Improving specificity of the musical mood induction procedure.

The musical mood induction procedure was used to induce 3 negative moods: sadness, fatigue and anxiety. Induction was validated using subjective and physiological measures. One hundred twenty-seven participants listened to one of 18 film soundtrack excerpts for 20 minutes. Physiological response (heart rate, respiration, skin conductance level (SCL), and facial electromyography) was recorded throughout the induction and postinduction phases. Subjective mood ratings (sadness, anxiety, tiredness, valence, arousal) were provided before induction and throughout the postinduction phase. Repeated measures ANOVAs showed increase in valence and decrease in arousal in all conditions after induction, which persisted in the postinduction phase, and an increase in tiredness immediately after induction. Reduction in SCL was strongest in the fatigue condition. However, difference between groups was only evident when comparing fatigue and sadness conditions between 3-10 minutes. Lack of between-group differences and mixed physiological findings suggest that specificity is difficult to achieve through musical mood induction.

Improving specificity of the musical mood induction procedure.

The musical mood induction procedure was used to induce 3 negative moods: sadness, fatigue and anxiety. Induction was validated using subjective and physiological measures. One hundred twenty-seven participants listened to one of 18 film soundtrack excerpts for 20 minutes. Physiological response (heart rate, respiration, skin conductance level (SCL), and facial electromyography) was recorded throughout the induction and postinduction phases. Subjective mood ratings (sadness, anxiety, tiredness, valence, arousal) were provided before induction and throughout the postinduction phase. Repeated measures ANOVAs showed increase in valence and decrease in arousal in all conditions after induction, which persisted in the postinduction phase, and an increase in tiredness immediately after induction. Reduction in SCL was strongest in the fatigue condition. However, difference between groups was only evident when comparing fatigue and sadness conditions between 3-10 minutes. Lack of between-group differences and mixed physiological findings suggest that specificity is difficult to achieve through musical mood induction.

Anxiety makes time pass quicker: neural correlates

Anxiety can be an adaptive process that promotes harm avoidance. It is accompanied by shifts in cognitive processing, but the precise nature of these changes and the neural mechanisms that underlie them are not fully understood. One theory is that anxiety impairs concurrent (non-harm related) cognitive processing by commandeering finite neurocognitive resources. For example, we have previously shown that anxiety reliably ‘speeds up time’, promoting temporal underestimation, possibly due to loss of temporal information. Whether this is due anxiety ‘overloading’ neurocognitive processing of time is unknown. We therefore set out to understand the neural correlates of this effect, examining whether anxiety and time processing overlap, particularly in regions of the cingulate cortex. Across two studies (an exploratory Study 1, N=13, followed by a pre-registered Study 2, N=29) we combined a well-established anxiety manipulation (threat of shock) with a temporal bisection task while participants were scanned using functional magnetic resonance imaging. Consistent with our previous work, time was perceived to pass more quickly under induced anxiety. Anxiety induction led to widespread activation in cingulate cortex, while the perception of longer intervals was associated with more circumscribed activation in a mid-cingulate area. Importantly, conjunction analysis identified convergence between anxiety and time processing in the insula and mid-cingulate cortex. These results provide tentative support for the hypothesis that anxiety impacts cognitive processing by overloading already-in-use neural resources. In particular, overloading mid-cingulate cortex capacity may drive emotion-related changes in temporal perception, consistent with the hypothesised role of this region in mediating cognitive affective and behavioural responses to anxiety.

The role of ritual behaviour in anxiety reduction: an investigation of Marathi religious practices in Mauritius

While the occurrence of rituals in anxiogenic contexts has been long noted and supported by ethnographic, quantitative and experimental studies, the purported effects of ritual behaviour on anxiety reduction have rarely been examined. In the present study, we investigate the anxiolytic effects of religious practices among the Marathi Hindu community in Mauritius and test whether these effects are facilitated by the degree of ritualization present in these practices. Seventy-five participants first experienced anxiety induction through the public speaking paradigm and were subsequently asked to either perform their habitual ritual in a local temple (ritual condition) or sit and relax (control condition). The results revealed that participants in the ritual condition reported lower perceived anxiety after the ritual treatment and displayed lower physiological anxiety, which was assessed as heart-rate variability. The degree of ritualization in the ritual condition showed suggestive albeit variable effects, and thus further investigation is needed. We conclude the paper with a discussion of various mechanisms that may facilitate the observed anxiolytic effects of ritual behaviour and should be investigated in the future. This article is part of the theme issue ‘Ritual renaissance: new insights into the most human of behaviours’.

Does Coloring Reduce Anxiety? Comparing the Psychological and Psychophysiological Benefits of Coloring Versus Drawing

In this study, we compared the psychological and psychophysiological benefits of coloring to drawing as a means of distraction versus expression. Participants were 60 undergraduates who experienced an anxiety induction. We then randomly assigned them to color a design, draw a design (distract), or draw to express their negative thoughts and feelings. Anxiety was measured before and after the anxiety induction and after drawing. Heart rate, respiratory sinus arrhythmia, and skin conductance were measured throughout the testing session. Finally, participants completed a flow and enjoyment questionnaire. All three activities reduced anxiety and decreased heart rate and increased respiratory sinus arrhythmia with no differences across conditions. Those in the draw a design condition enjoyed the activity more than those in the draw to express condition. We conclude that drawing, regardless of emotion regulation strategy used, reduces anxiety but that distracting graphic activities result in more enjoyment.

The impact of threat of shock-induced anxiety on the neural substrates of memory encoding and retrieval

Dysfunctional memory processes are widely reported in anxiety disorders, but the underlying neurocognitive mechanisms are unclear. Recent work shows that the impact of anxiety on memory depends on the context and memory modality. For instance, threat of shock, a translational within-subject anxiety induction, has been shown to impair the encoding of facial stimuli, while improving spatial working memory (WM) accuracy. The present study aimed to delineate the neural circuitry regulating these opposing behavioural effects. Thirty-three healthy volunteers performed the previously assessed facial recognition and a spatial WM tasks inside an fMRI scanner, under alternating within-subject conditions of threat or safe from shock across encoding and retrieval. Facial recognition impairments were replicated when threat was selectively induced at encoding. Neuroimaging results suggest that this effect was driven by increased competition for attentional resources within the anterior cingulate cortex, in which activation correlated positively with stress levels. The impact of threat on spatial WM performance did not, however, replicate in the fMRI environment. Nevertheless, state-dependent hippocampal activation was observed in both tasks. These findings suggest a neurocognitive mechanism by which anxiety impairs facial recognition as well as a state-dependent hippocampal activation pattern, which may putatively underline retrieval of negative experiences in anxiety.

Translating a rodent measure of negative bias into humans: the impact of induced anxiety and unmedicated mood and anxiety disorders

BackgroundMood and anxiety disorders are ubiquitous but current treatment options are ineffective for many sufferers. Moreover, a number of promising pre-clinical interventions have failed to translate into clinical efficacy in humans. Improved treatments are unlikely without better animal–human translational pipelines. Here, we translate a rodent measure of negative affective bias into humans, exploring its relationship with (1) pathological mood and anxiety symptoms and (2) transient induced anxiety.MethodsAdult participants (age = 29 ± 11) who met criteria for mood or anxiety disorder symptomatology according to a face-to-face neuropsychiatric interview were included in the symptomatic group. Study 1 included N = 77 (47 = asymptomatic [female = 21]; 30 = symptomatic [female = 25]), study 2 included N = 47 asymptomatic participants (25 = female). Outcome measures were choice ratios, reaction times and parameters recovered from a computational model of reaction time – the drift diffusion model (DDM) – from a two-alternative-forced-choice task in which ambiguous and unambiguous auditory stimuli were paired with high and low rewards.ResultsBoth groups showed over 93% accuracy on unambiguous tones indicating intact discrimination, but symptomatic individuals demonstrated increased negative affective bias on ambiguous tones [proportion high reward = 0.42 (s.d. = 0.14)] relative to asymptomatic individuals [0.53 (s.d. = 0.17)] as well as a significantly reduced DDM drift rate. No significant effects were observed for the within-subjects anxiety-induction.ConclusionsHumans with pathological anxiety symptoms directly mimic rodents undergoing anxiogenic manipulation. The lack of sensitivity to transient anxiety suggests the paradigm might be more sensitive to clinically relevant symptoms. Our results establish a direct translational pipeline (and candidate therapeutics screen) from negative affective bias in rodents to pathological mood and anxiety symptoms in humans.

Analysis of female novice extroversion driver’s eye movement characteristics under anxiety

Anxiety is a common emotion of driver, which always affects the safety of driving. Eye movement characteristics can be used to understand the true emotion state of human beings. It is of great significance to study the law of eye movement for realizing active vehicle safety warning and human–machine cooperation. In this article, anxiety-induction experiment, real-vehicle driving experiments, and virtual driving experiments were designed and used to obtain the eye movement data of female novice extroversion driver under calm and anxiety, and mathematical statistics analysis was made on the fixation count, fixation duration, and visit duration in the area of interest within the driver horizon. The results showed that there are significant differences in fixation count and fixation duration of drivers ([Formula: see text], p is the accompanying probability), and the main effect of emotion is significant [Formula: see text].Compared with the situation of calm, fixation area, fixation count, and fixation duration of drivers under anxiety were more focused on the middle area, the fixation count and visit duration on the left area were relatively more, the fixation duration on the right area was relatively longer, and anxiety was more likely to cause driver’s attention bias.

Alterations in the amplitude and burst distribution of sensorimotor beta oscillations impair reward-dependent motor learning in anxiety

Anxiety results in sub-optimal motor performance and learning; yet, the precise mechanisms through which these modifications occur remain unknown. Using a reward-based motor sequence learning paradigm, we show that concurrent and prior anxiety states impair learning by biasing estimates about the hidden performance goal and the stability of such estimates over time (volatility). In an electroencephalography study, three groups of participants completed our motor task, which had separate phases for motor exploration (baseline) and reward-based learning. Anxiety was manipulated either during the initial baseline exploration phase or while learning. We show that anxiety induced at baseline reduced motor variability, undermining subsequent reward-based learning. Mechanistically, however, the most direct consequence of state anxiety was an underestimation of the hidden performance goal and a higher tendency to believe that the goal was unstable over time. Further, anxiety decreased uncertainty about volatility, which attenuated the update of beliefs about this quantity. Changes in the amplitude and burst distribution of sensorimotor and prefrontal beta oscillations were observed at baseline, which were primarily explained by the anxiety induction. These changes extended to the subsequent learning phase, where phasic increases in beta power and in the rate of long (> 500 ms) oscillation bursts following reward feedback were linked to smaller updates in predictions about volatility, with a higher anxiety-related increase explaining the biased volatility estimates. These data suggest that state anxiety alters the dynamics of beta oscillations during general performance, yet more prominently during reward processing, thereby impairing proper updating of motor predictions when learning in unstable environments.

The Effect of Gamification through a Virtual Reality on Preoperative Anxiety in Pediatric Patients Undergoing General Anesthesia: A Prospective, Randomized, and Controlled Trial

The use of gamification in healthcare has been gaining popularity. This prospective, randomized, clinical trial was designed to evaluate whether gamification of the preoperative process—via virtual reality (VR) gaming that provides a vivid, immersive and realistic experience—could reduce preoperative anxiety in children. Seventy children scheduled for elective surgery under general anesthesia were randomly divided into either the control or gamification group. Children in the control group received conventional education regarding the preoperative process, whereas those in the gamification group played a 5 min VR game experiencing the preoperative experience. Preoperative anxiety, induction compliance checklist (ICC), and procedural behavior rating scale (PBRS) were measured. Sixty-nine children were included in the final analysis (control group = 35, gamification = 34). Preoperative anxiety (28.3 [23.3–36.7] vs. 46.7 [31.7–51.7]; p < 0.001) and intraoperative compliance measured using ICC (p = 0.038) were lower in the gamification group than in the control group. However, PBRS (p = 0.092) and parent/guardian satisfaction (p = 0.268) were comparable between the two groups. VR experience of the preoperative process could reduce preoperative anxiety and improve compliance during anesthetic induction in children undergoing elective surgery and general anesthesia.