Senescent tumor cells: an overlooked adversary in the battle against cancer

Senescent cells in cancer tissue, including senescent fibroblasts and macrophages, have been reported to increase the malignant potency of cancer cells by secreting senescence-associated secretory phenotype (SASP). Otherwise, Senescence of tumor cells has been believed to inhibit tumor growth by halting the massive proliferation and increasing the chances of immune clearance. In particular, senescent tumor cells (STCs) have been thought that they rarely exist in carcinomas because oncogene-induced senescence needs to be overcome for protumorigenic cells to become malignant. However, recent studies have revealed that a considerable number of STCs are present in cancer tissue, even in metastatic sites. In fact, STCs are widely involved in cancer progression by leading to collective invasion and building a cytokine barrier to protect nonsenescent tumor cells from immune attack. Furthermore, therapy-induced STCs can induce tumor progression and recurrence by increasing stemness. However, obscure causative factors and their heterogeneity in various cancers make it difficult to establish the physiological role of STCs. Here, we summarize and review the current knowledge of the pathophysiology and role of STCs. We also outline the current status of therapeutic strategies for directly removing STCs or modulating the SASPs to maximize the positive functions of STCs while suppressing the negative functions.

Applications of new contraction mappings on existence and uniqueness results for implicit ϕ-Hilfer fractional pantograph differential equations

In this paper, we consider initial value problems for two different classes of implicit ϕ-Hilfer fractional pantograph differential equations. We use different approach that is based on $\alpha -\psi $ α − ψ -contraction mappings to demonstrate the existence and uniqueness of solutions for the proposed problems. The mappings are defined in appropriate cones of positive functions. The presented examples demonstrate the efficiency of the used method and the consistency of the proposed results.

On Some Fractional Integral Inequalities Involving Caputo–Fabrizio Integral Operator

In this paper, we deal with the Caputo–Fabrizio fractional integral operator with a nonsingular kernel and establish some new integral inequalities for the Chebyshev functional in the case of synchronous function by employing the fractional integral. Moreover, several fractional integral inequalities for extended Chebyshev functional by considering the Caputo–Fabrizio fractional integral operator are discussed. In addition, we obtain fractional integral inequalities for three positive functions involving the same operator.

Effect of swearing on strength: Disinhibition as a potential mediator

Introduction: Swearing fulfils positive functions including benefitting pain relief and physical strength. Here we present three experiments assessing a possible psychological mechanism, increased state disinhibition, for the effect of swearing on physical strength. Method: Three repeated measures experiments were carried out with sample sizes N=56, N=63 and N=118. All three included the Balloon Analogue Risk Task (BART) to measure risky behaviour. Experiments 1 and 3 included measures of physical performance assessing, respectively, grip and arm strength. Experiment 3, which was pre-registered, additionally assessed flow, self-confidence, anxiety, emotion including humour, and distraction including novelty.Results: Experiments 1 and 3 found that repeating a swear word benefitted physical strength and increased risky behaviour, but risky behaviour did not mediate the strength effect. Experiment 2 showed no effect of listening to an audio track of a repeated swear word. Experiment 3 found that repeating a swear word increased flow, self-confidence, positive emotion, humour and distraction. Humour mediated the effect of swearing on physical strength. Discussion: Consistent effects of swearing on physical strength indicate that this is a reliable effect. Swearing affected several constructs related to state disinhibition including increased self-confidence. Humour appeared to mediate the effect of swearing on physical strength, consistent with a hot cognitions explanation of swearing-induced state disinhibition. However, as this mediation effect was part of an exploratory analysis, further pre-registered experimental research including validated measures of humour is required.

Generalized proportional fractional integral functional bounds in Minkowski’s inequalities

In this research paper, we improve some fractional integral inequalities of Minkowski-type. Precisely, we use a proportional fractional integral operator with respect to another strictly increasing continuous function ψ. The functions used in this work are bounded by two positive functions to get reverse Minkowski inequalities in a new sense. Moreover, we introduce new fractional integral inequalities which have a close relationship to the reverse Minkowski-type inequalities via ψ-proportional fractional integral, then with the help of this fractional integral operator, we discuss some new special cases of reverse Minkowski-type inequalities through this work. An open issue is covered in the conclusion section to extend the current findings to be more general.

Generics in society

ABSTRACTThis article examines two interrelated issues: (i) how considering generics within their social contexts of use contributes to theories of generics, and (ii) how contemporary work on generics provides promising directions for the study of language as an aspect of social life. Examining the function of generics in meaningful interactions stands in contrast to standard treatments, which consider generics as isolated, context-free propositions. Additionally, recent psychological approaches suggest new questions that can enrich sociolinguistic and linguistic anthropological research. These include, for example, when and why generics serve not just negative functions (such as stereotyping) but also positive functions (such as meaning-making), how generics gain their power from what is unstated as opposed to stated, and how generic language distorts academic writing. Ultimately, the study of language in society has the potential to enrich the study of generics beyond what has been learned from their study in linguistics, philosophy, and psychology. (Generics, concepts, categories, stereotyping, induction)*

Microorganisms as vital additives in Waste Management

Microorganisms play necessary roles within the maintenance of the many natural and synthetic development within the environment. They serve positive functions that build life easier and higher for man. one in every of such areas that microorganism’s area unit adopted is in waste management. the right disposal of the voluminous waste that humans generate in their daily activities may be a nice challenge that government and environmental agencies area unit unceasingly seeking higher ways that of addressing. a crucial method of with success combating this menace is thru the utilization of microorganisms. Thus, this paper examines the varied applications of microorganisms within the management of municipal waste. It reviews the varied roles of microorganisms within the atmosphere, like in waste product and soil treatment, energy generation, oil spillage and hot contamination. It conjointly discusses waste generation and management ways, and a few specific uses of microorganisms (bacteria, fungi, algae, virus and protozoa) in waste management. It concludes by light some recent advances in microbiological waste management.

Clostridium butyricum Induces the Production and Glycosylation of Mucins in HT-29 Cells

C. butyricum is a common gut commensal bacterium, which has many positive functions in human intestine. In this study, we investigated the effects of monosaccharide and its derivatives on the adhesion of C. butyricum to the mucus of HT-29 cells. RNA interference was performed to assess the roles of MUC2 and glycan in the adhesion of C. butyricum to HT-29 cells. The effects of C. butyricum on the glycosylation of mucins were assayed with fluorescence microscope. The expression levels of mucins and glycotransferases were also determined. The results showed that C. butyricum could adhere to the mucins secreted by HT-29 cells. Several kinds of monosaccharides inhibited the adhesion of C. butyricum to HT-29 cells, which suggested that the mucus glycan was the attaching sites of this bacterium. Knockdown of MUC2, FUT2 or GALNT7 significantly decreased the numbers of the bacteria adhering to HT-29 cells. When colonizing on the surface of HT-29 cells, C. butyricum could increase the production of mucins, promote the expression of glycotransferase, and induce the glycosylation of mucins. These results demonstrated that the glycan of mucus played important roles in the adhesion of C. butyricum to HT-29 cells. This study indicates for the first time that C. butyricum possesses the ability to modulate the glycosylation profile of mucus secreted by HT-29 cells. These findings contribute to understanding the mechanism of interaction between colonic epithelial cells and commensal bacteria.

Research frameworks, methodologies, and assessment methods concerning the adaptive reuse of architectural heritage: a review

With the growing trend towards preserving global architectural heritage, the adaptive reuse of built heritage buildings is becoming increasingly popular; as commentators have noted, this popularity can in part be attributed to the economic, cultural, and social benefits they provide to urban communities. In considering adaptive reuse, urban developers and planners seek to reach an equilibrium in the battle between time and space. Both academically and practically, the adaptive reuse of heritage buildings requires compatible, appropriate, and scientific means for assessing built heritage assets; however, currently, research in this area is still relatively meagre. To address this gap, this paper investigates research frameworks, methodologies, and assessment methods that concern the adaptive reuse of architectural heritage. In this paper, we examine the current literature on the paradigms for applying mixed methodologies: the multi-criteria decision model (MCDM) and the preference measurement model (PMM). Specifically, in examining the extant literature, we explore the ways in which these methods are discussed, compared, and evaluated, and the positive functions of these methods are also highlighted. In addition, this review examines a range of cases to better clarify the research frameworks, methodologies, and assessment methods used in the study of the adaptive reuse of architectural heritage.

The dictatorship of bureaucratic ideology in modern school culture

The article presents the results of a study of the infuence of bureaucracy values on the functioning and development of a modern educational organization and, in particular, on its management, due to the traditionally conservative intention of the cultural activities of legitimate bearers of power. Analyzing the reasons for the bureaucratization of school management, the authors believes that they are determined both by the mental parameters of the value preferences of Russians and by changes in the political environment, stating the defeat of the democratic orientation of school life. Hypertrophied «with the load of all sorts of nonsense and absurd ideas» (N. A. Khrenov), bureaucratic culture, bringing to life previously unthinkable forms in education management, ceases to perform positive functions, destroying the value- existential meanings of school communication, pushing pedagogical creativity to the periphery, disrupting parity of values as parity of cultures. The methodological basis of the study, within which the methods of theoretical and empirical research were used: interdisciplinary analysis of scientifc literature, analytical interview, written survey, is an axiological approach that allows us to consider the current space of bureaucratic culture, in accordance with the norms of which the local reformatting of the school value system is carried out. The empirical basis of the scientifc work was the materials of the study of the problems of bureaucratization of education, prepared by undergraduates of the Department of General and Professional Pedagogy of Orenburg State University. In 2019, an anonymous written survey of teachers and heads of educational organizations of the Orenburg region and the Republic of Bashkortostan was conducted, in which 1457 people took part. The problem of bureaucratization of school management is relevant both in theoretical and applied terms, since the provision of normal life of an institutionally united school community depends on the degree of its development.