Electroanalysis of Fentanyl and Its New Analogs: A Review

The review describes fentanyl and its analogs as new synthetic opioids and the possibilities of their identification and determination using electrochemical methods (e.g., voltammetry, potentiometry, electrochemiluminescence) and electrochemical methods combined with various separation methods. The review also covers the analysis of new synthetic opioids, their parent compounds, and corresponding metabolites in body fluids, such as urine, blood, serum, and plasma, necessary for a fast and accurate diagnosis of intoxication. Identifying and quantifying these addictive and illicit substances and their metabolites is necessary for clinical, toxicological, and forensic purposes. As a reaction to the growing number of new synthetic opioid intoxications and increasing fatalities observed over the past ten years, we provide thorough background for developing new biosensors, screen-printed electrodes, or other point-of-care devices.

Recreational Drug Using Behaviour and Legal Benzylpiperazine Party Pills

<p>Benzylpiperazine (BZP) is a stimulant drug that produces effects similar to amphetamines (Campbell, Cline, Evans, Lloyd, & Peck, 1973). It has been sold legally in New Zealand in the form of 'party pills' since 2000. The legal status of BZP party pills has been debated in New Zealand as the media reported cases of apparent overdoses and adverse reactions leading to hospitalization (Brogden, 2005; Crewdson, 2007; Reiber, 2005; Rankin, 2006). Representatives of the BZP party pill industry publicly defended their product claiming that BZP party pills were reducing substance related harm by reducing illicit substance use (Bowden, 2007b, p.1). They also claimed that banning BZP would result in an increase in use of illicit substances, especially methamphetamine or 'P' (Barnett, 2007). The overall aim of this thesis is to test the claims that BZP party pills reduce substance related harm by reducing illicit substance use, and to identify potential outcomes of a BZP party pill ban. In addition, the perceived risks of party pill and other drug use will be examined. In chapter one I review key concepts relating to BZP party pill use: recreational drug use, harm reduction, and risk perception. In chapter two the history and New Zealand context of BZP party pills are reviewed. In chapter three, study one qualitatively analyzes BZP party pill marketing material in an attempt to describe the culture and discourse promoted by the BZP party pill industry. This analysis demonstrated that BZP party pills were primarily marketed as part of a recreational drug using culture. In chapter four, study two quantitatively investigated whether BZP party pill use was associated with reduced levels of illicit substance use in a sample (N=796) of first year university students. This study also examined the relationship between risk perception and frequency of substance use. Study two demonstrated that BZP party pill users are generally recreational poly-drug users who used illicit substances equally as often as illicit users who did not use BZP party pills. BZP party pills did not appear to reduce illicit substance use, and therefore harm. For the majority of substances there was no significant relationship between risk and use behaviour. The legal status of substances appeared to be important when participants rated the risks of use. Legal substances (including BZP) tended to be rated as safer than illegal substances. In chapter five, study three qualitatively analyzed 60 interviews with regular BZP party pill users to identify potential outcomes of a BZP party pill ban. A combination of alternatives were likely to be used by BZP party pill users, primarily illicit substances, especially ecstasy, as well as alcohol, and black market BZP. However methamphetamine (P) was an unpopular alternative. Study three also analyzed how BZP party pill users assess the costs and benefits of BZP party pill use. Decisions to use BZP party pills relied heavily on the benefits of use, rather than the costs. In chapter six, the general discussion describes the implications, ethical considerations, limitations, and outcomes of the research.</p>

Recreational Drug Using Behaviour and Legal Benzylpiperazine Party Pills

<p>Benzylpiperazine (BZP) is a stimulant drug that produces effects similar to amphetamines (Campbell, Cline, Evans, Lloyd, & Peck, 1973). It has been sold legally in New Zealand in the form of 'party pills' since 2000. The legal status of BZP party pills has been debated in New Zealand as the media reported cases of apparent overdoses and adverse reactions leading to hospitalization (Brogden, 2005; Crewdson, 2007; Reiber, 2005; Rankin, 2006). Representatives of the BZP party pill industry publicly defended their product claiming that BZP party pills were reducing substance related harm by reducing illicit substance use (Bowden, 2007b, p.1). They also claimed that banning BZP would result in an increase in use of illicit substances, especially methamphetamine or 'P' (Barnett, 2007). The overall aim of this thesis is to test the claims that BZP party pills reduce substance related harm by reducing illicit substance use, and to identify potential outcomes of a BZP party pill ban. In addition, the perceived risks of party pill and other drug use will be examined. In chapter one I review key concepts relating to BZP party pill use: recreational drug use, harm reduction, and risk perception. In chapter two the history and New Zealand context of BZP party pills are reviewed. In chapter three, study one qualitatively analyzes BZP party pill marketing material in an attempt to describe the culture and discourse promoted by the BZP party pill industry. This analysis demonstrated that BZP party pills were primarily marketed as part of a recreational drug using culture. In chapter four, study two quantitatively investigated whether BZP party pill use was associated with reduced levels of illicit substance use in a sample (N=796) of first year university students. This study also examined the relationship between risk perception and frequency of substance use. Study two demonstrated that BZP party pill users are generally recreational poly-drug users who used illicit substances equally as often as illicit users who did not use BZP party pills. BZP party pills did not appear to reduce illicit substance use, and therefore harm. For the majority of substances there was no significant relationship between risk and use behaviour. The legal status of substances appeared to be important when participants rated the risks of use. Legal substances (including BZP) tended to be rated as safer than illegal substances. In chapter five, study three qualitatively analyzed 60 interviews with regular BZP party pill users to identify potential outcomes of a BZP party pill ban. A combination of alternatives were likely to be used by BZP party pill users, primarily illicit substances, especially ecstasy, as well as alcohol, and black market BZP. However methamphetamine (P) was an unpopular alternative. Study three also analyzed how BZP party pill users assess the costs and benefits of BZP party pill use. Decisions to use BZP party pills relied heavily on the benefits of use, rather than the costs. In chapter six, the general discussion describes the implications, ethical considerations, limitations, and outcomes of the research.</p>

Psychoactive substance consumption: A Portuguese cross-sectional study

BACKGROUND: Increasing consumption of psychoactive substances is a major social concern worldwide. OBJECTIVES: To investigate the prevalence of psychoactive substances consumption in the Portuguese, throughout their life as well as recently, and the main reasons for the consumption and associated factors. METHODS: This cross-sectional study was based on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) applied to a sample of 385 Portuguese obtained for convenience. It was used descriptive statistics, the Cui-square, Mann-Whitney U and Kruskal-Wallis tests, with a significance level of 5%. RESULTS: Alcohol was the most consumed throughout life (86%), followed by xanthines (79%) and tobacco (60%). In the last 3 months, xanthines (49%) were the most consumed daily, followed by tobacco (22%) and alcohol (9%). Socializing was the main reason for consumption of alcohol (67%), tobacco (36%) and cannabis (34%) while anxiolytics have been used to sleep (50%) and xanthines to increase cognitive capacity (35%). Tobacco (p = 0.016), alcohol (p = 0.03) and illicit substances (p < 0.001) were more consumed by men and anxiolytics by women (p = 0.027). Alcohol (p = 0.008), cannabis (p = 0.027), and xanthines (p = 0.009) were mostly consumed by young adults. CONCLUSIONS: The results reveal sporadic and recreational use of illicit substances, and regular use of alcohol, tobacco and xanthines, mostly by young adults and men, and anxiolytics by women. Socializing was the main reason for psychoactive substances consumption.

Dried matrix spots in forensic toxicology

Dried matrix spots (DMS) has gained the attention of different professionals in different fields, including toxicology. Investigations have been carried out in order to assess the potential of using DMS for the analysis of illicit substances, the main interest of forensic toxicologists. This technique uses minimal volumes of samples and solvents, resulting in simple and rapid extraction procedures. Furthermore, it has proved to increase analyte stability, improving storage and transportation. However, DMS presents some limitations: the hematocrit influencing accuracy and inconsistencies regarding the means of spotting samples and adding internal standard on paper. Thus, we provide an overview of analytical methodologies with forensic applications focusing on drugs of abuse and discussing the main particularities, limitations and achievements.

198Prevalence of illicit substances in personal vaporisers on online cryptomarkets

Background Personal vaporisers or e-cigarettes are gaining popularity as an alternative route of administration for illicit substances. Data from the Centers for Disease Control and Prevention on the recent epidemic of vaping related lung injuries has confirmed that victims had vaped blackmarket tetrahydracannabidiol, including some sourced from online cryptomarkets. We examined the diversity and prevalence of illicit substances in vaping products available from these marketplaces. Methods Vaping related listings were extracted from three online cryptomarkets (‘Agartha’, ‘Cryptonia’, and ‘Tochka’) using The Onion Router browser. Data collection occurred between October and November 2019. Results We identified 1929 listings from 201 unique sellers. The top product across the three markets were vape cartridges (range = 39.4% to 70.4%). The most common substance in these products was cannabis oil (range = 82.1% to 96.1%), followed by synthetic cannabinoids (range = 3.7% to 9.8%) and psychedelic substances (range = 0.2% to 6.4%). Vendors were primarily from the USA. Many products offered worldwide shipping (range = 42.4% to 96.3%). Conclusions Our study fills knowledge gaps by providing information on what vaping products are being sold through online cryptomarkets. Future studies should continue to monitor cryptomarkets to identify emerging trends of substances used in personal vaporisers. Key messages Online cryptomarkets provide a new way of monitoring emerging vaping trends and identify factors that contributes to the current vaping epidemic.

Crisis Situations Among Children/Adolescents with Emotional and Behavioural Disorders in Education

Employees in education, especially in residential treatment centres, face crisis situations as a result of emotional and behavioural problems/disorders of children and adolescents. They most often face various types of violence, self-aggression, use of illicit substances and abuse. Cases of children and adolescents with mental health problems are frequent. Crisis interventions differ with the complexity of the situation, and regardless of the approach, an appropriate relationship is crucial to any solution. The purpose of this article is to present and elaborate the most common crisis situations and some successful interventions in such cases.