Safety and immunogenicity of the BBIBP-CorV vaccine in adolescents aged 12-17 years in Thai population, prospective cohort study.

Introduction: COVID-19 pandemic affects all populations worldwide, including adolescents. Adolescents can develop a severe form of COVID-19, especially with comorbidity underlying. The prior studies of the mRNA COVID-19 vaccine showed excellent effectiveness in adolescents. Therefore, this study aimed to evaluate the safety and effectiveness of the BBIBP-CorV vaccine with the immunobridging approach in Thai adolescents. Methods: This single-center, prospective cohort study compared the immunogenicity after 2 doses of the BBIBO-CorV vaccine with 21 days interval of participants aged 12-17 years with 18-30 years at Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand. The key eligible criteria were healthy or had stable pre-existing comorbidity participants, aged 12-17 years. The primary endpoint was the anti-receptor binding domain antibody concentration at 4 weeks after dose 2 of the vaccine. In addition, safety profiles were solicited adverse events within 7 days after each dose of vaccine and any adverse events through 1 month after dose 2 of the vaccine. Results: Four weeks after the second vaccination, the GMC of anti-RBD antibody in the adolescent cohort was 102.9 BAU/mL (95%CI; 91.0-116.4) and 36.9 BAU/mL (95%CI; 30.9-44.0) in the adult cohort. The GMR of the adolescent cohort was 2.79 (95%CI; 2.25-3.46, p-value; <0.0001) compared with the adult cohort which met non-inferiority criteria. The reactogenicity was slightly less reported in the adolescent cohort compared with the adult cohort. No serious adverse events were reported in both cohorts. Conclusion: Vaccination with the BBIBP-CorV vaccine in the adolescent participants was safe and effective.

Association Between Diet and Acne Severity: A Cross-sectional Study in Thai Adolescents and Adults

The association between diet and acne has been growing in concern. Every country has its own food culture. A few studies surveyed the influence of Asian cuisine on acne. This study investigated the association between acne severity and diet/lifestyle factors in 2,467 Thai adolescents and adults. The data were collected from the validated semi-quantitative food frequency questionnaire. The prevalence of mild acne was 52%, moderate acne was 22%, and 8% severe acne in Thai adolescents and adults. No acne was found in 18% of participants. The dietary factors associated with increased acne severity were the consumption of chocolate >100 grams/weeks (aOR, 1.29; 95% CI, 1.07-1.56), oily and fried food >3 times/week (aOR, 1.84; 95% CI, 1.07-3.16) and white rice (aOR, 1.80; 95% CI, 1.24-2.63). On the contrary, the factors associated with decreased acne severity were the consumption of sugar-free tea (aOR, 0.61; 95% CI, 0.43-0.87), and vegetables (aOR, 0.74; 95% CI, 0.62-0.89).

Thai Adolescent’s Scale of Flourishing During the COVID-19 Pandemic Analysed by the Subjective Well-Being (SWB)

The Coronavirus has been introduced to Thailand for almost 2 years. Students were forced to take online classes in order to gain social distance. As it is well known, adolescents had the highest levels of satisfaction with friends and with self. Due to this occurrence, many students are at risk of mental challenges, likely due to unexpected life changes. The research aims to analyze subjective well-being (SWB) and to compare the data to other studies. The Flourishing Scale of 8 uniform questionnaires by Diener et. al. (2009) is used as a measurement to conduct the research as a major research tool in 507 Thai adolescent participants aged 12-19 years old. The level of psychological well-being and respondent's selfperceived success in important areas such as relationships, self-esteem, purpose, and optimism were quantified and performed. The Flourishing Scale scores in relevant research, enable the researchers to signify the contrast in the level of subjective well-being in Thai- adolescents according to the COVID-19 existence. As a result, the mean of the subjective wellbeing of the Flourishing Scale in Thai adolescence was 37.22 which is one of the lowest scores so far compared to the previous research investigated before the pandemic of the Coronavirus. It can be found that young adolescents are showing a decline in psychological resources and strength compared to the previous years which should be carefully inspected by adults and mental health-related professionals.

Resting-state EEG datasets of adolescents with mild, minimal, and moderate depression

Objectives To measure depressive severity of 85 Thai adolescents by using the the Beck Depression Inventory-II and the Patient Health Questionnaire-9 and to record the resting-state EEG of these participants. Data description The current data note provides raw data of behavioral (i.e., group, BDI-II score, and PHQ-9 score) and electrophysiological parameters (i.e., absolute and relative EEG powers over 64 electrode sites) of 30, 27, and 28 participants with minimal, mild, and moderate depression, respectively. These data are especially useful to investigate the behavioral and electrophysiological markers of adolescents with subclinical depression. It can also be utilized in comparative analysis among age groups, and races.

Social Skills Training Using the Thai Version of UCLA PEERS® in Thai Adolescents with Autism Spectrum Disorder

Objective: To study the feasibility and effectiveness of the Thai version of UCLA PEERS® in Thai adolescents with autism spectrum disorder (ASD).Materials and Methods: The UCLA PEERS® was modified to fit with Thai culture. Twelve adolescents, aged 11-19 years old, with ASD participated in this modified 10-session weekly group intervention during March to October 2015 at Siriraj Hospital, Bangkok, Thailand. Feasibility was assessed by parent satisfaction and session attendance rate. Effectiveness was assessed by social skills improvement rated by parents, Vineland Adaptive Behavior Scales (VABS), the Children’s Depression Inventory (CDI), and the Clinical Global Impression-Improvement Scale (CGI-I).Results: All enrolled participants completed the study. Parents’ satisfaction with the program was 81.92%. The session attendance rates ranged from 83.3 to 100%. At the end of intervention, all of the skills trained in the program were rated as improved by at least half of parents. At 4-month follow-up, all but two skills (entering conversation and handling bullying) were still reported as improved by more than 50% of parents. VABS raw scores significantly increased in the domain of communication (95% confidence interval (CI): -2.25 to -0.89; p=0.036), daily living skills (95% CI: -3.70 to -0.47; p=0.016), and socialization (95% CI: -1.77 to -0.40; p=0.005), and significantly decreased in maladaptive behaviors domain (95% CI: 0.24 to 2.10; p=0.002). Six adolescents had CGI-I scores of very much improved or much improved.Conclusion: The Thai version of UCLA PEERS® is a feasible and effective social skills intervention for Thai adolescents with ASD.

A causal model for health-related quality of life among Thai adolescents with congenital heart disease

PurposeThe objective of this study was to examine the causal relationships among sex, social support, disease severity, symptoms, physical activity, general health perception and health-related quality of life (HRQOL) in Thai adolescents with congenital heart disease (CHD).Design/methodology/approachA cross-sectional study was conducted using convenience sampling to recruit 200 Thai adolescents with CHD aged between 13 and18 years from four tertiary university hospitals in Bangkok. Interview method and self-administered questionnaires were used for data collection held between November 2018 and February 2019. Data were analyzed using path analysis to test the hypothesized model of the relationships.FindingsThe causal model of HRQOL revealed a good fit with the data. This model of relationship could explain 48% of the variances in HRQOL. Only direct effects of disease severity, symptoms and social support on HRQOL were found while indirect effects were not.Originality/valueDue to the lack of study focusing on factors influencing HRQOL in Thai adolescents with CHD, this empirical study provides the evidence in Thai literature. The modifiable influencing factors for HRQOL found in this study can be manipulated through psycho-educational intervention given to the adolescents and significant others, especially parents, to help increase quality of life in adolescents with CHD.

Effect of a purpose in life program on the wellness of Southern Thai adolescents

PurposeThe study aimed to examine the effect of a purpose in life (PIL) program on the wellness of Thai adolescents.Design/methodology/approachTwo schools located in municipalities in southern Thailand were selected by simple random sampling. Students from each school were randomly allocated to either an experimental group (n = 35) or a control group (n = 32). The experimental group received the PIL program for 16 weeks. The control group received the routine education program. Participants' wellness was measured using the Wellness Scale (WS). The WS was validated for content validity by five Thai experts and tested for reliability with 30 junior high school students, yielding the Cronbach's alpha coefficient of 0.84. The differences in the mean score of wellness across time were analyzed using repeated measures ANOVA.FindingsThe mean scores of wellness of the experimental group and the control group were statistically significantly different across time (p < 0.001). Post hoc tests in the experimental group showed a statistically significant difference in the mean scores of wellness between Week 1 and Week 16, Week 1 and Week 20 and Week 16 and Week 20 (p < 0.05). In the control group, the results showed a statistically significant difference in the mean scores of wellness between Week 1 and Week 20 and Week 16 and Week 20 (p < 0.05).Originality/valueThe PIL program, originally developed within a Thai context and focused on the spiritual dimension, was effective in enhancing the wellness of Thai adolescents.

Metabolic syndrome in Thai adolescents and associated factors: the Thai National Health Examination Survey V (NHES V)

Background Presence of metabolic syndrome (MetS) in early life may influence cardiovascular outcome later in adulthood. There is limited data regarding MetS among Thai adolescents. This study aimed to estimate the prevalence of MetS and related factors in Thai adolescents. Methods Data on MetS components of 1934 Thai adolescents aged 10–16 years were obtained from the 5th National Health Examination Survey. Age at first screen time exposure, duration of screen time, frequency of food intake and physical activities were collected from interviews. MetS was defined according to 3 definitions: International Diabetes Federation (IDF), Cook’s, and de Ferranti’s. Results The prevalence of MetS was 4.1% by IDF, 8.0% by Cook’s, and 16.8% by de Ferranti’s definition. The overall prevalence was higher in male (19.0%) than female adolescents (15.3%). The most common MetS components composition among Thai adolescents was high waist circumference with high serum triglyceride and low HDL-cholesterol (40.0% for IDF, 22.6% for Cook’s and 43.5% for de Ferranti’s definition). Exposure to screen media during the first 2 years of life had a 1.3- fold increased odds of MetS by 1 out of 3 definitions (OR 1.30, 95% CI. 1.01–1.68). Duration of physical activity associated with decreased odds of MetS by Cook’s definition (OR 0.96, 95% CI. 0.92–0.99). Conclusions The prevalence of MetS among Thai adolescents was higher than previously reported by other studies. Screen media exposure during the first 2 years of life should be discouraged and measures to promote physical activity among children and adolescents should be strengthen.