A dynamic and thermodynamic coupling view of the linkages between Eurasian cooling and Arctic warming

Investigating the contrast between wintertime warming in the Arctic and cooling in Eurasia is of great importance for understanding regional climate change. In this study, we propose a dynamic and thermodynamic coupling view of the linkages between wintertime Arctic warming and Eurasian cooling since 1979. The key factors are the energy budget at the Earth’s surface, the diabatic heating and baroclinicity of the atmosphere, and subsurface ocean heat. A summertime origin of wintertime Arctic warming suggests a partial driving role of the Arctic in wintertime Eurasian cooling. The reasons for this finding are as follows. First, there is a dipole pattern in the diabatic heating change in winter over the Arctic Ocean corresponding to the anticyclonic circulation that links Eurasian cooling and Arctic warming. Second, the change in diabatic heating of the atmosphere is determined by sensible heat at the Earth’s surface through vertical diffusion. Third, the positive sensible heat change in the eastern Arctic sector in winter originates from the summertime enhanced absorption of solar radiation by the subsurface ocean over the sea ice loss region. Meanwhile, the negative sensible heat change in the western Arctic sector and wide Arctic warming can be explained by the circulation development triggered by the change in the east. Additionally, the background strong baroclinicity of the atmosphere in mid-high latitudes and corresponding two-way Arctic and mid-latitude interactions are necessary for circulation development in winter. Furthermore, the seasonality of the changes indicates that Eurasian cooling occurs only in winter because the diabatic heating change in the Arctic is strongest in winter. Overall, the comprehensive mechanisms from the summertime Earth’s surface and subsurface ocean to the wintertime atmosphere suggest a driving role of the Arctic. Note that the situation in interannual variability is more complex than the overall trend because the persistence of the influence of summertime sea ice is weakly established in terms of interannual variability.

Quantifying the role of ocean coupling in Arctic amplification and sea-ice loss over the 21st century

The enhanced warming of the Arctic, relative to other parts of the Earth, a phenomenon known as Arctic amplification, is one of the most striking features of climate change, and has important climatic impacts for the entire Northern Hemisphere. Several mechanisms are believed to be responsible for Arctic amplification; however, a quantitative understanding of their relative importance is still missing. Here, using ensembles of model integrations, we quantify the contribution of ocean coupling, both its thermodynamic and dynamic components, to Arctic amplification over the 20th and 21st centuries. We show that ocean coupling accounts for ~80% of the amplification by 2100. In particular, we show that thermodynamic coupling is responsible for future amplification and sea-ice loss as it overcomes the effect of dynamic coupling which reduces the amplification and sea-ice loss by ~35%. Our results demonstrate the utility of targeted numerical experiments to quantify the role of specific mechanisms in Arctic amplification, for better constraining climate projections.

Evaluation of the Performance of CMIP5 and CMIP6 Models in Simulating the Victoria Mode–El Niño Relationship

The Victoria mode (VM) is the second dominant sea surface temperature mode in the North Pacific, forced by North Pacific Oscillation–like extratropical atmospheric variability. Observational studies have shown that the boreal spring VM is closely connected to the following winter El Niño, with the VM efficiently acting as a precursor signal to El Niño events. This study evaluates the relationship of the spring VM with subsequent winter El Niño in the preindustrial simulations of phases 5 and 6 of the Coupled Model Intercomparison Project (CMIP5 and CMIP6). We found that most CMIP5 and CMIP6 models can simulate the basic characteristics of the VM reasonably well. The current CMIP6 models simulate the VM–El Niño connections more realistically as compared to the earlier CMIP5 models. The analysis further suggests that the improved capability of the CMIP6 models to simulate the VM–El Niño relationship is because the CMIP6 models are better able to capture the VM-related surface air–sea thermodynamic coupling process over the subtropical/tropical Pacific and the seasonal evolution of VM-related anomalous subsurface ocean temperature in the equatorial Pacific.

Evaluation of the performance of CMIP5 and CMIP6 models in simulating the Victoria mode-El Niño relationship

The Victoria mode (VM) is the second dominant sea surface temperature mode in the North Pacific, forced by North Pacific Oscillation-like extratropical atmospheric variability. Observational studies have shown that the boreal spring VM is closely connected to the following winter El Niño, with the VM efficiently acting as a precursor signal to El Niño events. This study evaluates the relationship of the spring VM with subsequent winter El Niño in the pre-industrial simulations of Phase 5 and Phase 6 of the Coupled Model Intercomparison Project (CMIP5 and CMIP6). We found that most CMIP5 and CMIP6 models can simulate the basic characteristics of the VM reasonably well. The current CMIP6 models simulate the VM-El Niño connections more realistically as compared to the earlier CMIP5 models. The analysis further suggests that the improved capability of the CMIP6 models to simulate the VM-El Niño relationship is because the CMIP6 models are better able to capture the VM-related surface air-sea thermodynamic coupling process over the subtropical/tropical Pacific and the seasonal evolution of VM-related anomalous subsurface ocean temperature in the equatorial Pacific.

Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system

With global vaccination efforts against SARS-CoV-2 underway, there is a need for rapid quantification methods for neutralizing antibodies elicited by vaccination and characterization of their strain dependence. Here, we describe a designed protein biosensor that enables sensitive and rapid detection of neutralizing antibodies against wild type and variant SARS-CoV-2 in serum samples. More generally, our thermodynamic coupling approach can better distinguish sample to sample differences in analyte binding affinity and abundance than traditional competition based assays.

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness

Cochlear hair cells each possess an exquisite bundle of actin-based stereocilia that detect sound. Unconventional myosin 15 (MYO15A) traffics and delivers critical molecules required for stereocilia development and thus is essential for building the mechanosensory hair bundle. Mutations in the human MYO15A gene interfere with stereocilia trafficking and cause hereditary hearing loss, DFNB3, but the impact of these mutations is not known, as MYO15A itself is poorly characterized. To learn more, we performed a kinetic study of the ATPase motor domain to characterize its mechano-chemical cycle. Using the baculovirus-Sf9 system, we purified a recombinant minimal motor domain (S1) by co-expressing the mouse MYO15 ATPase, essential and regulatory light chains that bind its IQ domains, and UNC45 and HSP90A chaperones required for correct folding of the ATPase. MYO15 purified with either UNC45A or UNC45B co-expression had similar ATPase activities (kcat = ~ 6 s-1 at 20°C). Using stopped-flow and quenched-flow transient kinetic analyses, we measured the major rate constants describing the ATPase cycle, including ATP , ADP and actin binding, hydrolysis and phosphate release. Actin-attached ADP release was the slowest measured transition (~ 12 s-1 at 20°C), although this did not rate-limit the ATPase cycle. The kinetic analysis shows the MYO15 motor domain has a moderate duty ratio (~ 0.5) and weak thermodynamic coupling between ADP and actin binding. These findings are consistent with MYO15 being kinetically adapted for processive motility when oligomerized. Our kinetic characterization enables future studies into how deafness-causing mutations affect MYO15 and disrupt stereocilia trafficking necessary for hearing.

Beta Type Stirling Engine. Schmidt and Finite Physical Dimensions Thermodynamics Methods Faced to Experiments

The paper presents experimental tests and theoretical studies of a Stirling engine cycle applied to a β-type machine. The finite physical dimension thermodynamics (FPDT) method and 0D modeling by the imperfectly regenerated Schmidt model are used to develop analytical models for the Stirling engine cycle. The purpose of this study is to show that two simple models that take into account only the irreversibility due to temperature difference in the heat exchangers and imperfect regeneration are able to indicate engine behavior. The share of energy loss for each is determined using these two models as well as the experimental results of a particular engine. The energies exchanged by the working gas are expressed according to the practical parameters, which are necessary for the engineer during the entire project, namely the maximum pressure, the maximum volume, the compression ratio, the temperature of the heat sources, etc. The numerical model allows for evaluation of the energy processes according to the angle of the crankshaft (kinematic–thermodynamic coupling). The theoretical results are compared with the experimental research. The effect of the engine rotation speed on the power and efficiency of the actual operating machine is highlighted. The two methods show a similar variation in performance, although heat loss due to imperfect regeneration is evaluated differently.