In the current conditions of unstable financial situation in the world, the most important task should be to increase the efficiency of agricultural production, which is the basis of the country's stability. The introduction of project management in the agro-industrial sector can become a growth point not only for individual organizations, but also for the economy of the region as a whole. The purpose of this study is to develop practical recommendations for using project activities in the management of the agricultural sector at the regional level. In studying the project management problem, the following methods were used: general scientific methods for analyzing science works, methods of systemic, comparative analysis, abstract-logical, expert-analytical and sociological methods. The algorithm of university's project activities implementation, on the basis of which its strategic goals are achieved, is considered in detail. A model of modern agricultural project management at the regional level is presented; its problems and solutions are identified. The effect of introducing project-oriented activities in the agricultural sector at the regional level, as well as the need to improve the economic mechanism for developing agriculture in the region, is substantiated. The results of the study are consistent with the hypothesis put forward. In accordance with it, the proposed measures will contribute to the effective implementation of project-oriented management in the regional economy of the agro-industrial complex on the part of factors of managing agricultural sector in the region. The implementation of the proposed development areas will significantly improve existing methods of managing the agro-industrial complex of the region, since the introduction of project management will allow not only to concentrate financial and managerial resources, but also to obtain sustainable indicators of agricultural development.