Avoiding the Interaction between S-protein of SARS-CoV-2 and ACE2, to Develop an Adjuvant Antiviral by Molecular Docking

The COVID-19 pandemic continues today without specific treatment; different treatments have been proposed during this pandemic. This study proposes to develop a new drug by molecular docking, using a library of compounds, almost 500,000 compounds directed to interact in the region between the amino acids (Lys417, Tyr453, Gly496, Gln498, Thr500, Gly502, and Tyr505) in the RBD in S-protein of SARS-CoV-2, to develop a new adjuvant antiviral against COVID-19. It selected ten compounds by molecular docking with a high probability to interact in the specific region in the RBD of SARS-CoV-2 (Lys417, Tyr453, Gly496, Gln498, Thr500, Gly502, and Tyr505), to reduce the interaction with the ACE2. Also, these compounds have a high probability of being safe in humans, validated by web servers of prediction of ADME and toxicity (PreADMET) to develop a new specific adjuvant antiviral against COVID-19.

Teler Real-time HTTP Intrusion Detection at Website with Nginx Web Server

Web servers and web-based applications are now widely used, but in this case, the crime rate in cyberspace has also increased. Crime in cyberspace can occur due to the exploitation of how a system works. For example, the way HTTP works are exploited to weaken the webserver. Various tools for attacking the internet are also starting to be easy to find, but so are the tools to detect these attacks. One of the useful tools for detecting attacks and sending warnings against threats is based on the weblogs on the webserver. Many have not reviewed Teler as an intrusion detection system on HTTP on web servers because the existing tools are relatively new. Teler detecting the weblog and run on the terminal with rule resources collected from the community. So here, the researcher tries to implement the use of Teler in detecting HTTP intrusions on a Nginx-based web server. Intrusion is carried out in attacks commonly used by attackers, for example, port scanning and directory brute force using the Nmap and OWASP ZAP tools. Then the detection results will be sent via the Telegram bot to the server admin. From the results of the experiments conducted, it has been found that Teler is still classified as being able to send warning notifications with a delay between the time of detection and the time when the alert is received, no more than 3 seconds.

Campus Network and Systems Security Assessment Using Penetration Testing: The Case of the University of Education Winneba, Kumasi

Network intruders are becoming more sophisticated in their approach, resulting in many difficulties in preventing them. They exploit both well-configured systems and vulnerable systems. Aims: To examines the performance of a campus network against attacks on the network systems. Place and Duration of Study: University of Education, Winneba- Kumasi campus. Methodology: Penetration testing was adopted to investigate the vulnerabilities that may occur in a university network. This helps to test for vulnerabilities on the network system that may expose the system to exploits. Results: The test revealed that system-based attacks might be propelled by malignant pariahs on the Internet and noxious insiders straightforwardly associated with inward systems. The perpetrators can exploit vulnerabilities in network foundations and frameworks, for example, servers (web servers, software servers, file and mail servers, etc.), routers, and firewalls. Conclusion: This work presents a way to deal with evaluating the security stance of a college utilizing penetration testing that meddles negligibly with the flow of traffic and activities on the network infrastructure. attack Insurance against network-based attacks is mind-boggling and, in the offer, to relieving one framework normally gives a stage that can be utilized to dispatch more attacks.

In-vitro Cytotoxicity and In-silico Insights of the Multi-target Anticancer Candidates from Haplophyllum tuberculatum

This study aimed to investigate the anticancer activity of Haplophyllum tuberculatum(Forsk.) aerial parts ethanol extract and fractions and reveal the potential anticancer targets, binding modes, pharmacokinetics, and toxicity properties of its phytoconstituents. MTT assay was used to investigate the anticancer activity. TargetNet, ChemProt version 2.0, and CLC-Pred web servers were used for virtual screening, and Cresset Flare software was used for molecular docking with the 26 predicted targets. Moreover, pkCSM, swiss ADME, and eMolTox web servers were used to predict pharmacokinetics and safety. Ethanolic extracts of H. tuberculatum on HepG2 and HeLa cell lines showed promising activities with IC50 values 54.12 and 48.1 µg/mL, respectively. Further, ethyl acetate fraction showed the highest cytotoxicity on HepG2 and HeLa cell lines with IC50 values 41.7 and 52.31 µg/mL. Of 70 compounds screened virtually, polygamain, justicidin A, justicidin B, haplotubine, kusunokinin, and flindersine were predicted as safe anticancer drugs candidates. They showed the highest binding scores with targets involved in cell growth, proliferation, survival, migration, tumor suppression, induction of apoptosis, metastasis, and drug resistance. Our findings revealed the potency of H. tuberculatum as a source of anticancer candidates that further studies should support.

PEMBUATAN FILE SYSTEM GLUSTERFS DISTRIBUTED- REPLICATED VOLUME DI SEKOLAH VOKASI IPB UNIVERSITY

College of Vocational IPB University (SV-IPB) uses a client-server system as an information technology architecture. The server provides several services that are used to assist the teaching and learning process at the IPB Vocational School. The application used to provide services is the Modular Object-Oriented Dynamic Learning Environment (MOODLE) which is used for e-learning. SV-IPB provides two Virtual Machines which are used as a web server and a database server. The use of a single web server to replace the request is certainly less stable because there is no web server to back it up so that the service will stop. This situation states that the use of a single web server does not have high information (high available). To overcome this problem, the cluster technology can be used to group several web servers in SV-IPB. The web server clustering technology used is the Gluster File System (GlusterFS) with the volume type used, namely Distributed-replicated volume. Based on the tests that have been carried out, this project can solve the problem that has been described earlier that "one web server is down, there is still another web server that can so that the client request process does not stop. In addition, the clustering technology used is required for the use of load balancing web servers so that it can reduce the load on each server because the request process will be sent alternately between web servers.

Lightron : A GUI Integrated, Rust Based Web Server

Day by day, the number of users are increasing on the internet and the web servers need to cater to the requests constantly, also if compared to the past years this year, due to a global pandemic and lockdown in various countries, the requests on the web have surged exponentially. The complexity of configuring a web server is also increasing as the development continues. In this paper, we propose a Lightron web server, which is highly scalable and can cater many requests at a time. Additionally, to ease users from the configuration of the web server we introduced Graphical User Interface which is beginner friendly.