The Accumulating Costs Hypothesis—to Better Understand Delayed “Hidden” Costs of Seemingly Mild Disease and Other Moderate Stressors

Mild diseases and moderate stressors are seemingly harmless and are therefore often assumed to have negligible impact on Darwinian fitness. Here we argue that the effects of “benign” parasites and other moderate stressors may have a greater impact on lifespan and other fitness traits than generally thought. We outline the “accumulating costs” hypothesis which proposes that moderate strains on the body caused by mild diseases and other moderate stressors that occur throughout life will result in small irreversible “somatic lesions” that initially are invisible (i.e., induce “hidden” costs). However, over time these somatic lesions accumulate until their summed effect reaches a critical point when cell senescence and malfunction begin to affect organ functionality and lead to the onset of degenerative diseases and aging. We briefly discuss three potential mechanisms through which the effects of moderate strains (e.g., mild diseases) could accumulate: Accelerated telomere shortening, loss of repetitious cell compartments and other uncorrected DNA damage in the genome. We suggest that telomere shortening may be a key candidate for further research with respect to the accumulating costs hypothesis. Telomeres can acquire lesions from moderate strains without immediate negative effects, lesions can be accumulated over time and lead to a critically short telomere length, which may eventually cause severe somatic malfunctioning, including aging. If effects of mild diseases, benign parasites and moderate stressors accrued throughout life can have severe delayed consequences, this might contribute to our understanding of life history strategies and trade-offs, and have important implications for medicine, including consideration of treatment therapies for mild (chronic) infections such as malaria.

Late Presentations of Acute Coronary Syndromes in Coronavirus Era: A Case Series

Although people with less critical symptoms should not visit hospitals in order to reduce exposure during a pandemic, it is of utmost importance that those experiencing risky symptoms visit in early stages to prevent delayed consequences. In this article, we reported three ST-segment Elevation Myocardial Infarction (STEMI) patients who would have benefited from visiting the hospital earlier while they were experiencing low threshold angina.

APPLYING SHORT STORY TECHNIQUE IN DEVELOPING EFL PUPILS VOCABULARY

This paper targets expanding vocabulary through short story for optional pupils in Indonesia. The paper was planned as Classroom Action Research. It was directed in two cycles; each cycle comprised of preparation, acting, noticing, and Reflecting. The researcher used insight and test to accumulate the data. The delayed consequences of the chief spelling test showed that from 100 students, there were 66 pupils out of 100 who got scores of least 70. It was identical to 66%. In cycle 2, without a doubt the quantity of students who got the scores of 70 or higher was 87. It was identical to 87%. The result of this assessment showed that Short Story was reasonable to grow pupils' vocabulary stock.

LEVERAGING ASSOCIATION METHOD IN EFL STUDENTS VOCABULARY LEARNING

This paper highlighted inspecting the leveraging of association method in showing EFL vocabulary to the students. This investigation used a helpful report corridor action research plan and it was done as cycles containing four huge advances: orchestrating, executing, seeing and reflecting. The subject of the investigation was 35 students in Indonesia. The instruments used to assemble data were test, discernment plans, and field notes. This investigation was done in two cycles considering the way that the delayed consequences of the assessment in the essential cycle didn't meet the guidelines of achievement. All of cycle includes four social events. The revelations of the investigation showed that the applying of methodology in preparing English can fabricate students' vocabulary strength. This is showed up by the students' productive rate in cycle I was 14 (40%), in Cycle II and the amount of the students who got scores at any rate 6.5 or more critical was 26 (74%). Similarly, the students gave positive response toward the discernment plan result, specifically: enthusiasm, motivation, interest, response, and progress. It might be contemplated that the association strategy is effective and material in teaching vocabulary.

Coronavirus Pandemic (Covid-19): Delayed Consequences for the Prevention of Social Orphanhood

The article presents an expert analysis of the impact of the restrictions imposed to prevent the spread of a new coronavirus infection (COVID-19) in Russia on the situation of families with children and the children, as well as the delayed consequences for the social orphancy system in Russia. The expert assessment is based on the results of sociological surveys of the child protection representatives, their opinion on the impact of the pandemic on the well-being of families with children and children in 9 regions, the analysis of individual organizations for orphans and children left without parental care. The data on the difference in the assessment of the situation of specialists and representatives of the non-profit sector are correlated. Conclusions are drawn about the strengthening of the “medical approach” in assessing the well-being of a child against social and personal needs, the lack of flexibility in organizing the work of the subjects of the orphancy prevention system during restrictive measures, as well as objective limitations of the remote form of providing social services and the unavailability of such services for certain family categories. The research was com- missioned by the Elena and Gennady Timchenko Charitable Foundation.

Underlying Principles of a Covid-19 Behavioral Vaccine for a Sustainable Cultural Change

Until pharmacological measures are effective at containing the COVID-19 outbreak, adopting protective behaviors is paramount. In this work, we aim at informing interventions to limit the spread of the contagion and prepare against any future outbreaks by developing a behavioral framework to interpret and prescribe both the individual and large-scale uptake of non-pharmaceutical measures. First, we analyze the barriers and facilitators to adherence to protective behaviors according to a three-term contingency by exploring potential gaps in terms of setting stimuli, motivating operations, delayed consequences, and positive or negative consequences. We explore their roles in the likelihood of individual compliance to protective behaviors, taking physical distancing as an example of functional analysis. Second, we interpret contagion control as the cumulative effect of large-scale adherence to protective behaviors. We explore the interrelations between societal problems caused or amplified by similar behaviors presented by many individuals and the coordination of agents or agencies aiming at promoting large-scale behavioral change. Then, we highlight the potential of developing a behavioral vaccine, and practical steps for applying it to promote sustainable cultural change that may protect against health, social, and economic losses in future outbreaks.

Demography, life-history trade-offs, and the gastrointestinal virome of wild chimpanzees

In humans, senescence increases susceptibility to viral infection. However, comparative data on viral infection in free-living non-human primates—even in our closest living relatives, chimpanzees and bonobos ( Pan troglodytes and P. paniscus )—are relatively scarce, thereby constraining an evolutionary understanding of age-related patterns of viral infection. We investigated a population of wild eastern chimpanzees ( P. t. schweinfurthii ), using metagenomics to characterize viromes (full viral communities) in the faeces of 42 sexually mature chimpanzees (22 males, 20 females) from the Kanyawara and Ngogo communities of Kibale National Park, Uganda. We identified 12 viruses from at least four viral families possessing genomes of both single-stranded RNA and single-stranded DNA. Faecal viromes of both sexes varied with chimpanzee age, but viral richness increased with age only in males. This effect was largely due to three viruses, salivirus, porprismacovirus and chimpanzee stool-associated RNA virus (chisavirus), which occurred most frequently in samples from older males. This finding is consistent with the hypothesis that selection on males for early-life reproduction compromises investment in somatic maintenance, which has delayed consequences for health later in life, in this case reflected in viral infection and/or shedding. Faecal viromes are therefore useful for studying processes related to the divergent reproductive strategies of males and females, ageing, and sex differences in longevity. This article is part of the theme issue ‘Evolution of the primate ageing process'.