This chapter describes the role of reprocessing cell layout design in reducing the material handling cost at the used product post-disassembly stage. The chapter begins with the discussion of material handling cost issues encountered at the reusable parts reprocessing phase. Then, related studies in the literature are discussed in the background section. Next, the focal problem of this chapter is stated in the problem statement section. A detailed description about the approach (i.e., the hybrid ant system) can be found in the proposed methodology section. Right after this, an illustrative numerical example and the corresponding comparison study are detailed in the experimental study section. The potential research directions regarding the main problem considered in this chapter are highlighted in the future trends section. Finally, the conclusion drawn in the last section closes this chapter.