Compact Itinerant Microwave Photonics with Superconducting High-Kinetic Inductance Microstrips

Microwave photonics is a remarkably powerful system for quantum simulation and technologies, but its integration in superconducting circuits, superior in many aspects, is constrained by the long wavelengths and impedance mismatches in this platform. We introduce a solution to these difficulties via compact networks of high-kinetic inductance microstrip waveguides and coupling wires with strongly reduced phase velocities. We demonstrate broadband capabilities for superconducting microwave photonics in terms of routing, emulation and generalized linear and nonlinear networks.

Three Perceptual Tools for Seeing and Understanding Visualized Data

The visual system evolved and develops to process the scenes, faces, and objects of the natural world, but people adapt this powerful system to process data within an artificial world of visualizations. To extract patterns in data from these artificial displays, viewers appear to use at least three perceptual tools, including a tool that extracts global statistics, one that extracts shapes within the data, and one that produces sentence-like comparisons. A better understanding of the power, limits, and deployment of these tools would lead to better guidelines for designing effective data displays.

Universe of the mind of the mass musical culture XX century

The article deals with the system of signs developed in the mass musical culture of the XX century. Analyzing the specifics of mass musical culture, the author notes that the factors of social and urban development of society, technological innovations, and trends in the visualization of culture as the main means of communication in various formats, including within the semiotic system of mass music of the XX century, are determining for it in the XX century. The types of signs are analyzed: iconic, index, symbolic, represented within the semiotic system of mass music. The author concludes, that the semiosphere of mass musical culture covers verbal and nonverbal, kinesthetic signs, representing a powerful system of multi-dimensional communication of subjects of the communication process in the conditions of modern post-industrial culture.

How to align arthropod leg segments

How to align leg segments between the four groups of arthropods (insects, crustaceans, myriapods, and chelicerates) has tantalized researchers for over a century. By comparing the loss-of-function phenotypes of leg patterning genes in diverged arthropod taxa, including a crustacean, insects, and arachnids, arthropod legs can be aligned in a one-to-one fashion. By comparing the expression of pannier and aurucan, the proximal leg segments can be aligned. A model is proposed wherein insects and myriapods incorporated the proximal leg region into the body wall, which moved an ancestral exite (for example, a gill) on the proximal leg into the body wall, where it invaginated independently in each lineage to form tracheae. For chelicerates with seven leg segments, it appears that one proximal leg segment was incorporated into the body wall. According to this model, the chelicerate exopod and the crustacean exopod emerge from different leg segments, and are therefore proposed to have arisen independently. A framework for how to align arthropod appendages now opens up a powerful system for studying the origins of novel structures, the plasticity of developmental fields across vast phylogenetic distances, and the convergent evolution of shared ancestral developmental fields.

Prospects for the use of artificial intelligence systems in gastroenterology

The lecture is devoted to a new direction in clinical medicine — the possibility of using artificial intelligence — the field of computer science, which is engaged in modeling the method of acquiring and using knowledge specific to humans. The basis for a correct diagnosis is a combination of experience, the ability to think and act non-standard in difficult cases. A powerful system of generalization and classification, implemented in intelligent systems, allows you to reduce a huge number of possible situations to a small number of typical situations by which decisions or hypotheses are formed.

Conserved actin machinery drives microtubule-independent motility and phagocytosis in Naegleria

Much of our understanding of actin-driven phenotypes in eukaryotes has come from the “yeast-to-human” opisthokont lineage and the related amoebozoa. Outside of these groups lies the genus Naegleria, which shared a common ancestor with humans >1 billion years ago and includes the “brain-eating amoeba.” Unlike nearly all other known eukaryotic cells, Naegleria amoebae lack interphase microtubules; this suggests that actin alone drives phenotypes like cell crawling and phagocytosis. Naegleria therefore represents a powerful system to probe actin-driven functions in the absence of microtubules, yet surprisingly little is known about its actin cytoskeleton. Using genomic analysis, microscopy, and molecular perturbations, we show that Naegleria encodes conserved actin nucleators and builds Arp2/3–dependent lamellar protrusions. These protrusions correlate with the capacity to migrate and eat bacteria. Because human cells also use Arp2/3–dependent lamellar protrusions for motility and phagocytosis, this work supports an evolutionarily ancient origin for these processes and establishes Naegleria as a natural model system for studying microtubule-independent cytoskeletal phenotypes.

A Unified Framework to Homologize Appendage Segments across Arthropoda

How to align leg segments between the four groups of arthropods (insects, crustaceans, myriapods, and chelicerates) has tantalized researchers for over a century. By comparing the loss-of-function phenotypes of leg patterning genes in diverged arthropod taxa, including a crustacean, insects, and spiders, we show that all arthropod legs can be aligned in a one-to-one fashion. We propose a model wherein insects incorporated two proximal leg segments into the body wall, which moved the ancestral leg lobe (exite) up onto the back to later form wings. For myriapods and chelicerates with seven leg segments, it appears that one proximal leg segment was incorporated into the body wall. According to this model, the chelicerate exopod and the crustacean exopod emerge from different leg segments, and are therefore proposed to have arisen independently. A framework for how to align arthropod appendages now opens up a powerful system for studying the origins of novel structures, the plasticity of developmental fields, and convergent evolution.

Metaphysics, Epistemology, and Ethics

This chapter provides an overview of Zhu Xi’s metaphysics epistemology, and ethics, with the aim of providing the basic foundations of his philosophical system. It explains how he developed, shaped, and codified earlier Confucian views about issues such as the relationship between pattern-principle and qi, the character of human nature, and proper course of learning into a new and powerful system of philosophy that could claim to continue the earlier Confucian tradition, address a range of pressing contemporary practical social and political problems, and offer an attractive and appealing alternative to Daoism and Buddhism.

Mayall: A Framework for Desktop JavaScript Auditing and Post-Exploitation Analysis

Writing desktop applications in JavaScript offers developers the opportunity to create cross-platform applications with cutting-edge capabilities. However, in doing so, they are potentially submitting their code to a number of unsanctioned modifications from malicious actors. Electron is one such JavaScript application framework which facilitates this multi-platform out-the-box paradigm and is based upon the Node.js JavaScript runtime—an increasingly popular server-side technology. By bringing this technology to the client-side environment, previously unrealized risks are exposed to users due to the powerful system programming interface that Node.js exposes. In a concerted effort to highlight previously unexposed risks in these rapidly expanding frameworks, this paper presents the Mayall Framework, an extensible toolkit aimed at JavaScript security auditing and post-exploitation analysis. This paper also exposes fifteen highly popular Electron applications and demonstrates that two-thirds of applications were found to be using known vulnerable elements with high CVSS (Common Vulnerability Scoring System) scores. Moreover, this paper discloses a wide-reaching and overlooked vulnerability within the Electron Framework which is a direct byproduct of shipping the runtime unaltered with each application, allowing malicious actors to modify source code and inject covert malware inside verified and signed applications without restriction. Finally, a number of injection vectors are explored and appropriate remediations are proposed.