Objective: This study explored the predictive role of body-related components, such as body compassion and body mass index, and components of the Acceptance and Commitment Therapy (ACT) model, such as mindfulness and experiential avoidance, on the experience of pain and quality of life quality of life in endometrial cancer survivors.Methods: Surveys were sent to members of a national online support group for endometrial cancer patients who had completed treatment. The study included 82 total participants.Results: ACT components and body-related components, as a set, predicted pain interference and quality of life but not pain severity. Experiential avoidance was determined to be an independent predictor of quality of life. Negative affect, used as a covariate, independently predicted unique variance in pain severity, pain interference, and quality of life. Age was an independent predictor of pain interference and quality of life. Lastly, obese endometrial cancer survivors endorsing higher experiential avoidance, lower mindfulness, and lower body compassion compared to non-obese endometrial cancer survivors.Conclusions: Body-related and ACT components, taken together, may be predictive of pain interference and quality of life, while experiential avoidance may contribute uniquely to quality of life, rendering it a key target of future intervention for endometrial cancer survivors post-treatment.