Notes on Potentilla (Rosaceae) of Altai. 9. A new species from Kuraisky Ridge

Based on morphological characters, a new species Potentilla friesenii collected from alpine belt of Kuraisky Ridge (Altai Mts.) is described. The novelty belongs to Potentilla sect. Chrysanthae; it is most closely related to P. asiatica but differs from the latter by styles not or somewhat widened and smooth to slightly verrucose (vs. always somewhat widened and strongly verrucose) at base as well as the presence of numerous violet glands on sepals. Stability of these differences are confirmed by several years of observation in the wild and in introduction. Illustration of the new species, image of its type specimen, and distribution map are adduced; the area of P. asiatica within Altai Mts. is also presented. A novel morphological feature separating P. asiatica and P. chrysantha is found: staminal ring in P. asiatica (as well as in the new species) is dark violet while it is pale in P. chrysantha. The name P. asiatica is lectotypified.

Morphodynamical cell-state description via live-cell imaging trajectory embedding

Time-lapse imaging provides powerful insight into the dynamical response of cells to perturbation, but the quantitative analysis of morphological changes over time is a challenge. Here, we exploit the concept of "morphodynamical trajectories" to analyze cellular behavior using morphological feature trajectory histories, rather than the common practice of examining morphological feature time courses in the space of single-timepoint (snapshot) morphological features. Our morphodynamical trajectory embedding analysis yielded quantitative and descriptive models of future time points based on the extended history information of MCF10A mammary epithelial cells treated with a panel of ligands. The trajectory analysis constructs a shared morphodynamical cell-state landscape, where the response of MCF10A cells induced by various extracellular signals is characterized by ligand-specific regulation of state transitions. Additionally, we show that including trajectories in single-cell morphological analysis enables (i) systematic characterization of cell state trajectories, and (ii) better separation of phenotypes and more descriptive models of ligand-induced differences as compared to snapshot-based analysis. This morphodynamical trajectory embedding is broadly applicable for the quantitative analysis of cell responses via live-cell imaging across many biological and biomedical applications.

/ka-/ negative prefix of Choswateng Tibetan of Khams (Shangri-La, Yunnan)

Choswateng Tibetan, spoken in the south-eastern corner of the Khams region, has three negative prefixes: /ȵi-/, /ma-/, and /ka-/. The first two are derived from two morphemes which are ubiquitous across Tibetic languages, whereas the third is a newly generated negative prefix found in Choswateng Tibetan as well as its surrounding dialects belonging to the rGyalthang subgroup of Khams and its neighbours. This article describes the morphological feature and use of the prefix /ka-/ in Choswateng Tibetan. Morphologically, the prefix /ka-/ can co-occur with most verbs except for the copulative verb /ˊreʔ/. Pragmatically, the prefix /ka-/ occurs and is restricted in the following ways: (1) expresses ‘definitely not’ for statements regarding the self, and ‘possibly not, judging from the speaker’s knowledge’ for statements regarding others; (2) co-occurs with egophoric and sensory evidentials; (3) is not used for a negation of accomplished aspect; and (4) does not deprive the function of the other two negative prefixes. These two analyzes are mutually related; it is suggested that the reason why /ka-/ cannot co-occur with the copulative verb /ˊreʔ/ is triggered by a contradiction of implied evidentials: /ka-/ is related to egophoric and sensory, whereas /ˊreʔ/ is statemental. Following the description of its use, we discuss the origin of /ka-/, claiming a possible grammaticalization from an interrogative word gar (‘where’ in Literary Tibetan and common throughout the rGyalthang area) in a rhetorical question to a prefix. Referring to several morphological features of /ka-/, we consider its grammaticalization as ongoing, but most advanced in Choswateng Tibetan.

Photogallery. Sarcoidosis (part 1)

Sarcoidosis (synonym: BenierBeckSchaumann disease, benign granulomatosis, chronic epithelioid cell reticuldoendotheliosis) ― is a multisystem disease from the group of granulomatosis, of unknown etiology, the morphological feature of which is the development of epithelioid cell granulomas without caseous necrosis fibrosis in the tissues of various organs. Taking into account the variety of clinical lesions, there are three main forms: extrathoracic, intrathoracic, mixed (generalized).

Morphological classification and origin of lake depressions in Mongolia

An improved classification of the origin of lake depressions due to geological, geomorphological factors and climate change is a requirement of the day in Mongolia. We present a new holistic classification using comparative analysis method. This study suggests a two-tier classification in terms of origin and morphological feature of the lakes, which replaces the previous one-tier classification. Mongolia has identified 11 main and 26 subtypes of origin, and 8 main types of morphology, based on the features of 32 lake depressions. The result of the study shows that the lakes of Mongolia developed in 3 stages, first, affected by tectonic movement, followed by glacial and finally, owing to other exogenic factors. This morphological classification study will create the basic conditions for preserving and using these lakes more efficiently and ecologically in the future by making the classification of the origin of lake depression.

The Association of Left Atrial Appendage Morphology to Atrial Fibrillation Recurrence After Radiofrequency Ablation

Objective: The probability of late recurrent atrial fibrillation (AF) after radiofrequency ablation (RFA) has not yet been fully clarified. This study aims to study the association of left atrial appendage (LAA) morphology with AF recurrence after RFA.Methods: We retrospectively enrolled 84 patients (24 patients had persistent AF, 60 patients had paroxysmal AF) who underwent RFA in Shanghai East Hospital from June 2014 to May 2018. The mean follow-up of these patients was 618.6 days. According to preoperative transesophageal echocardiography (TEE), the morphology feature of LAA was classified and evaluated by two classification methods. The first method was divided into chicken-wing, windsock, cactus, and cauliflower, and the second method was divided into one lobe, two lobes, and multiple lobes. The correlation between morphological feature of LAA and the recurrence rate of AF after RFA was analyzed.Results: During follow-up, 12 patients (50%) and 10 patients (16.7%) had AF recurrence in persistent and paroxysmal AF, respectively. The LAA morphology was associated with the recurrence of AF after RFA with the chicken-wing highest recurrence risk (68.2%). The structure type of LAA was also related to the AF recurrence rate (p < 0.01). Compared with one lobe and multiple lobes, two lobes (recurrence, 47.6%) were more likely associated with the recurrence of AF (p < 0.02). Logistic regression analysis showed that the chicken-wing group had a higher risk of recurrence after RFA (OR = 8.13, p = 0.004), and the windsock group had a lower risk of recurrence (OR = 0.17, p = 0.002).Conclusion: The morphological feature of LAA is related to the recurrence risk of AF after RFA. LAA morphology assessment can predict the risk of AF recurrence.

Correlation of Angle SNA to Angle NSAR in Normal Occlusion, Class II Division I and Class III Malocclusion in Vidarbha Region - A Cephalometric Study

BACKGROUND Facial prognathism may be because of prognathic maxilla, prognathic mandible or aggregate of both. Numerous studies performed to diagnose a single morphological feature commonly producing protrusive relationship, revealed that ‘a single morphological feature does not ordinarily produce a protrusive relationship. Existence of structural imbalance in one area also affects the nature of balance in other areas. A number of separate but inter-related cause and effect factors tend to augment each other in a cumulative and composite manner. Effect of marked discrepancy of an individual’s facial part could be cancelled or nullified by deviation of another part in opposite direction, ultimately resulting in good facial harmony. In this study by means of cephalometric roentgenography, the relation between Angle SNA and Angle NSAr was assessed in Vidharbhites, having normal occlusion, Class II division I and class III malocclusion. METHODS 40 individuals of normal occlusion, Class II division I and Class III Malocclusion, each between 16 and 25 years were analysed. These subjects were selected from patients reporting the outpatient department of Government Dental College, Nagpur. Statistically correlation between angles SNA and NSAr at level of significance 5 % was assessed. RESULTS After data collection a thorough observation & analysis was done and co-relation coefficient between SNA angle & NSAr (F--1.054 M--0.7981), also standard deviation of angular cephalometric measurement between males & females was found out in the population, leading to discussion on topic ‘Facial prognathism is due to maxillary prognathism, mandibular prognathism or combination of both’. In Females SNA was found to be 81 - 800 1.91310 and in males SNA was 82.1660 4. 380 respectively. CONCLUSIONS The results inferred that “Marked part of variation in Angle SNA can be explained by variation in Angle NSAr. KEY WORDS Angle SNA, Angle NSAr, Correlation