Comparison of seven modelling algorithms for GABA-edited 1H-MRS

Edited MRS sequences are widely used for studying GABA in the human brain. Several algorithms are available for modelling these data, deriving metabolite concentration estimates through peak fitting or a linear combination of basis spectra. The present study compares seven such algorithms, using data obtained in a large multi-site study. GABA-edited (GABA+, TE = 68 ms MEGA-PRESS) data from 222 subjects at 20 sites were processed via a standardised pipeline, before modelling with FSL-MRS, Gannet, AMARES, QUEST, LCModel, Osprey and Tarquin, using standardised vendor-specific basis sets (for GE, Philips and Siemens) where appropriate. After referencing metabolite estimates (to water or creatine), systematic differences in scale were observed between datasets acquired on different vendors' hardware, presenting across algorithms. Scale differences across algorithms were also observed. Using the correlation between metabolite estimates and voxel tissue fraction as a benchmark, most algorithms were found to be similarly effective in detecting differences in GABA+. An inter-class correlation across all algorithms showed single-rater consistency for GABA+ estimates of around 0.38, indicating moderate agreement. Upon inclusion of a basis set component explicitly modelling the macromolecule signal underlying the observed 3.0 ppm GABA peaks, single-rater consistency improved to 0.44. Correlation between discrete pairs of algorithms varied, and was concerningly weak in some cases. Our findings highlight the need for consensus on appropriate modelling parameters across different algorithms, and for detailed reporting of the parameters adopted in individual studies to ensure reproducibility and meaningful comparison of outcomes between different studies.

Comparative Analysis and Enhancement of CFG-based Hardware-Assisted CFI Schemes

Subverting the flow of instructions (e.g., by use of code-reuse attacks) still poses a serious threat to the security of today’s systems. Various control flow integrity (CFI) schemes have been proposed as a powerful technique to detect and mitigate such attacks. In recent years, many hardware-assisted implementations of CFI enforcement based on control flow graphs (CFGs) have been presented by academia. Such approaches check whether control flow transfers follow the intended CFG by limiting the valid target addresses. However, these papers all target different platforms and were evaluated with different sets of benchmark applications, which makes quantitative comparisons hardly possible. For this paper, we have implemented multiple promising CFG-based CFI schemes on a common platform comprising a RISC-V within FPGA. By porting almost 40 benchmark applications to this system we can present a meaningful comparison of the various techniques in terms of run-time performance, hardware utilization, and binary size. In addition, we present an enhanced CFI approach that is inspired by what we consider the best concepts and ideas of previously proposed mechanisms. We have made this approach more practical and feature-complete by tackling some problems largely ignored previously. We show with this fine-grained scheme that CFI can be achieved with even less overheads than previously demonstrated.

Robust, Universal Tree Balance Indices

Balance indices that quantify the symmetry of branching events and the compactness of trees are widely used to compare evolutionary processes or tree-generating algorithms. Yet existing indices have important shortcomings, including that they are unsuited to the tree types commonly used to describe the evolution of tumours, microbial populations, and cell lines. The contributions of this article are twofold. First, we define a new class of robust, universal tree balance indices. These indices take a form similar to Colless’ index but account for node sizes, are defined for trees with any degree distribution, and enable more meaningful comparison of trees with different numbers of leaves. Second, we show that for bifurcating and all other full m-ary cladograms (in which every internal node has the same out-degree), one such Colless-like index is equivalent to the normalised reciprocal of Sackin’s index. Hence we both unify and generalise the two most popular existing tree balance indices. Our indices are intrinsically normalised and can be computed in linear time. We conclude that these more widely applicable indices have potential to supersede those in current use.

Tribochemistry, Mechanical Alloying, Mechanochemistry: What is in a Name?

Over the decades, the application of mechanical force to influence chemical reactions has been called by various names: mechanochemistry, tribochemistry, mechanical alloying, to name but a few. The evolution of these terms has largely mirrored the understanding of the field. But what is meant by these terms, why have they evolved, and does it really matter how a process is called? Which parameters should be defined to describe unambiguously the experimental conditions such that others can reproduce the results, or to allow a meaningful comparison between processes explored under different conditions? Can the information on the process be encoded in a clear, concise, and self-explanatory way? We address these questions in this Opinion contribution, which we hope will spark timely and constructive discussion across the international mechanochemical community.

A Benchmark Environment for Neuromorphic Stereo Vision

Without neuromorphic hardware, artificial stereo vision suffers from high resource demands and processing times impeding real-time capability. This is mainly caused by high frame rates, a quality feature for conventional cameras, generating large amounts of redundant data. Neuromorphic visual sensors generate less redundant and more relevant data solving the issue of over- and undersampling at the same time. However, they require a rethinking of processing as established techniques in conventional stereo vision do not exploit the potential of their event-based operation principle. Many alternatives have been recently proposed which have yet to be evaluated on a common data basis. We propose a benchmark environment offering the methods and tools to compare different algorithms for depth reconstruction from two event-based sensors. To this end, an experimental setup consisting of two event-based and one depth sensor as well as a framework enabling synchronized, calibrated data recording is presented. Furthermore, we define metrics enabling a meaningful comparison of the examined algorithms, covering aspects such as performance, precision and applicability. To evaluate the benchmark, a stereo matching algorithm was implemented as a testing candidate and multiple experiments with different settings and camera parameters have been carried out. This work is a foundation for a robust and flexible evaluation of the multitude of new techniques for event-based stereo vision, allowing a meaningful comparison.

Cobalt catalyzed isomerization of alkenes

Catalytic isomerization of alkenes is a highly atom-economical approach to upgrade from lower- to higher-value alkenes. Consequently, tremendous attention has been devoted to the development of this transformation, approaches which exploit cobalt-catalysis are particularly attractive. This short review focuses on the cobalt-catalyzed alkene isomerization, including positional isomerization, geometric isomerization and cycloisomerization. Three main types of reaction mechanism have been discussed to help the reader to better understand and make meaningful comparison between the different transformations. 1 Introduction 2 Positional isomerization 3 Geometric isomerization 4 Cycloisomerization 5 Conclusion and Outlook

A Systematic Review of the Methods of Assessment of Gastro-Oesophageal Reflux in Anaesthetized Dogs

We reviewed the definitions and methods of assessment of gastro-oesophageal reflux (GOR) in anaesthetized dogs. Three databases were used. Titles and abstracts were screened by two of the authors independently. A total of 22 studies was included in the analysis. The definition of GOR implied the presence of fluids not reaching the mouth or nose in the oesophagus in all studies. Most studies considered a change in pH using oesophageal pH meters as the sole method of assessment. Calibration of the pH probe was inconsistently reported. The position of the tip of the oesophageal probe was inconsistent and not always precisely described. The correct positioning in the intended location was verified in a limited number of studies. Some studies considered that GOR had happened for changes in pH below 4.0 or above 7.5 while others considered that GOR had happened when the pH dropped below 4.0 only. Some studies stated that the pH change had to be sustained for a minimum period of time (20 or 30 s) whereas others did not mention any duration. The variability of definitions and methods of assessment of GOR in anaesthetized dogs precludes meaningful comparison of the findings. Re-evaluation and uniformization of the methods appear necessary.

Introduction

This chapter introduces how the book compares the allied health professions, both as a collective and as individual disciplines, in Australia and the UK. Australia and the UK were chosen as a basis for comparison because the allied health professions have emerged in each jurisdiction from similar philosophies, regulatory structures and training approaches, which allows meaningful comparison. The different funding and system contexts provide a comparative basis to understand the impact of different features on allied health professionalisation. It starts from the position of the similarities between the allied health contexts in both countries. Politically, neo-liberalism has been influential in driving the healthcare funding models and accountabilities in both nations, though different healthcare funding systems have facilitated varied flexibilities within the allied health workforces in each context. The modern allied health professions were heavily shaped by the formal organisation of labour that emerged within the colonies of the British Empire as a result of the Industrial Revolution. This book is largely focused on the way in which the allied health professions have emerged and developed within a Western context.

Friedrich Richard Ulbricht’s Kugelphotometer

With the rapid development of many new and varied sources of light in the 19th century—Argand lamps of different designs and which burned various fuels, Carcel lamps, stearin candles, paraffin candles, and spermaceti candles, electric arc lamps, Drummond lamps, incandescent lamps with various filaments, Nernst glowbars, and many others —some method was needed to compare their output. But with the sources varying in spectral content and the angular distribution of the light, how could a meaningful comparison be made? After various fruitless attempts were made to concentrate the light onto a uniform region a surprisingly simple solution was proposed.