adhesion system
Recently Published Documents


TOTAL DOCUMENTS

133
(FIVE YEARS 13)

H-INDEX

25
(FIVE YEARS 1)

2022 ◽  
Vol 218 ◽  
pp. 105294
Author(s):  
Guoyang Liu ◽  
Junfang Xia ◽  
Kan Zheng ◽  
Jian Cheng ◽  
Kaixuan Wang ◽  
...  

Author(s):  
Wei Wang ◽  
Yang Liu ◽  
Zongwu Xie

AbstractGecko has the ability to climb flexibly on various natural surfaces because of its fine layered adhesion system of foot, which has motivated researchers to carry out a lot of researches on it. Significant progresses have been made in the gecko-like dry adhesive surfaces in the past 2 decades, such as the mechanical measurement of adhesive characteristics, the theoretical modeling of adhesive mechanism and the production of synthetic dry adhesive surfaces. Relevant application researches have been carried out as well. This paper focuses on the investigations made in recent years on the gecko-like dry adhesive surfaces, so as to lay the foundation for further research breakthroughs. First, the adhesion system of gecko’s foot and its excellent adhesive characteristics are reviewed, and the adhesive models describing the gecko adhesion are summarily reviewed according to the different contact modes. Then, some gecko-like dry adhesive surfaces with outstanding adhesive characteristics are presented. Next, some application researches based on the gecko-like dry adhesive surfaces are introduced. Finally, the full text is summarized and the problems to be solved on the gecko-like dry adhesive surfaces are prospected.


Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1415
Author(s):  
Shanshan Chen ◽  
Changping Deng ◽  
Wenyun Zheng ◽  
Shihui Li ◽  
Yuping Liu ◽  
...  

Cannabidiol (CBD), a primary bioactive phytocannabinoid extracted from hemp, is reported to possess potent anti-tumorigenic activity in multiple cancers. However, the effects of CBD on bladder cancer (BC) and the underlying molecular mechanisms are rarely reported. Here, several experiments proved that CBD promoted BC cells (T24, 5637, and UM-UC-3) death. For example, T24 cells were treated with 12 µM CBD for 48 h, flow cytometry analysis demonstrated that early and late apoptotic cells were accounted for by 49.91%, indicating CBD enhanced cell apoptosis ability. To deeper explore molecular mechanisms, the CBD-treated T24 cell transcriptome libraries were established. KEGG analysis implied that the significantly changed genes were enriched in the PI3K/Akt pathway. qRT-PCR and Western blot assays verified that CBD regulated BC cells growth and migration and induced apoptosis by inactivating the PI3K/Akt pathway. Meanwhile, the developed chitosan to wrap CBD-loaded PLGA nanoparticles can significantly enhance the adhesion of the material to the mouse bladder wall, and the binding efficiency of mucin to chitosan-PLGA nanoparticles reached 97.04% ± 1.90%. In summary, this work demonstrates that CBD may become a novel reliable anticancer drug and the developed intravesical adhesion system is expected to turn into a potential means of BC chemotherapy drug delivery.


Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1117
Author(s):  
Miguel Hernando ◽  
Virgilio Gómez ◽  
Alberto Brunete ◽  
Ernesto Gambao

Adhesion systems are very important in robots for infrastructure inspection (especially in vertical walls). They present the challenge of optimizing the ratio vacuum/power consumption in battery-powered robots. In this paper, a CFD (computer fluid dynamics) modelling and optimization process of a robot adhesion system is carried out to determine the best performing configuration in terms of vacuum and power consumption. Analytical and numerical models were developed to predict the behaviour of the system for different configurations. The models were validated, using test rig measurements, by calibrating an arbitrary defined inlet height that simulates the leakage flow. Then, different geometric parameters were varied to determine the best performing configuration based on the vacuum/power consumption ratio value. The model presented in the paper was capable of predicting the behaviour of the system for different configurations, with a margin of error of 15% for the vacuum prediction and 25% for the motor power calculation. Finally, the model was used to optimize parameters of the system, like the number of blades of the impeller. The adhesion system was conceived for the modular autonomous climbing legged robot ROMERIN.


Author(s):  
Miguel Hernando ◽  
Virgilio Gómez ◽  
Alberto Brunete ◽  
Ernesto Gambao

Adhesion systems are very important in robots for infrastructure inspection (especially in vertical walls). They present the challenge of optimizing the ratio vacuum/power consumption in battery-powered robots. In this paper a CFD (Computer Fluid Dynamics) modelling and optimization process of a robot adhesion system is carried out to determine the best performing configuration in terms of vacuum and power consumption. Analytical and numerical models were developed to predict the behaviour of the system for different configurations. The models were validated, using test rig measurements, by calibrating an arbitrary defined inlet height that simulates the leakage flow. Then, different geometric parameters were varied to determine the best performing configuration based on the vacuum/power consumption ratio value. The model presented in the paper was capable of predicting the behaviour of the system for different configurations, with a margin of error of 15% for the vacuum prediction and a 25% for the motor power calculation. Finally, the model was used to optimize parameters of the system, like the number of blades of the impeller. The adhesion system was conceived for the modular autonomous climbing legged robot ROMERIN.


2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Norihiro Iijima ◽  
Katsuhiko Sato ◽  
Erina Kuranaga ◽  
Daiki Umetsu

AbstractMaintaining lineage restriction boundaries in proliferating tissues is vital to animal development. A long-standing thermodynamics theory, the differential adhesion hypothesis, attributes cell sorting phenomena to differentially expressed adhesion molecules. However, the contribution of the differential adhesion system during tissue morphogenesis has been unsubstantiated despite substantial theoretical support. Here, we report that Toll-1, a transmembrane receptor protein, acts as a differentially expressed adhesion molecule that straightens the fluctuating anteroposterior compartment boundary in the abdominal epidermal epithelium of the Drosophila pupa. Toll-1 is expressed across the entire posterior compartment under the control of the selector gene engrailed and displays a sharp expression boundary that coincides with the compartment boundary. Toll-1 corrects local distortions of the boundary in the absence of cable-like Myosin II enrichment along the boundary. The reinforced adhesion of homotypic cell contacts, together with pulsed cell contraction, achieves a biased vertex sliding action by resisting the separation of homotypic cell contacts in boundary cells. This work reveals a self-organizing system that integrates a differential adhesion system with pulsed contraction of cells to maintain lineage restriction boundaries.


Sign in / Sign up

Export Citation Format

Share Document