scholarly journals Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 968
Author(s):  
Katia Urso ◽  
Javier Leal Martínez-Bujanda ◽  
Jaime Moscoso del Prado
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Ferrous Sulphate ◽  
Deficiency Anemia ◽  
Tolerability Profile ◽  
Iron Protein ◽  
Elemental Iron ◽  
Therapeutic Doses ◽  
The Impact

Oral iron supplementation constitutes the first line treatment for iron deficiency anemia (IDA), with daily doses between 80 mg and 200 mg of elemental iron. Ferrous salts, such as ferrous sulphate (FeSO4), while efficacious, frequently give rise to gastrointestinal side effects. In the present paper we attempted to directly compare the efficacy of an alternative to the FeSO4 formulation, which presents a better tolerability profile, iron protein succinylate (Ferplex®). In a diet-induced anemia model, rats were treated by oral gavage with vehicle, FeSO4, or Ferplex® at a human-dose equivalent of 80 mg and 200 mg of elemental iron. We evaluated the change in anemia-related hematological and biochemical parameters, conducting a histological examination of the intestine at sacrifice. Results indicate that both types of iron supplementation are equally effective in the treatment of IDA, restoring hemoglobin, hematocrit, erythrocytes, free iron and transferrin levels in 15 days, with no statistical differences between treated groups and control. The impact of anemia on body weight was also attenuated following treatment with both iron supplements. Thrombocyte and reticulocyte levels, altered by the anemic condition, returned to homeostasis after 15 days of either FeSO4 or Ferplex® treatment. Importantly, the lower and higher doses of iron were equally effective, thus supporting the current school of thought which states that lower therapeutic doses are sufficient for management of IDA. In addition, the study shows for the first time that oral treatment with Ferplex® does not increase serum hepcidin. Finally, Ferplex® induced minimal iron depositions in the intestinal tissue compared to FeSO4.

Role of Iron Supplementation in Reducing Severity of Depression: A Review

2020 ◽  
pp. 67-76
Author(s):  
OJS Admin
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Reproductive Age ◽  
Deficiency Anemia ◽  
Essential Nutrient ◽  
Severity Of Depression ◽  
The Impact ◽  
Clinical Problems

Depression is a public health disorder, ranking third after respiratory and cardiac diseases. There were many evidences that iron deficiency anemia (IDA) is one of the foremost causes regarding nutritional pointof view for depression. We reviewed these evidences that IDAlinking to depression. We identified seventeen studies in four databases including randomized-controlled trials (RCTs) and observational studies assessing the impact of IDAand iron supplementation on the risk of depression. We extracted data on the basis of sample size, geographical region, measures of depression, hemoglobin, iron levels and intake of iron supplementation and critically appraised the results from the studies. Eleven out of sixty one studies were experimental, which indicated that dietary supplementation particularly iron supplementation had an association (r − 0.19 to −0.43 and ORs 1.70–4.64) with severity of depression. Evidences showed that women of reproductive age were more vulnerable to iron deficiency anemia than other population. Low ferritin and low hemoglobin level were associated with severity of depression. Iron is an essential nutrient for all living creatures, as a cofactor of various enzymes and plays significant role in environmental stimulant for the articulation of numerous virulence factors. Many clinical problems are caused by iron deficiency. Therefore, this review intended to highlight the important role of iron supplementation in reducing the severity of depression.

scholarly journals Association of Iron Supplementation Programs with Iron-Deficiency Anemia Outcomes among Children in Brazil

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1524
Author(s):  
Carolina Thalya da Silva Paulino ◽  
Marislei Nishijima ◽  
Flavia Mori Sarti
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Fixed Effects ◽  
Iron Supplementation ◽  
Deficiency Anemia ◽  
Federal Programs ◽  
Government Programs ◽  
Lengths Of Stay ◽  
Social Inequities ◽  
High Prevalence

Anemia remains a condition with high prevalence in populations worldwide, and the prevalence of anemia among children under five years old in Brazil is approximately 40%, being higher in communities marked by social inequities. Diverse government programs during recent decades targeted iron-deficiency anemia, considering its impacts throughout the lifetime. The objective of this study was to investigate the effects of two government iron supplementation programs on health outcomes related to iron-deficiency anemia among children up to 4 years old in Brazilian municipalities. A longitudinal panel encompassing data from 5570 municipalities from 1998 to 2019 was investigated using a difference-in-differences framework with multiple interventions and distinct times of adhesion, and fixed-effects models were estimated to control for invariant municipal characteristics throughout the period in order to ensure comparability. The results indicate significant effects of the federal programs in reducing hospitalizations and lengths of stay due to iron-deficiency anemia, especially in non-poor municipalities. There was complementarity in the effects of the programs; however, neither of the programs influenced mortality rates. Thus, it is important to consider possible improvements in the operationalization of the programs, in order to achieve better results in the reduction of severe iron-deficiency anemia among children up to 4 years old.

Effects of Different Doses and Duration of Iron Supplementation on Curing Iron Deficiency Anemia: an Experimental Study

2014 ◽  
Vol 162 (1-3) ◽  
pp. 242-251 ◽  
Author(s):  
Juan Ma ◽  
Xiaosha Wen ◽  
Fengfeng Mo ◽  
Xiaoli Wang ◽  
Zhilei Shen ◽  
...  
Keyword(s):  
Experimental Study ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Deficiency Anemia ◽  
Different Doses

scholarly journals The impact of Helicobacter pylori infection on iron deficiency anemia in pregnancy

2017 ◽  
Vol 6 (2) ◽  
pp. 60 ◽  
Author(s):  
EamanMarouf Muhammad ◽  
MiamiAbdul Hassan Ali ◽  
BanHadi Hameed ◽  
HalaHashim Hasoobe
Keyword(s):  
Helicobacter Pylori ◽  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Helicobacter Pylori Infection ◽  
Deficiency Anemia ◽  
Anemia In Pregnancy ◽  
The Impact ◽  
In Pregnancy

scholarly journals Iron supplementation in goitrous, iron-deficient children improves their response to oral iodized oil

2000 ◽  
pp. 217-223 ◽  
Author(s):  
M Zimmermann ◽  
P Adou ◽  
T Torresani ◽  
C Zeder ◽  
R Hurrell
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Iron Supplementation ◽  
Thyroid Volume ◽  
Oral Iron ◽  
Deficiency Anemia ◽  
Urinary Iodine Concentration ◽  
Iodized Oil ◽  
Iron Deficient ◽  
Group 2

OBJECTIVE: In developing countries, many children are at high risk for both goiter and iron-deficiency anemia. Because iron deficiency may impair thyroid metabolism, the aim of this study was to determine if iron supplementation improves the response to oral iodine in goitrous, iron-deficient anemic children. DESIGN: A trial of oral iodized oil followed by oral iron supplementation in an area of endemic goiter in the western Ivory Coast. METHODS: Goitrous, iodine-deficient children (aged 6-12 years; n=109) were divided into two groups: Group 1 consisted of goitrous children who were not anemic; Group 2 consisted of goitrous children who were iron-deficient anemic. Both groups were given 200mg oral iodine as iodized oil. Thyroid gland volume using ultrasound, urinary iodine concentration (UI), serum thyroxine (T(4)) and whole blood TSH were measured at baseline, and at 1, 5, 10, 15 and 30 weeks post intervention. Beginning at 30 weeks, the anemic group was given 60mg oral iron as ferrous sulfate four times/week for 12 weeks. At 50 and 65 weeks after oral iodine (8 and 23 weeks after completing iron supplementation), UI, TSH, T(4) and thyroid volume were remeasured. RESULTS: The prevalence of goiter at 30 weeks after oral iodine in Groups 1 and 2 was 12% and 64% respectively. Mean percent change in thyroid volume compared with baseline at 30 weeks in Groups 1 and 2 was -45.1% and -21.8% respectively (P<0.001 between groups). After iron supplementation in Group 2, there was a further decrease in mean thyroid volume from baseline in the anemic children (-34.8% and -38.4% at 50 and 65 weeks) and goiter prevalence fell to 31% and 20% at 50 and 65 weeks. CONCLUSION: Iron supplementation may improve the efficacy of oral iodized oil in goitrous children with iron-deficiency anemia.

scholarly journals Associations Between Iron Deficiency Anemia and Wages in India: A Secondary Data Analysis (P22-016-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Sanchit Makkar ◽  
Sumedha Minocha ◽  
Kishor Bhat ◽  
Anjaly John ◽  
Sumathi Swaminathan ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Least Square ◽  
Sample Survey ◽  
Deficiency Anemia ◽  
Research Centre ◽  
Iron Fortification ◽  
Percentage Points ◽  
Wide Range ◽  
The Impact

Abstract Objectives Economic analyses add value beyond evidence to the implementation of any policy. The study explored the association between iron deficiency anemia (IDA) and the wages of adult men and women between 15- 49 years in India so that the possible monetary benefits of iron fortification policies could be evaluated. Methods National sample survey organization (NSSO) Employment- Unemployment data was statistically matched with the NSSO Consumer Expenditure data at an individual level for the year 2011–12. The anemia levels (assuming 50% of anemia was due to iron deficiency) was mathematically modelled in response to a wide range of nutrient intakes, including iron intake from heme and non-heme sources along with inhibitors and enhancers in the diet, adjusting for bioavailability, sanitation and menstrual losses in women. A two-stage Heckman selection model was used to establish the association between wages and IDA. In the first stage, a probit model was used to determine labour force participation and in the second stage, an ordinary least square model, corrected for sample selection bias, was used to determine the impact of IDA on wages. Results The presence of IDA resulted in a decline of 15.3 percentage points in wages of regular salaried employed men as compared to those without IDA. Similar patterns was observed for women but the impact of anemia on wages was lower in comparison to men. Among women, a decline of 8.0 percentage points was observed in the wages of regular salaried employed women compared to those without IDA. However, the presence of IDA had no significant impact on the wages of casual labourers. This indicated that there were other random factors that affected the wages of this segment of population. Conclusions There is an association between IDA and wages for a segment of working population. Addressing anemia through iron fortification programs such as the usage of double fortified salt could possibly change living standards of the population through improvement in earnings. Funding Sources International Development Research Centre, Canada; Tata Trusts, India.

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