A Clinical Case of Aplastic Anemia After COVID-19 Infection

Aplastic anemia is a rare disease of the blood system characterized by suppression of hematopoiesis in all lines of hematopoiesis, replacement of hematopoietic tissue with fatty tissue and absence of other causes or diseases that can suppress hematopoiesis. The incidence is 2-3 cases per 1 million population per year in the regions of Europe and America, rates are 2-3 times higher in East Asia. The disease most often begins between the ages of 10 and 25 years and over 60 years. The etiology remains unknown in 70-80 % of cases. The frequency of acquired cases predominates over congenital cases. The triggering factors can be chemical, physical exposures, medications, and viral infections. This case report describes a case of a patient developing aplastic anemia, as a result of a coronavirus infection.

Pulsed magnetic field impact on adaptation and vegetation of strawberry microplants (Fragaria×ananassa Duch.)

Microplant adaptation to non-sterile conditions is critical in clonal micropropagation providing for plant establishment and the overall method efficiency. Various techniques are employed to facilitate microplant establishment, including physical exposures like pulsed magnetic field. The study aimed to investigate the effect of pulsed magnetic field on establishment during adaptation to non-sterile conditions and subsequent vegetation of adapted strawberry plants. Research focused on strawberry microplants of the Tsaritsa and Nashe Podmoskovye cultivars originated by the All-Russian Horticultural Institute for Breeding, Agrotechnology and Nursery. Magnetic pulse treatment (MPT) was carried out with an AMIS-8 magnetic stimulator developed at the Institute. A positive impact of some MPT modes on microplant establishment, leaf and stolon formation was registered during strawberry adaptation to non-sterile conditions. Relatively low frequencies of 0.8-21 Hz exerted best effect in strawberry for most criteria. MPT contributed to an 11.5 % improvement in microplant establishment in Nashe Podmoskovye and 23.1 % — in Tsaritsa cultivars vs. no treatment. In best MPT assays, the number of leaves increased by 9.2—15.4 % and of stolons — 6.2-6.5 times in adapted strawberry plants compared to control. No significant inter-varietal differences were observed in Nashe Podmoskovye and Tsaritsa for vegetation criteria during adaptation to non-sterile conditions.

Modeling the Multidimensional Predictors of Multisite Musculoskeletal Pain Across Adulthood—A Generalized Estimating Equations Approach

Background: Multisite pain is commonly chronic and often lacks its initial role as a potential tissue damage signal. Chronic pain among working-age individuals is a risk for disability and imposes a major burden on health care systems and society. As effective treatments for chronic pain are largely lacking, better identification of the factors associated with pain over working years is needed.Methods: Members of the Northern Finland Birth Cohort 1966 participated in data collection at the ages of 31 (n = 4,028) and 46 (n = 3,429). Using these two time points, we performed a multivariable analysis of the association of socioeconomic, occupational, psychological and lifestyle factors (i.e., low education, living alone, low household income, unemployment, occupational physical exposures [hard physical labor, leaning forward, back twisting, constant moving, lifting loads of ≥ 1 kg], physical inactivity, regular smoking, regular drinking, overweight, and psychiatric symptoms) with the number of musculoskeletal pain sites (i.e., upper extremity, lower extremity, lower back, and the neck-shoulder region; totalling 0–4 pain sites). The data were analyzed using generalized estimating equations.Results: At the age of 31, multisite pain was reported by 72.5% of men and 78.6% of women. At the age of 46, the prevalence of multisite pain was 75.7% among men and 82.7% among women. Among men, the number of pain sites was positively associated with age (rate ratio 1.05, 95% confidence interval 1.01–1.08), low household income (1.05, 1.01–1.08), unemployment (1.13, 1.06–1.19), any occupational exposure (1.17, 1.12–1.22), regular smoking (1.06, 1.02–1.11), and psychiatric symptoms (1.21, 1.17–1.26). Among women, the number of pain sites was positively associated with age (1.06, 1.04–1.10), unemployment (1.10, 1.05–1.15), any occupational exposure (1.10, 1.06–1.13), regular smoking (1.06, 1.02–1.10), overweight (1.08, 1.05–1.11), and psychiatric symptoms (1.19, 1.15–1.22); living alone was negatively associated with the number of pain sites (0.95, 0.91–0.99).Conclusion: Of the studied predictors, psychiatric symptoms, occupational physical exposures and unemployment were most strongly associated with multisite pain among both sexes. The results of this study deepen the understanding of the underlying factors of and comorbidities behind multisite pain, and help develop pain relief and rehabilitation strategies for working-age individuals with multisite pain.

The Exposome in the Era of the Quantified Self

Human health is regulated by complex interactions among the genome, the microbiome, and the environment. While extensive research has been conducted on the human genome and microbiome, little is known about the human exposome. The exposome comprises the totality of chemical, biological, and physical exposures that individuals encounter over their lifetimes. Traditional environmental and biological monitoring only targets specific substances, whereas exposomic approaches identify and quantify thousands of substances simultaneously using nontargeted high-throughput and high-resolution analyses. The quantified self (QS) aims at enhancing our understanding of human health and disease through self-tracking. QS measurements are critical in exposome research, as external exposures impact an individual's health, behavior, and biology. This review discusses both the achievements and the shortcomings of current research and methodologies on the QS and the exposome and proposes future research directions.

Between Two Rocks and in a Hard Place: Reflecting on the Biomechanical Basis of Shoulder Occupational Musculoskeletal Disorders

Objective The aim was to review the biomechanical origins of occupational shoulder damage, while considering the complexity of shoulder mechanics and musculoskeletal consequences of diverse task demands. Background Accessible measures of physical exposures are the primary focus of occupational shoulder assessments and analyses. This approach has led to guidelines and intervention strategies that are often inadequate for mitigating shoulder disorders amongst the complexity of modern workplace demands. Integration of complex shoulder mechanics into occupational assessments, analyses, and interventions is critical for reducing occupational shoulder injury risk. Method This narrative review describes shoulder biomechanics in the context of common injury mechanisms and consequent injuries, with a particular focus on subacromial impingement syndrome. Several modulators of shoulder injury risk are reviewed, including fatigue, overhead work, office ergonomics considerations, and pushing and pulling task configurations. Results Relationships between work requirements, muscular demands, fatigue, and biomechanical tissue loads exist. This review highlights that consideration of specific workplace factors should be integrated with our knowledge of the intricate arrangement and interpersonal variability of the shoulder complex to proactively evaluate occupational shoulder demands and exposures. Conclusion A standard method for evaluating shoulder muscle exposures during workplace tasks does not exist. An integrated approach is critical for improved work design and prevention of shoulder tissue damage and accompanying disability. Application This review is particularly relevant for researchers and practitioners, providing guidance for work design and evaluation for shoulder injury prevention by understanding the importance of the unique and complex mechanics of the shoulder.