Simultaneous Determination of Florfenicol and Diclazuril in Compound Powder by RP-HPLC-UV Method

A RP-HPLC-UV method was developed and validated for simultaneous determination of florfenicol and diclazuril in compound powder. The separation involved using a SinoChoom ODS-BP C18(5 μm, 4.6 mm × 250 mm) analytical column. The mobile phase was a mixture of acetonitrile-0.2% phosphoric acid (pH was adjusted to 3.0 with triethylamine). The ratio of acetonitrile and 0.2% phosphoric acid in the mobile phase was 60 : 40 (v/v) from 0 minutes to 6 minutes and 70 : 30 (v/v) from 6.1 minutes to 15 minutes. The flow rate was 1 mL/min. The temperature of the analytical column was maintained at 30°C. The detection was monitored at 225 nm and 277 nm for florfenicol and diclazuril, respectively. The excipients in the compound powder did not interfere with the drug peaks. The calibration curves of florfenicol and diclazuril were fairly linear over the concentration ranges between 50.0–500.0 μg/mL (r=0.9995) and 10.0–100.0 μg/mL (r=0.9992), respectively. The RSD of both the intraday and interday variations was below 2.1% for florfenicol and diclazuril. The method was successfully validated according to International Conference on Harmonisation and proved to be suitable for the simultaneous determination of florfenicol and diclazuril in compound powder.

Preparation and Properties of Tourmaline/Chitosan Composite Powder

Chitosan has good biocompatibility and physiological activity, tourmaline possesses characteristics of generation of anion, reduction of water molecular beam and emission of far infrared radiation, so the two composite materials will hopefully possesses the two excellent properties, thus show good application prospect in the biomedical and cosmetic field. Experiment utilized chitosan as wrapped base material, adopt method of suspension solution compound precipitation to manufacture chitosan/tourmaline compound powder, using XRD, SEM, IR and other means to represent powders prepared, and the experimental results show that the synthetic compound powder with irregular granular, chitosan wrapped tourmaline well, the composite of tourmaline and chitosan is physical composite, with the increment of tourmaline , the degree of crystallization of chitosan in compound powder weaken, the composite powder has good absorptive and preservative liquid ability.

Effect of Calcination Temperature on Phase Transformation and Microstructure of Al2O3/GdAlO3 Compound Powder Prepared by Co-Precipitation Method

A Coprecipitation Method Was Applied to Synthesize Al2O3/GdAlO3 Compound Powder, Using Ammonia as the Precipitator. Gadolinium Oxide and Aluminium Nitrate Were Used as the Raw Materials with the Eutectic Ratio( 77 mol% Al 3+ – 23 mol% Gd 3+ ). the Precursor Was Calcined at Different Temperatures from 1200 to 1600 °C. the Phase Identifications at Different Temperatures Were Characterized by X-ray Diffractometry (XRD). the Growth Morphology of Particles Were Investigated Using Field Emission Electro Microscopy (FE-SEM). the Results Reveal that GdAlO3 Crystallized Earlier than α-Al2O3. the Diffraction Peaks of α-Al2O3 Phase Were Observed after Calcination at 1300°C for 1 H. Metastable Phase Gd3Al5O12 Underwent Complete Decomposition at 1600°C for 1 H. Gadolinium Aluminate and α-Al2O3 Showed Different Growth Mechanism during the Calcination Process. the Average Grain Size of the Calcined Powder Increased from ~40 to ~900 Nm as the Calcination Temperature Increased from 1200 to 1600 °C.