Association of treatment procedures and resilience to symptom load three-years later in a clinical sample of adolescent psychiatric patients

Background We aimed to examine symptom load in a clinical adolescent population at three-year follow-up and explore associations with standard care treatment procedures and resilience factors upon first presenting at Child and Adolescent Mental Health Services. Methods This study is part of a prospective longitudinal cohort study: The Health Survey in Department of Children and Youth, St. Olavs hospital, Norway. A clinical population of 717 (43.5% of eligible) adolescents aged 13–18 years participated in the first study visit (T1, 2009–2011). Of these, 447 adolescents with psychiatric disorders, with treatment history from medical records and self-reported resilience factors (Resilience Scale for Adolescents; READ) at T1, reported symptom load (Achenbach System of Empirically Based Assessment - Youth Self Report; YSR) three years later aged 16–21 years (T2). Result At T1, 93.0% received individual treatment. The frequency of psychotherapy and medication varied by disorder group and between genders. Overall, psychotherapy was more frequent among girls, whereas medication was more common among boys. Total READ mean value (overall 3.5, SD 0.8), ranged from patients with mood disorders (3.0, SD 0.7) to patients with Attention Deficit Hyperactivity disorder (3.7, SD 0.7), and was lower for girls than boys in all diagnostic groups. At T2, the YSR Total Problem mean T-score ranged across the diagnostic groups (48.7, SD 24.0 to 62.7, SD 30.2), with highest symptom scores for those with mood disorders at T1, of whom 48.6% had T-scores in the borderline/clinical range (≥60) three years later. Number of psychotherapy sessions was positively associated and Total READ score was negatively associated with the YSR Total Problems T-score (regression coefficient β = 0.5, CI (0.3 to 0.7), p < 0.001 and β = − 15.7, CI (− 19.2 to − 12.1), p < 0.001, respectively). The subscale Personal Competence was associated with the lowest Total Problem score for both genders. Conclusions Self-reported symptom load was substantial after three years, despite comprehensive treatment procedures. Higher self-reported resilience characteristics were associated with lower symptom load after three years. These results highlight the burden of adolescent psychiatric disorders, the need for extensive interventions and the importance of resilience factors for a positive outcome.

Συγκριτική μελέτη των διαταραχών σίτισης και των παραγόντων κινδύνου σε παιδιά προσχολικής ηλικίας υγιή και με παθήσεις του πεπτικού συστήματος

Εισαγωγή: οι διαταραχές σίτισης είναι συχνές στην παιδική ηλικία. Σύμφωνα με τη βιβλιογραφία το 25%-45% των παιδιών τυπικής ανάπτυξης αντιμετωπίζουν προβλήματα σίτισης. Τα παιδιά με παθήσεις του πεπτικού συστήματος θεωρούνται ομάδα υψηλού κινδύνου για εκδήλωση τέτοιων προβλημάτων. Σκοπός της παρούσας μελέτης ήταν η διερεύνηση του επιπολασμού και των χαρακτηριστικών των προβλημάτων σίτισης σε υγιή παιδιά τυπικής ανάπτυξης και σε παιδιά με προβλήματα του πεπτικού συστήματος, ηλικίας 2-7 ετών, στην Ελλάδα. Στα πλαίσια της μελέτης αυτής διερευνήθηκαν παράγοντες που πιθανά σχετίζονται με την εμφάνιση διαταραχών σίτισης στις δύο ομάδες παιδιών, όπως τα δημογραφικά χαρακτηριστικά των παιδιών και των γονέων, το ιστορικό σίτισης βρεφικής ηλικίας και τα αναπτυξιακά στάδια σίτισης του παιδιού, το περιβάλλον σίτισης και οι γονικές πρακτικές σίτισης. Μέθοδος: μελέτη παρατήρησης χρονικής στιγμής, τύπου ασθενών και μαρτύρων. Μετά την εφαρμογή των κριτηρίων επιλογής και αποκλεισμού στη μελέτη συμπεριλήφθηκαν 928 παιδιά (787 στην ομάδα ελέγχου και 141 στην κλινική ομάδα). Για τα παιδιά αυτά συλλέχθηκαν πληροφορίες που αφορούν τα δημογραφικά και ανθρωπομετρικά στοιχεία, τη συμπεριφορά κατά τη σίτιση, το ιατρικό ιστορικό, το ιστορικό σίτισης, το περιβάλλον σίτισης και τις γονικές πρακτικές σίτισης. Αποτελέσματα: Στην ομάδα ελέγχου, το 8,2% των παιδιών είχαν παθολογικό Total Frequency Score (TFS) σκορ (συχνότητα δυσλειτουργικών συμπεριφορών) και το 27,5% είχαν παθολογικό Total Problem Score (TPS) σκορ (αριθμός προβλημάτων που ανέφεραν οι γονείς). Τα παιδιά με παθήσεις του πεπτικού συστήματος εμφάνισαν σημαντικά υψηλότερη συχνότητα προβληματικών συμπεριφορών και σημαντικά υψηλότερο αριθμό συμπεριφορών που οι γονείς θεωρούν πρόβλημα. Συγκεκριμένα, το 18,6% της κλινικής ομάδας είχε παθολογικό TFS σκορ και το 39,5% είχε παθολογικό TPS σκορ. Οι δύο ομάδες διέφεραν σημαντικά ως προς τα χαρακτηριστικά σίτισης των παιδιών. Ωστόσο, οι συμπεριφορές που φαίνονται να απασχολούν συχνότερα τους γονείς είναι κοινές και για τις δύο ομάδες και αφορούν την τροφική νεοφοβία, τη μειωμένη κατανάλωση λαχανικών, τη διαπραγμάτευση και τη χρονοτριβή. Ανάμεσα στις δύο ομάδες διαπιστώθηκαν στατιστικά σημαντικές διαφορές σε όλα τα αναπτυξιακά στάδια της σίτισης, σε πολλά χαρακτηριστικά του περιβάλλοντος σίτισης και σε πολλές γονικές πρακτικές. Συγκεκριμένοι δημογραφικοί παράγοντες, ο χαμηλός ΔΜΣ, η καθυστέρηση στη μετάβαση στις στερεές τροφές, αρκετά χαρακτηριστικά του περιβάλλοντος σίτισης και σχεδόν όλες οι γονικές πρακτικές, συσχετίστηκαν θετικά με τις διαταραχές σίτισης στην ομάδα ελέγχου. Λιγότερα χαρακτηριστικά συσχετίστηκαν θετικά με τις διαταραχές σίτισης στην κλινική ομάδα. Συμπεράσματα: Η μελέτη κατέδειξε ότι περίπου ένα στα δέκα υγιή παιδιά εκδηλώνει διαταραχές σίτισης, ενώ ένας στους τέσσερις γονείς θεωρούν προβληματική τη σίτιση του παιδιού τους. Σχεδόν διπλάσιο ποσοστό παιδιών με παθήσεις του πεπτικού συστήματος βρέθηκε να αντιμετωπίζει παρόμοια προβλήματα. Τα ευρήματα της μελέτης συμβάλουν στην πρόληψη, πρώιμη ανίχνευση και αξιολόγηση των διαταραχών σίτισης τόσο στα υγιή παιδιά, όπου τα προβλήματα σίτισης συχνά παραβλέπονται ή υποτιμώνται, όσο και στα παιδιά με παθήσεις του πεπτικού συστήματος που αποτελούν ομάδα υψηλού κινδύνου για την εκδήλωση τέτοιων προβλημάτων. Από τα ευρήματα της μελέτης αναδείχτηκαν επίσης σημαντικές πληροφορίες για τους παράγοντες που επιδρούν στη διατροφική συμπεριφορά, παρέχοντας ένα πλαίσιο αναφοράς για πρώιμη παρέμβαση και για το σχεδιασμό όσο το δυνατό πιο στοχευμένων και αποτελεσματικών θεραπευτικών μεθόδων σε παιδιά με διαταραχές σίτισης.

Psychiatric Comorbidities among Children with Attention Deficit Hyperactivity Disorders

Background and Purpose: Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder in children. The purpose of this study is to explore the rate of psychiatric comorbidities among children with ADHD and investigating the impact of comorbidities on function of children. Subjects and Methods: Sixty-four children of both genders who fulfilled DSM-5 criteria for ADHD were included. All subjects were subjected to IQ assessment, Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS), Conners Rating Scale, and Child Behavior Check List (CBCL). Results: Combined subtype was the commonest (50%) followed by hyperactive-impulsive (31.25%), then inattentive (18.75%). Psychiatric comorbid disorder among pediatric cases with ADHD was ODD (31.25%), followed by nocturnal enuresis (23.44%), conduct disorders (18.75%), motor tic disorders (15.63%), anxiety disorders (12.50%), depressive disorders (10.94%), substance abuse disorders (9.38%), autism spectrum disorders (7.81%), vocal tic disorders (1.56%). There was a statistically significant difference between gender and conduct disorder and SUDs (P <0.05). There was no significant difference in the distribution of comorbidities among subtypes except for conduct disorder (P<0.05). There was a significant difference between comorbidities and severity of ADHD, according to the Conners scale (P<0.05). There was a significant difference between comorbidities number and different CBCL parameters (P<0.05). There was a significant negative correlation between the number of comorbidities and total competence and positive correlation with the total problem (P<0.05). Conclusions: The presence of comorbid disorders among pediatric cases with ADHD is the rule rather than the exception. Oppositional defiant disorder, followed by nocturnal enuresis, are the most common comorbid diseases. Comorbidities number is negatively correlated with total competence and positively correlated with the total problem.

Racial and Ethnic Differences in Behavioral Problems and Medication Use Among Children With Autism Spectrum Disorders

We examined racial and ethnic differences in the prevalence of behavioral problems measured by the Child Behavioral Checklist (CBCL), sleep disturbances measured by the Child Sleep Habits Questionnaire (CSHQ), and medication use among children with Autism Spectrum Disorders (ASD). We analyzed data from the Autism Treatment Network (ATN) dataset for 2,576 children ages 6 to 18 years of age diagnosed with ASD. Multivariable logistic regression accounting for age, gender, Diagnostic and Statistical Manual of Mental Disorders (4th Edition – Text Revision), diagnosis (Autistic Disorder, PDD-NOS, Asperger's Disorder), and parents' education did not show any racial or ethnic differences in behavioral challenges, conduct problems, or sleep disturbances for any of the groups, but Black children had lower odds of Total Problem Behaviors and Asian children had lower odds of Hyperactivity compared to White children. As a group, children from racial and ethnic minorities had lower odds of Total Problem Behaviors and Conduct Problems compared to White children. Hispanic children had lower odds of medication use for Behavioral Challenges, Total Problem Behaviors, Hyperactivity, and Conduct Problems. Asian children had lower odds of medication use for Behavioral Challenges, Total Problem Behaviors, and Hyperactivity; and had close to lower odds in medication use for Conduct Problems. Black children had lower odds for medication use for Total Problem Behaviors only. As a group, children from racial and ethnic minorities had lower odds for medication use for Behavioral Challenges, Total Problem Behaviors, Hyperactivity, and Conduct problems, but not for Sleep Disturbances. While these results are consistent with previous studies showing that White children are significantly more likely to receive psychotropic medication compared to children from racial and ethnic minority groups, we found no such differences for sleep challenges, suggesting that they are more consistently identified and equitably treated than other behavioral problems associated with ASD. We draw upon Andersen's (1995) Behavioral Model of Healthcare Use to suggest predisposing, enabling, and needs factors that may contribute to this pattern of racial and ethnic differences in the use of medications among children ASD.

Long-lasting behavioural consequences of neonatal iron deficiency in high-risk children

Little consideration has been given to the long-term consequences of iron deficiency in new-born infants. Fetal iron accretion is compromised by multiple pregnancy complications including preterm birth, gestational diabetes mellitus and fetal growth restriction, while our work has identified increased risks from maternal lifestyle factors such as smoking and obesity for low iron stores at birth. Early-life events, including C-section delivery, also add to this cumulative risk of neonatal iron deficiency, predisposing infants to iron deficiency later in infancy and early childhood. This study aimed to investigate the effect of neonatal iron deficiency on neurological development up to 5 years of age in term-born participants of a maternal-infant birth cohort in Ireland. In the Cork BASELINE Birth Cohort, 697 maternal-infant dyads with prospectively collected lifestyle and clinical data from 15 weeks’ gestation had umbilical cord serum ferritin concentrations measured. Neurological assessments were performed at 2 (Bayley Scales of Infant Development and Child Behaviour Checklist [CBCL]) and 5 (Kaufman Brief Intelligence Test and CBCL) years of age. In the cohort, median [IQR] cord ferritin concentrations were 200.9 [139.0,265.8] μg/L; 7.5% had neonatal iron deficiency (< 76μg/L). Using the risk factors for neonatal iron deficiency that we previously identified (smoking, obesity, C-section delivery, SGA) in this cohort, as selection criteria, we conducted an a priori sensitivity analysis in 306 children. Of the 306 children identified as high-risk, 12.4% had neonatal iron deficiency. Those with neonatal iron deficiency had higher median [IQR] CBCL internal (9.0 [5.3,12.0] vs. 5.0 [3.0,10.0]), external (7.5 [4.0,14.8] vs. 5.0 [2.0,10.0]) and total problem (24.5 [15.3,40.8] vs. 16.0 [10.0,30.0], all P < 0.05) scores at 5 years compared to those without neonatal deficiency. This adverse effect was especially apparent in children of obese mothers (n = 85) who were iron deficient at birth, with a total problem score at 5 years of 42.0 [24.5,54.5] compared to 16.0 [8.8,29.3] in those not deficient (P = 0.008). Associations were robust to adjustment for confounding factors. No effect on cognition or intelligence at 2 or 5 years was observed in this cohort. This study has identified behavioural consequences of neonatal iron deficiency. Interventions targeting the fetal/neonatal period could, therefore, represent a key opportunity for prevention of iron deficiency and its associated long-term neurological consequences. A dual approach is required, comprising public health strategies targeting prevention, through improving nutrition and health in women, and the development of screening strategies for early detection of iron deficiency in new-borns.

Pengaruh Verifikasi Data Nasabah Kredit UMKM dan Nilai yang Diberikan untuk Menghindari Kredit Bermasalah

Variable used for this study consists of two variables independent that is Data Verification Influence of Micro, Small, and Medium Business Credit and Value Of Guarantees Provided with one variable dependent that is Avoid Problem Loans. Period of research conducted on quarterly financial statements from 2016-2017. Method used in this research is descriptive method. This study intend to find out the effect of verifying the exact data and value of guarantee provided by the debtor capable to avoid problem loans in the future. The study results showed that consumers verification data and the type of guarantee able to make debtor avoid problem loans, it proven from decreased number of total problem loans during 2016 – 2017, although total credit still increase significant.

Critical Thinking and Problem-Solving Skills of Visually Impaired Female National Judo Team Athletes

A high level of critical thinking and problem-solving skills in visually impaired female national judo team athletes is an important factor in increasing their performance and for their high performance. The aim of this study was to examine critical thinking and problem-solving skills of visually impaired female national judo team athletes. The sample of the study was composed of visually impaired female athletes (n=15) in 2015 national team. A Personal Information Form, the California Critical Thinking Disposition Inventory and the Problem Solving Inventory were used as data collection tools. The data obtained in this study were analyzed using SPSS 17 software. Evaluation of the data analysis revealed that there was no statistically significant difference among groups in total Problem Solving Inventory and Critical Thinking Disposition Inventory scores in terms of age group or age of starting judo (p>0.05). There was no statistically significant relationship between total problem-solving and total critical thinking disposition scores of athletes (p>0.05). As a result, judo coaches are thought to play an important role in the development of strategies for increasing athletes’ problem-solving and critical thinking skills and in the development of their sporting performance, particularly in the development of high performance.

Impact of Family Functioning on Classroom Problem Behavior of Children With Emotional and Behavioral Disorders in Special Education

This study examined the relation between family functioning and classroom problem behavior of children with emotional and behavioral disorders receiving special educational support. To this end, the Teachers’ Report Form and the Family Questionnaire were completed for 84 children ( M age of 9.8 years) 2 times with a time lag of 11 months. Cross-lagged path analyses showed that internalizing and externalizing problem behavior in the classroom were stable over time, just as poor family functioning. Continuity of (a) poor communication, (b) discordant partner relationship, and (c) lack of social support were strongly associated with future total problem behavior in the classroom. Furthermore, parental responsiveness to a child’s needs was associated with lower future total problem behavior. A direct association was also found between externalizing behavior in the classroom and future poor family functioning. Implications of these findings for future research and practice are discussed.

Surface Layer Composition Change under Irreversible Conditions of Particle Beam Action

The simple isothermal problem is formulated to describe the composition of surface layer change during particle beam action. The finiteness of relaxation time for mass flux is taken into account. The analytical solutions for some limiting cases are presented. Numerical solution of total problem is carried out. It is shown that concentration distributions for reactants and for reaction product depend on relation between various physical scales.