulted, in search of the following keywords, obesity, bariatric surgery, and nutritional deficiency, post-bariatric feeding.

Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses

Oral iron supplementation constitutes the first line treatment for iron deficiency anemia (IDA), with daily doses between 80 mg and 200 mg of elemental iron. Ferrous salts, such as ferrous sulphate (FeSO4), while efficacious, frequently give rise to gastrointestinal side effects. In the present paper we attempted to directly compare the efficacy of an alternative to the FeSO4 formulation, which presents a better tolerability profile, iron protein succinylate (Ferplex®). In a diet-induced anemia model, rats were treated by oral gavage with vehicle, FeSO4, or Ferplex® at a human-dose equivalent of 80 mg and 200 mg of elemental iron. We evaluated the change in anemia-related hematological and biochemical parameters, conducting a histological examination of the intestine at sacrifice. Results indicate that both types of iron supplementation are equally effective in the treatment of IDA, restoring hemoglobin, hematocrit, erythrocytes, free iron and transferrin levels in 15 days, with no statistical differences between treated groups and control. The impact of anemia on body weight was also attenuated following treatment with both iron supplements. Thrombocyte and reticulocyte levels, altered by the anemic condition, returned to homeostasis after 15 days of either FeSO4 or Ferplex® treatment. Importantly, the lower and higher doses of iron were equally effective, thus supporting the current school of thought which states that lower therapeutic doses are sufficient for management of IDA. In addition, the study shows for the first time that oral treatment with Ferplex® does not increase serum hepcidin. Finally, Ferplex® induced minimal iron depositions in the intestinal tissue compared to FeSO4.

Local Electric Fields as a Natural Switch of Heme-Iron Protein Reactivity

Heme-iron oxidoreductases operating through the high-valent Fe^IVO intermediates perform crucial and complicated transformations, such as oxidations of unreactive saturated hydrocarbons. These enzymes share the same Fe coordination, only differing by the axial ligation, e.g., Cys in P450 oxygenases, Tyr in catalases, and His in peroxidases. By examining ~200 heme-iron proteins, we show that the protein hosts exert highly specific intramolecular electric fields on the active sites, and there is a strong correlation between the direction and magnitude of this field and the protein function. In all heme proteins, the field is preferentially aligned with the Fe‒O bond (<b><i>F_z</i></b>). The Cys-ligated P450 oxygenases have the highest average <b><i>F_z</i></b> of 28.5 MV cm^-1, i.e., most enhancing the oxyl-radical character of the oxo group, and consistent with the ability of these proteins to activate strong C‒H bonds. In contrast, in Tyr-ligated proteins, the average <b><i>F_z</i></b> is only 3.0 MV cm^-1, apparently suppressing single-electron off-pathway oxidations, and in His-ligated proteins, <b><i>F_z</i></b> is –8.7 MV cm^-1. The operational field range is given by the trade-off between the low reactivity of the Fe^IVO Compound I at the more negative <b><i>F_z</i></b>, and the low selectivity at the more positive <b><i>F_z</i></b>. Consequently, a heme-iron site placed in the field characteristic of another heme-iron protein class loses its canonical function, and gains an adverse one. Thus, electric fields produced by the protein scaffolds, together with the nature of the axial ligand, control all heme-iron chemistry.

Local Electric Fields as a Natural Switch of Heme-Iron Protein Reactivity

Heme-iron oxidoreductases operating through the high-valent Fe^IVO intermediates perform crucial and complicated transformations, such as oxidations of unreactive saturated hydrocarbons. These enzymes share the same Fe coordination, only differing by the axial ligation, e.g., Cys in P450 oxygenases, Tyr in catalases, and His in peroxidases. By examining ~200 heme-iron proteins, we show that the protein hosts exert highly specific intramolecular electric fields on the active sites, and there is a strong correlation between the direction and magnitude of this field and the protein function. In all heme proteins, the field is preferentially aligned with the Fe‒O bond (<b><i>F_z</i></b>). The Cys-ligated P450 oxygenases have the highest average <b><i>F_z</i></b> of 28.5 MV cm^-1, i.e., most enhancing the oxyl-radical character of the oxo group, and consistent with the ability of these proteins to activate strong C‒H bonds. In contrast, in Tyr-ligated proteins, the average <b><i>F_z</i></b> is only 3.0 MV cm^-1, apparently suppressing single-electron off-pathway oxidations, and in His-ligated proteins, <b><i>F_z</i></b> is –8.7 MV cm^-1. The operational field range is given by the trade-off between the low reactivity of the Fe^IVO Compound I at the more negative <b><i>F_z</i></b>, and the low selectivity at the more positive <b><i>F_z</i></b>. Consequently, a heme-iron site placed in the field characteristic of another heme-iron protein class loses its canonical function, and gains an adverse one. Thus, electric fields produced by the protein scaffolds, together with the nature of the axial ligand, control all heme-iron chemistry.