4K-memristor analog-grade passive crossbar circuit

The superior density of passive analog-grade memristive crossbar circuits enables storing large neural network models directly on specialized neuromorphic chips to avoid costly off-chip communication. To ensure efficient use of such circuits in neuromorphic systems, memristor variations must be substantially lower than those of active memory devices. Here we report a 64 × 64 passive crossbar circuit with ~99% functional nonvolatile metal-oxide memristors. The fabrication technology is based on a foundry-compatible process with etch-down patterning and a low-temperature budget. The achieved <26% coefficient of variance in memristor switching voltages is sufficient for programming a 4K-pixel gray-scale pattern with a <4% relative tuning error on average. Analog properties are also successfully verified via experimental demonstration of a 64 × 10 vector-by-matrix multiplication with an average 1% relative conductance import accuracy to model the MNIST image classification by ex-situ trained single-layer perceptron, and modeling of a large-scale multilayer perceptron classifier based on more advanced conductance tuning algorithm.

Conductance-Based Interface Detection for Multi-Phase Pipe Flow

Sediment and flow depth monitoring in sewers is important for informing flow models and for predicting and mitigating against sewer blockage formation and surcharge. In this study, a novel sensor based on conductance measurement has been developed and tested under a laboratory environment and validated by a finite-element model. The relative conductance is measured between pairs of adjacent electrodes to provide a conductance profile along the sensor length. A piecewise linear relationship between conductance and electrode length was derived and the interface positions between sediment, water, and air can be determined from the profile. The results demonstrated that the root mean square error of the model and the measured interface level are within 1.4% and 2.6% of sensor’s measurement range. An error distribution of interface height shows that all anticipated errors are within the resolution of the electrode length increments. Furthermore, it was found that the conductivity of the measured medium is proportional to the gradient of the linear relationship of conductance and electrode length. It could therefore prove a valuable new tool for the accurate quantification of sediment and flow levels in sewer conduits, coastal environments, drainage systems for transport networks, and other industrial or academic applications.

Study of the correlation between sensing performance and surface morphology of inkjet-printed aqueous graphene-based chemiresistors for NO2 detection

The extremely high sensitivity to the external environment and the high specific surface area, as well as the absence of bulk phenomena that could interfere with the response signal, make graphene highly attractive for the applications in the field of sensing. Among the various methods for producing graphene over large areas, liquid phase exfoliation (LPE) appears to be very promising, especially if combined with inkjet printing (IJP), which offers several advantages, including the selective and controlled deposition of small ink volumes and the versatility of the exploitable inks and substrates. Herein we present a feasibility study of chemiresistive gas sensors inkjet-printed onto paper substrates, in which a LPE graphene suspension dispersed in a water/isopropanol (H2O/IPA) mixture is used as sensing ink. The device performances, in terms of relative conductance variations, upon exposure to NO2 at standard ambient temperature and pressure, are analysed. In addition, we examine the effect of the substrate morphology and, more specifically, of the ink/substrate interaction on the device performances, by comparing the response of different chemiresistors fabricated by dispensing the same suspension also onto Al2O3 and Si/SiO2 substrates and carrying out a supportive atomic force microscopy analysis. The results prove the possibility to produce sensor devices by means of a wholly environmentally friendly, low-cost process that meets the requests coming from the increasing field of paper-based electronics and paving the way towards a flexible, green-by-design mass production.

Shear-layers in magnetohydrodynamic spherical Couette flow with conducting walls

We consider the steady axisymmetric motion of an electrically conducting fluid contained within a spherical shell and permeated by a centred axial dipole magnetic field, which is strong as measured by the Hartmann number M. Slow axisymmetric motion is driven by rotating the inner boundary relative to the stationary outer boundary. For M ≫ 1, viscous effects are only important in Hartmann boundary layers adjacent to the inner and outer boundaries and a free shear-layer on the magnetic field line that is tangent to the outer boundary on the equatorial plane of symmetry. We measure the ability to leak electric current into the solid boundaries by the size of their relative conductance ɛ. Since the Hartmann layers are sustained by the electric current flow along them, the current inflow from the fluid mainstream needed to feed them increases in concert with the relative conductance, because of the increasing fraction ℒ of the current inflow leaked directly into the solids. Therefore the nature of the flow is sensitive to the relative sizes of ɛ−1 and M.The current work extends an earlier study of the case of a conducting inner boundary and an insulating outer boundary with conductance ɛo = 0 (Dormy, Jault & Soward, J. Fluid Mech., vol. 452, 2002, pp. 263–291) to other values of the outer boundary conductance. Firstly, analytic results are presented for the case of perfectly conducting inner and outer boundaries, which predict super-rotation rates Ωmax of order M1/2 in the free shear-layer. Successful comparisons are made with numerical results for both perfectly and finitely conducting boundaries. Secondly, in the case of a finitely conducting outer boundary our analytic results show that Ωmax is O(M1/2) for ɛo−1 ≪ 1 ≪ M3/4, O(ɛo2/3M1/2) for 1 ≪ ɛo−1 ≪ M3/4 and O(1) for 1 ≪ M3/4 ≪ ɛo−1. On increasing ɛo−1 from zero, substantial electric current leakage into the outer boundary, ℒo ≈ 1, occurs for ɛo−1 ≪ M3/4 with the shear-layer possessing the character appropriate to a perfectly conducting outer boundary. When ɛo−1 = O(M3/4) the current leakage is blocked near the equator, and the nature of the shear-layer changes. So, when M3/4 ≪ ɛo−1, the shear-layer has the character appropriate to an insulating outer boundary. More precisely, over the range M3/4 ≪ ɛo−1 ≪ M the blockage spreads outwards, reaching the pole when ɛo−1 = O(M). For M ≪ ɛo−1 current flow into the outer boundary is completely blocked, ℒo ≪ 1.

COMBINED EFFECTS OF RASHBA SPIN-ORBIT INTERACTION STRENGTH AND ITS EXTENDED LENGTH IN QUANTUM WIRES

The combined effects of Rashba spin-orbit interaction (SOI) strength and the length of SOI excited region, which can be controlled by the external gate voltage deposited on the heterostructure, and on the electron spin precession in quasi-one-dimensional quantum wires are investigated by evaluating the relative conductance change, i.e. the ratio of difference of the conductances of the spin-up and spin-down polarized electrons to the total conductance. It is found that for proper wire width, electron spin precession can be smoothly achieved by co-adjusting the SOI strength and the length of SOI excited region. However, for wide quantum wire and strong SOI, the electron spin precession is significantly reduced due to the appearance of inter-subband mixing.

Identification of a region of strong discrimination in the pore of CFTR

The variety of methods used to identify the structural determinants of anion selectivity in the cystic fibrosis transmembrane conductance regulator Cl− channel has made it difficult to assemble the data into a coherent framework that describes the three-dimensional structure of the pore. Here, we compare the relative importance of sites previously studied and identify new sites that contribute strongly to anion selectivity. We studied Cl−and substitute anions in oocytes expressing wild-type cystic fibrosis transmembrane conductance regulator or 12-pore-domain mutants to determine relative permeability and relative conductance for 9 monovalent anions and 1 divalent anion. The data indicate that the region of strong discrimination resides between T338 and S341 in transmembrane 6, where mutations affected selectivity between Cl− and both large and small anions. Mutations further toward the extracellular end of the pore only strongly affected selectivity between Cl− and larger anions. Only mutations at S341 affected selectivity between monovalent and divalent anions. The data are consistent with a narrowing of the pore between the extracellular end and a constriction near the middle of the pore.

Cation channels in basolateral membranes of sheep parotid secretory cells

We observed 240-pS K+ channels in 63% of cell-attached patches, and 30-pS K+ channels were observed in 95% of cell-attached patches. The 240-pS K+ channel had the relative permeability sequence of K+ (1) = Rb+ (1) > Cs+ (0.3) >> Na+ (0.03) and the relative conductance sequence of K+ (1) > Rb+ (0.22) > Cs+ (0.05) > Na+ (0). It was activated by intracellular free Ca2+ and by depolarization. It was blocked by 10 mmol/l tetraethylammonium (TEA) applied extracellularly. The 30-pS K+ channel had the relative permeability sequence of K+ (1) = Rb+ (1) > Cs+ (> Na+ (< 0.09) and the relative conductance sequence of K+ (1) > Rb+ (0.45) > Cs+ (0) = Na+ (0). Its activity was not sensitive to cytosolic free Ca2+ or membrane potential, and it was not blocked by 10 mmol/l TEA extracellularly. Acetylcholine (10 mumol/l) activated the 240-pS voltage-activated and Ca(2+)-activated K+ channels but did not activate the 30-pS K+ channels. We conclude that the 30-pS K+ channel probably determines the properties of the basolateral membrane in unstimulated sheep parotid secretory cells, whereas the 240-pS voltage-activated and Ca(2+)-activated K+ channel may be important during parasympathomimetic stimulation.

Theoretical perspectives on ion-channel electrostatics: continuum and microscopic approaches

Peter Läuger introduced me (P.C.J.) to the field of ion-channel electrostatics while I was a sabbatical visitor at Konstanz in 1978–79. Läuger pointed out that the relative conductance of hydrophobic ions through phosphatidyl choline (PC) and glyceryl monooleate (GMO) membranes differed by a factor of about 100 (Hladky & Haydon, 1973), quite consistent with the difference in the water-membrane potential differences in the two systems (Pickar & Benz, 1978). However, cation conductance through gramicidin channels spanning these membranes only differs by a factor of 2–3 (Bamberg et al. 1976). Why? It is the pursuit of an answer to this question which led me into my researches in this field.

Physiological role and selectivity of the in situ potassium channel of the sarcoplasmic reticulum in skinned frog skeletal muscle fibers.

The role of K+ as a counterion during Ca2+ release from the sarcoplasmic reticulum (SR) has been investigated. An optical technique using the Ca2+-sensitive dye antipyrylazo III monitored Ca2+ release from skinned (sarcolemma removed) muscle fibers of the frog. Skinned fibers were used since the removal of the sarcolemma allows direct access to the SR membrane. Releases were stimulated by caffeine, which activates Ca2+ release directly by binding to a receptor on the SR. Two different methods were used to decrease the SR K+ conductance so that its effect on Ca2+ release could be assessed: (a) the SR K+ channel blocker, 1,10-bis-quanidino-n-decane (bisG10) was used to eliminate current pathways and (b) substitution of the impermeant ion choline for K+ was used to decrease charge carriers. Both bisG10 and choline substitution caused a concentration-dependent decrease in the Ca2+ release rate. Therefore we conclude that K+ is an important counterion for Ca2+ during its release from the SR. The selectivity of the in situ SR K+ channel to several monovalent cations was determined by substituting them for K+ and comparing their effect on Ca2+ release. The substituted ions were expected to affect Ca2+ release in proportion to their ability to support a counterion flux, which is, in turn, a function of their relative conductance through the SR K+ channel. The selectivity sequence determined by these experiments was K+ = Rb+ = Na+ greater than Cs+ greater than Li+ greater than choline.