In Vivo Reflectance Microscopy of Meissner Corpuscles and Bedside Measures of Large Fiber Sensory Function: A Normative Data Cohort

Background and Objectives:To establish age-, gender- and body dimension-adjusted normal cut-off values for Meissner’s corpuscle (MC) densities via in-vivo reflectance confocal microscopy (RCM), timed vibration sensory thresholds using a 128Hz tuning fork, and touch-pressure sensory thresholds using standardized monofilaments, for clinical and research application.Methods:77 prospectively recruited individuals without signs or symptoms of peripheral neuropathy or a condition or neurotoxin exposure that can alter sensory function underwent cross-sectional evaluation of MC densities via in-vivo RCM, monofilament touch-pressure sensory thresholds, and timed vibration sensory thresholds in non-dominant upper and lower extremities. Age-, gender-, and body dimension- (e.g., height) adjusted normal values were developed. The 5th percentile for MC densities and timed vibration thresholds and 95th percentile for MF touch-pressure thresholds were selected as normal cut-off points.Results:Subjects were aged 9 to 89 years old. Age and gender were uniformly distributed. Timed vibration and touch-pressure thresholds were less sensitive with increasing age and were more sensitive in the hand than in the leg or foot within individuals. Timed vibration thresholds did not differ by gender or body dimensions. Touch-pressure thresholds were lower (more sensitive) at the thenar eminence and digit V in the hand in women compared to men but otherwise did not differ by gender at other measurement locations. Body dimensions did not affect touch-pressure thresholds. There were no apparent age-related floor effects for the 5th and 95th percentile normal cutoff values for timed vibration or touch-pressure thresholds, respectively. MC densities also declined with age and were highest at digit V and lowest at the arch within individuals. MC densities were affected by gender or body dimensions at all imaging sites, with lower densities seen in males or larger individuals. MC densities were quantifiable in the hand of all participants and were associated with touch-pressure thresholds at all locations.Discussion:This study establishes age-, gender- and body dimension-adjusted normal cut-off values for two easily applied measures of large fiber sensory function and RCM assessment of MC densities for multiple limb locations. These results will aid in the detection and monitoring of peripheral sensory nerve disorders.

Ergonomic Consideration in Pillow Height Determinants and Evaluation

(1) Background: Sleep problems have become one of the current serious public health issues. Pillow height affects the alignment of the cervical spine and is closely related to the mechanical environment of the cervical spine. An appropriate pillow height can provide adequate support for the head and neck to reduce the stress in the cervical spine and relax the muscles of the neck and shoulder, thereby relieving pain and improving sleep quality. (2) Methods: We reviewed the current trends, research methodologies, and determinants of pillow height evaluation, summarizing the evidences published since 1997. In particular, we scrutinized articles dealing with the physiological and mechanical characteristics of the head-neck-shoulder complex. (3) Results: Through the investigation and analysis of these articles, we presented several quantitative and objective determinants for pillow height evaluation, including cervical spine alignment, body dimension, contact pressure, and muscle activity. The measurement methods and selection criteria for these parameters are described in detail. However, the suggested range for achieving optimal cervical spine alignment, appropriate pressure distribution, and minimal muscle activity during sleep cannot yet be identified considering the lack of sufficient evidence. Moreover, there remain no firm conclusions about the optimal pillow height for the supine and lateral positions. (4) Conclusions: A comprehensive evaluation combining the above determinants provides a unique solution for ergonomic pillow design and proper pillow height selection, which can effectively promote the public sleep health. Therefore, it is necessary to develop a reasonable algorithm to weigh multiple determinants.

Designing Statistical Models for Holstein Rearing Heifers’ Weight Estimation from Birth to 15 Months Old Using Body Measurements

Body measurements could be used to estimate body weight (BW) with no need for a scale. The aim was to estimate heifers weight based on their body dimension characteristics. Twenty-five Holstein heifers represent the study group (SG); another 13 animals were evaluated as a validation group (VG). All the heifers were weighed (BW) and their wither height (WH), shin circumference (SC), heart girth circumference (HG), body length (BL), hip width (HW) and body condition score (BCS) were measured immediately after birth, and then weekly until 2 months and monthly until 15 months old. Equations were built with a stepwise regression in order to estimate the BW at each time using body measures for the SG. A linear regression was applied to evaluate the relationship between the estimated BW and the real BW. Equations found were to be statistically significant (r2 = 0.688 to 0.894; p < 0.0001). Three variables or fewer were needed for BW estimation a total of 11/23 times. Regression analysis indicated that the use of HG was promising in all the equations built for BW estimation. These models were feasible in the field; further studies will evaluate possible modifications to our equations based on different growing rate targets.

Emergency evacuation simulation of commercial aircraft

In order to receive certification approval for new products, aircraft manufacturers have to comply with the specifications regarding cabin evacuation. In case of real evacuation trials, agent-based simulation can be deployed, as they are a less cost-intensive mean of analysing passenger behaviour during the evacuation of commercial aircraft. This paper aims at examining the suitability of agent-based simulation software to reproduce passenger behaviour during evacuation processes. For this purpose, the algorithms and methods of the software PATHFINDER are introduced. Besides, the cabin of a single aisle aircraft is reconstructed in a high-density configuration using software-specific tools. A representative passenger distribution is implemented according to EASA regulations. Evacuation simulations for a single-aisle aircraft are conducted taking EASA standards into account. The effect of vital parameters such as walking speed, body dimension, conflict behaviour, collision response, acceleration time and exit allocation on evacuation times are examined. Results are discussed and examined for plausibility in order to determine whether evacuation simulations of commercial aircraft are possible using agent-based simulation software.

Feed intake, morphological characteristics and economics of production of Red Sokoto goats fed urea treated ensiled cowpea husk based diets

Body dimension measurements have been used in estimating body weight and appropriate pricing of meat animals. Thus, 18 healthy intact growing Red Sokoto male goats, with 13.4±0.59 kg body weight (BW), were used in a completely randomized design to evaluate the inclusion rates of urea treated ensiled cowpea husk (UECH) at 0, 35 and 70% to replace 0, 50 and 100% of dried brewers' grains (DBG) on voluntary intake, body weight, morphological and testicular characteristics, and economics of production for 70 d. Daily intakes of dry matter (g/d and % BW), crude protein, organic matter, nitrogen free extract, neutral detergent fibre and lignin were not (p>0.05) affected by diets. Whereas intakes of ether extract and hemicellulose progressively decreased (p<0.05), intakes of cellulose and mineral contrastingly increased (p<005) with increasing UECH replacement for DBG. Intake of acid detergent fibre was greater (p<0.05) for the treatment diets relative to the control diet. Diet effects on the body weight, linear body measurements and testicular morphology of the goats were marginal (p>0.05), except for initial scrotal length which was markedly (p<0.05) affected. Cost of feeding declined with the increasing UECH rate in the diet. Cost of feed consumed/goat and cost of feeding/kg BW gain were higher (p<0.05) for the control diet than for the treatment diets. In contrast to savings on cost of feeding which was higher (p<0.05) for 70%UECHthan 35%UECH, differential and relative benefitswere outstanding (p<0.05) for 35%UECH. Value of chevon and net benefitwere greater (p<0.05) for 35% UECH relative to 0 and 70% UECH. These findings suggest that UECH can be safely used up to 70% level in a concentrate mixture for growing goats, completely substituting dried brewers' grains, without depressing voluntary intake, body weight, morphological and testicular parameters, and improve economic benefits to farmers. However, for better economic returns, 35%UECHis superior to70%UECH.

Shared variability in body shape characters at growing phase of indigenous piglets

Body measurement traits, body length (BL) , rump height (RH), rump length (RL), rump width (RW), shoulder width (SW), wither height (WH), heart girth (HG), and flank length (FL) of 52 piglets of indigenous breed, managed under traditional system were obtained at birth and at weaning, to evaluate the sources of shared variability and efficiency of weight determination. Factor analysis reveals four factors accounting for 89.53% at birth and three factors accounting for 73.52% at weaning. Most common variability in body dimension at birth and at weaning could be accounted for by factors representing general size and RL in both cases. Body conformation “shape” was controlled by common and unique factors at both ages. Amount of variation associated with shape characters increased with advancing age and accuracy of weight estimation decreased with increase in age.

Bayesian principal component analysis of Nigerian indigenous normal feather chickens' body linear measurements

The indigenous chicken is a store house of unique genes that could be used in other parts of the world for improving other breeds. This study was carried out using bayesian principal component analysis and aimed objectively at determining the effect of sex on Nigerian indigenous normal feather chickens' body dimension, describing their body shape, and predicting their body weights from body measurements using orthogonal conformation traits derived from the principal components score. The parameters measured at 16 weeks of age were body weight, body length, breast girth, thigh length, shank length, shank diameter, keel length, wing length, wing span, and tail length on 233 randomly selected adult chickens. Sexual dimorphism was observed in all the traits with higher values recorded for males. Bayesian correlations among body weight and biometric traits were positive (r = 0.09 to 0.651 and 0.017 to 0.579 in male and female chickens respectively). The descriptive statistics showed that the mean body weight was 1.8085 ± 0.263 kg for males and 1.403 ± 0.226 kg for females. The first two principal components (PCs) were extracted for the males, both PCs components account for 72.21%. For the females, three PCs were extracted and they account for 77%. The first PC in each case accounted for the greatest percentage of the total variation. The use of orthogonal body shape characteristics derived from components' scores was more appropriate than the use of original traits in body weight prediction as multi-collinearity problems were eliminated. This led to simultaneous analysis of these body measurements rather than on individual basis. These components could be used as selection criteria for improving body weight of indigenous Nigerian chickens.